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Protein

Gap junction alpha-5 protein

Gene

GJA5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-42
Short name:
Cx42
Gene namesi
Name:GJA5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 16972CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 21020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Topological domaini232 – 369138CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 369368Gap junction alpha-5 proteinPRO_0000057822Add
BLAST

Proteomic databases

PaxDbiP18860.

Expressioni

Tissue specificityi

Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024929.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45265.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP18860.
KOiK07614.
PhylomeDBiP18860.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS
60 70 80 90 100
DFMCDTQQPG CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMEEKRKMKE AEREAQEMKN SGDTYYQQKC PVAEKTELSC WDESGGKIIL
160 170 180 190 200
RGSLLNTYVY SILIRTAMEI AFIVGQYILY GIFLETLYIC QRAPCPHPVN
210 220 230 240 250
CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK ERCSRAYKPS
260 270 280 290 300
PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN
310 320 330 340 350
TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR
360
RFSKASRASS KARSDDLSV
Length:369
Mass (Da):41,745
Last modified:January 22, 2007 - v2
Checksum:i18D7A242765E0EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35043 mRNA. Translation: AAA48716.1.
PIRiB37819.
RefSeqiNP_990835.1. NM_205504.1.
UniGeneiGga.863.

Genome annotation databases

GeneIDi396502.
KEGGigga:396502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35043 mRNA. Translation: AAA48716.1.
PIRiB37819.
RefSeqiNP_990835.1. NM_205504.1.
UniGeneiGga.863.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024929.

Proteomic databases

PaxDbiP18860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396502.
KEGGigga:396502.

Organism-specific databases

CTDi2702.

Phylogenomic databases

eggNOGiNOG45265.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP18860.
KOiK07614.
PhylomeDBiP18860.

Miscellaneous databases

NextBioi20816541.
PROiP18860.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and developmental expression of two chick embryo gap junction proteins."
    Beyer E.C.
    J. Biol. Chem. 265:14439-14443(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCXA5_CHICK
AccessioniPrimary (citable) accession number: P18860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1990
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.