P18835 (COL19_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cuticle collagen 19

Gene names

Name:	col-19
ORF Names:	ZK1193.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
Subunit structure	Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
Sequence similarities	Belongs to the cuticular collagen family.

Ontologies

Keywords
Cellular component	Cuticle
Domain	Collagen Repeat Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	collagen and cuticulin-based cuticle development Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	alae of collagen and cuticulin-based cuticle extracellular matrix Inferred from direct assay PubMed 12619137PubMed 16254074. Source: WormBase annuli extracellular matrix Inferred from direct assay PubMed 12619137PubMed 16254074. Source: WormBase collagen Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of cuticle Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 289	271	Cuticle collagen 19		PRO_0000006426
Regions
	Region	101 – 130	30	Triple-helical region
	Region	147 – 269	123	Triple-helical region
Experimental info
	Sequence conflict	3	1	K → T in AAA27987. Ref.1
	Sequence conflict	25 – 45	21	NLLNE…MVEFR → TFSMRSRSFKLSSRM in AAA27987. Ref.1
	Sequence conflict	69	1	P → L in AAA27987. Ref.1
	Sequence conflict	96	1	E → D in AAA27987. Ref.1
	Sequence conflict	148	1	R → C in AAA27987. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P18835 [UniParc]. Last modified August 2, 2002. Version 2. Checksum: F48B037BAEDF053A	FASTA	289	28,375
	10 20 30 40 50 60 MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD TWARMVSKHI 70 80 90 100 110 120 NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA GPPGPPGEGG QKGNPGHDGD 130 140 150 160 170 180 DGKPGAPGVI VAITHDIPGG CIKCPPGRPG PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG 190 200 210 220 230 240 EQGPQGDAGR PGAAGRPGPA GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG 250 260 270 280 EAGKNGNAGR PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans." Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D. Gene 76:331-344(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25481 Genomic DNA. Translation: AAA27987.1. FO081441 Genomic DNA. Translation: CCD71633.1.
PIR	JS0170. T27708.
RefSeq	NP_001033577.1. NM_001038488.3.
UniGene	Cel.11111.
3D structure databases
ProteinModelPortal	P18835.
SMR	P18835. Positions 99-135, 148-184.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26658N.
IntAct	P18835. 1 interaction.
MINT	MINT-1103210.
STRING	6239.ZK1193.1.
Proteomic databases
PaxDb	P18835.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1193.1; ZK1193.1; ZK1193.1.
GeneID	180397.
KEGG	cel:CELE_ZK1193.1.
UCSC	ZK1193.1. c. elegans.
Organism-specific databases
CTD	180397.
WormBase	ZK1193.1; CE05126; WBGene00000608; col-19.
Phylogenomic databases
eggNOG	NOG275011.
GeneTree	ENSGT00530000064674.
HOGENOM	HOG000085656.
InParanoid	P18835.
OMA	QDTWARM.
Family and domain databases
InterPro	IPR002486. Col_cuticle_N. IPR008160. Collagen. [Graphical view]
Pfam	PF01484. Col_cuticle_N. 1 hit. PF01391. Collagen. 2 hits. [Graphical view]
SMART	SM01088. Col_cuticle_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	909176.

Entry information

Entry name

COL19_CAEEL

Accession

Primary (citable) accession number: P18835
Secondary accession number(s): Q23411

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	August 2, 2002
Last modified:	May 29, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project