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Protein

Hexaprenyl pyrophosphate synthase, mitochondrial

Gene

COQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84Isopentenyl diphosphateBy similarity1
Binding sitei87Isopentenyl diphosphateBy similarity1
Binding sitei186Isopentenyl diphosphateBy similarity1
Metal bindingi193Magnesium 1By similarity1
Metal bindingi193Magnesium 2By similarity1
Metal bindingi197Magnesium 1By similarity1
Metal bindingi197Magnesium 2By similarity1
Binding sitei202Polyprenyl diphosphateBy similarity1
Binding sitei203Isopentenyl diphosphateBy similarity1
Binding sitei323Polyprenyl diphosphateBy similarity1
Binding sitei324Polyprenyl diphosphateBy similarity1
Binding sitei361Polyprenyl diphosphateBy similarity1
Metal bindingi364Magnesium 3By similarity1
Binding sitei378Polyprenyl diphosphateBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • trans-hexaprenyltranstransferase activity Source: SGD

GO - Biological processi

  • isoprenoid biosynthetic process Source: UniProtKB-KW
  • ubiquinone biosynthetic process Source: SGD

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:YBR003W-MONOMER
YEAST:YBR003W-MONOMER
ReactomeiR-SCE-2142789 Ubiquinol biosynthesis
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Hexaprenyl pyrophosphate synthase, mitochondrial (EC:2.5.1.-)
Short name:
HPS
Gene namesi
Name:COQ1
Ordered Locus Names:YBR003W
ORF Names:YBR0109
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR003W
SGDiS000000207 COQ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000016477? – 473Hexaprenyl pyrophosphate synthase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP18900
PaxDbiP18900
PRIDEiP18900

PTM databases

CarbonylDBiP18900

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA2P105922EBI-4912,EBI-8603

Protein-protein interaction databases

BioGridi32704, 44 interactors
DIPiDIP-1103N
IntActiP18900, 8 interactors
MINTiP18900
STRINGi4932.YBR003W

Structurei

3D structure databases

ProteinModelPortaliP18900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063378
HOGENOMiHOG000009104
InParanoidiP18900
KOiK05355
OMAiAFTNKMA
OrthoDBiEOG092C36G8

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
IPR033749 Polyprenyl_synt_CS
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 3 hits
PROSITEiView protein in PROSITE
PS00723 POLYPRENYL_SYNTHASE_1, 1 hit
PS00444 POLYPRENYL_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRSGAAHH IKLISSRRCR FKSSFAVALN AASKLVTPKI LWNNPISLVS
60 70 80 90 100
KEMNTLAKNI VALIGSGHPV LNKVTSYYFE TEGKKVRPLL VLLLSRALSE
110 120 130 140 150
IPMTERNHLK IDKSDVPEDP IYSKPSQNQL FQRPASSISP LHILHGIKPL
160 170 180 190 200
NPLTKGPEPL PEETFDKQRG ILPKQRRLAE IVEMIHTASL LHDDVIDHSD
210 220 230 240 250
TRRGRPSGNA AFTNKMAVLA GDFLLGRATV SISRLHNPEV VELMSNSIAN
260 270 280 290 300
LVEGEFMQLK NTSIDADIDT IENGHKLLPV PSKKLEVKEH DFRVPSRQQG
310 320 330 340 350
LQLSHDQIIE TAFEYYIHKT YLKTAALISK SCRCAAILSG ASPAVIDECY
360 370 380 390 400
DFGRNLGICF QLVDDMLDFT VSGKDLGKPS GADLKLGIAT APVLFAWKED
410 420 430 440 450
PSLGPLISRN FSERGDVEKT IDSVRLHNGI AKTKILAEEY RDKALQNLRD
460 470
SLPESDARSA LEFLTNSILT RRK
Length:473
Mass (Da):52,560
Last modified:November 1, 1990 - v1
Checksum:i676191C9DCA18E3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05547 Genomic DNA Translation: AAA34686.1
Z35872 Genomic DNA Translation: CAA84939.1
AY558099 Genomic DNA Translation: AAS56425.1
Z26494 Genomic DNA Translation: CAA81272.1
BK006936 Genomic DNA Translation: DAA07124.1
PIRiA36625 XUBYTP
RefSeqiNP_009557.1, NM_001178351.1

Genome annotation databases

EnsemblFungiiYBR003W; YBR003W; YBR003W
GeneIDi852288
KEGGisce:YBR003W

Similar proteinsi

Entry informationi

Entry nameiCOQ1_YEAST
AccessioniPrimary (citable) accession number: P18900
Secondary accession number(s): D6VQ04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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