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P18846

- ATF1_HUMAN

UniProt

P18846 - ATF1_HUMAN

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Protein
Cyclic AMP-dependent transcription factor ATF-1
Gene
ATF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei110 – 1101Breakpoint for translocation to form chimeric EWSR1/ATF1 protein
Sitei112 – 1121Breakpoint for translocation to form chimeric FUS/ATF1 protein

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  2. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  3. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  4. cellular protein complex assembly Source: Ensembl
  5. innate immune response Source: Reactome
  6. neurotrophin TRK receptor signaling pathway Source: Reactome
  7. positive regulation of DNA replication Source: Ensembl
  8. positive regulation of neuron projection development Source: Ensembl
  9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. response to cobalt ion Source: Ensembl
  11. response to organic cyclic compound Source: Ensembl
  12. stress-activated MAPK cascade Source: Reactome
  13. toll-like receptor 10 signaling pathway Source: Reactome
  14. toll-like receptor 2 signaling pathway Source: Reactome
  15. toll-like receptor 3 signaling pathway Source: Reactome
  16. toll-like receptor 4 signaling pathway Source: Reactome
  17. toll-like receptor 5 signaling pathway Source: Reactome
  18. toll-like receptor 9 signaling pathway Source: Reactome
  19. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  20. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  21. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_12524. CREB phosphorylation.
SignaLinkiP18846.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-1
Short name:
cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
Protein TREB36
Gene namesi
Name:ATF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:783. ATF1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: HPA
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Note: The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi63 – 631S → A: Impaired CDK3-mediated phosphorylation and altered transactivation and transcriptional activities. 1 Publication

Organism-specific databases

MIMi612160. phenotype.
Orphaneti97338. Melanoma of soft parts.
PharmGKBiPA25083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Cyclic AMP-dependent transcription factor ATF-1
PRO_0000076575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5 Inferred
Modified residuei198 – 1981Phosphoserine; by HIPK23 Publications

Post-translational modificationi

Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP18846.
PaxDbiP18846.
PRIDEiP18846.

PTM databases

PhosphoSiteiP18846.

Expressioni

Gene expression databases

ArrayExpressiP18846.
BgeeiP18846.
CleanExiHS_ATF1.
GenevestigatoriP18846.

Organism-specific databases

HPAiCAB016222.
HPA055069.
HPA055406.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with HIPK2 and CDK3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P03259-22EBI-852794,EBI-7225021From a different organism.

Protein-protein interaction databases

BioGridi106956. 12 interactions.
DIPiDIP-652N.
IntActiP18846. 3 interactions.
MINTiMINT-142718.
STRINGi9606.ENSP00000262053.

Structurei

3D structure databases

ProteinModelPortaliP18846.
SMRiP18846. Positions 215-269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060KID
Add
BLAST
Domaini213 – 27159bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 23925Basic motif By similarity
Add
BLAST
Regioni241 – 26222Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Phylogenomic databases

eggNOGiNOG255464.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP18846.
KOiK09053.
OMAiHIAQQMS.
PhylomeDBiP18846.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P18846-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS    50
SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP 100
IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ 150
YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV 200
TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC LENRVAVLEN 250
QNKTLIEELK TLKDLYSNKS V 271
Length:271
Mass (Da):29,233
Last modified:November 1, 1995 - v2
Checksum:iBAFECBFFB244FCED
GO
Isoform 2 (identifier: P18846-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Note: No experimental confirmation available.

Show »
Length:136
Mass (Da):15,295
Checksum:i86343F1CF592889F
GO

Sequence cautioni

The sequence CAC15058.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911P → A.
Corresponds to variant rs2230674 [ dbSNP | Ensembl ].
VAR_024382

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135Missing in isoform 2.
VSP_055559Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551H → A no nucleotide entry 1 Publication
Sequence conflicti227 – 2271Missing no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55544 Genomic DNA. Translation: CAA39150.1.
AK299240 mRNA. Translation: BAG61271.1.
AC013244 Genomic DNA. No translation available.
BC029619 mRNA. Translation: AAH29619.1.
AJ295163 mRNA. Translation: CAC15058.1. Different initiation.
CCDSiCCDS8803.1.
PIRiS12560.
RefSeqiNP_005162.1. NM_005171.4.
UniGeneiHs.648565.

