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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei113 – 1131Implicated in ligand bindingBy similarity
Sitei200 – 2001Implicated in catechol agonist bindingBy similarity
Sitei204 – 2041Implicated in catechol agonist bindingBy similarity

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • alpha2-adrenergic receptor activity Source: BHF-UCL
  • epinephrine binding Source: BHF-UCL
  • norepinephrine binding Source: Ensembl
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-390696. Adrenoceptors.
R-SSC-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-SSC-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-418597. G alpha (z) signalling events.
R-SSC-5683826. Surfactant metabolism.
SABIO-RKP18871.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:ADRA2A
Synonyms:A2AR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Transmembranei34 – 5926Helical; Name=1By similarityAdd
BLAST
Topological domaini60 – 7011CytoplasmicBy similarityAdd
BLAST
Transmembranei71 – 9626Helical; Name=2By similarityAdd
BLAST
Topological domaini97 – 10610ExtracellularBy similarity
Transmembranei107 – 12923Helical; Name=3By similarityAdd
BLAST
Topological domaini130 – 14920CytoplasmicBy similarityAdd
BLAST
Transmembranei150 – 17324Helical; Name=4By similarityAdd
BLAST
Topological domaini174 – 19219ExtracellularBy similarityAdd
BLAST
Transmembranei193 – 21725Helical; Name=5By similarityAdd
BLAST
Topological domaini218 – 374157CytoplasmicBy similarityAdd
BLAST
Transmembranei375 – 39925Helical; Name=6By similarityAdd
BLAST
Topological domaini400 – 40910ExtracellularBy similarity
Transmembranei410 – 43021Helical; Name=7By similarityAdd
BLAST
Topological domaini431 – 45020CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi442 – 4421C → A or S: Loss of palmitoylation. 1 Publication

Chemistry

ChEMBLiCHEMBL2350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei331 – 3311PhosphoserineBy similarity
Lipidationi442 – 4421S-palmitoyl cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP18871.

PTM databases

SwissPalmiP18871.

Expressioni

Gene expression databases

BgeeiENSSSCG00000010629.
GenevisibleiP18871. SS.

Interactioni

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323.

Chemistry

BindingDBiP18871.

Structurei

3D structure databases

ProteinModelPortaliP18871.
SMRiP18871. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP18871.
KOiK04138.
OMAiAIIITVW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPEAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SIEKKAGGGG QQPAEPRCEI NDQKWYVISS
210 220 230 240 250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAAA ALPGGAERRP
260 270 280 290 300
NGLGPERGVG RVGAEAEPLP VQLNGAPGEP APAGPRDADG LDLEESSSSE
310 320 330 340 350
HAERPPGPRR SERGPRAKSK ARASQVKPGD SLPRRGPGAP GPGAPATGAG
360 370 380 390 400
EERGGVAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG
410 420 430 440 450
CSVPPTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,976
Last modified:November 1, 1990 - v1
Checksum:i79D7D5B47372074E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA. Translation: AAA30984.1.
PIRiA38316.
RefSeqiNP_999565.1. NM_214400.1.
UniGeneiSsc.27594.

Genome annotation databases

EnsembliENSSSCT00000011625; ENSSSCP00000011323; ENSSSCG00000010629.
GeneIDi399501.
KEGGissc:399501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA. Translation: AAA30984.1.
PIRiA38316.
RefSeqiNP_999565.1. NM_214400.1.
UniGeneiSsc.27594.

3D structure databases

ProteinModelPortaliP18871.
SMRiP18871. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323.

Chemistry

BindingDBiP18871.
ChEMBLiCHEMBL2350.

Protein family/group databases

GPCRDBiSearch...

PTM databases

SwissPalmiP18871.

Proteomic databases

PaxDbiP18871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000011625; ENSSSCP00000011323; ENSSSCG00000010629.
GeneIDi399501.
KEGGissc:399501.

Organism-specific databases

CTDi150.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP18871.
KOiK04138.
OMAiAIIITVW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-SSC-390696. Adrenoceptors.
R-SSC-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-SSC-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-418597. G alpha (z) signalling events.
R-SSC-5683826. Surfactant metabolism.
SABIO-RKP18871.

Gene expression databases

BgeeiENSSSCG00000010629.
GenevisibleiP18871. SS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_PIG
AccessioniPrimary (citable) accession number: P18871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Alpha2-adrenergic receptor shows an allosteric modulation by Na+, H+ and amiloride analogs.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.