ID ATF3_HUMAN Reviewed; 181 AA. AC P18847; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 03-NOV-2009, entry version 100. DE RecName: Full=Cyclic AMP-dependent transcription factor ATF-3; DE Short=cAMP-dependent transcription factor ATF-3; DE AltName: Full=Activating transcription factor 3; GN Name=ATF3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RX MEDLINE=94253175; PubMed=7515060; RA Chen B.P.C., Liang G., Whelan J., Hai T.; RT "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation RT by alternatively spliced isoforms."; RL J. Biol. Chem. 269:15819-15826(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-38. RG NIEHS SNPs program; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-181. RX MEDLINE=90185187; PubMed=2516827; RA Hai T., Liu F., Coukos W.J., Green M.R.; RT "Transcription factor ATF cDNA clones: an extensive family of leucine RT zipper proteins able to selectively form DNA-binding heterodimers."; RL Genes Dev. 3:2083-2090(1989). RN [5] RP ERRATUM. RA Hai T., Liu F., Coukos W.J., Green M.R.; RL Genes Dev. 4:682-682(1990). RN [6] RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S). RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8; RA Hillman R.T., Green R.E., Brenner S.E.; RT "An unappreciated role for RNA surveillance."; RL Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004). CC -!- FUNCTION: This protein binds the cAMP response element (CRE) CC (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many CC viral and cellular promoters. Represses transcription from CC promoters with ATF sites. It may repress transcription by CC stabilizing the binding of inhibitory cofactors at the promoter. CC Isoform 2 activates transcription presumably by sequestering CC inhibitory cofactors away from the promoters. CC -!- SUBUNIT: Binds DNA as a homodimer or a heterodimer. CC -!- INTERACTION: CC Self; NbExp=1; IntAct=EBI-712767, EBI-712767; CC Q14192:FHL2; NbExp=1; IntAct=EBI-712767, EBI-701903; CC Q04206:RELA; NbExp=1; IntAct=EBI-712767, EBI-73886; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=ATF3; CC IsoId=P18847-1; Sequence=Displayed; CC Name=2; Synonyms=ATF3-delta-Zip; CC IsoId=P18847-2; Sequence=VSP_000592; CC Note=May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay; CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. CC -!- SIMILARITY: Contains 1 bZIP domain. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/atf3/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L19871; AAA20506.1; -; mRNA. DR EMBL; AY426987; AAQ93358.1; -; Genomic_DNA. DR EMBL; BC006322; AAH06322.1; -; mRNA. DR IPI; IPI00002502; -. DR IPI; IPI00413177; -. DR PIR; A54025; A54025. DR PIR; B54025; B54025. DR PIR; C34223; C34223. DR RefSeq; NP_001025458.1; -. DR RefSeq; NP_001665.1; -. DR UniGene; Hs.460; -. DR HSSP; P01100; 1FOS. DR DIP; DIP:254N; -. DR DIP; DIP:344N; -. DR IntAct; P18847; 10. DR STRING; P18847; -. DR PRIDE; P18847; -. DR Ensembl; ENST00000336937; ENSP00000336908; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000341491; ENSP00000344352; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000366981; ENSP00000355948; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000366983; ENSP00000355950; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000366984; ENSP00000355951; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000366985; ENSP00000355952; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000366987; ENSP00000355954; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000391902; ENSP00000375771; ENSG00000162772; Homo sapiens. DR Ensembl; ENST00000426071; ENSP00000415193; ENSG00000162772; Homo sapiens. DR GeneID; 467; -. DR KEGG; hsa:467; -. DR UCSC; uc001hjf.1; human. DR CTD; 467; -. DR GeneCards; GC01P210805; -. DR H-InvDB; HIX0001571; -. DR HGNC; HGNC:785; ATF3. DR HPA; HPA001562; -. DR MIM; 603148; gene. DR PharmGKB; PA25085; -. DR HOGENOM; P18847; -. DR HOVERGEN; P18847; -. DR OMA; ATAIVPC; -. DR Pathway_Interaction_DB; smad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling. DR Reactome; REACT_15380; Diabetes pathways. DR NextBio; 1925; -. DR ArrayExpress; P18847; -. DR Bgee; P18847; -. DR CleanEx; HS_ATF3; -. DR Genevestigator; P18847; -. DR GermOnline; ENSG00000162772; Homo sapiens. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0003714; F:transcription corepressor activity; TAS:ProtInc. DR GO; GO:0003700; F:transcription factor activity; TAS:ProtInc. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR011700; bZIP_2. DR InterPro; IPR000837; Leuzip_Fos. DR InterPro; IPR004827; TF_bZIP. DR Pfam; PF07716; bZIP_2; 1. DR PRINTS; PR00042; LEUZIPPRFOS. DR SMART; SM00338; BRLZ; 1. DR PROSITE; PS50217; BZIP; 1. DR PROSITE; PS00036; BZIP_BASIC; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; DNA-binding; Nucleus; KW Polymorphism; Repressor; Transcription; Transcription regulation. FT CHAIN 1 181 Cyclic AMP-dependent transcription factor FT ATF-3. FT /FTId=PRO_0000076581. FT DOMAIN 114 142 Leucine-zipper. FT DNA_BIND 88 110 Basic motif. FT VAR_SEQ 116 181 KESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVR FT AQNGRTPEDERNLFIQQIKEGTLQS -> LQY (in FT isoform 2). FT /FTId=VSP_000592. FT VARIANT 38 38 T -> M (in dbSNP:rs11571541). FT /FTId=VAR_048442. FT CONFLICT 132 132 I -> L (in Ref. 4). SQ SEQUENCE 181 AA; 20576 MW; EC5D8F065EEE2D9C CRC64; MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S //