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P18835

- COL19_CAEEL

UniProt

P18835 - COL19_CAEEL

Protein

Cuticle collagen 19

Gene

col-19

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (02 Aug 2002)
      Previous versions | rss
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    Functioni

    Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

    GO - Molecular functioni

    1. structural constituent of cuticle Source: UniProtKB

    GO - Biological processi

    1. collagen and cuticulin-based cuticle development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cuticle collagen 19
    Gene namesi
    Name:col-19
    ORF Names:ZK1193.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiZK1193.1; CE05126; WBGene00000608; col-19.

    Subcellular locationi

    GO - Cellular componenti

    1. alae of collagen and cuticulin-based cuticle extracellular matrix Source: WormBase
    2. annuli extracellular matrix Source: WormBase
    3. collagen trimer Source: UniProtKB-KW
    4. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Cuticle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 289271Cuticle collagen 19PRO_0000006426Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP18835.
    PRIDEiP18835.

    Interactioni

    Subunit structurei

    Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

    Protein-protein interaction databases

    BioGridi45350. 3 interactions.
    DIPiDIP-26658N.
    IntActiP18835. 1 interaction.
    MINTiMINT-1103210.
    STRINGi6239.ZK1193.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP18835.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 13030Triple-helical regionAdd
    BLAST
    Regioni147 – 269123Triple-helical regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cuticular collagen family.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG275011.
    GeneTreeiENSGT00730000111339.
    HOGENOMiHOG000085656.
    InParanoidiP18835.
    OMAiHEGHIES.
    OrthoDBiEOG7N0C9C.
    PhylomeDBiP18835.

    Family and domain databases

    InterProiIPR002486. Col_cuticle_N.
    IPR008160. Collagen.
    [Graphical view]
    PfamiPF01484. Col_cuticle_N. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view]
    SMARTiSM01088. Col_cuticle_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18835-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD    50
    TWARMVSKHI NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA 100
    GPPGPPGEGG QKGNPGHDGD DGKPGAPGVI VAITHDIPGG CIKCPPGRPG 150
    PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG EQGPQGDAGR PGAAGRPGPA 200
    GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG EAGKNGNAGR 250
    PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA 289
    Length:289
    Mass (Da):28,375
    Last modified:August 2, 2002 - v2
    Checksum:iF48B037BAEDF053A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31K → T in AAA27987. (PubMed:2753356)Curated
    Sequence conflicti25 – 4521NLLNE…MVEFR → TFSMRSRSFKLSSRM in AAA27987. (PubMed:2753356)CuratedAdd
    BLAST
    Sequence conflicti69 – 691P → L in AAA27987. (PubMed:2753356)Curated
    Sequence conflicti96 – 961E → D in AAA27987. (PubMed:2753356)Curated
    Sequence conflicti148 – 1481R → C in AAA27987. (PubMed:2753356)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25481 Genomic DNA. Translation: AAA27987.1.
    FO081441 Genomic DNA. Translation: CCD71633.1.
    PIRiJS0170.
    T27708.
    RefSeqiNP_001033577.1. NM_001038488.3.
    UniGeneiCel.11111.

    Genome annotation databases

    EnsemblMetazoaiZK1193.1; ZK1193.1; WBGene00000608.
    GeneIDi180397.
    KEGGicel:CELE_ZK1193.1.
    UCSCiZK1193.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25481 Genomic DNA. Translation: AAA27987.1 .
    FO081441 Genomic DNA. Translation: CCD71633.1 .
    PIRi JS0170.
    T27708.
    RefSeqi NP_001033577.1. NM_001038488.3.
    UniGenei Cel.11111.

    3D structure databases

    ProteinModelPortali P18835.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45350. 3 interactions.
    DIPi DIP-26658N.
    IntActi P18835. 1 interaction.
    MINTi MINT-1103210.
    STRINGi 6239.ZK1193.1.

    Proteomic databases

    PaxDbi P18835.
    PRIDEi P18835.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK1193.1 ; ZK1193.1 ; WBGene00000608 .
    GeneIDi 180397.
    KEGGi cel:CELE_ZK1193.1.
    UCSCi ZK1193.1. c. elegans.

    Organism-specific databases

    CTDi 180397.
    WormBasei ZK1193.1 ; CE05126 ; WBGene00000608 ; col-19.

    Phylogenomic databases

    eggNOGi NOG275011.
    GeneTreei ENSGT00730000111339.
    HOGENOMi HOG000085656.
    InParanoidi P18835.
    OMAi HEGHIES.
    OrthoDBi EOG7N0C9C.
    PhylomeDBi P18835.

    Miscellaneous databases

    NextBioi 909176.

    Family and domain databases

    InterProi IPR002486. Col_cuticle_N.
    IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01484. Col_cuticle_N. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view ]
    SMARTi SM01088. Col_cuticle_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans."
      Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.
      Gene 76:331-344(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCOL19_CAEEL
    AccessioniPrimary (citable) accession number: P18835
    Secondary accession number(s): Q23411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: August 2, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3