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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei113Implicated in ligand bindingBy similarity1
Sitei200Implicated in catechol agonist bindingBy similarity1
Sitei204Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • alpha2-adrenergic receptor activity Source: BHF-UCL
  • epinephrine binding Source: BHF-UCL
  • norepinephrine binding Source: Ensembl
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-390696. Adrenoceptors.
R-SSC-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-SSC-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-418597. G alpha (z) signalling events.
R-SSC-5683826. Surfactant metabolism.
SABIO-RKP18871.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:ADRA2A
Synonyms:A2AR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 149CytoplasmicBy similarityAdd BLAST20
Transmembranei150 – 173Helical; Name=4By similarityAdd BLAST24
Topological domaini174 – 192ExtracellularBy similarityAdd BLAST19
Transmembranei193 – 217Helical; Name=5By similarityAdd BLAST25
Topological domaini218 – 374CytoplasmicBy similarityAdd BLAST157
Transmembranei375 – 399Helical; Name=6By similarityAdd BLAST25
Topological domaini400 – 409ExtracellularBy similarity10
Transmembranei410 – 430Helical; Name=7By similarityAdd BLAST21
Topological domaini431 – 450CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi442C → A or S: Loss of palmitoylation. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690821 – 450Alpha-2A adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei331PhosphoserineBy similarity1
Modified residuei353Omega-N-methylarginineBy similarity1
Lipidationi442S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP18871.
PRIDEiP18871.

PTM databases

SwissPalmiP18871.

Expressioni

Gene expression databases

BgeeiENSSSCG00000010629.
GenevisibleiP18871. SS.

Interactioni

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323.

Chemistry databases

BindingDBiP18871.

Structurei

3D structure databases

ProteinModelPortaliP18871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP18871.
KOiK04138.
OMAiAIIITVW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPEAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SIEKKAGGGG QQPAEPRCEI NDQKWYVISS
210 220 230 240 250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAAA ALPGGAERRP
260 270 280 290 300
NGLGPERGVG RVGAEAEPLP VQLNGAPGEP APAGPRDADG LDLEESSSSE
310 320 330 340 350
HAERPPGPRR SERGPRAKSK ARASQVKPGD SLPRRGPGAP GPGAPATGAG
360 370 380 390 400
EERGGVAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG
410 420 430 440 450
CSVPPTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,976
Last modified:November 1, 1990 - v1
Checksum:i79D7D5B47372074E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA. Translation: AAA30984.1.
PIRiA38316.
RefSeqiNP_999565.1. NM_214400.1.
UniGeneiSsc.27594.

Genome annotation databases

EnsembliENSSSCT00000011625; ENSSSCP00000011323; ENSSSCG00000010629.
GeneIDi399501.
KEGGissc:399501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA. Translation: AAA30984.1.
PIRiA38316.
RefSeqiNP_999565.1. NM_214400.1.
UniGeneiSsc.27594.

3D structure databases

ProteinModelPortaliP18871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323.

Chemistry databases

BindingDBiP18871.
ChEMBLiCHEMBL2350.

Protein family/group databases

GPCRDBiSearch...

PTM databases

SwissPalmiP18871.

Proteomic databases

PaxDbiP18871.
PRIDEiP18871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000011625; ENSSSCP00000011323; ENSSSCG00000010629.
GeneIDi399501.
KEGGissc:399501.

Organism-specific databases

CTDi150.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP18871.
KOiK04138.
OMAiAIIITVW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-SSC-390696. Adrenoceptors.
R-SSC-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-SSC-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-418597. G alpha (z) signalling events.
R-SSC-5683826. Surfactant metabolism.
SABIO-RKP18871.

Gene expression databases

BgeeiENSSSCG00000010629.
GenevisibleiP18871. SS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_PIG
AccessioniPrimary (citable) accession number: P18871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Alpha2-adrenergic receptor shows an allosteric modulation by Na+, H+ and amiloride analogs.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.