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Protein

Transcription factor AP-1

Gene

JUN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-437986. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-1
Alternative name(s):
Proto-oncogene c-Jun
Gene namesi
Name:JUN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBLiCHEMBL1075084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764331 – 314Transcription factor AP-1Add BLAST314

Proteomic databases

PaxDbiP18870.

PTM databases

iPTMnetiP18870.

Interactioni

Subunit structurei

Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

ELMiP18870.
IntActiP18870. 3 interactors.
STRINGi9031.ENSGALP00000037247.

Structurei

3D structure databases

ProteinModelPortaliP18870.
SMRiP18870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 298bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 262Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni263 – 291Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP18870.
KOiK04448.
PhylomeDBiP18870.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR015558. C_Jun/v-Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
PANTHERiPTHR11462:SF8. PTHR11462:SF8. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P18870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKMEPTFY EDALNASFAP PESGGYGYNN AKVLKQSMTL NLSDAASSLK
60 70 80 90 100
PHLRNKNADI LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP
110 120 130 140 150
KNVTDEQEGF AEGFVRALAE LHNQNTLPSV TSAAQPVSGG MAPVSSMAGG
160 170 180 190 200
GSFNTSLHSE PPVYANLSNF NPNALNSAPN YNANGMGYAP QHHINPQMPV
210 220 230 240 250
QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS
260 270 280 290 300
KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN
310
SGCQLMLTQQ LQTF
Length:314
Mass (Da):34,358
Last modified:November 22, 2005 - v2
Checksum:iB882DBFACEDDE1B1
GO

Sequence cautioni

P18870: The sequence AAA48927 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57467 Genomic DNA. Translation: AAA48927.1. Different initiation.
PIRiI50373.
RefSeqiNP_001026460.1. NM_001031289.1.
UniGeneiGga.1473.

Genome annotation databases

GeneIDi424673.
KEGGigga:424673.

Similar proteinsi

Entry informationi

Entry nameiJUN_CHICK
AccessioniPrimary (citable) accession number: P18870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families