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Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. myeloid cell differentiation Source: Ensembl
  4. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein R1B
Gene namesi
Name:Hoxb7
Synonyms:Hoxb-7, R1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1559918. Hoxb7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Homeobox protein Hox-B7PRO_0000200144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

PTM databases

PhosphoSiteiP18864.

Expressioni

Tissue specificityi

Predominantly spinal cord and kidney.

Gene expression databases

GenevestigatoriP18864.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033609.

Structurei

3D structure databases

ProteinModelPortaliP18864.
SMRiP18864. Positions 137-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1316Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 644Poly-Gly
Compositional biasi213 – 2197Poly-Glu

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP18864.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP18864.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP
60 70 80 90 100
FSASVQGLYS GGGGMAGQSA AGVYEAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTERKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KWKKENKTSG
210
PGTTGQDKAE ADEEEEEEE
Length:219
Mass (Da):24,243
Last modified:December 6, 2005 - v2
Checksum:i4917EA7ACC635DF9
GO

Sequence cautioni

The sequence AAA41342.2 differs from that shown.Intron retention.Curated
The sequence AAA41342.2 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1742AL → GV in AAA41342 (PubMed:2907739).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079340 mRNA. Translation: AAH79340.1.
M37566 Genomic DNA. Translation: AAA41342.2. Sequence problems.
PIRiT10775.
RefSeqiNP_001017480.1. NM_001017480.1.
UniGeneiRn.113631.

Genome annotation databases

EnsembliENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
GeneIDi497985.
KEGGirno:497985.
UCSCiRGD:1559918. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079340 mRNA. Translation: AAH79340.1.
M37566 Genomic DNA. Translation: AAA41342.2. Sequence problems.
PIRiT10775.
RefSeqiNP_001017480.1. NM_001017480.1.
UniGeneiRn.113631.

3D structure databases

ProteinModelPortaliP18864.
SMRiP18864. Positions 137-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033609.

PTM databases

PhosphoSiteiP18864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
GeneIDi497985.
KEGGirno:497985.
UCSCiRGD:1559918. rat.

Organism-specific databases

CTDi3217.
RGDi1559918. Hoxb7.

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP18864.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP18864.
TreeFamiTF316310.

Miscellaneous databases

NextBioi698299.
PROiP18864.

Gene expression databases

GenevestigatoriP18864.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "The expression of rat homeobox-containing genes is developmentally regulated and tissue specific."
    Falzon M., Chung S.Y.
    Development 103:601-610(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-199.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiHXB7_RAT
AccessioniPrimary (citable) accession number: P18864
Secondary accession number(s): Q68FU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: January 7, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.