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P18901

- DRD1_RAT

UniProt

P18901 - DRD1_RAT

Protein

D(1A) dopamine receptor

Gene

Drd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 May 1991)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. angiotensin receptor binding Source: RGD
    2. ATPase binding Source: RGD
    3. D3 dopamine receptor binding Source: RGD
    4. dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
    5. drug binding Source: RGD
    6. G-protein alpha-subunit binding Source: RGD
    7. G-protein coupled receptor activity Source: RGD
    8. protein binding Source: UniProtKB
    9. protein complex binding Source: RGD
    10. protein heterodimerization activity Source: RGD
    11. protein phosphatase binding Source: RGD
    12. receptor binding Source: RGD

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: BHF-UCL
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
    3. associative learning Source: RGD
    4. behavioral response to cocaine Source: RGD
    5. calcium-mediated signaling Source: RGD
    6. cellular response to hypoxia Source: RGD
    7. cellular response to insulin stimulus Source: RGD
    8. dopamine receptor signaling pathway Source: RGD
    9. intracellular protein transport Source: RGD
    10. locomotory behavior Source: RGD
    11. negative regulation of cell migration Source: RGD
    12. negative regulation of circadian sleep/wake cycle, sleep Source: RGD
    13. negative regulation of protein kinase activity Source: RGD
    14. operant conditioning Source: RGD
    15. orbitofrontal cortex development Source: RGD
    16. phosphatidylinositol catabolic process Source: BHF-UCL
    17. phosphatidylinositol metabolic process Source: BHF-UCL
    18. positive regulation of adenylate cyclase activity Source: BHF-UCL
    19. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
    20. positive regulation of cAMP biosynthetic process Source: RGD
    21. positive regulation of feeding behavior Source: RGD
    22. positive regulation of long-term synaptic potentiation Source: RGD
    23. positive regulation of membrane potential Source: RGD
    24. regulation of ion transport Source: RGD
    25. regulation of long-term neuronal synaptic plasticity Source: RGD
    26. regulation of vasoconstriction Source: RGD
    27. response to activity Source: RGD
    28. response to amino acid Source: RGD
    29. response to amphetamine Source: RGD
    30. response to antidepressant Source: RGD
    31. response to drug Source: RGD
    32. response to estradiol Source: RGD
    33. response to ethanol Source: RGD
    34. response to food Source: RGD
    35. response to morphine Source: RGD
    36. response to nicotine Source: RGD
    37. response to organic cyclic compound Source: RGD
    38. response to organonitrogen compound Source: RGD
    39. response to retinoic acid Source: RGD
    40. response to steroid hormone Source: RGD
    41. social behavior Source: RGD
    42. striatum development Source: RGD
    43. synapse assembly Source: BHF-UCL
    44. synaptic transmission, dopaminergic Source: RGD
    45. vasodilation Source: InterPro
    46. visual learning Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(1A) dopamine receptor
    Alternative name(s):
    Dopamine D1 receptor
    Gene namesi
    Name:Drd1
    Synonyms:Drd1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2518. Drd1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.

    GO - Cellular componenti

    1. axon Source: RGD
    2. axon terminus Source: RGD
    3. caveola Source: RGD
    4. dendrite Source: RGD
    5. dendritic shaft Source: RGD
    6. dendritic spine Source: RGD
    7. dendritic spine head Source: RGD
    8. dendritic spine neck Source: RGD
    9. endoplasmic reticulum Source: RGD
    10. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    11. integral component of membrane Source: RGD
    12. integral component of plasma membrane Source: InterPro
    13. neuronal cell body Source: RGD
    14. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi333 – 3331F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication
    Mutagenesisi337 – 3371F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication
    Mutagenesisi341 – 3411F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446D(1A) dopamine receptorPRO_0000069378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
    Lipidationi347 – 3471S-palmitoyl cysteineBy similarity
    Lipidationi351 – 3511S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiP18901.

    Expressioni

    Tissue specificityi

    Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.

    Gene expression databases

    GenevestigatoriP18901.

    Interactioni

    Subunit structurei

    Interacts with calcyon By similarity. Interacts with DNAJC14 via its C-terminus.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi246496. 2 interactions.
    DIPiDIP-49024N.
    STRINGi10116.ENSRNOP00000034820.

    Structurei

    3D structure databases

    ProteinModelPortaliP18901.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 5911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 959ExtracellularSequence Analysis
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 27254CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini300 – 31213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini338 – 446109CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4826Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8627Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11823Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 16225Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29927Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei313 – 33725Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262978.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP18901.
    KOiK04144.
    PhylomeDBiP18901.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001413. Dopamine_D1_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00565. DOPAMINED1AR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18901-1 [UniParc]FASTAAdd to Basket

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    MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF    50
    RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA 100
    FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS 150
    VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL 200
    ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP 250
    VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 300
    EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL 350
    CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED 400
    LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST 446
    Length:446
    Mass (Da):49,428
    Last modified:May 1, 1991 - v2
    Checksum:i0380042E8590F470
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911L → F(PubMed:1402930)Curated
    Sequence conflicti93 – 931P → S(PubMed:1402930)Curated
    Sequence conflicti165 – 1651A → T(PubMed:2168520)Curated
    Sequence conflicti190 – 1901L → F(PubMed:2168520)Curated
    Sequence conflicti227 – 2271R → G(PubMed:2168520)Curated
    Sequence conflicti253 – 2531C → W(PubMed:2168520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35077 mRNA. Translation: AAA70428.1.
    S46131 Genomic DNA. Translation: AAB23803.1.
    PIRiA36049. DYRTD1.
    RefSeqiNP_036678.2. NM_012546.2.
    UniGeneiRn.24039.

    Genome annotation databases

    GeneIDi24316.
    KEGGirno:24316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35077 mRNA. Translation: AAA70428.1 .
    S46131 Genomic DNA. Translation: AAB23803.1 .
    PIRi A36049. DYRTD1.
    RefSeqi NP_036678.2. NM_012546.2.
    UniGenei Rn.24039.

    3D structure databases

    ProteinModelPortali P18901.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246496. 2 interactions.
    DIPi DIP-49024N.
    STRINGi 10116.ENSRNOP00000034820.

    Chemistry

    BindingDBi P18901.
    ChEMBLi CHEMBL2096910.
    GuidetoPHARMACOLOGYi 214.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P18901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24316.
    KEGGi rno:24316.

    Organism-specific databases

    CTDi 1812.
    RGDi 2518. Drd1.

    Phylogenomic databases

    eggNOGi NOG262978.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P18901.
    KOi K04144.
    PhylomeDBi P18901.

    Miscellaneous databases

    NextBioi 602967.
    PROi P18901.

    Gene expression databases

    Genevestigatori P18901.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001413. Dopamine_D1_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00565. DOPAMINED1AR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation."
      Monsma F.J. Jr., Mahan L.C., McVittie L.D., Gerfen C.R., Sibley D.R.
      Proc. Natl. Acad. Sci. U.S.A. 87:6723-6727(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Characterization of gene organization and promoter region of the rat dopamine D1 receptor gene."
      Zhou Q.Y., Li C., Civelli O.
      J. Neurochem. 59:1875-1883(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of two additional catecholamine receptors from rat brain."
      O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P., Niznik H.B.
      FEBS Lett. 262:8-12(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 114-263.
      Tissue: Corpus striatum.
    5. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
      Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
      Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNAJC14, GLYCOSYLATION, MUTAGENESIS OF PHE-333; PHE-337 AND PHE-341, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDRD1_RAT
    AccessioniPrimary (citable) accession number: P18901
    Secondary accession number(s): P21669
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3