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P18901

- DRD1_RAT

UniProt

P18901 - DRD1_RAT

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Protein

D(1A) dopamine receptor

Gene
Drd1, Drd1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. angiotensin receptor binding Source: RGD
  2. ATPase binding Source: RGD
  3. D3 dopamine receptor binding Source: RGD
  4. dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
  5. drug binding Source: RGD
  6. G-protein alpha-subunit binding Source: RGD
  7. G-protein coupled receptor activity Source: RGD
  8. protein binding Source: UniProtKB
  9. protein complex binding Source: RGD
  10. protein heterodimerization activity Source: RGD
  11. protein phosphatase binding Source: RGD
  12. receptor binding Source: RGD

GO - Biological processi

  1. activation of adenylate cyclase activity Source: BHF-UCL
  2. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  3. associative learning Source: RGD
  4. behavioral response to cocaine Source: RGD
  5. calcium-mediated signaling Source: RGD
  6. cellular response to hypoxia Source: RGD
  7. cellular response to insulin stimulus Source: RGD
  8. dopamine receptor signaling pathway Source: RGD
  9. intracellular protein transport Source: RGD
  10. locomotory behavior Source: RGD
  11. negative regulation of cell migration Source: RGD
  12. negative regulation of circadian sleep/wake cycle, sleep Source: RGD
  13. negative regulation of protein kinase activity Source: RGD
  14. operant conditioning Source: RGD
  15. orbitofrontal cortex development Source: RGD
  16. phosphatidylinositol catabolic process Source: BHF-UCL
  17. phosphatidylinositol metabolic process Source: BHF-UCL
  18. positive regulation of adenylate cyclase activity Source: BHF-UCL
  19. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  20. positive regulation of cAMP biosynthetic process Source: RGD
  21. positive regulation of feeding behavior Source: RGD
  22. positive regulation of long-term synaptic potentiation Source: RGD
  23. positive regulation of membrane potential Source: RGD
  24. regulation of ion transport Source: RGD
  25. regulation of long-term neuronal synaptic plasticity Source: RGD
  26. regulation of vasoconstriction Source: RGD
  27. response to activity Source: RGD
  28. response to amino acid Source: RGD
  29. response to amphetamine Source: RGD
  30. response to antidepressant Source: RGD
  31. response to drug Source: RGD
  32. response to estradiol Source: RGD
  33. response to ethanol Source: RGD
  34. response to food Source: RGD
  35. response to morphine Source: RGD
  36. response to nicotine Source: RGD
  37. response to organic cyclic compound Source: RGD
  38. response to organonitrogen compound Source: RGD
  39. response to retinoic acid Source: RGD
  40. response to steroid hormone Source: RGD
  41. social behavior Source: RGD
  42. striatum development Source: RGD
  43. synapse assembly Source: BHF-UCL
  44. synaptic transmission, dopaminergic Source: RGD
  45. vasodilation Source: InterPro
  46. visual learning Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:Drd1
Synonyms:Drd1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2518. Drd1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Extracellular Reviewed predictionAdd
BLAST
Transmembranei23 – 4826Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini49 – 5911Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei60 – 8627Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini87 – 959Extracellular Reviewed prediction
Transmembranei96 – 11823Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13719Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei138 – 16225Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini163 – 19230Extracellular Reviewed predictionAdd
BLAST
Transmembranei193 – 21826Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 27254Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei273 – 29927Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini300 – 31213Extracellular Reviewed predictionAdd
BLAST
Transmembranei313 – 33725Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini338 – 446109Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: RGD
  2. axon terminus Source: RGD
  3. caveola Source: RGD
  4. dendrite Source: RGD
  5. dendritic shaft Source: RGD
  6. dendritic spine Source: RGD
  7. dendritic spine head Source: RGD
  8. dendritic spine neck Source: RGD
  9. endoplasmic reticulum Source: RGD
  10. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  11. integral component of membrane Source: RGD
  12. integral component of plasma membrane Source: InterPro
  13. neuronal cell body Source: RGD
  14. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi333 – 3331F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication
Mutagenesisi337 – 3371F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication
Mutagenesisi341 – 3411F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446D(1A) dopamine receptorPRO_0000069378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 186 By similarity
Lipidationi347 – 3471S-palmitoyl cysteine By similarity
Lipidationi351 – 3511S-palmitoyl cysteine By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP18901.

Expressioni

Tissue specificityi

Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.

Gene expression databases

GenevestigatoriP18901.

Interactioni

Subunit structurei

Interacts with calcyon By similarity. Interacts with DNAJC14 via its C-terminus.1 Publication

Protein-protein interaction databases

BioGridi246496. 2 interactions.
DIPiDIP-49024N.
STRINGi10116.ENSRNOP00000034820.

Structurei

3D structure databases

ProteinModelPortaliP18901.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP18901.
KOiK04144.
PhylomeDBiP18901.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18901-1 [UniParc]FASTAAdd to Basket

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MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF    50
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA 100
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS 150
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL 200
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP 250
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 300
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL 350
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED 400
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST 446
Length:446
Mass (Da):49,428
Last modified:May 1, 1991 - v2
Checksum:i0380042E8590F470
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911L → F1 Publication
Sequence conflicti93 – 931P → S1 Publication
Sequence conflicti165 – 1651A → T1 Publication
Sequence conflicti190 – 1901L → F1 Publication
Sequence conflicti227 – 2271R → G1 Publication
Sequence conflicti253 – 2531C → W1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35077 mRNA. Translation: AAA70428.1.
S46131 Genomic DNA. Translation: AAB23803.1.
PIRiA36049. DYRTD1.
RefSeqiNP_036678.2. NM_012546.2.
UniGeneiRn.24039.

Genome annotation databases

GeneIDi24316.
KEGGirno:24316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35077 mRNA. Translation: AAA70428.1 .
S46131 Genomic DNA. Translation: AAB23803.1 .
PIRi A36049. DYRTD1.
RefSeqi NP_036678.2. NM_012546.2.
UniGenei Rn.24039.

3D structure databases

ProteinModelPortali P18901.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246496. 2 interactions.
DIPi DIP-49024N.
STRINGi 10116.ENSRNOP00000034820.

Chemistry

BindingDBi P18901.
ChEMBLi CHEMBL2096910.
GuidetoPHARMACOLOGYi 214.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P18901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24316.
KEGGi rno:24316.

Organism-specific databases

CTDi 1812.
RGDi 2518. Drd1.

Phylogenomic databases

eggNOGi NOG262978.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P18901.
KOi K04144.
PhylomeDBi P18901.

Miscellaneous databases

NextBioi 602967.
PROi P18901.

Gene expression databases

Genevestigatori P18901.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation."
    Monsma F.J. Jr., Mahan L.C., McVittie L.D., Gerfen C.R., Sibley D.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:6723-6727(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterization of gene organization and promoter region of the rat dopamine D1 receptor gene."
    Zhou Q.Y., Li C., Civelli O.
    J. Neurochem. 59:1875-1883(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of two additional catecholamine receptors from rat brain."
    O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P., Niznik H.B.
    FEBS Lett. 262:8-12(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 114-263.
    Tissue: Corpus striatum.
  5. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
    Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
    Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNAJC14, GLYCOSYLATION, MUTAGENESIS OF PHE-333; PHE-337 AND PHE-341, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDRD1_RAT
AccessioniPrimary (citable) accession number: P18901
Secondary accession number(s): P21669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 1, 1991
Last modified: June 11, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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