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P18864

- HXB7_RAT

UniProt

P18864 - HXB7_RAT

Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system morphogenesis Source: Ensembl
    3. myeloid cell differentiation Source: Ensembl
    4. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B7
    Alternative name(s):
    Homeobox protein R1B
    Gene namesi
    Name:Hoxb7
    Synonyms:Hoxb-7, R1b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1559918. Hoxb7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Homeobox protein Hox-B7PRO_0000200144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    PTM databases

    PhosphoSiteiP18864.

    Expressioni

    Tissue specificityi

    Predominantly spinal cord and kidney.

    Gene expression databases

    GenevestigatoriP18864.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000033609.

    Structurei

    3D structure databases

    ProteinModelPortaliP18864.
    SMRiP18864. Positions 137-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi126 – 1316Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi61 – 644Poly-Gly
    Compositional biasi213 – 2197Poly-Glu

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238660.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP18864.
    KOiK09307.
    OMAiSMQGLYP.
    OrthoDBiEOG780RP4.
    PhylomeDBiP18864.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP    50
    FSASVQGLYS GGGGMAGQSA AGVYEAGYGL EPSSFNMHCA PFEQNLSGVC 100
    PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTERKRG RQTYTRYQTL 150
    ELEKEFHYNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KWKKENKTSG 200
    PGTTGQDKAE ADEEEEEEE 219
    Length:219
    Mass (Da):24,243
    Last modified:December 6, 2005 - v2
    Checksum:i4917EA7ACC635DF9
    GO

    Sequence cautioni

    The sequence AAA41342.2 differs from that shown. Reason: Intron retention.
    The sequence AAA41342.2 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1742AL → GV in AAA41342. (PubMed:2907739)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079340 mRNA. Translation: AAH79340.1.
    M37566 Genomic DNA. Translation: AAA41342.2. Sequence problems.
    PIRiT10775.
    RefSeqiNP_001017480.1. NM_001017480.1.
    UniGeneiRn.113631.

    Genome annotation databases

    EnsembliENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
    GeneIDi497985.
    KEGGirno:497985.
    UCSCiRGD:1559918. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079340 mRNA. Translation: AAH79340.1 .
    M37566 Genomic DNA. Translation: AAA41342.2 . Sequence problems.
    PIRi T10775.
    RefSeqi NP_001017480.1. NM_001017480.1.
    UniGenei Rn.113631.

    3D structure databases

    ProteinModelPortali P18864.
    SMRi P18864. Positions 137-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000033609.

    PTM databases

    PhosphoSitei P18864.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000031035 ; ENSRNOP00000033609 ; ENSRNOG00000007611 .
    GeneIDi 497985.
    KEGGi rno:497985.
    UCSCi RGD:1559918. rat.

    Organism-specific databases

    CTDi 3217.
    RGDi 1559918. Hoxb7.

    Phylogenomic databases

    eggNOGi NOG238660.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P18864.
    KOi K09307.
    OMAi SMQGLYP.
    OrthoDBi EOG780RP4.
    PhylomeDBi P18864.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 698299.
    PROi P18864.

    Gene expression databases

    Genevestigatori P18864.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. "The expression of rat homeobox-containing genes is developmentally regulated and tissue specific."
      Falzon M., Chung S.Y.
      Development 103:601-610(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-199.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiHXB7_RAT
    AccessioniPrimary (citable) accession number: P18864
    Secondary accession number(s): Q68FU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3