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P18895

- ALGE_PSEAE

UniProt

P18895 - ALGE_PSEAE

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Protein

Alginate production protein AlgE

Gene

algE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore.

Pathwayi

GO - Biological processi

  1. alginic acid biosynthetic process Source: PseudoCAP
Complete GO annotation...

Keywords - Biological processi

Alginate biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00286.

Protein family/group databases

TCDBi1.B.13.1.1. the alginate export porin (aep) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Alginate production protein AlgE
Gene namesi
Name:algE
Synonyms:alg76
Ordered Locus Names:PA3544
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3544.

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 490458Alginate production protein AlgEPRO_0000020663Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3544.

Structurei

Secondary structure

1
490
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 5413
Turni56 – 594
Beta strandi60 – 634
Beta strandi66 – 8116
Beta strandi84 – 9714
Helixi117 – 1193
Beta strandi123 – 13513
Beta strandi138 – 1403
Beta strandi144 – 15411
Beta strandi158 – 1603
Beta strandi162 – 17312
Beta strandi175 – 18511
Beta strandi191 – 1933
Turni199 – 2035
Beta strandi204 – 21613
Beta strandi219 – 23012
Beta strandi247 – 26216
Beta strandi270 – 29526
Beta strandi297 – 31923
Beta strandi321 – 33313
Helixi338 – 3403
Beta strandi358 – 3614
Turni368 – 3703
Beta strandi374 – 38815
Turni389 – 3913
Beta strandi392 – 40514
Beta strandi411 – 4144
Beta strandi425 – 43713
Beta strandi439 – 4413
Helixi448 – 4514
Beta strandi457 – 46711
Turni469 – 4713
Beta strandi479 – 48911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RBHX-ray2.30A/B/C/D33-490[»]
4AFKX-ray1.90A33-490[»]
4AZLX-ray2.80A/B33-490[»]
4B61X-ray2.40A/B33-490[»]
ProteinModelPortaliP18895.
SMRiP18895. Positions 38-490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18895.

Family & Domainsi

Sequence similaritiesi

Belongs to the AlgE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44459.
HOGENOMiHOG000247758.
KOiK16081.
OMAiHRFGEAF.
OrthoDBiEOG6NWBKV.

Family and domain databases

InterProiIPR025388. Alginate_export_dom.
[Graphical view]
PfamiPF13372. Alginate_exp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18895-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSSRSVNPR PSFAPRALSL AIALLLGAPA FAANSGEAPK NFGLDVKITG
60 70 80 90 100
ESENDRDLGT APGGTLNDIG IDLRPWAFGQ WGDWSAYFMG QAVAATDTIE
110 120 130 140 150
TDTLQSDTDD GNNSRNDGRE PDKSYLAARE FWVDYAGLTA YPGEHLRFGR
160 170 180 190 200
QRLREDSGQW QDTNIEALNW SFETTLLNAH AGVAQRFSEY RTDLDELAPE
210 220 230 240 250
DKDRTHVFGD ISTQWAPHHR IGVRIHHADD SGHLRRPGEE VDNLDKTYTG
260 270 280 290 300
QLTWLGIEAT GDAYNYRSSM PLNYWASATW LTGDRDNLTT TTVDDRRIAT
310 320 330 340 350
GKQSGDVNAF GVDLGLRWNI DEQWKAGVGY ARGSGGGKDG EEQFQQTGLE
360 370 380 390 400
SNRSNFTGTR SRVHRFGEAF RGELSNLQAA TLFGSWQLRE DYDASLVYHK
410 420 430 440 450
FWRVDDDSDI GTSGINAALQ PGEKDIGQEL DLVVTKYFKQ GLLPASMSQY
460 470 480 490
VDEPSALIRF RGGLFKPGDA YGPGTDSTMH RAFVDFIWRF
Length:490
Mass (Da):54,422
Last modified:December 8, 2000 - v2
Checksum:i13B7A9627CE36C8C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341N → G in AAA25699. (PubMed:1743507)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37181 Genomic DNA. Translation: AAA25699.1.
AE004091 Genomic DNA. Translation: AAG06932.1.
PIRiE83202.
JS0586.
RefSeqiNP_252234.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06932; AAG06932; PA3544.
GeneIDi879838.
KEGGipae:PA3544.
PATRICi19841701. VBIPseAer58763_3708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37181 Genomic DNA. Translation: AAA25699.1 .
AE004091 Genomic DNA. Translation: AAG06932.1 .
PIRi E83202.
JS0586.
RefSeqi NP_252234.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RBH X-ray 2.30 A/B/C/D 33-490 [» ]
4AFK X-ray 1.90 A 33-490 [» ]
4AZL X-ray 2.80 A/B 33-490 [» ]
4B61 X-ray 2.40 A/B 33-490 [» ]
ProteinModelPortali P18895.
SMRi P18895. Positions 38-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3544.

Protein family/group databases

TCDBi 1.B.13.1.1. the alginate export porin (aep) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06932 ; AAG06932 ; PA3544 .
GeneIDi 879838.
KEGGi pae:PA3544.
PATRICi 19841701. VBIPseAer58763_3708.

Organism-specific databases

PseudoCAPi PA3544.

Phylogenomic databases

eggNOGi NOG44459.
HOGENOMi HOG000247758.
KOi K16081.
OMAi HRFGEAF.
OrthoDBi EOG6NWBKV.

Enzyme and pathway databases

UniPathwayi UPA00286 .

Miscellaneous databases

EvolutionaryTracei P18895.

Family and domain databases

InterProi IPR025388. Alginate_export_dom.
[Graphical view ]
Pfami PF13372. Alginate_exp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression of the algE gene involved in alginate biosynthesis by Pseudomonas aeruginosa."
    Chu L., May T.B., Chakrabarty A.M., Misra T.K.
    Gene 107:1-10(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 33-42.
    Strain: 8830.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  3. "Overexpression of algE in Escherichia coli: subcellular localization, purification, and ion channel properties."
    Rehm B.H., Boheim G., Tommassen J., Winkler U.K.
    J. Bacteriol. 176:5639-5647(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: CF3/M1.

Entry informationi

Entry nameiALGE_PSEAE
AccessioniPrimary (citable) accession number: P18895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 8, 2000
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3