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Reviewed, UniProtKB/Swiss-Prot P18893 (IL10_MOUSE)

Last modified January 19, 2010. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Interleukin-10
      Short name=IL-10
Alternative name(s):
    Cytokine synthesis inhibitory factor
      Short name=CSIF
Gene names
Name: Il10
Synonyms: Il-10
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-10 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 178160Interleukin-10
PRO_0000015367

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 126 Ref.3
Disulfide bond80 ↔ 132 Ref.3

Experimental info

Sequence conflict1311K → P in AAA39274. Ref.2
Sequence conflict1311K → P in AAA39275. Ref.2
Sequence conflict1501E → Q in AAA39274. Ref.2
Sequence conflict1501E → Q in AAA39275. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P18893-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: CA282E7FE9D86537

FASTA17820,673
        10         20         30         40         50         60 
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 

        70         80         90        100        110        120 
LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLGEKLKTLR 

       130        140        150        160        170 
MRLRRCHRFL KCENKSKAVE QVKSDFNKLE DQGVYKAMNE FDIFINCIEA YMMIKMKS

« Hide

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References

[1]"Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI."
Moore K.W., Vieira P., Fiorentino D.F., Trounstine M.L., Khan T.A., Mosmann T.R.
Science 248:1230-1234(1990) [PubMed: 2161559] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes."
Kim J.M., Brannan C.I., Copeland N.G., Jenkins N.A., Khan T.A., Moore K.W.
J. Immunol. 148:3618-3623(1992) [PubMed: 1350294] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10."
Windsor W.T., Syto R., Tsarbopoulos A., Zhang R., Durkin J., Baldwin S., Paliwal S., Mui P.W., Pramanik B., Trotta P.P.
Biochemistry 32:8807-8815(1993) [PubMed: 8364028] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M37897 mRNA. Translation: AAA39274.1.
M84340 Genomic DNA. Translation: AAA39275.1.
IPIIPI00115602.
PIRA34853.
RefSeqNP_034678.1.
UniGeneMm.874

3D structure databases

SMRP18893. Positions 24-178.
ModBaseSearch...

Protein-protein interaction databases

STRINGP18893.

Proteomic databases

PRIDEP18893.

Genome annotation databases

EnsemblENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529; Mus musculus. [Genome view]
GeneID16153.
KEGGmmu:16153.

Organism-specific databases

CTD16153.
MGIMGI:96537. Il10.

Phylogenomic databases

eggNOGroNOG16135.
HOGENOMHBG279172.
HOVERGENP18893.
InParanoidP18893.

Gene expression databases

ArrayExpressP18893.
BgeeP18893.
CleanExMM_IL10.
GenevestigatorP18893.
GermOnlineENSMUSG00000016529. Mus musculus.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR012352. IL-10_add_helix.
IPR020443. Interleukin-10/19/20/24.
IPR020423. Interleukin-10_CS.
IPR000098. Interleukin_10.
[Graphical view]
Gene3DG3DSA:4.10.340.10. IL-10_add_helix. 1 hit.
PANTHERPTHR11585. Interleukin_10. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01294. INTRLEUKIN10.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio288951.
SOURCESearch...

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Entry information

Entry nameIL10_MOUSE
AccessionPrimary (citable) accession number: P18893
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: January 19, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents