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P18835 (COL19_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cuticle collagen 19
Gene names
Name:col-19
ORF Names:ZK1193.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Subunit structure

Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

Sequence similarities

Belongs to the cuticular collagen family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 289271Cuticle collagen 19
PRO_0000006426

Regions

Region101 – 13030Triple-helical region
Region147 – 269123Triple-helical region

Experimental info

Sequence conflict31K → T in AAA27987. Ref.1
Sequence conflict25 – 4521NLLNE…MVEFR → TFSMRSRSFKLSSRM in AAA27987. Ref.1
Sequence conflict691P → L in AAA27987. Ref.1
Sequence conflict961E → D in AAA27987. Ref.1
Sequence conflict1481R → C in AAA27987. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P18835 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: F48B037BAEDF053A

FASTA28928,375
        10         20         30         40         50         60 
MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD TWARMVSKHI 

        70         80         90        100        110        120 
NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA GPPGPPGEGG QKGNPGHDGD 

       130        140        150        160        170        180 
DGKPGAPGVI VAITHDIPGG CIKCPPGRPG PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG 

       190        200        210        220        230        240 
EQGPQGDAGR PGAAGRPGPA GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG 

       250        260        270        280 
EAGKNGNAGR PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans."
Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.
Gene 76:331-344(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25481 Genomic DNA. Translation: AAA27987.1.
FO081441 Genomic DNA. Translation: CCD71633.1.
PIRJS0170.
T27708.
RefSeqNP_001033577.1. NM_001038488.3.
UniGeneCel.11111.

3D structure databases

ProteinModelPortalP18835.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45350. 3 interactions.
DIPDIP-26658N.
IntActP18835. 1 interaction.
MINTMINT-1103210.
STRING6239.ZK1193.1.

Proteomic databases

PaxDbP18835.
PRIDEP18835.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK1193.1; ZK1193.1; WBGene00000608.
GeneID180397.
KEGGcel:CELE_ZK1193.1.
UCSCZK1193.1. c. elegans.

Organism-specific databases

CTD180397.
WormBaseZK1193.1; CE05126; WBGene00000608; col-19.

Phylogenomic databases

eggNOGNOG275011.
GeneTreeENSGT00730000111339.
HOGENOMHOG000085656.
InParanoidP18835.
OMAHEGHIES.
OrthoDBEOG7N0C9C.
PhylomeDBP18835.

Family and domain databases

InterProIPR002486. Col_cuticle_N.
IPR008160. Collagen.
[Graphical view]
PfamPF01484. Col_cuticle_N. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
SMARTSM01088. Col_cuticle_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio909176.

Entry information

Entry nameCOL19_CAEEL
AccessionPrimary (citable) accession number: P18835
Secondary accession number(s): Q23411
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 2, 2002
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase