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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularBy similarityAdd
BLAST
Transmembranei46 – 7025Helical; Name=1By similarityAdd
BLAST
Topological domaini71 – 8313CytoplasmicBy similarityAdd
BLAST
Transmembranei84 – 10522Helical; Name=2By similarityAdd
BLAST
Topological domaini106 – 11510ExtracellularBy similarity
Transmembranei116 – 14126Helical; Name=3By similarityAdd
BLAST
Topological domaini142 – 16120CytoplasmicBy similarityAdd
BLAST
Transmembranei162 – 18423Helical; Name=4By similarityAdd
BLAST
Topological domaini185 – 20117ExtracellularBy similarityAdd
BLAST
Transmembranei202 – 22423Helical; Name=5By similarityAdd
BLAST
Topological domaini225 – 29571CytoplasmicBy similarityAdd
BLAST
Transmembranei296 – 31924Helical; Name=6By similarityAdd
BLAST
Topological domaini320 – 3267ExtracellularBy similarity
Transmembranei327 – 35125Helical; Name=7By similarityAdd
BLAST
Topological domaini352 – 515164CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi293 – 2931A → X: Confers constitutive activity. 1 Publication

Chemistry

ChEMBLiCHEMBL3122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Alpha-1B adrenergic receptorPRO_0000069070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Modified residuei264 – 2641PhosphothreonineBy similarity
Lipidationi365 – 3651S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

iPTMnetiP18841.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C1qbpO357965EBI-6391008,EBI-915544From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP18841. 1 interaction.

Chemistry

BindingDBiP18841.

Structurei

3D structure databases

ProteinModelPortaliP18841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi368 – 37811Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi371 – 3788Poly-Arg

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAQWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP
110 120 130 140 150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFM RILGCQCRSG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS
410 420 430 440 450
RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGAQPPLELC AYPEWKSGAL
460 470 480 490 500
LSLPEPPGRR GRLDSGPLFT FKLLGEPESP GTEGDASNGG CDATTDLANG
510
QPGFKSNMPL APGHF
Length:515
Mass (Da):56,493
Last modified:November 1, 1990 - v1
Checksum:i6DAF1576D1C1CE2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04084 mRNA. Translation: AAA58964.1.
PIRiA40491.
RefSeqiNP_001268623.1. NM_001281694.1.

Genome annotation databases

GeneIDi101843941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04084 mRNA. Translation: AAA58964.1.
PIRiA40491.
RefSeqiNP_001268623.1. NM_001281694.1.

3D structure databases

ProteinModelPortaliP18841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18841. 1 interaction.

Chemistry

BindingDBiP18841.
ChEMBLiCHEMBL3122.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP18841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101843941.

Organism-specific databases

CTDi147.

Phylogenomic databases

HOVERGENiHBG106962.

Miscellaneous databases

PROiP18841.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor."
    Cotecchia S., Schwinn D.A., Randall R.R., Lefkowitz R.J., Caron M.G., Kobilka B.K.
    Proc. Natl. Acad. Sci. U.S.A. 85:7159-7163(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation."
    Kjelsberg M.A., Cotecchia S., Ostrowski J., Caron M.G., Lefkowitz R.J.
    J. Biol. Chem. 267:1430-1433(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ALA-293.

Entry informationi

Entry nameiADA1B_MESAU
AccessioniPrimary (citable) accession number: P18841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.