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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-112303 Electric Transmission Across Gap Junctions
R-GGA-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 176CytoplasmicSequence analysisAdd BLAST81
Transmembranei177 – 199HelicalSequence analysisAdd BLAST23
Topological domaini200 – 229ExtracellularSequence analysisAdd BLAST30
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23
Topological domaini253 – 394CytoplasmicSequence analysisAdd BLAST142

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578281 – 394Gap junction gamma-1 proteinAdd BLAST394

Proteomic databases

PaxDbiP18861

Expressioni

Tissue specificityi

Mostly in heart and stomach.

Gene expression databases

BgeeiENSGALG00000000997

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001471

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiP18861
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
PhylomeDBiP18861
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLSVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
RMVEHSDVDR RFRSKSFSTR WKQHRGLEEA EDDHEEDPMM YPEIELESER
160 170 180 190 200
ENKEQQPPAK AKHDGRRRIR EDGLMRIYVL QLLVRATFEV GFLIGQYLLY
210 220 230 240 250
GFEVSPVFVC SRKPCPHKID CFISRPTEKT IFLLIMYGVS CMCLLLNVWE
260 270 280 290 300
MLHLGFGTIR DTLNNKRKEL EDSGTYNYPF TWNTPSAPPG YNIAVKPDQM
310 320 330 340 350
QYTELSNAKM AYKQNKANIA QEQQYGSNEE NIPADLENLQ REIKVAQERL
360 370 380 390
DMAIQAYNNQ NNPGSSSREK KSKAGSNKSS ASSKSGDGKN SVWI
Length:394
Mass (Da):45,372
Last modified:November 1, 1990 - v1
Checksum:iA270AEDCD5FFCC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35044 mRNA Translation: AAA48717.1
PIRiA37819
RefSeqiNP_990834.1, NM_205503.1
XP_015154699.1, XM_015299213.1
XP_015154700.1, XM_015299214.1
XP_015154701.1, XM_015299215.1
XP_015154702.1, XM_015299216.1
XP_015154704.1, XM_015299218.1
XP_015154705.1, XM_015299219.1
XP_015154706.1, XM_015299220.1
XP_015154707.1, XM_015299221.1
XP_015154708.1, XM_015299222.1
UniGeneiGga.862

Genome annotation databases

EnsembliENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997
ENSGALT00000080009; ENSGALP00000056304; ENSGALG00000000997
GeneIDi396501
KEGGigga:396501

Similar proteinsi

Entry informationi

Entry nameiCXG1_CHICK
AccessioniPrimary (citable) accession number: P18861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health