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P18888

- SNF6_YEAST

UniProt

P18888 - SNF6_YEAST

Protein

Transcription regulatory protein SNF6

Gene

SNF6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. chromatin remodeling Source: SGD
    3. nucleotide-excision repair Source: SGD
    4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    5. sucrose catabolic process Source: SGD
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31045-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription regulatory protein SNF6
    Alternative name(s):
    SWI/SNF complex component SNF6
    Gene namesi
    Name:SNF6
    Ordered Locus Names:YHL025W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL025w.
    SGDiS000001017. SNF6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD
    3. SWI/SNF complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Transcription regulatory protein SNF6PRO_0000072006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP18888.
    PaxDbiP18888.
    PeptideAtlasiP18888.

    Expressioni

    Gene expression databases

    GenevestigatoriP18888.

    Interactioni

    Subunit structurei

    Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RAD23P326282EBI-17550,EBI-14668
    SNF11P389565EBI-17550,EBI-17560
    SWI3P325915EBI-17550,EBI-18622
    TAF14P351894EBI-17550,EBI-18920

    Protein-protein interaction databases

    BioGridi36397. 148 interactions.
    DIPiDIP-1226N.
    IntActiP18888. 37 interactions.
    MINTiMINT-409138.
    STRINGi4932.YHL025W.

    Structurei

    3D structure databases

    ProteinModelPortaliP18888.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2 – 87Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi264 – 27613Gln-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG38849.
    KOiK11773.
    OMAiSSAGMNG.
    OrthoDBiEOG75F4SJ.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform Long (identifier: P18888-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MGVIKKKRSH HGKASRQQYY SGVQVGGVGS MGAINNNIPS LTSFAEENNY    50
    QYGYSGSSAG MNGRSLTYAQ QQLNKQRQDF ERVRLRPEQL SNIIHDESDT 100
    ISFRSNLLKN FISSNDAFNM LSLTTVPCDR IEKSRLFSEK TIRYLMQKQH 150
    EMKTQAAELQ EKPLTPLKYT KLIAAAEDGS RSTKDMIDAV FEQDSHLRYQ 200
    PDGVVVHRDD PALVGKLRGD LREAPADYWT HAYRDVLAQY HEAKERIRQK 250
    EVTAGEAQDE ASLQQQQQQD LQQQQQVVTT VASQSPHATA TEKEPVPAVV 300
    DDPLENMFGD YSNEPFNTNF DDEFGDLDAV FF 332
    Length:332
    Mass (Da):37,607
    Last modified:November 1, 1990 - v1
    Checksum:iED9EA9F313F9079F
    GO
    Isoform Short (identifier: P18888-2)

    Sequence is not available

    Note: Partially functional.

    Length:
    Mass (Da):

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37132 Genomic DNA. Translation: AAA35063.1.
    M32028 Genomic DNA. Translation: AAA35064.1.
    U11582 Genomic DNA. Translation: AAB65078.1.
    BK006934 Genomic DNA. Translation: DAA06660.1.
    PIRiA36313.
    RefSeqiNP_011838.1. NM_001179105.1. [P18888-1]

    Genome annotation databases

    EnsemblFungiiYHL025W; YHL025W; YHL025W. [P18888-1]
    GeneIDi856360.
    KEGGisce:YHL025W.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37132 Genomic DNA. Translation: AAA35063.1 .
    M32028 Genomic DNA. Translation: AAA35064.1 .
    U11582 Genomic DNA. Translation: AAB65078.1 .
    BK006934 Genomic DNA. Translation: DAA06660.1 .
    PIRi A36313.
    RefSeqi NP_011838.1. NM_001179105.1. [P18888-1 ]

    3D structure databases

    ProteinModelPortali P18888.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36397. 148 interactions.
    DIPi DIP-1226N.
    IntActi P18888. 37 interactions.
    MINTi MINT-409138.
    STRINGi 4932.YHL025W.

    Proteomic databases

    MaxQBi P18888.
    PaxDbi P18888.
    PeptideAtlasi P18888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL025W ; YHL025W ; YHL025W . [P18888-1 ]
    GeneIDi 856360.
    KEGGi sce:YHL025W.

    Organism-specific databases

    CYGDi YHL025w.
    SGDi S000001017. SNF6.

    Phylogenomic databases

    eggNOGi NOG38849.
    KOi K11773.
    OMAi SSAGMNG.
    OrthoDBi EOG75F4SJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31045-MONOMER.

    Miscellaneous databases

    NextBioi 981817.

    Gene expression databases

    Genevestigatori P18888.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae."
      Estruch F., Carlson M.
      Mol. Cell. Biol. 10:2544-2553(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
      Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
      Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.

    Entry informationi

    Entry nameiSNF6_YEAST
    AccessioniPrimary (citable) accession number: P18888
    Secondary accession number(s): D3DKU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3