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Protein

Cyclic AMP-dependent transcription factor ATF-4

Gene

ATF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.By similarity3 Publications

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. leucine zipper domain binding Source: ParkinsonsUK-UCL
  4. protein heterodimerization activity Source: ParkinsonsUK-UCL
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  7. RNA polymerase II transcription factor binding Source: ParkinsonsUK-UCL
  8. RNA polymerase II transcription factor binding transcription factor activity Source: ParkinsonsUK-UCL
  9. sequence-specific DNA binding Source: ParkinsonsUK-UCL
  10. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ParkinsonsUK-UCL
  11. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  12. transcription regulatory region DNA binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. cellular amino acid metabolic process Source: UniProtKB
  3. cellular protein metabolic process Source: Reactome
  4. cellular response to glucose starvation Source: ParkinsonsUK-UCL
  5. circadian regulation of gene expression Source: UniProtKB
  6. endoplasmic reticulum unfolded protein response Source: ParkinsonsUK-UCL
  7. gamma-aminobutyric acid signaling pathway Source: Ensembl
  8. gluconeogenesis Source: UniProtKB
  9. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  10. negative regulation of oxidative stress-induced neuron death Source: ParkinsonsUK-UCL
  11. negative regulation of potassium ion transport Source: Ensembl
  12. positive regulation of apoptotic process Source: ParkinsonsUK-UCL
  13. positive regulation of neuron apoptotic process Source: UniProtKB
  14. positive regulation of transcription, DNA-templated Source: UniProtKB
  15. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  16. positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: ParkinsonsUK-UCL
  17. positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
  18. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: ParkinsonsUK-UCL
  19. positive regulation of transcription from RNA polymerase I promoter Source: ParkinsonsUK-UCL
  20. positive regulation vascular endothelial growth factor production Source: ParkinsonsUK-UCL
  21. regulation of transcription, DNA-templated Source: UniProtKB
  22. response to endoplasmic reticulum stress Source: BHF-UCL
  23. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_18277. PERK regulates gene expression.
REACT_18355. ATF4 activates genes.
REACT_18423. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-4
Short name:
cAMP-dependent transcription factor ATF-4
Alternative name(s):
Activating transcription factor 4
Cyclic AMP-responsive element-binding protein 2
Short name:
CREB-2
Short name:
cAMP-responsive element-binding protein 2
DNA-binding protein TAXREB67
Tax-responsive enhancer element-binding protein 67
Short name:
TaxREB67
Gene namesi
Name:ATF4
Synonyms:CREB2, TXREB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:786. ATF4.

Subcellular locationi

Cytoplasm. Cell membrane. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome.By similarity

GO - Cellular componenti

  1. ATF1-ATF4 transcription factor complex Source: ParkinsonsUK-UCL
  2. ATF4-CREB1 transcription factor complex Source: ParkinsonsUK-UCL
  3. CHOP-ATF4 complex Source: ParkinsonsUK-UCL
  4. cytoplasm Source: UniProtKB
  5. dendrite membrane Source: Ensembl
  6. Lewy body core Source: ParkinsonsUK-UCL
  7. microtubule organizing center Source: UniProtKB-SubCell
  8. neuron projection Source: ParkinsonsUK-UCL
  9. nuclear periphery Source: ParkinsonsUK-UCL
  10. nucleoplasm Source: Reactome
  11. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25086.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Cyclic AMP-dependent transcription factor ATF-4PRO_0000076584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131PhosphothreonineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity
Modified residuei224 – 2241PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.By similarity
Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1 (By similarity).By similarity
Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Lipoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP18848.
PaxDbiP18848.
PRIDEiP18848.

PTM databases

PhosphoSiteiP18848.

Expressioni

Gene expression databases

BgeeiP18848.
CleanExiHS_ATF4.
ExpressionAtlasiP18848. baseline and differential.
GenevestigatoriP18848.

Organism-specific databases

HPAiCAB011596.
HPA036934.

