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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

STE18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response.

GO - Molecular functioni

  • signal transducer activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-31714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma
Gene namesi
Name:STE18
Ordered Locus Names:YJR086W
ORF Names:J1866
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR086W.
SGDiS000003846. STE18.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • heterotrimeric G-protein complex Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi106 – 1061C → S: Partial loss of function. 1 Publication
Mutagenesisi107 – 1071C → X: Loss of function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Guanine nucleotide-binding protein subunit gammaPRO_0000194812Add
BLAST
Propeptidei108 – 1103Removed in mature formPRO_0000396775

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi106 – 1061S-palmitoyl cysteine2 Publications
Modified residuei107 – 1071Cysteine methyl ester1 Publication
Lipidationi107 – 1071S-farnesyl cysteine2 Publications

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP18852.

PTM databases

iPTMnetiP18852.
SwissPalmiP18852.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The beta-gamma subunit complex (STE4-STE18 complex) interacts with PLP1 and PLP2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STE4P188514EBI-7397,EBI-7390

Protein-protein interaction databases

BioGridi33841. 13 interactions.
DIPiDIP-314N.
IntActiP18852. 3 interactions.
MINTiMINT-394213.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SCGmodel-G1-110[»]
ProteinModelPortaliP18852.
SMRiP18852. Positions 38-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 2212Gln-richAdd
BLAST
Compositional biasi96 – 1049Asn/Ser-rich

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

HOGENOMiHOG000210889.
InParanoidiP18852.
KOiK07973.
OMAiHEETSAC.
OrthoDBiEOG092C5WCC.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVQNSPRL QQPQEQQQQQ QQLSLKIKQL KLKRINELNN KLRKELSRER
60 70 80 90 100
ITASNACLTI INYTSNTKDY TLPELWGYPV AGSNHFIEGL KNAQKNSQMS
110
NSNSVCCTLM
Length:110
Mass (Da):12,625
Last modified:November 1, 1990 - v1
Checksum:i6A78E946DA5059FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23983 Genomic DNA. Translation: AAA35110.1.
L47993 Genomic DNA. Translation: AAB39309.1.
Z49586 Genomic DNA. Translation: CAA89613.1.
AY557888 Genomic DNA. Translation: AAS56214.1.
BK006943 Genomic DNA. Translation: DAA08871.1.
PIRiB30102.
RefSeqiNP_012619.1. NM_001181743.1.

Genome annotation databases

EnsemblFungiiYJR086W; YJR086W; YJR086W.
GeneIDi853548.
KEGGisce:YJR086W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23983 Genomic DNA. Translation: AAA35110.1.
L47993 Genomic DNA. Translation: AAB39309.1.
Z49586 Genomic DNA. Translation: CAA89613.1.
AY557888 Genomic DNA. Translation: AAS56214.1.
BK006943 Genomic DNA. Translation: DAA08871.1.
PIRiB30102.
RefSeqiNP_012619.1. NM_001181743.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SCGmodel-G1-110[»]
ProteinModelPortaliP18852.
SMRiP18852. Positions 38-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33841. 13 interactions.
DIPiDIP-314N.
IntActiP18852. 3 interactions.
MINTiMINT-394213.

PTM databases

iPTMnetiP18852.
SwissPalmiP18852.

Proteomic databases

MaxQBiP18852.

Protocols and materials databases

DNASUi853548.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR086W; YJR086W; YJR086W.
GeneIDi853548.
KEGGisce:YJR086W.

Organism-specific databases

EuPathDBiFungiDB:YJR086W.
SGDiS000003846. STE18.

Phylogenomic databases

HOGENOMiHOG000210889.
InParanoidiP18852.
KOiK07973.
OMAiHEETSAC.
OrthoDBiEOG092C5WCC.

Enzyme and pathway databases

BioCyciYEAST:G3O-31714-MONOMER.

Miscellaneous databases

PROiP18852.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG_YEAST
AccessioniPrimary (citable) accession number: P18852
Secondary accession number(s): D6VWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.