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Protein

Alginate production protein AlgE

Gene

algE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore.

Pathwayi: alginate biosynthesis

This protein is involved in the pathway alginate biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway alginate biosynthesis and in Glycan biosynthesis.

GO - Biological processi

  • alginic acid biosynthetic process Source: PseudoCAP
Complete GO annotation...

Keywords - Biological processi

Alginate biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00286.

Protein family/group databases

TCDBi1.B.13.1.1. the alginate export porin (aep) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Alginate production protein AlgE
Gene namesi
Name:algE
Synonyms:alg76
Ordered Locus Names:PA3544
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3544.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000002066333 – 490Alginate production protein AlgEAdd BLAST458

Proteomic databases

PaxDbiP18895.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3544.

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 54Combined sources13
Turni56 – 59Combined sources4
Beta strandi60 – 63Combined sources4
Beta strandi66 – 81Combined sources16
Beta strandi84 – 97Combined sources14
Beta strandi102 – 104Combined sources3
Helixi105 – 107Combined sources3
Helixi117 – 119Combined sources3
Beta strandi123 – 135Combined sources13
Beta strandi138 – 140Combined sources3
Beta strandi144 – 154Combined sources11
Beta strandi158 – 160Combined sources3
Beta strandi162 – 173Combined sources12
Beta strandi175 – 185Combined sources11
Beta strandi191 – 193Combined sources3
Turni199 – 203Combined sources5
Beta strandi204 – 216Combined sources13
Beta strandi219 – 230Combined sources12
Beta strandi243 – 245Combined sources3
Beta strandi247 – 262Combined sources16
Beta strandi270 – 295Combined sources26
Beta strandi297 – 319Combined sources23
Beta strandi321 – 333Combined sources13
Helixi338 – 340Combined sources3
Beta strandi358 – 361Combined sources4
Turni368 – 370Combined sources3
Beta strandi374 – 388Combined sources15
Turni389 – 391Combined sources3
Beta strandi392 – 405Combined sources14
Beta strandi406 – 408Combined sources3
Beta strandi412 – 414Combined sources3
Beta strandi425 – 437Combined sources13
Beta strandi439 – 441Combined sources3
Helixi448 – 451Combined sources4
Beta strandi457 – 467Combined sources11
Turni469 – 471Combined sources3
Beta strandi473 – 475Combined sources3
Beta strandi479 – 489Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBHX-ray2.30A/B/C/D33-490[»]
4AFKX-ray1.90A33-490[»]
4AZLX-ray2.80A/B33-490[»]
4B61X-ray2.40A/B33-490[»]
4XNKX-ray2.80A1-490[»]
4XNLX-ray2.90A1-490[»]
5D5DX-ray2.40A1-490[»]
ProteinModelPortaliP18895.
SMRiP18895.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18895.

Family & Domainsi

Sequence similaritiesi

Belongs to the AlgE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105Y9T. Bacteria.
ENOG411265P. LUCA.
HOGENOMiHOG000247758.
KOiK16081.
OMAiRFSEYRT.

Family and domain databases

InterProiIPR025388. Alginate_export_dom.
[Graphical view]
PfamiPF13372. Alginate_exp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSRSVNPR PSFAPRALSL AIALLLGAPA FAANSGEAPK NFGLDVKITG
60 70 80 90 100
ESENDRDLGT APGGTLNDIG IDLRPWAFGQ WGDWSAYFMG QAVAATDTIE
110 120 130 140 150
TDTLQSDTDD GNNSRNDGRE PDKSYLAARE FWVDYAGLTA YPGEHLRFGR
160 170 180 190 200
QRLREDSGQW QDTNIEALNW SFETTLLNAH AGVAQRFSEY RTDLDELAPE
210 220 230 240 250
DKDRTHVFGD ISTQWAPHHR IGVRIHHADD SGHLRRPGEE VDNLDKTYTG
260 270 280 290 300
QLTWLGIEAT GDAYNYRSSM PLNYWASATW LTGDRDNLTT TTVDDRRIAT
310 320 330 340 350
GKQSGDVNAF GVDLGLRWNI DEQWKAGVGY ARGSGGGKDG EEQFQQTGLE
360 370 380 390 400
SNRSNFTGTR SRVHRFGEAF RGELSNLQAA TLFGSWQLRE DYDASLVYHK
410 420 430 440 450
FWRVDDDSDI GTSGINAALQ PGEKDIGQEL DLVVTKYFKQ GLLPASMSQY
460 470 480 490
VDEPSALIRF RGGLFKPGDA YGPGTDSTMH RAFVDFIWRF
Length:490
Mass (Da):54,422
Last modified:December 8, 2000 - v2
Checksum:i13B7A9627CE36C8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34N → G in AAA25699 (PubMed:1743507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37181 Genomic DNA. Translation: AAA25699.1.
AE004091 Genomic DNA. Translation: AAG06932.1.
PIRiE83202.
JS0586.
RefSeqiNP_252234.1. NC_002516.2.
WP_003092105.1. NZ_ASJY01000573.1.

Genome annotation databases

EnsemblBacteriaiAAG06932; AAG06932; PA3544.
GeneIDi879838.
KEGGipae:PA3544.
PATRICi19841701. VBIPseAer58763_3708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37181 Genomic DNA. Translation: AAA25699.1.
AE004091 Genomic DNA. Translation: AAG06932.1.
PIRiE83202.
JS0586.
RefSeqiNP_252234.1. NC_002516.2.
WP_003092105.1. NZ_ASJY01000573.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBHX-ray2.30A/B/C/D33-490[»]
4AFKX-ray1.90A33-490[»]
4AZLX-ray2.80A/B33-490[»]
4B61X-ray2.40A/B33-490[»]
4XNKX-ray2.80A1-490[»]
4XNLX-ray2.90A1-490[»]
5D5DX-ray2.40A1-490[»]
ProteinModelPortaliP18895.
SMRiP18895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3544.

Protein family/group databases

TCDBi1.B.13.1.1. the alginate export porin (aep) family.

Proteomic databases

PaxDbiP18895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06932; AAG06932; PA3544.
GeneIDi879838.
KEGGipae:PA3544.
PATRICi19841701. VBIPseAer58763_3708.

Organism-specific databases

PseudoCAPiPA3544.

Phylogenomic databases

eggNOGiENOG4105Y9T. Bacteria.
ENOG411265P. LUCA.
HOGENOMiHOG000247758.
KOiK16081.
OMAiRFSEYRT.

Enzyme and pathway databases

UniPathwayiUPA00286.

Miscellaneous databases

EvolutionaryTraceiP18895.

Family and domain databases

InterProiIPR025388. Alginate_export_dom.
[Graphical view]
PfamiPF13372. Alginate_exp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALGE_PSEAE
AccessioniPrimary (citable) accession number: P18895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 8, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.