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P18892

- BT1A1_BOVIN

UniProt

P18892 - BT1A1_BOVIN

Protein

Butyrophilin subfamily 1 member A1

Gene

BTN1A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrophilin subfamily 1 member A1
    Short name:
    BT
    Gene namesi
    Name:BTN1A1
    Synonyms:BTN
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Membrane; Single-pass type I membrane protein
    Note: Secreted in association with the milk-fat-globule membrane during lactation.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 526500Butyrophilin subfamily 1 member A1PRO_0000014526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
    Glycosylationi55 – 551N-linked (GlcNAc...) (complex)1 Publication
    Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
    Glycosylationi215 – 2151N-linked (GlcNAc...) (hybrid)1 Publication

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP18892.

    Expressioni

    Tissue specificityi

    Expressed in mammary tissue.

    Interactioni

    Subunit structurei

    Seems to associate with xanthine dehydrogenase/oxidase.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000042450.

    Structurei

    Secondary structure

    1
    526
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 323
    Beta strandi38 – 414
    Beta strandi46 – 549
    Beta strandi61 – 7818
    Helixi84 – 863
    Turni89 – 935
    Beta strandi94 – 1018
    Helixi102 – 1043
    Beta strandi106 – 1116
    Helixi116 – 1183
    Beta strandi120 – 1289
    Beta strandi131 – 14313
    Beta strandi149 – 1546
    Helixi156 – 1583
    Beta strandi160 – 17112
    Beta strandi174 – 1796
    Beta strandi188 – 1947
    Beta strandi200 – 2089
    Beta strandi215 – 2228
    Turni223 – 2264
    Beta strandi227 – 2348

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HH8X-ray2.30A27-238[»]
    ProteinModelPortaliP18892.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 242216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 526257CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei243 – 26927HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 140114Ig-like V-type 1Add
    BLAST
    Domaini148 – 23487Ig-like V-type 2Add
    BLAST
    Domaini285 – 479195B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45068.
    HOGENOMiHOG000230860.
    HOVERGENiHBG050747.
    InParanoidiP18892.
    KOiK06712.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR013162. CD80_C2-set.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18892-1 [UniParc]FASTAAdd to Basket

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    MAVFPNSCLA GCLLIFILLQ LPKLDSAPFD VIGPQEPILA VVGEDAELPC    50
    RLSPNVSAKG MELRWFREKV SPAVFVSREG QEQEGEEMAE YRGRVSLVED 100
    HIAEGSVAVR IQEVKASDDG EYRCFFRQDE NYEEAIVHLK VAALGSDPHI 150
    SMKVQESGEI QLECTSVGWY PEPQVQWRTH RGEEFPSMSE SRNPDEEGLF 200
    TVRASVIIRD SSMKNVSCCI RNLLLGQEKE VEVSIPASFF PRLTPWMVAV 250
    AVILVVLGLL TIGSIFFTWR LYKERSRQRR NEFSSKEKLL EELKWKRATL 300
    HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKPER FDSWPCVMGR 350
    EAFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG 400
    NGYWALTPLR TPLPLAGPPR RVGVFLDYES GDIFFYNMTD GSHIYTFSKA 450
    SFSGPLRPFF CLWSCGKKPL TICPVTDGLE GVMVVADAKD ISKEIPLSPM 500
    GEDSASGDIE TLHSKLIPLQ PSQGVP 526
    Length:526
    Mass (Da):59,277
    Last modified:July 15, 1998 - v2
    Checksum:iA14126802BD19284
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161F → Y in AAB92578. 1 PublicationCurated
    Sequence conflicti35 – 351Q → P in CAB07533. 1 PublicationCurated
    Sequence conflicti230 – 2301E → D(PubMed:2387867)Curated
    Sequence conflicti230 – 2301E → D1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35551 mRNA. Translation: AAB39766.1.
    AF005497 Genomic DNA. Translation: AAB62889.1.
    Z93323 Genomic DNA. Translation: CAB07533.1.
    AF037402 Genomic DNA. Translation: AAB92578.2.
    AY491469 Genomic DNA. Translation: AAR85488.1.
    PIRiA37821.
    RefSeqiNP_776933.1. NM_174508.2.
    UniGeneiBt.59359.

    Genome annotation databases

    GeneIDi282157.
    KEGGibta:282157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35551 mRNA. Translation: AAB39766.1 .
    AF005497 Genomic DNA. Translation: AAB62889.1 .
    Z93323 Genomic DNA. Translation: CAB07533.1 .
    AF037402 Genomic DNA. Translation: AAB92578.2 .
    AY491469 Genomic DNA. Translation: AAR85488.1 .
    PIRi A37821.
    RefSeqi NP_776933.1. NM_174508.2.
    UniGenei Bt.59359.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HH8 X-ray 2.30 A 27-238 [» ]
    ProteinModelPortali P18892.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000042450.

    Proteomic databases

    PaxDbi P18892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282157.
    KEGGi bta:282157.

    Organism-specific databases

    CTDi 696.

    Phylogenomic databases

    eggNOGi NOG45068.
    HOGENOMi HOG000230860.
    HOVERGENi HBG050747.
    InParanoidi P18892.
    KOi K06712.

    Miscellaneous databases

    NextBioi 20805991.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR013162. CD80_C2-set.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation."
      Jack L.J.W., Mather I.H.
      J. Biol. Chem. 265:14481-14486(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
    2. Davey H.W., Ogg S.L., Husaini Y., Snell R.G., Korobko I.V., Mather I.H., Wilkins R.J.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Holstein-Friesian.
    3. Seyfert H.-M., Luethen F.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    4. "Identification of five allelic polymorphisms in the bovine butyrophilin gene."
      Husaini Y., Wilkins R.J., Davey H.W.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
    5. Bhattacharya T.K., Misra S.S., Sheikh F.D., Dayal S., Vohra V., Kumar P., Sharma A.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-526.
      Tissue: Blood.
    6. "Site-specific glycosylation of bovine butyrophilin."
      Sato T., Takio K., Kobata A., Greenwalt D.E., Furukawa K.
      J. Biochem. 117:147-157(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-55 AND ASN-215.

    Entry informationi

    Entry nameiBT1A1_BOVIN
    AccessioniPrimary (citable) accession number: P18892
    Secondary accession number(s): O18955
    , O18959, O46535, Q6RUS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3