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Protein

Hexaprenyl pyrophosphate synthase, mitochondrial

Gene

COQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Isopentenyl diphosphateBy similarity
Binding sitei87 – 871Isopentenyl diphosphateBy similarity
Binding sitei186 – 1861Isopentenyl diphosphateBy similarity
Metal bindingi193 – 1931Magnesium 1By similarity
Metal bindingi193 – 1931Magnesium 2By similarity
Metal bindingi197 – 1971Magnesium 1By similarity
Metal bindingi197 – 1971Magnesium 2By similarity
Binding sitei202 – 2021Polyprenyl diphosphateBy similarity
Binding sitei203 – 2031Isopentenyl diphosphateBy similarity
Binding sitei323 – 3231Polyprenyl diphosphateBy similarity
Binding sitei324 – 3241Polyprenyl diphosphateBy similarity
Binding sitei361 – 3611Polyprenyl diphosphateBy similarity
Metal bindingi364 – 3641Magnesium 3By similarity
Binding sitei378 – 3781Polyprenyl diphosphateBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • trans-hexaprenyltranstransferase activity Source: SGD

GO - Biological processi

  • isoprenoid biosynthetic process Source: UniProtKB-KW
  • ubiquinone biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13702.
YEAST:YBR003W-MONOMER.
ReactomeiR-SCE-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexaprenyl pyrophosphate synthase, mitochondrial (EC:2.5.1.-)
Short name:
HPS
Gene namesi
Name:COQ1
Ordered Locus Names:YBR003W
ORF Names:YBR0109
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR003W.
SGDiS000000207. COQ1.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: WormBase
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 473Hexaprenyl pyrophosphate synthase, mitochondrialPRO_0000016477
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP18900.
PRIDEiP18900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA2P105922EBI-4912,EBI-8603

Protein-protein interaction databases

BioGridi32704. 15 interactions.
DIPiDIP-1103N.
IntActiP18900. 8 interactions.
MINTiMINT-427151.

Structurei

3D structure databases

ProteinModelPortaliP18900.
SMRiP18900. Positions 128-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063378.
HOGENOMiHOG000009104.
InParanoidiP18900.
KOiK05355.
OMAiPEVCEIA.
OrthoDBiEOG72ZCQ7.

Family and domain databases

Gene3Di1.10.600.10. 3 hits.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 3 hits.
PfamiPF00348. polyprenyl_synt. 2 hits.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRSGAAHH IKLISSRRCR FKSSFAVALN AASKLVTPKI LWNNPISLVS
60 70 80 90 100
KEMNTLAKNI VALIGSGHPV LNKVTSYYFE TEGKKVRPLL VLLLSRALSE
110 120 130 140 150
IPMTERNHLK IDKSDVPEDP IYSKPSQNQL FQRPASSISP LHILHGIKPL
160 170 180 190 200
NPLTKGPEPL PEETFDKQRG ILPKQRRLAE IVEMIHTASL LHDDVIDHSD
210 220 230 240 250
TRRGRPSGNA AFTNKMAVLA GDFLLGRATV SISRLHNPEV VELMSNSIAN
260 270 280 290 300
LVEGEFMQLK NTSIDADIDT IENGHKLLPV PSKKLEVKEH DFRVPSRQQG
310 320 330 340 350
LQLSHDQIIE TAFEYYIHKT YLKTAALISK SCRCAAILSG ASPAVIDECY
360 370 380 390 400
DFGRNLGICF QLVDDMLDFT VSGKDLGKPS GADLKLGIAT APVLFAWKED
410 420 430 440 450
PSLGPLISRN FSERGDVEKT IDSVRLHNGI AKTKILAEEY RDKALQNLRD
460 470
SLPESDARSA LEFLTNSILT RRK
Length:473
Mass (Da):52,560
Last modified:November 1, 1990 - v1
Checksum:i676191C9DCA18E3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05547 Genomic DNA. Translation: AAA34686.1.
Z35872 Genomic DNA. Translation: CAA84939.1.
AY558099 Genomic DNA. Translation: AAS56425.1.
Z26494 Genomic DNA. Translation: CAA81272.1.
BK006936 Genomic DNA. Translation: DAA07124.1.
PIRiA36625. XUBYTP.
RefSeqiNP_009557.1. NM_001178351.1.

Genome annotation databases

EnsemblFungiiYBR003W; YBR003W; YBR003W.
GeneIDi852288.
KEGGisce:YBR003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05547 Genomic DNA. Translation: AAA34686.1.
Z35872 Genomic DNA. Translation: CAA84939.1.
AY558099 Genomic DNA. Translation: AAS56425.1.
Z26494 Genomic DNA. Translation: CAA81272.1.
BK006936 Genomic DNA. Translation: DAA07124.1.
PIRiA36625. XUBYTP.
RefSeqiNP_009557.1. NM_001178351.1.

3D structure databases

ProteinModelPortaliP18900.
SMRiP18900. Positions 128-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32704. 15 interactions.
DIPiDIP-1103N.
IntActiP18900. 8 interactions.
MINTiMINT-427151.

Proteomic databases

MaxQBiP18900.
PRIDEiP18900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR003W; YBR003W; YBR003W.
GeneIDi852288.
KEGGisce:YBR003W.

Organism-specific databases

EuPathDBiFungiDB:YBR003W.
SGDiS000000207. COQ1.

Phylogenomic databases

GeneTreeiENSGT00530000063378.
HOGENOMiHOG000009104.
InParanoidiP18900.
KOiK05355.
OMAiPEVCEIA.
OrthoDBiEOG72ZCQ7.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciMetaCyc:MONOMER-13702.
YEAST:YBR003W-MONOMER.
ReactomeiR-SCE-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiP18900.

Family and domain databases

Gene3Di1.10.600.10. 3 hits.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 3 hits.
PfamiPF00348. polyprenyl_synt. 2 hits.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase."
    Ashby M.N., Edwards P.A.
    J. Biol. Chem. 265:13157-13164(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D273-10B/A1.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4."
    Wolfe K.H., Lohan A.J.E.
    Yeast 10:S41-S46(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-285.
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOQ1_YEAST
AccessioniPrimary (citable) accession number: P18900
Secondary accession number(s): D6VQ04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.