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P18888

- SNF6_YEAST

UniProt

P18888 - SNF6_YEAST

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Protein

Transcription regulatory protein SNF6

Gene

SNF6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. chromatin remodeling Source: SGD
  3. nucleotide-excision repair Source: SGD
  4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. sucrose catabolic process Source: SGD
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31045-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulatory protein SNF6
Alternative name(s):
SWI/SNF complex component SNF6
Gene namesi
Name:SNF6
Ordered Locus Names:YHL025W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL025w.
SGDiS000001017. SNF6.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
  3. SWI/SNF complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Transcription regulatory protein SNF6PRO_0000072006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP18888.
PaxDbiP18888.
PeptideAtlasiP18888.

Expressioni

Gene expression databases

GenevestigatoriP18888.

Interactioni

Subunit structurei

Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

Binary interactionsi

WithEntry#Exp.IntActNotes
RAD23P326282EBI-17550,EBI-14668
SNF11P389565EBI-17550,EBI-17560
SWI3P325915EBI-17550,EBI-18622
TAF14P351894EBI-17550,EBI-18920

Protein-protein interaction databases

BioGridi36397. 148 interactions.
DIPiDIP-1226N.
IntActiP18888. 37 interactions.
MINTiMINT-409138.
STRINGi4932.YHL025W.

Structurei

3D structure databases

ProteinModelPortaliP18888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2 – 87Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 27613Gln-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG38849.
InParanoidiP18888.
KOiK11773.
OMAiSSAGMNG.
OrthoDBiEOG75F4SJ.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Long (identifier: P18888-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVIKKKRSH HGKASRQQYY SGVQVGGVGS MGAINNNIPS LTSFAEENNY
60 70 80 90 100
QYGYSGSSAG MNGRSLTYAQ QQLNKQRQDF ERVRLRPEQL SNIIHDESDT
110 120 130 140 150
ISFRSNLLKN FISSNDAFNM LSLTTVPCDR IEKSRLFSEK TIRYLMQKQH
160 170 180 190 200
EMKTQAAELQ EKPLTPLKYT KLIAAAEDGS RSTKDMIDAV FEQDSHLRYQ
210 220 230 240 250
PDGVVVHRDD PALVGKLRGD LREAPADYWT HAYRDVLAQY HEAKERIRQK
260 270 280 290 300
EVTAGEAQDE ASLQQQQQQD LQQQQQVVTT VASQSPHATA TEKEPVPAVV
310 320 330
DDPLENMFGD YSNEPFNTNF DDEFGDLDAV FF
Length:332
Mass (Da):37,607
Last modified:November 1, 1990 - v1
Checksum:iED9EA9F313F9079F
GO
Isoform Short (identifier: P18888-2)

Sequence is not available

Note: Partially functional.

Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37132 Genomic DNA. Translation: AAA35063.1.
M32028 Genomic DNA. Translation: AAA35064.1.
U11582 Genomic DNA. Translation: AAB65078.1.
BK006934 Genomic DNA. Translation: DAA06660.1.
PIRiA36313.
RefSeqiNP_011838.1. NM_001179105.1. [P18888-1]

Genome annotation databases

EnsemblFungiiYHL025W; YHL025W; YHL025W. [P18888-1]
GeneIDi856360.
KEGGisce:YHL025W.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37132 Genomic DNA. Translation: AAA35063.1 .
M32028 Genomic DNA. Translation: AAA35064.1 .
U11582 Genomic DNA. Translation: AAB65078.1 .
BK006934 Genomic DNA. Translation: DAA06660.1 .
PIRi A36313.
RefSeqi NP_011838.1. NM_001179105.1. [P18888-1 ]

3D structure databases

ProteinModelPortali P18888.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36397. 148 interactions.
DIPi DIP-1226N.
IntActi P18888. 37 interactions.
MINTi MINT-409138.
STRINGi 4932.YHL025W.

Proteomic databases

MaxQBi P18888.
PaxDbi P18888.
PeptideAtlasi P18888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL025W ; YHL025W ; YHL025W . [P18888-1 ]
GeneIDi 856360.
KEGGi sce:YHL025W.

Organism-specific databases

CYGDi YHL025w.
SGDi S000001017. SNF6.

Phylogenomic databases

eggNOGi NOG38849.
InParanoidi P18888.
KOi K11773.
OMAi SSAGMNG.
OrthoDBi EOG75F4SJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-31045-MONOMER.

Miscellaneous databases

NextBioi 981817.

Gene expression databases

Genevestigatori P18888.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae."
    Estruch F., Carlson M.
    Mol. Cell. Biol. 10:2544-2553(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
    Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
    Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.

Entry informationi

Entry nameiSNF6_YEAST
AccessioniPrimary (citable) accession number: P18888
Secondary accession number(s): D3DKU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3