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P18860 (CXA5_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-42
Short name=Cx42
Gene names
Name:GJA5
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 369368Gap junction alpha-5 protein
PRO_0000057822

Regions

Topological domain2 – 1918Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 7636Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 16972Cytoplasmic Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 21020Extracellular Potential
Transmembrane211 – 23121Helical; Potential
Topological domain232 – 369138Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P18860 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 18D7A242765E0EC4

FASTA36941,745
        10         20         30         40         50         60 
MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS DFMCDTQQPG 

        70         80         90        100        110        120 
CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV RMEEKRKMKE AEREAQEMKN 

       130        140        150        160        170        180 
SGDTYYQQKC PVAEKTELSC WDESGGKIIL RGSLLNTYVY SILIRTAMEI AFIVGQYILY 

       190        200        210        220        230        240 
GIFLETLYIC QRAPCPHPVN CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK 

       250        260        270        280        290        300 
ERCSRAYKPS PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN 

       310        320        330        340        350        360 
TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR RFSKASRASS 


KARSDDLSV 

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References

[1]"Molecular cloning and developmental expression of two chick embryo gap junction proteins."
Beyer E.C.
J. Biol. Chem. 265:14439-14443(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M35043 mRNA. Translation: AAA48716.1.
PIRB37819.
RefSeqNP_990835.1. NM_205504.1.
UniGeneGga.863.

3D structure databases

ProteinModelPortalP18860.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000024929.

Proteomic databases

PaxDbP18860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396502.
KEGGgga:396502.

Organism-specific databases

CTD2702.

Phylogenomic databases

eggNOGNOG45265.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidP18860.
KOK07614.
PhylomeDBP18860.

Family and domain databases

InterProIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816541.
PROP18860.

Entry information

Entry nameCXA5_CHICK
AccessionPrimary (citable) accession number: P18860
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families