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Protein

Gap junction alpha-5 protein

Gene

GJA5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-42
Short name:
Cx42
Gene namesi
Name:GJA5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 19CytoplasmicSequence analysisAdd BLAST18
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 169CytoplasmicSequence analysisAdd BLAST72
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 210ExtracellularSequence analysisAdd BLAST20
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 369CytoplasmicSequence analysisAdd BLAST138

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578222 – 369Gap junction alpha-5 proteinAdd BLAST368

Proteomic databases

PaxDbiP18860

Expressioni

Tissue specificityi

Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024929

Structurei

3D structure databases

ProteinModelPortaliP18860
SMRiP18860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP18860
PhylomeDBiP18860

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit
PRINTSiPR00206 CONNEXIN
PR01135 CONNEXINA5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS
60 70 80 90 100
DFMCDTQQPG CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMEEKRKMKE AEREAQEMKN SGDTYYQQKC PVAEKTELSC WDESGGKIIL
160 170 180 190 200
RGSLLNTYVY SILIRTAMEI AFIVGQYILY GIFLETLYIC QRAPCPHPVN
210 220 230 240 250
CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK ERCSRAYKPS
260 270 280 290 300
PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN
310 320 330 340 350
TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR
360
RFSKASRASS KARSDDLSV
Length:369
Mass (Da):41,745
Last modified:January 23, 2007 - v2
Checksum:i18D7A242765E0EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35043 mRNA Translation: AAA48716.1
PIRiB37819
UniGeneiGga.863

Similar proteinsi

Entry informationi

Entry nameiCXA5_CHICK
AccessioniPrimary (citable) accession number: P18860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health