Interactioni

Subunit structurei

Binds DNA as a homo- or heterodimer. Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with CEP290 (via an N-terminal region). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3. Forms a heterodimer with TXLNG in osteoblasts. Interacts with DDIT3/CHOP.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTRCQ9Y2974EBI-492498,EBI-307461
BTRCQ9Y297-25EBI-492498,EBI-8826333
CREBZFQ9NS375EBI-492498,EBI-632965
DAPK2Q9UIK4-22EBI-492498,EBI-9693115
Dapk3O547842EBI-492498,EBI-77359From a different organism.
DISC1Q9NRI53EBI-492498,EBI-529989
JUNP054122EBI-492498,EBI-852823
TRIB3Q96RU72EBI-492498,EBI-492476

Protein-protein interaction databases

BioGridi106958. 76 interactions.
DIPiDIP-207N.
DIP-354N.
IntActiP18848. 28 interactions.
MINTiMINT-146610.
STRINGi9606.ENSP00000336790.

Structurei

Secondary structure

1
351
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi288 – 34053Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CI6X-ray2.60A280-341[»]
ProteinModelPortaliP18848.
SMRiP18848. Positions 286-341.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18848.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 34164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 30021Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni305 – 34137Interaction with GABBR1By similarityAdd
BLAST
Regioni306 – 33429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili280 – 34061Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi215 – 22410BetaTrCP degron motif

Domaini

The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.By similarity

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG325856.
HOGENOMiHOG000004844.
HOVERGENiHBG004301.
InParanoidiP18848.
KOiK04374.
OMAiGECRELE.
OrthoDBiEOG72JWGW.
PhylomeDBiP18848.
TreeFamiTF316136.

Family and domain databases

InterProiIPR029811. ATF4.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF2. PTHR13044:SF2. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS
60 70 80 90 100
SDKAKAGSSE WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL
110 120 130 140 150
GIDDLETMPD DLLTTLDDTC DLFAPLVQET NKQPPQTVNP IGHLPESLTK
160 170 180 190 200
PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL ELGSEVDITE GDRKPDYTAY
210 220 230 240 250
VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG SPNRSLPSPG
260 270 280 290 300
VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR
310 320 330 340 350
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV

P
Length:351
Mass (Da):38,590
Last modified:October 16, 2006 - v3
Checksum:i3BBB7379DC3B0D07
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841K → R no nucleotide entry (PubMed:2516827).Curated
Sequence conflicti290 – 2901T → R no nucleotide entry (PubMed:2516827).Curated
Sequence conflicti329 – 3313KEI → REK no nucleotide entry (PubMed:2516827).Curated
Sequence conflicti338 – 3381I → L no nucleotide entry (PubMed:2516827).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221Q → P.3 Publications
Corresponds to variant rs4894 [ dbSNP | Ensembl ].
VAR_028253
Natural varianti258 – 2581P → A.
Corresponds to variant rs1803323 [ dbSNP | Ensembl ].
VAR_029259
Natural varianti322 – 3221E → D.
Corresponds to variant rs1803324 [ dbSNP | Ensembl ].
VAR_014768

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90209 mRNA. Translation: BAA14234.1.
M86842 mRNA. Translation: AAA52071.1.
AL022312 Genomic DNA. Translation: CAB45284.1.
BC008090 mRNA. Translation: AAH08090.1.
BC011994 mRNA. Translation: AAH11994.1.
BC024775 mRNA. Translation: AAH24775.1.
BC073990 mRNA. Translation: AAH73990.1.
CCDSiCCDS13996.1.
PIRiA45377.
RefSeqiNP_001666.2. NM_001675.4.
NP_877962.1. NM_182810.2.
UniGeneiHs.496487.

Genome annotation databases

EnsembliENST00000337304; ENSP00000336790; ENSG00000128272.
ENST00000396680; ENSP00000379912; ENSG00000128272.
ENST00000404241; ENSP00000384587; ENSG00000128272.
GeneIDi468.
KEGGihsa:468.
UCSCiuc003axz.3. human.

Polymorphism databases

DMDMi116241262.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90209 mRNA. Translation: BAA14234.1.
M86842 mRNA. Translation: AAA52071.1.
AL022312 Genomic DNA. Translation: CAB45284.1.
BC008090 mRNA. Translation: AAH08090.1.
BC011994 mRNA. Translation: AAH11994.1.
BC024775 mRNA. Translation: AAH24775.1.
BC073990 mRNA. Translation: AAH73990.1.
CCDSiCCDS13996.1.
PIRiA45377.
RefSeqiNP_001666.2. NM_001675.4.
NP_877962.1. NM_182810.2.
UniGeneiHs.496487.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CI6X-ray2.60A280-341[»]
ProteinModelPortaliP18848.
SMRiP18848. Positions 286-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106958. 76 interactions.
DIPiDIP-207N.
DIP-354N.
IntActiP18848. 28 interactions.
MINTiMINT-146610.
STRINGi9606.ENSP00000336790.

