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P18835

- COL19_CAEEL

UniProt

P18835 - COL19_CAEEL

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Protein

Cuticle collagen 19

Gene
col-19, ZK1193.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

GO - Molecular functioni

  1. structural constituent of cuticle Source: UniProtKB

GO - Biological processi

  1. collagen and cuticulin-based cuticle development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cuticle collagen 19
Gene namesi
Name:col-19
ORF Names:ZK1193.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZK1193.1; CE05126; WBGene00000608; col-19.

Subcellular locationi

GO - Cellular componenti

  1. alae of collagen and cuticulin-based cuticle extracellular matrix Source: WormBase
  2. annuli extracellular matrix Source: WormBase
  3. collagen trimer Source: UniProtKB-KW
  4. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 289271Cuticle collagen 19PRO_0000006426Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP18835.
PRIDEiP18835.

Interactioni

Subunit structurei

Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

Protein-protein interaction databases

BioGridi45350. 3 interactions.
DIPiDIP-26658N.
IntActiP18835. 1 interaction.
MINTiMINT-1103210.
STRINGi6239.ZK1193.1.

Structurei

3D structure databases

ProteinModelPortaliP18835.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 13030Triple-helical regionAdd
BLAST
Regioni147 – 269123Triple-helical regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG275011.
GeneTreeiENSGT00730000111339.
HOGENOMiHOG000085656.
InParanoidiP18835.
OMAiHEGHIES.
OrthoDBiEOG7N0C9C.
PhylomeDBiP18835.

Family and domain databases

InterProiIPR002486. Col_cuticle_N.
IPR008160. Collagen.
[Graphical view]
PfamiPF01484. Col_cuticle_N. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
SMARTiSM01088. Col_cuticle_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18835-1 [UniParc]FASTAAdd to Basket

« Hide

MGKLIVVGSC GVLVCVLASL YTIGNLLNEI EELQVEFQDG MVEFRAITQD    50
TWARMVSKHI NPTGHTNAPP TFETLFGART ARQAGFEQCN CGPKSEGCPA 100
GPPGPPGEGG QKGNPGHDGD DGKPGAPGVI VAITHDIPGG CIKCPPGRPG 150
PKGPSGLPGS AGPAGGNGRR GPPGPVGGPG EQGPQGDAGR PGAAGRPGPA 200
GPRGEPGTEY KPGQPGRPGP QGPRGETGPA GNPGAPGNDG EAGKNGNAGR 250
PGPPGHPGKN GVPGQKGEDA APGPDAGYCP CPSRAAYKA 289
Length:289
Mass (Da):28,375
Last modified:August 2, 2002 - v2
Checksum:iF48B037BAEDF053A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31K → T in AAA27987. 1 Publication
Sequence conflicti25 – 4521NLLNE…MVEFR → TFSMRSRSFKLSSRM in AAA27987. 1 PublicationAdd
BLAST
Sequence conflicti69 – 691P → L in AAA27987. 1 Publication
Sequence conflicti96 – 961E → D in AAA27987. 1 Publication
Sequence conflicti148 – 1481R → C in AAA27987. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25481 Genomic DNA. Translation: AAA27987.1.
FO081441 Genomic DNA. Translation: CCD71633.1.
PIRiJS0170.
T27708.
RefSeqiNP_001033577.1. NM_001038488.3.
UniGeneiCel.11111.

Genome annotation databases

EnsemblMetazoaiZK1193.1; ZK1193.1; WBGene00000608.
GeneIDi180397.
KEGGicel:CELE_ZK1193.1.
UCSCiZK1193.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25481 Genomic DNA. Translation: AAA27987.1 .
FO081441 Genomic DNA. Translation: CCD71633.1 .
PIRi JS0170.
T27708.
RefSeqi NP_001033577.1. NM_001038488.3.
UniGenei Cel.11111.

3D structure databases

ProteinModelPortali P18835.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45350. 3 interactions.
DIPi DIP-26658N.
IntActi P18835. 1 interaction.
MINTi MINT-1103210.
STRINGi 6239.ZK1193.1.

Proteomic databases

PaxDbi P18835.
PRIDEi P18835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK1193.1 ; ZK1193.1 ; WBGene00000608 .
GeneIDi 180397.
KEGGi cel:CELE_ZK1193.1.
UCSCi ZK1193.1. c. elegans.

Organism-specific databases

CTDi 180397.
WormBasei ZK1193.1 ; CE05126 ; WBGene00000608 ; col-19.

Phylogenomic databases

eggNOGi NOG275011.
GeneTreei ENSGT00730000111339.
HOGENOMi HOG000085656.
InParanoidi P18835.
OMAi HEGHIES.
OrthoDBi EOG7N0C9C.
PhylomeDBi P18835.

Miscellaneous databases

NextBioi 909176.

Family and domain databases

InterProi IPR002486. Col_cuticle_N.
IPR008160. Collagen.
[Graphical view ]
Pfami PF01484. Col_cuticle_N. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view ]
SMARTi SM01088. Col_cuticle_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans."
    Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.
    Gene 76:331-344(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCOL19_CAEEL
AccessioniPrimary (citable) accession number: P18835
Secondary accession number(s): Q23411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 2, 2002
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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