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P18828

- SDC1_MOUSE

UniProt

P18828 - SDC1_MOUSE

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Protein
Syndecan-1
Gene
Sdc1, Synd-1, Synd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei243 – 2442Cleavage

GO - Molecular functioni

  1. glycoprotein binding Source: MGI

GO - Biological processi

  1. Sertoli cell development Source: Ensembl
  2. canonical Wnt signaling pathway Source: MGI
  3. inflammatory response Source: Ensembl
  4. myoblast development Source: UniProtKB
  5. odontogenesis Source: Ensembl
  6. response to cAMP Source: Ensembl
  7. response to calcium ion Source: Ensembl
  8. response to glucocorticoid Source: Ensembl
  9. response to hydrogen peroxide Source: Ensembl
  10. response to toxic substance Source: Ensembl
  11. striated muscle cell development Source: Ensembl
  12. ureteric bud development Source: Ensembl
  13. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_197897. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_216017. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-1
Short name:
SYND1
Alternative name(s):
CD_antigen: CD138
Gene namesi
Name:Sdc1
Synonyms:Synd-1, Synd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1349162. Sdc1.

Subcellular locationi

Membrane; Single-pass type I membrane protein. Secreted
Note: Shedding of the ectodomain produces a soluble form.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 255233Extracellular Reviewed prediction
Add
BLAST
Transmembranei256 – 27621Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 31135Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. cell surface Source: MGI
  3. external side of plasma membrane Source: MGI
  4. extracellular region Source: Reactome
  5. focal adhesion Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 311289Syndecan-1
PRO_0000033501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371O-linked (Xyl...) (chondroitin sulfate) Inferred
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi45 – 451O-linked (Xyl...) (heparan sulfate) Inferred
Glycosylationi47 – 471O-linked (Xyl...) (heparan sulfate) Inferred
Glycosylationi207 – 2071O-linked (Xyl...) (chondroitin sulfate)1 Publication
Glycosylationi217 – 2171O-linked (Xyl...) (chondroitin sulfate)1 Publication

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 By similarity.

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiP18828.
PRIDEiP18828.

PTM databases

PhosphoSiteiP18828.

Miscellaneous databases

PMAP-CutDBP18828.

Expressioni

Gene expression databases

ArrayExpressiP18828.
BgeeiP18828.
CleanExiMM_SDC1.
GenevestigatoriP18828.

Interactioni

Subunit structurei

Interacts with CDCP1 By similarity. Interacts (via C-terminus) with TIAM1 (via PDZ domain).1 Publication

Protein-protein interaction databases

BioGridi203602. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP18828.
SMRiP18828. Positions 278-311.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86393.
HOGENOMiHOG000133092.
HOVERGENiHBG017783.
InParanoidiP18828.
KOiK06257.
OMAiPTKQEEF.
OrthoDBiEOG79KPG2.
PhylomeDBiP18828.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P18828-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG    50
ALPDTLSRQT PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE 100
GEPVLHVEAE PGFTARDKEK EVTTRPRETV QLPITQRAST VRVTTAQAAV 150
TSHPHGGMQP GLHETSAPTA PGQPDHQPPR VEGGGTSVIK EVVEDGTANQ 200
LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA TGASQSLLDR 250
KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 300
QKPTKQEEFY A 311

Note: Major isoform.

Length:311
Mass (Da):32,905
Last modified:November 1, 1990 - v1
Checksum:i283FEC396FF40FCE
GO
Isoform 2 (identifier: P18828-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-93: Missing.

Note: Minor isoform.

Show »
Length:267
Mass (Da):28,235
Checksum:iB4481F155D7E5454
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 9344Missing in isoform 2.
VSP_007542Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211L → V in AAA40159. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15487 mRNA. Translation: CAA33514.1.
Z22532 Genomic DNA. Translation: CAA80254.1.
AF134897 mRNA. Translation: AAD42345.1.
BC010560 mRNA. Translation: AAH10560.1.
L11565 Genomic DNA. Translation: AAA40159.1.
CCDSiCCDS25803.1. [P18828-1]
PIRiS06619.
RefSeqiNP_035649.1. NM_011519.2. [P18828-1]
UniGeneiMm.2580.