Chemistry

DrugBankiDB00852. Pseudoephedrine.

PTM databases

PhosphoSiteiP18848.

Polymorphism databases

DMDMi116241262.

Proteomic databases

MaxQBiP18848.
PaxDbiP18848.
PRIDEiP18848.

Protocols and materials databases

DNASUi468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337304; ENSP00000336790; ENSG00000128272.
ENST00000396680; ENSP00000379912; ENSG00000128272.
ENST00000404241; ENSP00000384587; ENSG00000128272.
GeneIDi468.
KEGGihsa:468.
UCSCiuc003axz.3. human.

Organism-specific databases

CTDi468.
GeneCardsiGC22P039916.
HGNCiHGNC:786. ATF4.
HPAiCAB011596.
HPA036934.
MIMi604064. gene.
neXtProtiNX_P18848.
PharmGKBiPA25086.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325856.
HOGENOMiHOG000004844.
HOVERGENiHBG004301.
InParanoidiP18848.
KOiK04374.
OMAiGECRELE.
OrthoDBiEOG72JWGW.
PhylomeDBiP18848.
TreeFamiTF316136.

Enzyme and pathway databases

ReactomeiREACT_18277. PERK regulates gene expression.
REACT_18355. ATF4 activates genes.
REACT_18423. ATF6-alpha activates chaperone genes.

Miscellaneous databases

ChiTaRSiATF4. human.
EvolutionaryTraceiP18848.
GeneWikiiATF4.
GenomeRNAii468.
NextBioi1935.
PROiP18848.
SOURCEiSearch...

Gene expression databases

BgeeiP18848.
CleanExiHS_ATF4.
ExpressionAtlasiP18848. baseline and differential.
GenevestigatoriP18848.

Family and domain databases

InterProiIPR029811. ATF4.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF2. PTHR13044:SF2. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."
    Tsujimoto A., Nyunoya H., Morita T., Sato T., Shimotohno K.
    J. Virol. 65:1420-1426(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-22.
    Tissue: Fibroblast.
  2. "Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element."
    Karpinski B.A., Morle G.D., Huggenvik J., Uhler M.D., Leiden J.M.
    Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-22.
    Tissue: Leukemic T-cell.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-22.
    Tissue: Lung and Placenta.
  5. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
    Hai T., Liu F., Coukos W.J., Green M.R.
    Genes Dev. 3:2083-2090(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 274-341.
  6. Erratum
    Hai T., Liu F., Coukos W.J., Green M.R.
    Genes Dev. 4:682-682(1989)
  7. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
    Ohoka N., Yoshii S., Hattori T., Onozaki K., Hayashi H.
    EMBO J. 24:1243-1255(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."
    Yu V.W., Ambartsoumian G., Verlinden L., Moir J.M., Prud'homme J., Gauthier C., Roughley P.J., St-Arnaud R.
    J. Cell Biol. 169:591-601(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TXLNG.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CEP290.
  10. "C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."
    Su N., Kilberg M.S.
    J. Biol. Chem. 283:35106-35117(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDIT3.
  11. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
    Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J.
    J. Proteome Res. 9:6298-6316(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NEK6, PHOSPHORYLATION.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
    Shoval Y., Berissi H., Kimchi A., Pietrokovski S.
    PLoS ONE 6:E17344-E17344(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAPK2 AND ZIPK/DAPK3.
  14. "Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA."
    Podust L.M., Krezel A.M., Kim Y.
    J. Biol. Chem. 276:505-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 279-341 IN COMPLEX WITH MOUSE CEBPB.

Entry informationi

Entry nameiATF4_HUMAN
AccessioniPrimary (citable) accession number: P18848
Secondary accession number(s): Q9UH31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1990
Last sequence update: October 16, 2006
Last modified: March 31, 2015
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.