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Protein

Interleukin-10

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-10 receptor binding Source: GO_Central

GO - Biological processi

  • aging Source: Ensembl
  • branching involved in labyrinthine layer morphogenesis Source: MGI
  • cellular response to estradiol stimulus Source: Ensembl
  • cellular response to hepatocyte growth factor stimulus Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • defense response to bacterium Source: MGI
  • defense response to protozoan Source: MGI
  • immune response Source: Ensembl
  • inflammatory response Source: MGI
  • liver regeneration Source: Ensembl
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
  • negative regulation of cytokine activity Source: MGI
  • negative regulation of cytokine secretion involved in immune response Source: MGI
  • negative regulation of endothelial cell apoptotic process Source: BHF-UCL
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interferon-gamma production Source: MGI
  • negative regulation of interleukin-12 production Source: MGI
  • negative regulation of interleukin-6 production Source: MGI
  • negative regulation of membrane protein ectodomain proteolysis Source: MGI
  • negative regulation of myeloid dendritic cell activation Source: MGI
  • negative regulation of nitric oxide biosynthetic process Source: Ensembl
  • negative regulation of sensory perception of pain Source: Ensembl
  • negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • negative regulation of tumor necrosis factor production Source: MGI
  • negative regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of cell cycle Source: BHF-UCL
  • positive regulation of cytokine secretion Source: MGI
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of JAK-STAT cascade Source: GO_Central
  • positive regulation of macrophage activation Source: Ensembl
  • positive regulation of MHC class II biosynthetic process Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • receptor biosynthetic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of response to wounding Source: BHF-UCL
  • regulation of synapse organization Source: Ensembl
  • response to activity Source: Ensembl
  • response to carbon monoxide Source: Ensembl
  • response to drug Source: Ensembl
  • response to glucocorticoid Source: MGI
  • response to inactivity Source: Ensembl
  • response to insulin Source: Ensembl
  • response to molecule of bacterial origin Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:Il10
Synonyms:Il-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96537. Il10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001536719 – 178Interleukin-10Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi30 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18893.
PaxDbiP18893.
PRIDEiP18893.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016529.
CleanExiMM_IL10.
GenevisibleiP18893. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-10 receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi200603. 1 interactor.
STRINGi10090.ENSMUSP00000016673.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 49Combined sources11
Helixi52 – 56Combined sources5
Helixi68 – 75Combined sources8
Helixi79 – 92Combined sources14
Helixi94 – 100Combined sources7
Helixi103 – 105Combined sources3
Helixi106 – 125Combined sources20
Turni127 – 129Combined sources3
Helixi131 – 133Combined sources3
Helixi137 – 149Combined sources13
Helixi151 – 159Combined sources9
Helixi161 – 174Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X51X-ray2.05A/B27-178[»]
ProteinModelPortaliP18893.
SMRiP18893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP18893.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ
60 70 80 90 100
VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK
110 120 130 140 150
HGPEIKEHLN SLGEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ
160 170
DQGVYKAMNE FDIFINCIEA YMMIKMKS
Length:178
Mass (Da):20,641
Last modified:October 3, 2012 - v2
Checksum:i9A283E6FFC99312B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37897 mRNA. Translation: AAA39274.1.
M84340 Genomic DNA. Translation: AAA39275.1.
AL513351 Genomic DNA. Translation: CAM14013.1.
CH466520 Genomic DNA. Translation: EDL39722.1.
BC120612 mRNA. Translation: AAI20613.1.
BC137844 mRNA. Translation: AAI37845.1.
CCDSiCCDS15265.1.
PIRiA34853.
RefSeqiNP_034678.1. NM_010548.2.
UniGeneiMm.874.

Genome annotation databases

EnsembliENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529.
GeneIDi16153.
KEGGimmu:16153.
UCSCiuc007cmu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37897 mRNA. Translation: AAA39274.1.
M84340 Genomic DNA. Translation: AAA39275.1.
AL513351 Genomic DNA. Translation: CAM14013.1.
CH466520 Genomic DNA. Translation: EDL39722.1.
BC120612 mRNA. Translation: AAI20613.1.
BC137844 mRNA. Translation: AAI37845.1.
CCDSiCCDS15265.1.
PIRiA34853.
RefSeqiNP_034678.1. NM_010548.2.
UniGeneiMm.874.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X51X-ray2.05A/B27-178[»]
ProteinModelPortaliP18893.
SMRiP18893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200603. 1 interactor.
STRINGi10090.ENSMUSP00000016673.

Proteomic databases

EPDiP18893.
PaxDbiP18893.
PRIDEiP18893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016673; ENSMUSP00000016673; ENSMUSG00000016529.
GeneIDi16153.
KEGGimmu:16153.
UCSCiuc007cmu.2. mouse.

Organism-specific databases

CTDi3586.
MGIiMGI:96537. Il10.

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP18893.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
TreeFamiTF333253.

Miscellaneous databases

PROiP18893.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016529.
CleanExiMM_IL10.
GenevisibleiP18893. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL10_MOUSE
AccessioniPrimary (citable) accession number: P18893
Secondary accession number(s): Q0VBJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.