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Reviewed, UniProtKB/Swiss-Prot P18892 (BT1A1_BOVIN)

Last modified November 24, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Butyrophilin subfamily 1 member A1
      Short name=BT
Gene names
Name: BTN1A1
Synonyms: BTN
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane.

Subunit structure

Seems to associate with xanthine dehydrogenase/oxidase By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in mammary tissue and secreted in association with the milk-fat-globule membrane during lactation.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 B30.2/SPRY domain.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.1
Chain27 – 526500Butyrophilin subfamily 1 member A1
PRO_0000014526

Regions

Topological domain27 – 242216Extracellular Potential
Transmembrane243 – 26927 Potential
Topological domain270 – 526257Cytoplasmic Potential
Domain27 – 140114Ig-like V-type 1
Domain148 – 23487Ig-like V-type 2
Domain285 – 479195B30.2/SPRY

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) (complex) Ref.6
Glycosylation2151N-linked (GlcNAc...) (hybrid) Ref.6
Disulfide bond50 ↔ 124 By similarity
Disulfide bond164 ↔ 218 By similarity

Experimental info

Sequence conflict161F → Y in AAB92578. Ref.4
Sequence conflict351Q → P in CAB07533. Ref.3
Sequence conflict2301E → D Ref.1
Sequence conflict2301E → D Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P18892-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: A14126802BD19284

FASTA52659,277
        10         20         30         40         50         60 
MAVFPNSCLA GCLLIFILLQ LPKLDSAPFD VIGPQEPILA VVGEDAELPC RLSPNVSAKG 

        70         80         90        100        110        120 
MELRWFREKV SPAVFVSREG QEQEGEEMAE YRGRVSLVED HIAEGSVAVR IQEVKASDDG 

       130        140        150        160        170        180 
EYRCFFRQDE NYEEAIVHLK VAALGSDPHI SMKVQESGEI QLECTSVGWY PEPQVQWRTH 

       190        200        210        220        230        240 
RGEEFPSMSE SRNPDEEGLF TVRASVIIRD SSMKNVSCCI RNLLLGQEKE VEVSIPASFF 

       250        260        270        280        290        300 
PRLTPWMVAV AVILVVLGLL TIGSIFFTWR LYKERSRQRR NEFSSKEKLL EELKWKRATL 

       310        320        330        340        350        360 
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKPER FDSWPCVMGR EAFTSGRHYW 

       370        380        390        400        410        420 
EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR 

       430        440        450        460        470        480 
RVGVFLDYES GDIFFYNMTD GSHIYTFSKA SFSGPLRPFF CLWSCGKKPL TICPVTDGLE 

       490        500        510        520 
GVMVVADAKD ISKEIPLSPM GEDSASGDIE TLHSKLIPLQ PSQGVP

« Hide

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References

[1]"Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation."
Jack L.J.W., Mather I.H.
J. Biol. Chem. 265:14481-14486(1990) [PubMed: 2387867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
[2]Davey H.W., Ogg S.L., Husaini Y., Snell R.G., Korobko I.V., Mather I.H., Wilkins R.J.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Holstein-Friesian.
[3]Seyfert H.-M., Luethen F.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[4]"Identification of five allelic polymorphisms in the bovine butyrophilin gene."
Husaini Y., Wilkins R.J., Davey H.W.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
[5]Bhattacharya T.K., Misra S.S., Sheikh F.D., Dayal S., Vohra V., Kumar P., Sharma A.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-526.
Tissue: Blood.
[6]"Site-specific glycosylation of bovine butyrophilin."
Sato T., Takio K., Kobata A., Greenwalt D.E., Furukawa K.
J. Biochem. 117:147-157(1995) [PubMed: 7775382] [Abstract]
Cited for: GLYCOSYLATION AT ASN-55 AND ASN-215.

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Cross-references

Sequence databases

M35551 mRNA. Translation: AAB39766.1.
AF005497 Genomic DNA. Translation: AAB62889.1.
Z93323 Genomic DNA. Translation: CAB07533.1.
AF037402 Genomic DNA. Translation: AAB92578.2.
AY491469 Genomic DNA. Translation: AAR85488.1.
IPIIPI00708535.
PIRA37821.
RefSeqNP_776933.1.
UniGeneBt.59359

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP18892.

Genome annotation databases

EnsemblENSBTAT00000045021; ENSBTAP00000042450; ENSBTAG00000031753; Bos taurus. [Genome view]
GeneID282157.
KEGGbta:282157.

Organism-specific databases

CTD282157.

Phylogenomic databases

HOVERGENP18892.

Family and domain databases

InterProIPR001870. B302.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_sg.
IPR003877. SPRY_rcpt.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF08205. C2-set_2. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
PROSITEPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBT1A1_BOVIN
AccessionPrimary (citable) accession number: P18892
Secondary accession number(s): O18955 expand/collapse secondary AC list , O18959, O46535, Q6RUS3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 15, 1998
Last modified: November 24, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents