Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lutropin subunit beta

Gene

LHB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Lutropin beta chain
Gene namesi
Name:LHB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 17Add BLAST›17
ChainiPRO_000001172018 – 138Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 74By similarity
Glycosylationi30N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi40 ↔ 89By similarity
Disulfide bondi43 ↔ 127By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi55 ↔ 107By similarity
Disulfide bondi110 ↔ 117By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18842.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005719.

Structurei

3D structure databases

ProteinModelPortaliP18842.
SMRiP18842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP18842.
KOiK08521.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiView protein in Pfam
PF00007. Cys_knot. 1 hit.
SMARTiView protein in SMART
SM00068. GHB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LQGLLLWLLL SVGGVWASRG PLRPLCRPIN ATLAAENEAC PVCITFTTTI
60 70 80 90 100
CAGYCPSMVR VLPAALPPVP QPVCTYHELH FASIRLPGCP PGVDPMVSFP
110 120 130
VALSCRCGPC RLSNSDCGGP RAQSLACDRP LLPGLLFL
Length:138
Mass (Da):14,594
Last modified:November 1, 1990 - v1
Checksum:iE3639FE6B03F1948
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00518 mRNA. Translation: CAA68572.1.
PIRiS00512.
RefSeqiNP_001183962.1. NM_001197033.1.
UniGeneiCfa.3817.

Genome annotation databases

GeneIDi403959.
KEGGicfa:403959.

Similar proteinsi

Entry informationi

Entry nameiLSHB_CANLF
AccessioniPrimary (citable) accession number: P18842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 10, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families