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P18860

- CXA5_CHICK

UniProt

P18860 - CXA5_CHICK

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Protein
Gap junction alpha-5 protein
Gene
GJA5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-42
Short name:
Cx42
Gene namesi
Name:GJA5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1918Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei20 – 4021Helical; Reviewed prediction
Add
BLAST
Topological domaini41 – 7636Extracellular Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 16972Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 21020Extracellular Reviewed prediction
Add
BLAST
Transmembranei211 – 23121Helical; Reviewed prediction
Add
BLAST
Topological domaini232 – 369138Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 369368Gap junction alpha-5 protein
PRO_0000057822Add
BLAST

Proteomic databases

PaxDbiP18860.

Expressioni

Tissue specificityi

Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024929.

Structurei

3D structure databases

ProteinModelPortaliP18860.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45265.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP18860.
KOiK07614.
PhylomeDBiP18860.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18860-1 [UniParc]FASTAAdd to Basket

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MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS    50
DFMCDTQQPG CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV 100
RMEEKRKMKE AEREAQEMKN SGDTYYQQKC PVAEKTELSC WDESGGKIIL 150
RGSLLNTYVY SILIRTAMEI AFIVGQYILY GIFLETLYIC QRAPCPHPVN 200
CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK ERCSRAYKPS 250
PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN 300
TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR 350
RFSKASRASS KARSDDLSV 369
Length:369
Mass (Da):41,745
Last modified:January 23, 2007 - v2
Checksum:i18D7A242765E0EC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35043 mRNA. Translation: AAA48716.1.
PIRiB37819.
RefSeqiNP_990835.1. NM_205504.1.
UniGeneiGga.863.

Genome annotation databases

GeneIDi396502.
KEGGigga:396502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35043 mRNA. Translation: AAA48716.1 .
PIRi B37819.
RefSeqi NP_990835.1. NM_205504.1.
UniGenei Gga.863.

3D structure databases

ProteinModelPortali P18860.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000024929.

Proteomic databases

PaxDbi P18860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396502.
KEGGi gga:396502.

Organism-specific databases

CTDi 2702.

Phylogenomic databases

eggNOGi NOG45265.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi P18860.
KOi K07614.
PhylomeDBi P18860.

Miscellaneous databases

NextBioi 20816541.
PROi P18860.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and developmental expression of two chick embryo gap junction proteins."
    Beyer E.C.
    J. Biol. Chem. 265:14439-14443(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCXA5_CHICK
AccessioniPrimary (citable) accession number: P18860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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