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P18893

- IL10_MOUSE

UniProt

P18893 - IL10_MOUSE

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Protein

Interleukin-10

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. branching involved in labyrinthine layer morphogenesis Source: MGI
  2. cellular response to estradiol stimulus Source: Ensembl
  3. cellular response to lipopolysaccharide Source: MGI
  4. defense response to bacterium Source: MGI
  5. immune response Source: Ensembl
  6. inflammatory response Source: Ensembl
  7. negative regulation of apoptotic process Source: Ensembl
  8. negative regulation of B cell proliferation Source: MGI
  9. negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
  10. negative regulation of cytokine secretion involved in immune response Source: Ensembl
  11. negative regulation of growth of symbiont in host Source: MGI
  12. negative regulation of inflammatory response Source: MGI
  13. negative regulation of interferon-gamma production Source: MGI
  14. negative regulation of interleukin-12 production Source: MGI
  15. negative regulation of interleukin-6 production Source: Ensembl
  16. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
  17. negative regulation of myeloid dendritic cell activation Source: MGI
  18. negative regulation of nitric oxide biosynthetic process Source: Ensembl
  19. negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  20. negative regulation of tumor necrosis factor production Source: MGI
  21. positive regulation of B cell apoptotic process Source: MGI
  22. positive regulation of cytokine secretion Source: Ensembl
  23. positive regulation of MHC class II biosynthetic process Source: MGI
  24. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. receptor biosynthetic process Source: Ensembl
  27. regulation of gene expression Source: MGI
  28. regulation of sensory perception of pain Source: Ensembl
  29. response to activity Source: Ensembl
  30. response to carbon monoxide Source: Ensembl
  31. response to drug Source: Ensembl
  32. response to glucocorticoid Source: Ensembl
  33. response to inactivity Source: Ensembl
  34. response to insulin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:Il10
Synonyms:Il-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96537. Il10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 178160Interleukin-10PRO_0000015367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi30 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP18893.

PTM databases

PhosphoSiteiP18893.

Expressioni

Gene expression databases

CleanExiMM_IL10.
GenevestigatoriP18893.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi200603. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP18893.
SMRiP18893. Positions 39-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43085.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP18893.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG7C2R33.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18893 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ
60 70 80 90 100
VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK
110 120 130 140 150
HGPEIKEHLN SLGEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ
160 170
DQGVYKAMNE FDIFINCIEA YMMIKMKS
Length:178
Mass (Da):20,641
Last modified:October 3, 2012 - v2
Checksum:i9A283E6FFC99312B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37897 mRNA. Translation: AAA39274.1.
M84340 Genomic DNA. Translation: AAA39275.1.
AL513351 Genomic DNA. Translation: CAM14013.1.
CH466520 Genomic DNA. Translation: EDL39722.1.
BC120612 mRNA. Translation: AAI20613.1.
BC137844 mRNA. Translation: AAI37845.1.
CCDSiCCDS15265.1.
PIRiA34853.
RefSeqiNP_034678.1. NM_010548.2.
UniGeneiMm.874.

Genome annotation databases

EnsembliENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529.
GeneIDi16153.
KEGGimmu:16153.
UCSCiuc007cmu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37897 mRNA. Translation: AAA39274.1 .
M84340 Genomic DNA. Translation: AAA39275.1 .
AL513351 Genomic DNA. Translation: CAM14013.1 .
CH466520 Genomic DNA. Translation: EDL39722.1 .
BC120612 mRNA. Translation: AAI20613.1 .
BC137844 mRNA. Translation: AAI37845.1 .
CCDSi CCDS15265.1.
PIRi A34853.
RefSeqi NP_034678.1. NM_010548.2.
UniGenei Mm.874.

3D structure databases

ProteinModelPortali P18893.
SMRi P18893. Positions 39-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200603. 1 interaction.

PTM databases

PhosphoSitei P18893.

Proteomic databases

PRIDEi P18893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016673 ; ENSMUSP00000016673 ; ENSMUSG00000016529 .
GeneIDi 16153.
KEGGi mmu:16153.
UCSCi uc007cmu.2. mouse.

Organism-specific databases

CTDi 3586.
MGIi MGI:96537. Il10.

Phylogenomic databases

eggNOGi NOG43085.
GeneTreei ENSGT00510000048535.
HOGENOMi HOG000072692.
HOVERGENi HBG004110.
InParanoidi P18893.
KOi K05443.
OMAi PHMLREL.
OrthoDBi EOG7C2R33.
TreeFami TF333253.

Miscellaneous databases

NextBioi 288951.
PROi P18893.
SOURCEi Search...

Gene expression databases

CleanExi MM_IL10.
Genevestigatori P18893.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view ]
PANTHERi PTHR11585. PTHR11585. 1 hit.
Pfami PF00726. IL10. 1 hit.
[Graphical view ]
PRINTSi PR01294. INTRLEUKIN10.
SMARTi SM00188. IL10. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI."
    Moore K.W., Vieira P., Fiorentino D.F., Trounstine M.L., Khan T.A., Mosmann T.R.
    Science 248:1230-1234(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes."
    Kim J.M., Brannan C.I., Copeland N.G., Jenkins N.A., Khan T.A., Moore K.W.
    J. Immunol. 148:3618-3623(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10."
    Windsor W.T., Syto R., Tsarbopoulos A., Zhang R., Durkin J., Baldwin S., Paliwal S., Mui P.W., Pramanik B., Trotta P.P.
    Biochemistry 32:8807-8815(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiIL10_MOUSE
AccessioniPrimary (citable) accession number: P18893
Secondary accession number(s): Q0VBJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3