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P18893

- IL10_MOUSE

UniProt

P18893 - IL10_MOUSE

Protein

Interleukin-10

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. branching involved in labyrinthine layer morphogenesis Source: MGI
    2. cellular response to estradiol stimulus Source: Ensembl
    3. defense response to bacterium Source: MGI
    4. immune response Source: Ensembl
    5. inflammatory response Source: Ensembl
    6. negative regulation of apoptotic process Source: Ensembl
    7. negative regulation of B cell proliferation Source: MGI
    8. negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
    9. negative regulation of cytokine secretion involved in immune response Source: Ensembl
    10. negative regulation of growth of symbiont in host Source: MGI
    11. negative regulation of inflammatory response Source: MGI
    12. negative regulation of interferon-gamma production Source: MGI
    13. negative regulation of interleukin-12 production Source: MGI
    14. negative regulation of interleukin-6 production Source: Ensembl
    15. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
    16. negative regulation of myeloid dendritic cell activation Source: MGI
    17. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    18. negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
    19. negative regulation of tumor necrosis factor production Source: MGI
    20. positive regulation of B cell apoptotic process Source: MGI
    21. positive regulation of cytokine secretion Source: Ensembl
    22. positive regulation of MHC class II biosynthetic process Source: MGI
    23. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    25. receptor biosynthetic process Source: Ensembl
    26. regulation of gene expression Source: MGI
    27. regulation of sensory perception of pain Source: Ensembl
    28. response to activity Source: Ensembl
    29. response to carbon monoxide Source: Ensembl
    30. response to drug Source: Ensembl
    31. response to glucocorticoid Source: Ensembl
    32. response to inactivity Source: Ensembl
    33. response to insulin Source: Ensembl
    34. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-10
    Short name:
    IL-10
    Alternative name(s):
    Cytokine synthesis inhibitory factor
    Short name:
    CSIF
    Gene namesi
    Name:Il10
    Synonyms:Il-10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96537. Il10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 178160Interleukin-10PRO_0000015367Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi30 ↔ 1261 Publication
    Disulfide bondi80 ↔ 1321 Publication
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP18893.

    PTM databases

    PhosphoSiteiP18893.

    Expressioni

    Gene expression databases

    CleanExiMM_IL10.
    GenevestigatoriP18893.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi200603. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP18893.
    SMRiP18893. Positions 39-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43085.
    GeneTreeiENSGT00510000048535.
    HOGENOMiHOG000072692.
    HOVERGENiHBG004110.
    InParanoidiP18893.
    KOiK05443.
    OMAiPHMLREL.
    OrthoDBiEOG7C2R33.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000098. IL-10.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PfamiPF00726. IL10. 1 hit.
    [Graphical view]
    PRINTSiPR01294. INTRLEUKIN10.
    SMARTiSM00188. IL10. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ    50
    VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK 100
    HGPEIKEHLN SLGEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ 150
    DQGVYKAMNE FDIFINCIEA YMMIKMKS 178
    Length:178
    Mass (Da):20,641
    Last modified:October 3, 2012 - v2
    Checksum:i9A283E6FFC99312B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37897 mRNA. Translation: AAA39274.1.
    M84340 Genomic DNA. Translation: AAA39275.1.
    AL513351 Genomic DNA. Translation: CAM14013.1.
    CH466520 Genomic DNA. Translation: EDL39722.1.
    BC120612 mRNA. Translation: AAI20613.1.
    BC137844 mRNA. Translation: AAI37845.1.
    CCDSiCCDS15265.1.
    PIRiA34853.
    RefSeqiNP_034678.1. NM_010548.2.
    UniGeneiMm.874.

    Genome annotation databases

    EnsembliENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529.
    GeneIDi16153.
    KEGGimmu:16153.
    UCSCiuc007cmu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37897 mRNA. Translation: AAA39274.1 .
    M84340 Genomic DNA. Translation: AAA39275.1 .
    AL513351 Genomic DNA. Translation: CAM14013.1 .
    CH466520 Genomic DNA. Translation: EDL39722.1 .
    BC120612 mRNA. Translation: AAI20613.1 .
    BC137844 mRNA. Translation: AAI37845.1 .
    CCDSi CCDS15265.1.
    PIRi A34853.
    RefSeqi NP_034678.1. NM_010548.2.
    UniGenei Mm.874.

    3D structure databases

    ProteinModelPortali P18893.
    SMRi P18893. Positions 39-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200603. 1 interaction.

    PTM databases

    PhosphoSitei P18893.

    Proteomic databases

    PRIDEi P18893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016673 ; ENSMUSP00000016673 ; ENSMUSG00000016529 .
    GeneIDi 16153.
    KEGGi mmu:16153.
    UCSCi uc007cmu.2. mouse.

    Organism-specific databases

    CTDi 3586.
    MGIi MGI:96537. Il10.

    Phylogenomic databases

    eggNOGi NOG43085.
    GeneTreei ENSGT00510000048535.
    HOGENOMi HOG000072692.
    HOVERGENi HBG004110.
    InParanoidi P18893.
    KOi K05443.
    OMAi PHMLREL.
    OrthoDBi EOG7C2R33.
    TreeFami TF333253.

    Miscellaneous databases

    NextBioi 288951.
    PROi P18893.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IL10.
    Genevestigatori P18893.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000098. IL-10.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    Pfami PF00726. IL10. 1 hit.
    [Graphical view ]
    PRINTSi PR01294. INTRLEUKIN10.
    SMARTi SM00188. IL10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI."
      Moore K.W., Vieira P., Fiorentino D.F., Trounstine M.L., Khan T.A., Mosmann T.R.
      Science 248:1230-1234(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes."
      Kim J.M., Brannan C.I., Copeland N.G., Jenkins N.A., Khan T.A., Moore K.W.
      J. Immunol. 148:3618-3623(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10."
      Windsor W.T., Syto R., Tsarbopoulos A., Zhang R., Durkin J., Baldwin S., Paliwal S., Mui P.W., Pramanik B., Trotta P.P.
      Biochemistry 32:8807-8815(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL10_MOUSE
    AccessioniPrimary (citable) accession number: P18893
    Secondary accession number(s): Q0VBJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3