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P18828

- SDC1_MOUSE

UniProt

P18828 - SDC1_MOUSE

Protein

Syndecan-1

Gene

Sdc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei243 – 2442Cleavage

    GO - Molecular functioni

    1. glycoprotein binding Source: MGI

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: MGI
    2. inflammatory response Source: Ensembl
    3. myoblast development Source: UniProtKB
    4. odontogenesis Source: Ensembl
    5. response to calcium ion Source: Ensembl
    6. response to cAMP Source: Ensembl
    7. response to glucocorticoid Source: Ensembl
    8. response to hydrogen peroxide Source: Ensembl
    9. response to toxic substance Source: Ensembl
    10. Sertoli cell development Source: Ensembl
    11. striated muscle cell development Source: Ensembl
    12. ureteric bud development Source: Ensembl
    13. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_197897. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.
    REACT_216017. Chylomicron-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syndecan-1
    Short name:
    SYND1
    Alternative name(s):
    CD_antigen: CD138
    Gene namesi
    Name:Sdc1
    Synonyms:Synd-1, Synd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1349162. Sdc1.

    Subcellular locationi

    Membrane; Single-pass type I membrane protein. Secreted
    Note: Shedding of the ectodomain produces a soluble form.

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. external side of plasma membrane Source: MGI
    3. extracellular region Source: Reactome
    4. focal adhesion Source: Ensembl
    5. Golgi lumen Source: Reactome
    6. integral component of membrane Source: UniProtKB-KW
    7. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 311289Syndecan-1PRO_0000033501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371O-linked (Xyl...) (chondroitin sulfate)1 Publication
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi45 – 451O-linked (Xyl...) (heparan sulfate)Curated
    Glycosylationi47 – 471O-linked (Xyl...) (heparan sulfate)Curated
    Glycosylationi207 – 2071O-linked (Xyl...) (chondroitin sulfate)1 Publication
    Glycosylationi217 – 2171O-linked (Xyl...) (chondroitin sulfate)1 Publication

    Post-translational modificationi

    Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Heparan sulfate, Proteoglycan

    Proteomic databases

    PaxDbiP18828.
    PRIDEiP18828.

    PTM databases

    PhosphoSiteiP18828.

    Miscellaneous databases

    PMAP-CutDBP18828.

    Expressioni

    Gene expression databases

    ArrayExpressiP18828.
    BgeeiP18828.
    CleanExiMM_SDC1.
    GenevestigatoriP18828.

    Interactioni

    Subunit structurei

    Interacts with CDCP1 By similarity. Interacts (via C-terminus) with TIAM1 (via PDZ domain).By similarity1 Publication

    Protein-protein interaction databases

    BioGridi203602. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP18828.
    SMRiP18828. Positions 278-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 255233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini277 – 31135CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the syndecan proteoglycan family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86393.
    HOGENOMiHOG000133092.
    HOVERGENiHBG017783.
    InParanoidiP18828.
    KOiK06257.
    OMAiPTKQEEF.
    OrthoDBiEOG79KPG2.
    PhylomeDBiP18828.
    TreeFamiTF320463.

    Family and domain databases

    InterProiIPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PANTHERiPTHR10915. PTHR10915. 1 hit.
    PfamiPF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    [Graphical view]
    PROSITEiPS00964. SYNDECAN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P18828-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG    50
    ALPDTLSRQT PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE 100
    GEPVLHVEAE PGFTARDKEK EVTTRPRETV QLPITQRAST VRVTTAQAAV 150
    TSHPHGGMQP GLHETSAPTA PGQPDHQPPR VEGGGTSVIK EVVEDGTANQ 200
    LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA TGASQSLLDR 250
    KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 300
    QKPTKQEEFY A 311

    Note: Major isoform.

    Length:311
    Mass (Da):32,905
    Last modified:November 1, 1990 - v1
    Checksum:i283FEC396FF40FCE
    GO
    Isoform 2 (identifier: P18828-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-93: Missing.

    Note: Minor isoform.

    Show »
    Length:267
    Mass (Da):28,235
    Checksum:iB4481F155D7E5454
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211L → V in AAA40159. (PubMed:8496192)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei50 – 9344Missing in isoform 2. 1 PublicationVSP_007542Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15487 mRNA. Translation: CAA33514.1.
    Z22532 Genomic DNA. Translation: CAA80254.1.
    AF134897 mRNA. Translation: AAD42345.1.
    BC010560 mRNA. Translation: AAH10560.1.
    L11565 Genomic DNA. Translation: AAA40159.1.
    CCDSiCCDS25803.1. [P18828-1]
    PIRiS06619.
    RefSeqiNP_035649.1. NM_011519.2. [P18828-1]
    UniGeneiMm.2580.

