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P18828 (SDC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syndecan-1

Short name=SYND1
Alternative name(s):
CD_antigen=CD138
Gene names
Name:Sdc1
Synonyms:Synd-1, Synd1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Subunit structure

Interacts with CDCP1 By similarity. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Ref.9

Subcellular location

Membrane; Single-pass type I membrane protein. Secreted. Note: Shedding of the ectodomain produces a soluble form.

Post-translational modification

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 By similarity.

Sequence similarities

Belongs to the syndecan proteoglycan family.

Ontologies

Keywords
   Cellular componentMembrane
Secreted
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
Heparan sulfate
Proteoglycan
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSertoli cell development

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 14681683. Source: MGI

inflammatory response

Inferred from electronic annotation. Source: Ensembl

myoblast development

Inferred from direct assay PubMed 9218485. Source: UniProtKB

odontogenesis

Inferred from electronic annotation. Source: Ensembl

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from electronic annotation. Source: Ensembl

striated muscle cell development

Inferred from electronic annotation. Source: Ensembl

ureteric bud development

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

cell surface

Inferred from direct assay PubMed 15381701. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 18762567. Source: MGI

extracellular region

Traceable author statement. Source: Reactome

focal adhesion

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionglycoprotein binding

Inferred from physical interaction PubMed 8769660. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P18828-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Major isoform.
Isoform 2 (identifier: P18828-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-93: Missing.
Note: Minor isoform.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 311289Syndecan-1
PRO_0000033501

Regions

Topological domain23 – 255233Extracellular Potential
Transmembrane256 – 27621Helical; Potential
Topological domain277 – 31135Cytoplasmic Potential

Sites

Site243 – 2442Cleavage

Amino acid modifications

Glycosylation371O-linked (Xyl...) (chondroitin sulfate) Probable
Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation451O-linked (Xyl...) (heparan sulfate) Probable
Glycosylation471O-linked (Xyl...) (heparan sulfate) Probable
Glycosylation2071O-linked (Xyl...) (chondroitin sulfate) Ref.6
Glycosylation2171O-linked (Xyl...) (chondroitin sulfate) Ref.6

Natural variations

Alternative sequence50 – 9344Missing in isoform 2.
VSP_007542

Experimental info

Sequence conflict211L → V in AAA40159. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 283FEC396FF40FCE

FASTA31132,905
        10         20         30         40         50         60 
MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG ALPDTLSRQT 

        70         80         90        100        110        120 
PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE GEPVLHVEAE PGFTARDKEK 

       130        140        150        160        170        180 
EVTTRPRETV QLPITQRAST VRVTTAQAAV TSHPHGGMQP GLHETSAPTA PGQPDHQPPR 

       190        200        210        220        230        240 
VEGGGTSVIK EVVEDGTANQ LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA 

       250        260        270        280        290        300 
TGASQSLLDR KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 

       310 
QKPTKQEEFY A 

« Hide

Isoform 2 [UniParc].

Checksum: B4481F155D7E5454
Show »

FASTA26728,235

References

« Hide 'large scale' references
[1]"Molecular cloning of syndecan, an integral membrane proteoglycan."
Saunders S., Jalkanen M., O'Farrell S., Bernfield M.
J. Cell Biol. 108:1547-1556(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[2]"Structural organization and genomic sequence of mouse syndecan-1 gene."
Vihinen T., Auvinen P., Alanen-Kurki L., Jalkanen M.
J. Biol. Chem. 268:17261-17269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Strain: BALB/c.
Tissue: Liver.
[3]"Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant."
Romaris M., Coomans C., Ceulemans H., Bruystens A.-M., Vekemans S., David G.
J. Biol. Chem. 274:18667-18674(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: NMRI.
Tissue: Embryo.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary gland.
[5]"Organization and promoter activity of the mouse syndecan-1 gene."
Hinkes M.T., Goldberger O., Neumann P., Kokenyeji R., Bernfield M.
J. Biol. Chem. 268:11440-11448(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
Strain: BALB/c.
Tissue: Liver.
[6]"Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1."
Kokenyesi R., Bernfield M.
J. Biol. Chem. 269:12304-12309(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT SER-37; SER-207 AND SER-217.
[7]"Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase."
Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M.
J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SHEDDING.
[8]"Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site."
Wang Z., Gotte M., Bernfield M., Reizes O.
Biochemistry 44:12355-12361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE SITE AT ALA-243, IDENTIFICATION BY MASS SPECTROMETRY.
[9]"The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion."
Shepherd T.R., Klaus S.M., Liu X., Ramaswamy S., DeMali K.A., Fuentes E.J.
J. Mol. Biol. 398:730-746(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TIAM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15487 mRNA. Translation: CAA33514.1.
Z22532 Genomic DNA. Translation: CAA80254.1.
AF134897 mRNA. Translation: AAD42345.1.
BC010560 mRNA. Translation: AAH10560.1.
L11565 Genomic DNA. Translation: AAA40159.1.
PIRS06619.
RefSeqNP_035649.1. NM_011519.2.
UniGeneMm.2580.

3D structure databases

ProteinModelPortalP18828.
SMRP18828. Positions 278-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203602. 1 interaction.

PTM databases

PhosphoSiteP18828.

Proteomic databases

PaxDbP18828.
PRIDEP18828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592. [P18828-1]
ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592. [P18828-1]
GeneID20969.
KEGGmmu:20969.
UCSCuc007nac.1. mouse. [P18828-1]
uc007nad.1. mouse. [P18828-2]

Organism-specific databases

CTD6382.
MGIMGI:1349162. Sdc1.

Phylogenomic databases

eggNOGNOG86393.
HOGENOMHOG000133092.
HOVERGENHBG017783.
InParanoidP18828.
KOK06257.
OMAPTKQEEF.
OrthoDBEOG79KPG2.
PhylomeDBP18828.
TreeFamTF320463.

Enzyme and pathway databases

ReactomeREACT_188937. Metabolism.
REACT_189085. Disease.
REACT_196873. Extracellular matrix organization.

Gene expression databases

ArrayExpressP18828.
BgeeP18828.
CleanExMM_SDC1.
GenevestigatorP18828.

Family and domain databases

InterProIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERPTHR10915. PTHR10915. 1 hit.
PfamPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSDC1. mouse.
NextBio299930.
PMAP-CutDBP18828.
PROP18828.
SOURCESearch...

Entry information

Entry nameSDC1_MOUSE
AccessionPrimary (citable) accession number: P18828
Secondary accession number(s): Q62278, Q9WVD2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot