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Protein

D(1A) dopamine receptor

Gene

Drd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
  • drug binding Source: RGD
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  • associative learning Source: RGD
  • behavioral response to cocaine Source: RGD
  • calcium-mediated signaling Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • dopamine receptor signaling pathway Source: RGD
  • intracellular protein transport Source: RGD
  • locomotory behavior Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of cell migration Source: RGD
  • negative regulation of circadian sleep/wake cycle, sleep Source: RGD
  • negative regulation of protein kinase activity Source: RGD
  • operant conditioning Source: RGD
  • orbitofrontal cortex development Source: RGD
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of adenylate cyclase activity Source: BHF-UCL
  • positive regulation of feeding behavior Source: RGD
  • positive regulation of long-term synaptic potentiation Source: RGD
  • positive regulation of membrane potential Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of ion transport Source: RGD
  • regulation of long-term neuronal synaptic plasticity Source: RGD
  • regulation of vasoconstriction Source: RGD
  • response to activity Source: RGD
  • response to amino acid Source: RGD
  • response to amphetamine Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to food Source: RGD
  • response to morphine Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • social behavior Source: RGD
  • striatum development Source: RGD
  • synapse assembly Source: BHF-UCL
  • synaptic transmission, dopaminergic Source: RGD
  • vasodilation Source: InterPro
  • visual learning Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:Drd1
Synonyms:Drd1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2518 Drd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 48Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini49 – 59CytoplasmicSequence analysisAdd BLAST11
Transmembranei60 – 86Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini87 – 95ExtracellularSequence analysis9
Transmembranei96 – 118Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 162Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi333F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication1
Mutagenesisi337F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication1
Mutagenesisi341F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL265
GuidetoPHARMACOLOGYi214

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693781 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteineBy similarity1
Lipidationi351S-palmitoyl cysteineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP18901

PTM databases

iPTMnetiP18901
PhosphoSitePlusiP18901

Expressioni

Tissue specificityi

Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.

Interactioni

Subunit structurei

Interacts with calcyon (By similarity). Interacts with DNAJC14 via its C-terminus.By similarity1 Publication

Protein-protein interaction databases

BioGridi246496, 4 interactors
CORUMiP18901
DIPiDIP-49024N
IntActiP18901, 2 interactors
STRINGi10116.ENSRNOP00000034820

Chemistry databases

BindingDBiP18901

Structurei

3D structure databases

ProteinModelPortaliP18901
SMRiP18901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP18901
PhylomeDBiP18901

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF
60 70 80 90 100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA
110 120 130 140 150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS
160 170 180 190 200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP
260 270 280 290 300
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
310 320 330 340 350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED
410 420 430 440
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST
Length:446
Mass (Da):49,428
Last modified:May 1, 1991 - v2
Checksum:i0380042E8590F470
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91L → F (PubMed:1402930).Curated1
Sequence conflicti93P → S (PubMed:1402930).Curated1
Sequence conflicti165A → T (PubMed:2168520).Curated1
Sequence conflicti190L → F (PubMed:2168520).Curated1
Sequence conflicti227R → G (PubMed:2168520).Curated1
Sequence conflicti253C → W (PubMed:2168520).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35077 mRNA Translation: AAA70428.1
S46131 Genomic DNA Translation: AAB23803.1
PIRiA36049 DYRTD1
UniGeneiRn.24039

Similar proteinsi

Entry informationi

Entry nameiDRD1_RAT
AccessioniPrimary (citable) accession number: P18901
Secondary accession number(s): P21669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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