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Protein

Cuticle collagen 19

Gene

col-19

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

GO - Molecular functioni

  • structural constituent of cuticle Source: UniProtKB

GO - Biological processi

  • collagen and cuticulin-based cuticle development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_307771. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cuticle collagen 19
Gene namesi
Name:col-19
ORF Names:ZK1193.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK1193.1; CE05126; WBGene00000608; col-19.

Subcellular locationi

GO - Cellular componenti

  • alae of collagen and cuticulin-based cuticle extracellular matrix Source: WormBase
  • annuli extracellular matrix Source: WormBase
  • collagen trimer Source: UniProtKB-KW
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 289271Cuticle collagen 19PRO_0000006426Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP18835.
PRIDEiP18835.

Interactioni

Subunit structurei

Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

Protein-protein interaction databases

BioGridi45350. 3 interactions.
DIPiDIP-26658N.
IntActiP18835. 1 interaction.
MINTiMINT-1103210.
STRINGi6239.ZK1193.1.

Structurei

3D structure databases

ProteinModelPortaliP18835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 13030Triple-helical regionAdd
BLAST
Regioni147 – 269123Triple-helical regionAdd
BLAST

Sequence similaritiesi

Belongs to the cuticular collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG275011.
GeneTreeiENSGT00760000119051.
HOGENOMiHOG000085656.
InParanoidiP18835.
OMAiQDTWARM.
OrthoDBiEOG7N0C9C.
PhylomeDBiP18835.

Family and domain databases

InterProiIPR002486. Col_cuticle_N.
IPR008160. Collagen.
[Graphical view]
PfamiPF01484. Col_cuticle_N. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
SMARTiSM01088. Col_cuticle_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD
60 70 80 90 100
TWARMVSKHI NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA
110 120 130 140 150
GPPGPPGEGG QKGNPGHDGD DGKPGAPGVI VAITHDIPGG CIKCPPGRPG
160 170 180 190 200
PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG EQGPQGDAGR PGAAGRPGPA
210 220 230 240 250
GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG EAGKNGNAGR
260 270 280
PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA
Length:289
Mass (Da):28,375
Last modified:August 2, 2002 - v2
Checksum:iF48B037BAEDF053A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31K → T in AAA27987 (PubMed:2753356).Curated
Sequence conflicti25 – 4521NLLNE…MVEFR → TFSMRSRSFKLSSRM in AAA27987 (PubMed:2753356).CuratedAdd
BLAST
Sequence conflicti69 – 691P → L in AAA27987 (PubMed:2753356).Curated
Sequence conflicti96 – 961E → D in AAA27987 (PubMed:2753356).Curated
Sequence conflicti148 – 1481R → C in AAA27987 (PubMed:2753356).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25481 Genomic DNA. Translation: AAA27987.1.
FO081441 Genomic DNA. Translation: CCD71633.1.
PIRiJS0170.
T27708.
RefSeqiNP_001033577.1. NM_001038488.3.
UniGeneiCel.11111.

Genome annotation databases

EnsemblMetazoaiZK1193.1; ZK1193.1; WBGene00000608.
GeneIDi180397.
KEGGicel:CELE_ZK1193.1.
UCSCiZK1193.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25481 Genomic DNA. Translation: AAA27987.1.
FO081441 Genomic DNA. Translation: CCD71633.1.
PIRiJS0170.
T27708.
RefSeqiNP_001033577.1. NM_001038488.3.
UniGeneiCel.11111.

3D structure databases

ProteinModelPortaliP18835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45350. 3 interactions.
DIPiDIP-26658N.
IntActiP18835. 1 interaction.
MINTiMINT-1103210.
STRINGi6239.ZK1193.1.

Proteomic databases

PaxDbiP18835.
PRIDEiP18835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1193.1; ZK1193.1; WBGene00000608.
GeneIDi180397.
KEGGicel:CELE_ZK1193.1.
UCSCiZK1193.1. c. elegans.

Organism-specific databases

CTDi180397.
WormBaseiZK1193.1; CE05126; WBGene00000608; col-19.

Phylogenomic databases

eggNOGiNOG275011.
GeneTreeiENSGT00760000119051.
HOGENOMiHOG000085656.
InParanoidiP18835.
OMAiQDTWARM.
OrthoDBiEOG7N0C9C.
PhylomeDBiP18835.

Enzyme and pathway databases

ReactomeiREACT_307771. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi909176.
PROiP18835.

Family and domain databases

InterProiIPR002486. Col_cuticle_N.
IPR008160. Collagen.
[Graphical view]
PfamiPF01484. Col_cuticle_N. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
SMARTiSM01088. Col_cuticle_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans."
    Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.
    Gene 76:331-344(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCOL19_CAEEL
AccessioniPrimary (citable) accession number: P18835
Secondary accession number(s): Q23411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 2, 2002
Last modified: May 27, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.