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Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein R1B
Gene namesi
Name:Hoxb7
Synonyms:Hoxb-7, R1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1559918. Hoxb7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001441 – 219Homeobox protein Hox-B7Add BLAST219

Proteomic databases

PaxDbiP18864.

PTM databases

PhosphoSitePlusiP18864.

Expressioni

Tissue specificityi

Predominantly spinal cord and kidney.

Gene expression databases

BgeeiENSRNOG00000007611.
GenevisibleiP18864. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033609.

Structurei

3D structure databases

ProteinModelPortaliP18864.
SMRiP18864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 131Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 64Poly-Gly4
Compositional biasi213 – 219Poly-Glu7

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP18864.
KOiK09307.
OMAiCAPFEQN.
OrthoDBiEOG091G09XD.
PhylomeDBiP18864.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P18864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP
60 70 80 90 100
FSASVQGLYS GGGGMAGQSA AGVYEAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTERKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KWKKENKTSG
210
PGTTGQDKAE ADEEEEEEE
Length:219
Mass (Da):24,243
Last modified:December 6, 2005 - v2
Checksum:i4917EA7ACC635DF9
GO

Sequence cautioni

The sequence AAA41342 differs from that shown. Intron retention.Curated
The sequence AAA41342 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173 – 174AL → GV in AAA41342 (PubMed:2907739).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079340 mRNA. Translation: AAH79340.1.
M37566 Genomic DNA. Translation: AAA41342.2. Sequence problems.
PIRiT10775.
RefSeqiNP_001017480.1. NM_001017480.1.
UniGeneiRn.113631.

Genome annotation databases

EnsembliENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
GeneIDi497985.
KEGGirno:497985.
UCSCiRGD:1559918. rat.

Similar proteinsi

Entry informationi

Entry nameiHXB7_RAT
AccessioniPrimary (citable) accession number: P18864
Secondary accession number(s): Q68FU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: November 22, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families