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P18846

- ATF1_HUMAN

UniProt

P18846 - ATF1_HUMAN

Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene

ATF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei110 – 1101Breakpoint for translocation to form chimeric EWSR1/ATF1 protein
    Sitei112 – 1121Breakpoint for translocation to form chimeric FUS/ATF1 protein

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding Source: Ensembl
    6. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cellular protein complex assembly Source: Ensembl
    2. innate immune response Source: Reactome
    3. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    4. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    5. neurotrophin TRK receptor signaling pathway Source: Reactome
    6. positive regulation of DNA replication Source: Ensembl
    7. positive regulation of neuron projection development Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    9. response to cobalt ion Source: Ensembl
    10. response to organic cyclic compound Source: Ensembl
    11. stress-activated MAPK cascade Source: Reactome
    12. toll-like receptor 10 signaling pathway Source: Reactome
    13. toll-like receptor 2 signaling pathway Source: Reactome
    14. toll-like receptor 3 signaling pathway Source: Reactome
    15. toll-like receptor 4 signaling pathway Source: Reactome
    16. toll-like receptor 5 signaling pathway Source: Reactome
    17. toll-like receptor 9 signaling pathway Source: Reactome
    18. toll-like receptor signaling pathway Source: Reactome
    19. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    20. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    21. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_12524. CREB phosphorylation.
    SignaLinkiP18846.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-1
    Short name:
    cAMP-dependent transcription factor ATF-1
    Alternative name(s):
    Activating transcription factor 1
    Protein TREB36
    Gene namesi
    Name:ATF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:783. ATF1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: HPA
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
    Note: The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi63 – 631S → A: Impaired CDK3-mediated phosphorylation and altered transactivation and transcriptional activities. 1 Publication

    Organism-specific databases

    MIMi612160. phenotype.
    Orphaneti97338. Melanoma of soft parts.
    PharmGKBiPA25083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Cyclic AMP-dependent transcription factor ATF-1PRO_0000076575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA52 Publications
    Modified residuei198 – 1981Phosphoserine; by HIPK24 PublicationsPROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP18846.
    PaxDbiP18846.
    PRIDEiP18846.

    PTM databases

    PhosphoSiteiP18846.

    Expressioni

    Gene expression databases

    ArrayExpressiP18846.
    BgeeiP18846.
    CleanExiHS_ATF1.
    GenevestigatoriP18846.

    Organism-specific databases

    HPAiCAB016222.
    HPA055069.
    HPA055406.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with HIPK2 and CDK3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P03259-22EBI-852794,EBI-7225021From a different organism.

    Protein-protein interaction databases

    BioGridi106956. 12 interactions.
    DIPiDIP-652N.
    IntActiP18846. 3 interactions.
    MINTiMINT-142718.
    STRINGi9606.ENSP00000262053.

    Structurei

    3D structure databases

    ProteinModelPortaliP18846.
    SMRiP18846. Positions 215-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 9060KIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini213 – 27159bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 23925Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni241 – 26222Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
    Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG255464.
    HOGENOMiHOG000007365.
    HOVERGENiHBG011077.
    InParanoidiP18846.
    KOiK09053.
    OMAiHIAQQMS.
    PhylomeDBiP18846.
    TreeFamiTF106464.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view]
    PRINTSiPR00041. LEUZIPPRCREB.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P18846-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS    50
    SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP 100
    IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ 150
    YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV 200
    TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC LENRVAVLEN 250
    QNKTLIEELK TLKDLYSNKS V 271
    Length:271
    Mass (Da):29,233
    Last modified:November 1, 1995 - v2
    Checksum:iBAFECBFFB244FCED
    GO
    Isoform 2 (identifier: P18846-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:136
    Mass (Da):15,295
    Checksum:i86343F1CF592889F
    GO

    Sequence cautioni

    The sequence CAC15058.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551H → A no nucleotide entry (PubMed:2516827)Curated
    Sequence conflicti227 – 2271Missing no nucleotide entry (PubMed:2516827)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911P → A.
    Corresponds to variant rs2230674 [ dbSNP | Ensembl ].
    VAR_024382

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135Missing in isoform 2. 1 PublicationVSP_055559Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55544 Genomic DNA. Translation: CAA39150.1.
    AK299240 mRNA. Translation: BAG61271.1.
    AC013244 Genomic DNA. No translation available.
    BC029619 mRNA. Translation: AAH29619.1.
    AJ295163 mRNA. Translation: CAC15058.1. Different initiation.
    CCDSiCCDS8803.1.
    PIRiS12560.
    RefSeqiNP_005162.1. NM_005171.4.
    UniGeneiHs.648565.

