ID   COL19_CAEEL             Reviewed;         289 AA.
AC   P18835; Q23411;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2002, sequence version 2.
DT   27-MAR-2024, entry version 163.
DE   RecName: Full=Cuticle collagen 19;
DE   Flags: Precursor;
GN   Name=col-19; ORFNames=ZK1193.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=2753356; DOI=10.1016/0378-1119(89)90173-x;
RA   Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.;
RT   "Sequence comparisons of developmentally regulated collagen genes of
RT   Caenorhabditis elegans.";
RL   Gene 76:331-344(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; M25481; AAA27987.1; -; Genomic_DNA.
DR   EMBL; FO081441; CCD71633.1; -; Genomic_DNA.
DR   PIR; JS0170; JS0170.
DR   PIR; T27708; T27708.
DR   RefSeq; NP_001033577.1; NM_001038488.3.
DR   AlphaFoldDB; P18835; -.
DR   SMR; P18835; -.
DR   BioGRID; 45350; 3.
DR   DIP; DIP-26658N; -.
DR   IntAct; P18835; 1.
DR   STRING; 6239.ZK1193.1.1; -.
DR   EPD; P18835; -.
DR   PaxDb; 6239-ZK1193-1; -.
DR   PeptideAtlas; P18835; -.
DR   EnsemblMetazoa; ZK1193.1.1; ZK1193.1.1; WBGene00000608.
DR   GeneID; 180397; -.
DR   KEGG; cel:CELE_ZK1193.1; -.
DR   UCSC; ZK1193.1; c. elegans.
DR   AGR; WB:WBGene00000608; -.
DR   WormBase; ZK1193.1; CE05126; WBGene00000608; col-19.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00970000196588; -.
DR   HOGENOM; CLU_001074_4_3_1; -.
DR   InParanoid; P18835; -.
DR   OMA; AGFEQCN; -.
DR   OrthoDB; 2883637at2759; -.
DR   PhylomeDB; P18835; -.
DR   SignaLink; P18835; -.
DR   PRO; PR:P18835; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000608; Expressed in adult organism and 2 other cell types or tissues.
DR   GO; GO:0060111; C:alae of collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR   GO; GO:0060107; C:annuli extracellular matrix; IDA:WormBase.
DR   GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0042329; F:structural constituent of collagen and cuticulin-based cuticle; IDA:WormBase.
DR   GO; GO:0042302; F:structural constituent of cuticle; NAS:UniProtKB.
DR   GO; GO:0040002; P:collagen and cuticulin-based cuticle development; NAS:UniProtKB.
DR   GO; GO:0042338; P:cuticle development involved in collagen and cuticulin-based cuticle molting cycle; IMP:WormBase.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   InterPro; IPR008160; Collagen.
DR   PANTHER; PTHR24637; COLLAGEN; 1.
DR   PANTHER; PTHR24637:SF377; CUTICLE COLLAGEN 19; 1.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   3: Inferred from homology;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..289
FT                   /note="Cuticle collagen 19"
FT                   /id="PRO_0000006426"
FT   REGION          95..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..130
FT                   /note="Triple-helical region"
FT   REGION          147..269
FT                   /note="Triple-helical region"
FT   CONFLICT        3
FT                   /note="K -> T (in Ref. 1; AAA27987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25..45
FT                   /note="NLLNEIEELQVEFQDGMVEFR -> TFSMRSRSFKLSSRM (in Ref. 1;
FT                   AAA27987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        69
FT                   /note="P -> L (in Ref. 1; AAA27987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="E -> D (in Ref. 1; AAA27987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="R -> C (in Ref. 1; AAA27987)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   289 AA;  28375 MW;  F48B037BAEDF053A CRC64;
     MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD TWARMVSKHI
     NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA GPPGPPGEGG QKGNPGHDGD
     DGKPGAPGVI VAITHDIPGG CIKCPPGRPG PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG
     EQGPQGDAGR PGAAGRPGPA GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG
     EAGKNGNAGR PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA
//