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P18893 (IL10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-10

Short name=IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name=CSIF
Gene names
Name:Il10
Synonyms:Il-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-10 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbranching involved in labyrinthine layer morphogenesis

Inferred from mutant phenotype PubMed 12842419. Source: MGI

cellular response to estradiol stimulus

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from direct assay PubMed 10899905. Source: MGI

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of B cell proliferation

Inferred from sequence orthology PubMed 9184696. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of chronic inflammatory response to antigenic stimulus

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of cytokine secretion involved in immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 18270204. Source: MGI

negative regulation of interferon-gamma production

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 15240714. Source: MGI

negative regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

negative regulation of myeloid dendritic cell activation

Inferred from mutant phenotype PubMed 15240714. Source: MGI

negative regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of tumor necrosis factor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 12452830. Source: MGI

positive regulation of B cell apoptotic process

Inferred from sequence orthology PubMed 9184696. Source: MGI

positive regulation of MHC class II biosynthetic process

Inferred from direct assay PubMed 11027433. Source: MGI

positive regulation of cytokine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15187136. Source: BHF-UCL

receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

regulation of gene expression

Inferred from sequence orthology PubMed 9184696. Source: MGI

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to carbon monoxide

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to inactivity

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from direct assay PubMed 10545106PubMed 10899905PubMed 10940872PubMed 15220916PubMed 15240714PubMed 16275384PubMed 16949315PubMed 17137799PubMed 19139201PubMed 23892723. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 11027433PubMed 11342597. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 178160Interleukin-10
PRO_0000015367

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 126 Ref.6
Disulfide bond80 ↔ 132 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P18893 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 9A283E6FFC99312B

FASTA17820,641
        10         20         30         40         50         60 
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 

        70         80         90        100        110        120 
LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLGEKLKTLR 

       130        140        150        160        170 
MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ DQGVYKAMNE FDIFINCIEA YMMIKMKS 

« Hide

References

« Hide 'large scale' references
[1]"Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI."
Moore K.W., Vieira P., Fiorentino D.F., Trounstine M.L., Khan T.A., Mosmann T.R.
Science 248:1230-1234(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes."
Kim J.M., Brannan C.I., Copeland N.G., Jenkins N.A., Khan T.A., Moore K.W.
J. Immunol. 148:3618-3623(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10."
Windsor W.T., Syto R., Tsarbopoulos A., Zhang R., Durkin J., Baldwin S., Paliwal S., Mui P.W., Pramanik B., Trotta P.P.
Biochemistry 32:8807-8815(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37897 mRNA. Translation: AAA39274.1.
M84340 Genomic DNA. Translation: AAA39275.1.
AL513351 Genomic DNA. Translation: CAM14013.1.
CH466520 Genomic DNA. Translation: EDL39722.1.
BC120612 mRNA. Translation: AAI20613.1.
BC137844 mRNA. Translation: AAI37845.1.
CCDSCCDS15265.1.
PIRA34853.
RefSeqNP_034678.1. NM_010548.2.
UniGeneMm.874.

3D structure databases

ProteinModelPortalP18893.
SMRP18893. Positions 39-175.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200603. 1 interaction.

PTM databases

PhosphoSiteP18893.

Proteomic databases

PRIDEP18893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529.
GeneID16153.
KEGGmmu:16153.
UCSCuc007cmu.2. mouse.

Organism-specific databases

CTD3586.
MGIMGI:96537. Il10.

Phylogenomic databases

eggNOGNOG43085.
GeneTreeENSGT00510000048535.
HOGENOMHOG000072692.
HOVERGENHBG004110.
InParanoidP18893.
KOK05443.
OMAPHMLREL.
OrthoDBEOG7C2R33.
TreeFamTF333253.

Gene expression databases

CleanExMM_IL10.
GenevestigatorP18893.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01294. INTRLEUKIN10.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288951.
PROP18893.
SOURCESearch...

Entry information

Entry nameIL10_MOUSE
AccessionPrimary (citable) accession number: P18893
Secondary accession number(s): Q0VBJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot