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P18860

- CXA5_CHICK

UniProt

P18860 - CXA5_CHICK

Protein

Gap junction alpha-5 protein

Gene

GJA5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Biological processi

    1. cell communication Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-5 protein
    Alternative name(s):
    Connexin-42
    Short name:
    Cx42
    Gene namesi
    Name:GJA5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 369368Gap junction alpha-5 proteinPRO_0000057822Add
    BLAST

    Proteomic databases

    PaxDbiP18860.

    Expressioni

    Tissue specificityi

    Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000024929.

    Structurei

    3D structure databases

    ProteinModelPortaliP18860.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 16972CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 21020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 369138CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45265.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiP18860.
    KOiK07614.
    PhylomeDBiP18860.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002264. Connexin40.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF13. PTHR11984:SF13. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01135. CONNEXINA5.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18860-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS    50
    DFMCDTQQPG CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV 100
    RMEEKRKMKE AEREAQEMKN SGDTYYQQKC PVAEKTELSC WDESGGKIIL 150
    RGSLLNTYVY SILIRTAMEI AFIVGQYILY GIFLETLYIC QRAPCPHPVN 200
    CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK ERCSRAYKPS 250
    PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN 300
    TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR 350
    RFSKASRASS KARSDDLSV 369
    Length:369
    Mass (Da):41,745
    Last modified:January 23, 2007 - v2
    Checksum:i18D7A242765E0EC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35043 mRNA. Translation: AAA48716.1.
    PIRiB37819.
    RefSeqiNP_990835.1. NM_205504.1.
    UniGeneiGga.863.

    Genome annotation databases

    GeneIDi396502.
    KEGGigga:396502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35043 mRNA. Translation: AAA48716.1 .
    PIRi B37819.
    RefSeqi NP_990835.1. NM_205504.1.
    UniGenei Gga.863.

    3D structure databases

    ProteinModelPortali P18860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000024929.

    Proteomic databases

    PaxDbi P18860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396502.
    KEGGi gga:396502.

    Organism-specific databases

    CTDi 2702.

    Phylogenomic databases

    eggNOGi NOG45265.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi P18860.
    KOi K07614.
    PhylomeDBi P18860.

    Miscellaneous databases

    NextBioi 20816541.
    PROi P18860.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002264. Connexin40.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF13. PTHR11984:SF13. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01135. CONNEXINA5.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and developmental expression of two chick embryo gap junction proteins."
      Beyer E.C.
      J. Biol. Chem. 265:14439-14443(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCXA5_CHICK
    AccessioniPrimary (citable) accession number: P18860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3