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P18864 (HXB7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein R1B
Gene names
Name:Hoxb7
Synonyms:Hoxb-7, R1b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Predominantly spinal cord and kidney.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA41342.2 differs from that shown. Reason: Frameshift at several positions.

The sequence AAA41342.2 differs from that shown. Reason: Intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Homeobox protein Hox-B7
PRO_0000200144

Regions

DNA binding137 – 19660Homeobox
Motif126 – 1316Antp-type hexapeptide
Compositional bias61 – 644Poly-Gly
Compositional bias213 – 2197Poly-Glu

Amino acid modifications

Cross-link191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict173 – 1742AL → GV in AAA41342. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P18864 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 4917EA7ACC635DF9

FASTA21924,243
        10         20         30         40         50         60 
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS 

        70         80         90        100        110        120 
GGGGMAGQSA AGVYEAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA 

       130        140        150        160        170        180 
ESNFRIYPWM RSSGTERKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHALCLTERQ 

       190        200        210 
IKIWFQNRRM KWKKENKTSG PGTTGQDKAE ADEEEEEEE

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"The expression of rat homeobox-containing genes is developmentally regulated and tissue specific."
Falzon M., Chung S.Y.
Development 103:601-610(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-199.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC079340 mRNA. Translation: AAH79340.1.
M37566 Genomic DNA. Translation: AAA41342.2. Sequence problems.
IPIIPI00195529.
PIRT10775.
RefSeqNP_001017480.1. NM_001017480.1.
UniGeneRn.113631.

3D structure databases

ProteinModelPortalP18864.
SMRP18864. Positions 137-202.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000033609.

PTM databases

PhosphoSiteP18864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
GeneID497985.
KEGGrno:497985.
UCSCRGD:1559918. rat.

Organism-specific databases

CTD3217.
RGD1559918. Hoxb7.

Phylogenomic databases

eggNOGNOG238660.
GeneTreeENSGT00700000104090.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP18864.
KOK09307.
OMAWMRSSGT.
OrthoDBEOG4W9J4Z.

Gene expression databases

GenevestigatorP18864.
GermOnlineENSRNOG00000007611. Rattus norvegicus.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_metazoa.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio698299.

Entry information

Entry nameHXB7_RAT
AccessionPrimary (citable) accession number: P18864
Secondary accession number(s): Q68FU9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: April 3, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families

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