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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-112303. Electric Transmission Across Gap Junctions.
R-GGA-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4523HelicalSequence analysisAdd
BLAST
Topological domaini46 – 7530ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9520HelicalSequence analysisAdd
BLAST
Topological domaini96 – 17681CytoplasmicSequence analysisAdd
BLAST
Transmembranei177 – 19923HelicalSequence analysisAdd
BLAST
Topological domaini200 – 22930ExtracellularSequence analysisAdd
BLAST
Transmembranei230 – 25223HelicalSequence analysisAdd
BLAST
Topological domaini253 – 394142CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Gap junction gamma-1 proteinPRO_0000057828Add
BLAST

Proteomic databases

PaxDbiP18861.

Expressioni

Tissue specificityi

Mostly in heart and stomach.

Gene expression databases

BgeeiENSGALG00000000997.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

MINTiMINT-197055.
STRINGi9031.ENSGALP00000001471.

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiP18861.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
PhylomeDBiP18861.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLSVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
RMVEHSDVDR RFRSKSFSTR WKQHRGLEEA EDDHEEDPMM YPEIELESER
160 170 180 190 200
ENKEQQPPAK AKHDGRRRIR EDGLMRIYVL QLLVRATFEV GFLIGQYLLY
210 220 230 240 250
GFEVSPVFVC SRKPCPHKID CFISRPTEKT IFLLIMYGVS CMCLLLNVWE
260 270 280 290 300
MLHLGFGTIR DTLNNKRKEL EDSGTYNYPF TWNTPSAPPG YNIAVKPDQM
310 320 330 340 350
QYTELSNAKM AYKQNKANIA QEQQYGSNEE NIPADLENLQ REIKVAQERL
360 370 380 390
DMAIQAYNNQ NNPGSSSREK KSKAGSNKSS ASSKSGDGKN SVWI
Length:394
Mass (Da):45,372
Last modified:November 1, 1990 - v1
Checksum:iA270AEDCD5FFCC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35044 mRNA. Translation: AAA48717.1.
PIRiA37819.
RefSeqiNP_990834.1. NM_205503.1.
XP_015154699.1. XM_015299213.1.
XP_015154700.1. XM_015299214.1.
XP_015154701.1. XM_015299215.1.
XP_015154702.1. XM_015299216.1.
XP_015154704.1. XM_015299218.1.
XP_015154705.1. XM_015299219.1.
XP_015154706.1. XM_015299220.1.
XP_015154707.1. XM_015299221.1.
XP_015154708.1. XM_015299222.1.
UniGeneiGga.862.

Genome annotation databases

EnsembliENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997.
GeneIDi396501.
KEGGigga:396501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35044 mRNA. Translation: AAA48717.1.
PIRiA37819.
RefSeqiNP_990834.1. NM_205503.1.
XP_015154699.1. XM_015299213.1.
XP_015154700.1. XM_015299214.1.
XP_015154701.1. XM_015299215.1.
XP_015154702.1. XM_015299216.1.
XP_015154704.1. XM_015299218.1.
XP_015154705.1. XM_015299219.1.
XP_015154706.1. XM_015299220.1.
XP_015154707.1. XM_015299221.1.
XP_015154708.1. XM_015299222.1.
UniGeneiGga.862.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-197055.
STRINGi9031.ENSGALP00000001471.

Proteomic databases

PaxDbiP18861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997.
GeneIDi396501.
KEGGigga:396501.

Organism-specific databases

CTDi10052.

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiP18861.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
PhylomeDBiP18861.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-GGA-112303. Electric Transmission Across Gap Junctions.
R-GGA-190861. Gap junction assembly.

Miscellaneous databases

PROiP18861.

Gene expression databases

BgeeiENSGALG00000000997.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_CHICK
AccessioniPrimary (citable) accession number: P18861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.