    Genome annotation databases

    EnsembliENST00000262053; ENSP00000262053; ENSG00000123268. [P18846-1]
    GeneIDi466.
    KEGGihsa:466.
    UCSCiuc001rww.4. human.

    Polymorphism databases

    DMDMi1168542.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55544 Genomic DNA. Translation: CAA39150.1 .
    AK299240 mRNA. Translation: BAG61271.1 .
    AC013244 Genomic DNA. No translation available.
    BC029619 mRNA. Translation: AAH29619.1 .
    AJ295163 mRNA. Translation: CAC15058.1 . Different initiation.
    CCDSi CCDS8803.1.
    PIRi S12560.
    RefSeqi NP_005162.1. NM_005171.4.
    UniGenei Hs.648565.

    3D structure databases

    ProteinModelPortali P18846.
    SMRi P18846. Positions 215-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106956. 12 interactions.
    DIPi DIP-652N.
    IntActi P18846. 3 interactions.
    MINTi MINT-142718.
    STRINGi 9606.ENSP00000262053.

    Chemistry

    BindingDBi P18846.
    ChEMBLi CHEMBL3255.
    DrugBanki DB00852. Pseudoephedrine.

    PTM databases

    PhosphoSitei P18846.

    Polymorphism databases

    DMDMi 1168542.

    Proteomic databases

    MaxQBi P18846.
    PaxDbi P18846.
    PRIDEi P18846.

    Protocols and materials databases

    DNASUi 466.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262053 ; ENSP00000262053 ; ENSG00000123268 . [P18846-1 ]
    GeneIDi 466.
    KEGGi hsa:466.
    UCSCi uc001rww.4. human.

    Organism-specific databases

    CTDi 466.
    GeneCardsi GC12P051189.
    HGNCi HGNC:783. ATF1.
    HPAi CAB016222.
    HPA055069.
    HPA055406.
    MIMi 123803. gene.
    612160. phenotype.
    neXtProti NX_P18846.
    Orphaneti 97338. Melanoma of soft parts.
    PharmGKBi PA25083.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255464.
    HOGENOMi HOG000007365.
    HOVERGENi HBG011077.
    InParanoidi P18846.
    KOi K09053.
    OMAi HIAQQMS.
    PhylomeDBi P18846.
    TreeFami TF106464.

    Enzyme and pathway databases

    Reactomei REACT_12524. CREB phosphorylation.
    SignaLinki P18846.

    Miscellaneous databases

    ChiTaRSi ATF1. human.
    GeneWikii ATF1.
    GenomeRNAii 466.
    NextBioi 1921.
    PROi P18846.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18846.
    Bgeei P18846.
    CleanExi HS_ATF1.
    Genevestigatori P18846.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view ]
    PRINTSi PR00041. LEUZIPPRCREB.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
      Yoshimura T., Fujisawa J., Yoshida M.
      EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
      Rehfuss R.P., Walton K.M., Loriaux M.M., Goodman R.H.
      J. Biol. Chem. 266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    6. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
      Hai T., Liu F., Coukos W.J., Green M.R.
      Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-271 (ISOFORM 1).
    7. Erratum
      Hai T., Liu F., Coukos W.J., Green M.R.
      Genes Dev. 4:682-682(1990)
    8. "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."
      Waters B.L., Panagopoulos I., Allen E.F.
      Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-246 (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH FUS, ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA.
    9. "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."
      Sun P., Lou L., Maurer R.A.
      J. Biol. Chem. 271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-63, PHOSPHORYLATION BY CAMK1.
    10. "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."
      Hallor K.H., Mertens F., Jin Y., Meis-Kindblom J.M., Kindblom L.-G., Behrendtz M., Kalen A., Mandahl N., Panagopoulos I.
      Genes Chromosomes Cancer 44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1, ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA.
    11. "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."
      Zheng D., Cho Y.-Y., Lau A.T.Y., Zhang J., Ma W.-Y., Bode A.M., Dong Z.
      Cancer Res. 68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-63 BY CDK3, INTERACTION WITH CDK3, MUTAGENESIS OF SER-63.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."
      Hailemariam K., Iwasaki K., Huang B.W., Sakamoto K., Tsuji Y.
      J. Cell Sci. 123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS REPRESSOR, PHOSPHORYLATION AT SER-198 BY HIPK2, INTERACTION WITH HIPK2.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiATF1_HUMAN
    AccessioniPrimary (citable) accession number: P18846
    Secondary accession number(s): B4DRF9, P25168, Q9H4A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3