    Genome annotation databases

    EnsembliENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592. [P18828-1]
    ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592. [P18828-1]
    GeneIDi20969.
    KEGGimmu:20969.
    UCSCiuc007nac.1. mouse. [P18828-1]
    uc007nad.1. mouse. [P18828-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15487 mRNA. Translation: CAA33514.1 .
    Z22532 Genomic DNA. Translation: CAA80254.1 .
    AF134897 mRNA. Translation: AAD42345.1 .
    BC010560 mRNA. Translation: AAH10560.1 .
    L11565 Genomic DNA. Translation: AAA40159.1 .
    CCDSi CCDS25803.1. [P18828-1 ]
    PIRi S06619.
    RefSeqi NP_035649.1. NM_011519.2. [P18828-1 ]
    UniGenei Mm.2580.

    3D structure databases

    ProteinModelPortali P18828.
    SMRi P18828. Positions 278-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203602. 1 interaction.

    PTM databases

    PhosphoSitei P18828.

    Proteomic databases

    PaxDbi P18828.
    PRIDEi P18828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020911 ; ENSMUSP00000020911 ; ENSMUSG00000020592 . [P18828-1 ]
    ENSMUST00000171158 ; ENSMUSP00000131491 ; ENSMUSG00000020592 . [P18828-1 ]
    GeneIDi 20969.
    KEGGi mmu:20969.
    UCSCi uc007nac.1. mouse. [P18828-1 ]
    uc007nad.1. mouse. [P18828-2 ]

    Organism-specific databases

    CTDi 6382.
    MGIi MGI:1349162. Sdc1.

    Phylogenomic databases

    eggNOGi NOG86393.
    HOGENOMi HOG000133092.
    HOVERGENi HBG017783.
    InParanoidi P18828.
    KOi K06257.
    OMAi PTKQEEF.
    OrthoDBi EOG79KPG2.
    PhylomeDBi P18828.
    TreeFami TF320463.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_197897. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.
    REACT_216017. Chylomicron-mediated lipid transport.

    Miscellaneous databases

    ChiTaRSi SDC1. mouse.
    NextBioi 299930.
    PMAP-CutDB P18828.
    PROi P18828.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18828.
    Bgeei P18828.
    CleanExi MM_SDC1.
    Genevestigatori P18828.

    Family and domain databases

    InterProi IPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    PANTHERi PTHR10915. PTHR10915. 1 hit.
    Pfami PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    [Graphical view ]
    PROSITEi PS00964. SYNDECAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of syndecan, an integral membrane proteoglycan."
      Saunders S., Jalkanen M., O'Farrell S., Bernfield M.
      J. Cell Biol. 108:1547-1556(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    2. "Structural organization and genomic sequence of mouse syndecan-1 gene."
      Vihinen T., Auvinen P., Alanen-Kurki L., Jalkanen M.
      J. Biol. Chem. 268:17261-17269(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Liver.
    3. "Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant."
      Romaris M., Coomans C., Ceulemans H., Bruystens A.-M., Vekemans S., David G.
      J. Biol. Chem. 274:18667-18674(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: NMRI.
      Tissue: Embryo.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary gland.
    5. "Organization and promoter activity of the mouse syndecan-1 gene."
      Hinkes M.T., Goldberger O., Neumann P., Kokenyeji R., Bernfield M.
      J. Biol. Chem. 268:11440-11448(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
      Strain: BALB/c.
      Tissue: Liver.
    6. "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1."
      Kokenyesi R., Bernfield M.
      J. Biol. Chem. 269:12304-12309(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-37; SER-207 AND SER-217.
    7. "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase."
      Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M.
      J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SHEDDING.
    8. "Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site."
      Wang Z., Gotte M., Bernfield M., Reizes O.
      Biochemistry 44:12355-12361(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE SITE AT ALA-243, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion."
      Shepherd T.R., Klaus S.M., Liu X., Ramaswamy S., DeMali K.A., Fuentes E.J.
      J. Mol. Biol. 398:730-746(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIAM1.

    Entry informationi

    Entry nameiSDC1_MOUSE
    AccessioniPrimary (citable) accession number: P18828
    Secondary accession number(s): Q62278, Q9WVD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3