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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

STE18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response.

Miscellaneous

Present with 5550 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: SGD

GO - Biological processi

Keywordsi

Molecular functionTransducer
Biological processPheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-31714-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma
Gene namesi
Name:STE18
Ordered Locus Names:YJR086W
ORF Names:J1866
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR086W
SGDiS000003846 STE18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi106C → S: Partial loss of function. 1 Publication1
Mutagenesisi107C → X: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948121 – 107Guanine nucleotide-binding protein subunit gammaAdd BLAST107
PropeptideiPRO_0000396775108 – 110Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi106S-palmitoyl cysteine2 Publications1
Modified residuei107Cysteine methyl ester1 Publication1
Lipidationi107S-farnesyl cysteine2 Publications1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP18852
PaxDbiP18852
PRIDEiP18852

PTM databases

iPTMnetiP18852
SwissPalmiP18852

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The beta-gamma subunit complex (STE4-STE18 complex) interacts with PLP1 and PLP2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STE4P188513EBI-7397,EBI-7390

Protein-protein interaction databases

BioGridi33841, 13 interactors
DIPiDIP-314N
IntActiP18852, 3 interactors
MINTiP18852
STRINGi4932.YJR086W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SCGmodel-G1-110[»]
ProteinModelPortaliP18852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 22Gln-richAdd BLAST12
Compositional biasi96 – 104Asn/Ser-rich9

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

HOGENOMiHOG000210889
InParanoidiP18852
KOiK07973
OMAiHEETSAC
OrthoDBiEOG092C5WCC

Family and domain databases

CDDicd00068 GGL, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
SMARTiView protein in SMART
SM00224 GGL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVQNSPRL QQPQEQQQQQ QQLSLKIKQL KLKRINELNN KLRKELSRER
60 70 80 90 100
ITASNACLTI INYTSNTKDY TLPELWGYPV AGSNHFIEGL KNAQKNSQMS
110
NSNSVCCTLM
Length:110
Mass (Da):12,625
Last modified:November 1, 1990 - v1
Checksum:i6A78E946DA5059FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23983 Genomic DNA Translation: AAA35110.1
L47993 Genomic DNA Translation: AAB39309.1
Z49586 Genomic DNA Translation: CAA89613.1
AY557888 Genomic DNA Translation: AAS56214.1
BK006943 Genomic DNA Translation: DAA08871.1
PIRiB30102
RefSeqiNP_012619.1, NM_001181743.1

Genome annotation databases

EnsemblFungiiYJR086W; YJR086W; YJR086W
GeneIDi853548
KEGGisce:YJR086W

Similar proteinsi

Entry informationi

Entry nameiGBG_YEAST
AccessioniPrimary (citable) accession number: P18852
Secondary accession number(s): D6VWQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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