Genome annotation databases

EnsembliENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592. [P18828-1]
ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592. [P18828-1]
GeneIDi20969.
KEGGimmu:20969.
UCSCiuc007nac.1. mouse. [P18828-1]
uc007nad.1. mouse. [P18828-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15487 mRNA. Translation: CAA33514.1 .
Z22532 Genomic DNA. Translation: CAA80254.1 .
AF134897 mRNA. Translation: AAD42345.1 .
BC010560 mRNA. Translation: AAH10560.1 .
L11565 Genomic DNA. Translation: AAA40159.1 .
CCDSi CCDS25803.1. [P18828-1 ]
PIRi S06619.
RefSeqi NP_035649.1. NM_011519.2. [P18828-1 ]
UniGenei Mm.2580.

3D structure databases

ProteinModelPortali P18828.
SMRi P18828. Positions 278-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203602. 1 interaction.

PTM databases

PhosphoSitei P18828.

Proteomic databases

PaxDbi P18828.
PRIDEi P18828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020911 ; ENSMUSP00000020911 ; ENSMUSG00000020592 . [P18828-1 ]
ENSMUST00000171158 ; ENSMUSP00000131491 ; ENSMUSG00000020592 . [P18828-1 ]
GeneIDi 20969.
KEGGi mmu:20969.
UCSCi uc007nac.1. mouse. [P18828-1 ]
uc007nad.1. mouse. [P18828-2 ]

Organism-specific databases

CTDi 6382.
MGIi MGI:1349162. Sdc1.

Phylogenomic databases

eggNOGi NOG86393.
HOGENOMi HOG000133092.
HOVERGENi HBG017783.
InParanoidi P18828.
KOi K06257.
OMAi PTKQEEF.
OrthoDBi EOG79KPG2.
PhylomeDBi P18828.
TreeFami TF320463.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_197897. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_216017. Chylomicron-mediated lipid transport.

Miscellaneous databases

ChiTaRSi SDC1. mouse.
NextBioi 299930.
PMAP-CutDB P18828.
PROi P18828.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18828.
Bgeei P18828.
CleanExi MM_SDC1.
Genevestigatori P18828.

Family and domain databases

InterProi IPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
PANTHERi PTHR10915. PTHR10915. 1 hit.
Pfami PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
[Graphical view ]
PROSITEi PS00964. SYNDECAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of syndecan, an integral membrane proteoglycan."
    Saunders S., Jalkanen M., O'Farrell S., Bernfield M.
    J. Cell Biol. 108:1547-1556(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "Structural organization and genomic sequence of mouse syndecan-1 gene."
    Vihinen T., Auvinen P., Alanen-Kurki L., Jalkanen M.
    J. Biol. Chem. 268:17261-17269(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Liver.
  3. "Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant."
    Romaris M., Coomans C., Ceulemans H., Bruystens A.-M., Vekemans S., David G.
    J. Biol. Chem. 274:18667-18674(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: NMRI.
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary gland.
  5. "Organization and promoter activity of the mouse syndecan-1 gene."
    Hinkes M.T., Goldberger O., Neumann P., Kokenyeji R., Bernfield M.
    J. Biol. Chem. 268:11440-11448(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
    Strain: BALB/c.
    Tissue: Liver.
  6. "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1."
    Kokenyesi R., Bernfield M.
    J. Biol. Chem. 269:12304-12309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-37; SER-207 AND SER-217.
  7. "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase."
    Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M.
    J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHEDDING.
  8. "Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site."
    Wang Z., Gotte M., Bernfield M., Reizes O.
    Biochemistry 44:12355-12361(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE SITE AT ALA-243, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion."
    Shepherd T.R., Klaus S.M., Liu X., Ramaswamy S., DeMali K.A., Fuentes E.J.
    J. Mol. Biol. 398:730-746(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIAM1.

Entry informationi

Entry nameiSDC1_MOUSE
AccessioniPrimary (citable) accession number: P18828
Secondary accession number(s): Q62278, Q9WVD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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