Genome annotation databases

EnsembliENST00000262053; ENSP00000262053; ENSG00000123268.
ENST00000539132; ENSP00000438403; ENSG00000123268.
GeneIDi466.
KEGGihsa:466.
UCSCiuc001rww.4. human.

Polymorphism databases

DMDMi1168542.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55544 Genomic DNA. Translation: CAA39150.1 .
AK299240 mRNA. Translation: BAG61271.1 .
AC013244 Genomic DNA. No translation available.
BC029619 mRNA. Translation: AAH29619.1 .
AJ295163 mRNA. Translation: CAC15058.1 . Different initiation.
CCDSi CCDS8803.1.
PIRi S12560.
RefSeqi NP_005162.1. NM_005171.4.
UniGenei Hs.648565.

3D structure databases

ProteinModelPortali P18846.
SMRi P18846. Positions 215-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106956. 12 interactions.
DIPi DIP-652N.
IntActi P18846. 3 interactions.
MINTi MINT-142718.
STRINGi 9606.ENSP00000262053.

Chemistry

BindingDBi P18846.
ChEMBLi CHEMBL3255.

PTM databases

PhosphoSitei P18846.

Polymorphism databases

DMDMi 1168542.

Proteomic databases

MaxQBi P18846.
PaxDbi P18846.
PRIDEi P18846.

Protocols and materials databases

DNASUi 466.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262053 ; ENSP00000262053 ; ENSG00000123268 .
ENST00000539132 ; ENSP00000438403 ; ENSG00000123268 .
GeneIDi 466.
KEGGi hsa:466.
UCSCi uc001rww.4. human.

Organism-specific databases

CTDi 466.
GeneCardsi GC12P051189.
HGNCi HGNC:783. ATF1.
HPAi CAB016222.
HPA055069.
HPA055406.
MIMi 123803. gene.
612160. phenotype.
neXtProti NX_P18846.
Orphaneti 97338. Melanoma of soft parts.
PharmGKBi PA25083.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255464.
HOGENOMi HOG000007365.
HOVERGENi HBG011077.
InParanoidi P18846.
KOi K09053.
OMAi HIAQQMS.
PhylomeDBi P18846.
TreeFami TF106464.

Enzyme and pathway databases

Reactomei REACT_12524. CREB phosphorylation.
SignaLinki P18846.

Miscellaneous databases

ChiTaRSi ATF1. human.
GeneWikii ATF1.
GenomeRNAii 466.
NextBioi 1921.
PROi P18846.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18846.
Bgeei P18846.
CleanExi HS_ATF1.
Genevestigatori P18846.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
    Yoshimura T., Fujisawa J., Yoshida M.
    EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
    Rehfuss R.P., Walton K.M., Loriaux M.M., Goodman R.H.
    J. Biol. Chem. 266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  6. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
    Hai T., Liu F., Coukos W.J., Green M.R.
    Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-271 (ISOFORM 1).
  7. Erratum
    Hai T., Liu F., Coukos W.J., Green M.R.
    Genes Dev. 4:682-682(1990)
  8. "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."
    Waters B.L., Panagopoulos I., Allen E.F.
    Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-246 (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH FUS, ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA.
  9. "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."
    Sun P., Lou L., Maurer R.A.
    J. Biol. Chem. 271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-63, PHOSPHORYLATION BY CAMK1.
  10. "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."
    Hallor K.H., Mertens F., Jin Y., Meis-Kindblom J.M., Kindblom L.-G., Behrendtz M., Kalen A., Mandahl N., Panagopoulos I.
    Genes Chromosomes Cancer 44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1, ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA.
  11. "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."
    Zheng D., Cho Y.-Y., Lau A.T.Y., Zhang J., Ma W.-Y., Bode A.M., Dong Z.
    Cancer Res. 68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-63 BY CDK3, INTERACTION WITH CDK3, MUTAGENESIS OF SER-63.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."
    Hailemariam K., Iwasaki K., Huang B.W., Sakamoto K., Tsuji Y.
    J. Cell Sci. 123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS REPRESSOR, PHOSPHORYLATION AT SER-198 BY HIPK2, INTERACTION WITH HIPK2.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiATF1_HUMAN
AccessioniPrimary (citable) accession number: P18846
Secondary accession number(s): B4DRF9, P25168, Q9H4A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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