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Protein

Interleukin-10

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-10 receptor binding Source: Ensembl

GO - Biological processi

  • aging Source: Ensembl
  • branching involved in labyrinthine layer morphogenesis Source: MGI
  • cellular response to estradiol stimulus Source: Ensembl
  • cellular response to hepatocyte growth factor stimulus Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • defense response to bacterium Source: MGI
  • defense response to protozoan Source: MGI
  • immune response Source: Ensembl
  • inflammatory response Source: MGI
  • liver regeneration Source: Ensembl
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
  • negative regulation of cytokine activity Source: MGI
  • negative regulation of cytokine secretion involved in immune response Source: MGI
  • negative regulation of endothelial cell apoptotic process Source: BHF-UCL
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
  • negative regulation of hydrogen peroxide-induced neuron death Source: ARUK-UCL
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interferon-gamma production Source: MGI
  • negative regulation of interleukin-12 production Source: MGI
  • negative regulation of interleukin-6 production Source: MGI
  • negative regulation of membrane protein ectodomain proteolysis Source: MGI
  • negative regulation of myeloid dendritic cell activation Source: MGI
  • negative regulation of nitric oxide biosynthetic process Source: Ensembl
  • negative regulation of sensory perception of pain Source: Ensembl
  • negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • negative regulation of tumor necrosis factor production Source: MGI
  • negative regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of cell cycle Source: BHF-UCL
  • positive regulation of cytokine secretion Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of macrophage activation Source: Ensembl
  • positive regulation of MHC class II biosynthetic process Source: MGI
  • positive regulation of sprouting angiogenesis Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • receptor biosynthetic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of response to wounding Source: BHF-UCL
  • regulation of synapse organization Source: Ensembl
  • response to activity Source: Ensembl
  • response to carbon monoxide Source: Ensembl
  • response to glucocorticoid Source: MGI
  • response to inactivity Source: Ensembl
  • response to insulin Source: Ensembl
  • response to molecule of bacterial origin Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:Il10
Synonyms:Il-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96537 Il10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001536719 – 178Interleukin-10Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi30 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18893
PaxDbiP18893
PRIDEiP18893

Expressioni

Gene expression databases

BgeeiENSMUSG00000016529
CleanExiMM_IL10
GenevisibleiP18893 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-10 receptor binding Source: Ensembl

Protein-protein interaction databases

BioGridi200603, 1 interactor
STRINGi10090.ENSMUSP00000016673

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 49Combined sources11
Helixi52 – 56Combined sources5
Helixi68 – 75Combined sources8
Helixi79 – 92Combined sources14
Helixi94 – 100Combined sources7
Helixi103 – 105Combined sources3
Helixi106 – 125Combined sources20
Turni127 – 129Combined sources3
Helixi131 – 133Combined sources3
Helixi137 – 149Combined sources13
Helixi151 – 159Combined sources9
Helixi161 – 174Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X51X-ray2.05A/B27-178[»]
ProteinModelPortaliP18893
SMRiP18893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiP18893
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ
60 70 80 90 100
VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK
110 120 130 140 150
HGPEIKEHLN SLGEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ
160 170
DQGVYKAMNE FDIFINCIEA YMMIKMKS
Length:178
Mass (Da):20,641
Last modified:October 3, 2012 - v2
Checksum:i9A283E6FFC99312B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37897 mRNA Translation: AAA39274.1
M84340 Genomic DNA Translation: AAA39275.1
AL513351 Genomic DNA Translation: CAM14013.1
CH466520 Genomic DNA Translation: EDL39722.1
BC120612 mRNA Translation: AAI20613.1
BC137844 mRNA Translation: AAI37845.1
CCDSiCCDS15265.1
PIRiA34853
RefSeqiNP_034678.1, NM_010548.2
UniGeneiMm.874

Genome annotation databases

EnsembliENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529
GeneIDi16153
KEGGimmu:16153
UCSCiuc007cmu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL10_MOUSE
AccessioniPrimary (citable) accession number: P18893
Secondary accession number(s): Q0VBJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: April 25, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health