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P18892

- BT1A1_BOVIN

UniProt

P18892 - BT1A1_BOVIN

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Protein

Butyrophilin subfamily 1 member A1

Gene

BTN1A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 1 member A1
Short name:
BT
Gene namesi
Name:BTN1A1
Synonyms:BTN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Membrane; Single-pass type I membrane protein
Note: Secreted in association with the milk-fat-globule membrane during lactation.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 526500Butyrophilin subfamily 1 member A1PRO_0000014526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
Glycosylationi215 – 2151N-linked (GlcNAc...) (hybrid)1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18892.

Expressioni

Tissue specificityi

Expressed in mammary tissue.

Interactioni

Subunit structurei

Seems to associate with xanthine dehydrogenase/oxidase.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042450.

Structurei

Secondary structure

1
526
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 323
Beta strandi38 – 414
Beta strandi46 – 549
Beta strandi61 – 7818
Helixi84 – 863
Turni89 – 935
Beta strandi94 – 1018
Helixi102 – 1043
Beta strandi106 – 1116
Helixi116 – 1183
Beta strandi120 – 1289
Beta strandi131 – 14313
Beta strandi149 – 1546
Helixi156 – 1583
Beta strandi160 – 17112
Beta strandi174 – 1796
Beta strandi188 – 1947
Beta strandi200 – 2089
Beta strandi215 – 2228
Turni223 – 2264
Beta strandi227 – 2348

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HH8X-ray2.30A27-238[»]
ProteinModelPortaliP18892.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 242216ExtracellularSequence AnalysisAdd
BLAST
Topological domaini270 – 526257CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei243 – 26927HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 140114Ig-like V-type 1Add
BLAST
Domaini148 – 23487Ig-like V-type 2Add
BLAST
Domaini285 – 479195B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45068.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiP18892.
KOiK06712.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18892-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVFPNSCLA GCLLIFILLQ LPKLDSAPFD VIGPQEPILA VVGEDAELPC
60 70 80 90 100
RLSPNVSAKG MELRWFREKV SPAVFVSREG QEQEGEEMAE YRGRVSLVED
110 120 130 140 150
HIAEGSVAVR IQEVKASDDG EYRCFFRQDE NYEEAIVHLK VAALGSDPHI
160 170 180 190 200
SMKVQESGEI QLECTSVGWY PEPQVQWRTH RGEEFPSMSE SRNPDEEGLF
210 220 230 240 250
TVRASVIIRD SSMKNVSCCI RNLLLGQEKE VEVSIPASFF PRLTPWMVAV
260 270 280 290 300
AVILVVLGLL TIGSIFFTWR LYKERSRQRR NEFSSKEKLL EELKWKRATL
310 320 330 340 350
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKPER FDSWPCVMGR
360 370 380 390 400
EAFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG
410 420 430 440 450
NGYWALTPLR TPLPLAGPPR RVGVFLDYES GDIFFYNMTD GSHIYTFSKA
460 470 480 490 500
SFSGPLRPFF CLWSCGKKPL TICPVTDGLE GVMVVADAKD ISKEIPLSPM
510 520
GEDSASGDIE TLHSKLIPLQ PSQGVP
Length:526
Mass (Da):59,277
Last modified:July 15, 1998 - v2
Checksum:iA14126802BD19284
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161F → Y in AAB92578. 1 PublicationCurated
Sequence conflicti35 – 351Q → P in CAB07533. 1 PublicationCurated
Sequence conflicti230 – 2301E → D(PubMed:2387867)Curated
Sequence conflicti230 – 2301E → D1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35551 mRNA. Translation: AAB39766.1.
AF005497 Genomic DNA. Translation: AAB62889.1.
Z93323 Genomic DNA. Translation: CAB07533.1.
AF037402 Genomic DNA. Translation: AAB92578.2.
AY491469 Genomic DNA. Translation: AAR85488.1.
PIRiA37821.
RefSeqiNP_776933.1. NM_174508.2.
UniGeneiBt.59359.

Genome annotation databases

GeneIDi282157.
KEGGibta:282157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35551 mRNA. Translation: AAB39766.1 .
AF005497 Genomic DNA. Translation: AAB62889.1 .
Z93323 Genomic DNA. Translation: CAB07533.1 .
AF037402 Genomic DNA. Translation: AAB92578.2 .
AY491469 Genomic DNA. Translation: AAR85488.1 .
PIRi A37821.
RefSeqi NP_776933.1. NM_174508.2.
UniGenei Bt.59359.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HH8 X-ray 2.30 A 27-238 [» ]
ProteinModelPortali P18892.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000042450.

Proteomic databases

PaxDbi P18892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282157.
KEGGi bta:282157.

Organism-specific databases

CTDi 696.

Phylogenomic databases

eggNOGi NOG45068.
HOGENOMi HOG000230860.
HOVERGENi HBG050747.
InParanoidi P18892.
KOi K06712.

Miscellaneous databases

NextBioi 20805991.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation."
    Jack L.J.W., Mather I.H.
    J. Biol. Chem. 265:14481-14486(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
  2. Davey H.W., Ogg S.L., Husaini Y., Snell R.G., Korobko I.V., Mather I.H., Wilkins R.J.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Holstein-Friesian.
  3. Seyfert H.-M., Luethen F.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. "Identification of five allelic polymorphisms in the bovine butyrophilin gene."
    Husaini Y., Wilkins R.J., Davey H.W.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
  5. Bhattacharya T.K., Misra S.S., Sheikh F.D., Dayal S., Vohra V., Kumar P., Sharma A.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-526.
    Tissue: Blood.
  6. "Site-specific glycosylation of bovine butyrophilin."
    Sato T., Takio K., Kobata A., Greenwalt D.E., Furukawa K.
    J. Biochem. 117:147-157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-55 AND ASN-215.

Entry informationi

Entry nameiBT1A1_BOVIN
AccessioniPrimary (citable) accession number: P18892
Secondary accession number(s): O18955
, O18959, O46535, Q6RUS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3