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Protein

Transcription factor AP-1

Gene

JUN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-437986. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-1
Alternative name(s):
Proto-oncogene c-Jun
Gene namesi
Name:JUN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: GO_Central
  • nucleus Source: AgBase
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry

ChEMBLiCHEMBL1075084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Transcription factor AP-1PRO_0000076433Add
BLAST

Proteomic databases

PaxDbiP18870.

Interactioni

Subunit structurei

Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MDV005Q9DGW54EBI-445826,EBI-10889526From a different organism.
R-LORF7Q77Q712EBI-445826,EBI-10766689From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP18870. 2 interactions.
STRINGi9031.ENSGALP00000037247.

Structurei

3D structure databases

ProteinModelPortaliP18870.
SMRiP18870. Positions 240-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 29864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 26228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni263 – 29129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP18870.
KOiK04448.
PhylomeDBiP18870.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR015558. C_Jun/v-Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF8. PTHR11462:SF8. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKMEPTFY EDALNASFAP PESGGYGYNN AKVLKQSMTL NLSDAASSLK
60 70 80 90 100
PHLRNKNADI LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP
110 120 130 140 150
KNVTDEQEGF AEGFVRALAE LHNQNTLPSV TSAAQPVSGG MAPVSSMAGG
160 170 180 190 200
GSFNTSLHSE PPVYANLSNF NPNALNSAPN YNANGMGYAP QHHINPQMPV
210 220 230 240 250
QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS
260 270 280 290 300
KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN
310
SGCQLMLTQQ LQTF
Length:314
Mass (Da):34,358
Last modified:November 22, 2005 - v2
Checksum:iB882DBFACEDDE1B1
GO

Sequence cautioni

The sequence AAA48927 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57467 Genomic DNA. Translation: AAA48927.1. Different initiation.
PIRiI50373.
RefSeqiNP_001026460.1. NM_001031289.1.
UniGeneiGga.1473.

Genome annotation databases

GeneIDi424673.
KEGGigga:424673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57467 Genomic DNA. Translation: AAA48927.1. Different initiation.
PIRiI50373.
RefSeqiNP_001026460.1. NM_001031289.1.
UniGeneiGga.1473.

3D structure databases

ProteinModelPortaliP18870.
SMRiP18870. Positions 240-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18870. 2 interactions.
STRINGi9031.ENSGALP00000037247.

Chemistry

ChEMBLiCHEMBL1075084.

Proteomic databases

PaxDbiP18870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi424673.
KEGGigga:424673.

Organism-specific databases

CTDi3725.

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP18870.
KOiK04448.
PhylomeDBiP18870.

Enzyme and pathway databases

ReactomeiR-GGA-437986. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Miscellaneous databases

PROiP18870.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR015558. C_Jun/v-Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF8. PTHR11462:SF8. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJUN_CHICK
AccessioniPrimary (citable) accession number: P18870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 22, 2005
Last modified: June 8, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.