Reviewed,
UniProtKB/Swiss-Prot P18888 (SNF6_YEAST)
Last modified
November 24, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription regulatory protein SNF6 Alternative name(s): SWI/SNF complex component SNF6 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 332 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. |
| Subunit structure | Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29. |
| Subcellular location | |
| Miscellaneous | Present with 2900 molecules/cell in log phase SD medium. Ref.3 |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative initiation |
| Molecular function | Activator |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ATP-dependent chromatin remodeling Inferred from direct assay. Source: SGD nucleotide-excision repairInferred from mutant phenotype. Source: SGD positive regulation of transcription, DNA-dependentInferred from direct assay. Source: SGD transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | SWI/SNF complex Inferred from direct assay. Source: SGD |
| Molecular function | general RNA polymerase II transcription factor activity Traceable author statement. Source: SGD protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| RAD23 | P32628 | 1 | EBI-17550,EBI-14668 | |
| RAD4 | P14736 | 1 | EBI-17550,EBI-14766 | |
| SNF11 | P38956 | 1 | EBI-17550,EBI-17560 | |
| TAF14 | P35189 | 1 | EBI-17550,EBI-18920 |
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Select] | ||||||
| Isoform Long (identifier: P18888-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Short (identifier: P18888-2) The sequence of this isoform is not available. | ||||||
| Note: Partially functional. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 332 | 332 | Transcription regulatory protein SNF6 | PRO_0000072006 | |||||
Regions | |||||||||
| Motif | 2 – 8 | 7 | Nuclear localization signal Potential | ||||||
| Compositional bias | 264 – 276 | 13 | Gln-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 165 | 1 | Phosphothreonine Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae." Estruch F., Carlson M. Mol. Cell. Biol. 10:2544-2553(1990) [PubMed: 2188093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M.Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [3] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [4] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-165, MASS SPECTROMETRY. |
| [5] | "Structural analysis of the yeast SWI/SNF chromatin remodeling complex." Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L. Nat. Struct. Biol. 10:141-145(2003) [PubMed: 12524530] [Abstract] Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M37132 Genomic DNA. Translation: AAA35063.1. M32028 Genomic DNA. Translation: AAA35064.1. U11582 Genomic DNA. Translation: AAB65078.1. | |
| PIR | A36313. |
| RefSeq | NP_011838.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:1226N. |
| IntAct | P18888. 36 interactions. |
| STRING | P18888. |
Proteomic databases | |
| PeptideAtlas | P18888. |
Genome annotation databases | |
| Ensembl | YHL025W; YHL025W; YHL025W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 856360. |
| KEGG | sce:YHL025W. |
| NMPDR | fig|4932.3.peg.2976. |
Organism-specific databases | |
| CYGD | YHL025w. |
| SGD | S000001017. SNF6. |
Phylogenomic databases | |
| OMA | HDESDTI |
| OrthoDB | EOG9NZW9F |
Gene expression databases | |
| ArrayExpress | P18888. |
| Genevestigator | P18888. |
| GermOnline | YHL025W. Saccharomyces cerevisiae. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 981817. |
Entry information
| Entry name | SNF6_YEAST | ||||||||
| Accession | Primary (citable) accession number: P18888 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VIII Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names |

Clusters with


