P18828 (SDC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syndecan-1
Short name=SYND1

Alternative name(s):
CD_antigen=CD138

Gene names

Name:	Sdc1
Synonyms:	Synd-1, Synd1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Subunit structure	Interacts with CDCP1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein. Secreted. Note: Shedding of the ectodomain produces a soluble form.
Post-translational modification	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 By similarity.
Sequence similarities	Belongs to the syndecan proteoglycan family.

Ontologies

Keywords
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Heparan sulfate Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Sertoli cell development Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 14681683. Source: MGI myoblast development Inferred from direct assay PubMed 9218485. Source: UniProtKB odontogenesis Inferred from electronic annotation. Source: Compara response to cAMP Inferred from electronic annotation. Source: Compara response to calcium ion Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara striated muscle cell development Inferred from electronic annotation. Source: Compara ureteric bud development Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome external side of plasma membrane Inferred from direct assay PubMed 18762567. Source: MGI extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell focal adhesion Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW protein complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P18828-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Major isoform.

Isoform 2 (identifier: P18828-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-93: Missing.

Note: Minor isoform.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 311	289	Syndecan-1		PRO_0000033501
Regions
	Topological domain	23 – 255	233	Extracellular Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Topological domain	277 – 311	35	Cytoplasmic Potential
Sites
	Site	243 – 244	2	Cleavage
Amino acid modifications
	Glycosylation	37	1	O-linked (Xyl...) (chondroitin sulfate) Probable
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	45	1	O-linked (Xyl...) (heparan sulfate) Probable
	Glycosylation	47	1	O-linked (Xyl...) (heparan sulfate) Probable
	Glycosylation	207	1	O-linked (Xyl...) (chondroitin sulfate) Ref.6
	Glycosylation	217	1	O-linked (Xyl...) (chondroitin sulfate) Ref.6
Natural variations
	Alternative sequence	50 – 93	44	Missing in isoform 2.		VSP_007542
Experimental info
	Sequence conflict	21	1	L → V in AAA40159. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 283FEC396FF40FCE	FASTA	311	32,905
	10 20 30 40 50 60 MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG ALPDTLSRQT 70 80 90 100 110 120 PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE GEPVLHVEAE PGFTARDKEK 130 140 150 160 170 180 EVTTRPRETV QLPITQRAST VRVTTAQAAV TSHPHGGMQP GLHETSAPTA PGQPDHQPPR 190 200 210 220 230 240 VEGGGTSVIK EVVEDGTANQ LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA 250 260 270 280 290 300 TGASQSLLDR KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 310 QKPTKQEEFY A
	Isoform 2 [UniParc]. Checksum: B4481F155D7E5454	FASTA	267	28,235
	10 20 30 40 50 60 MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTA GEKPEEGEPV 70 80 90 100 110 120 LHVEAEPGFT ARDKEKEVTT RPRETVQLPI TQRASTVRVT TAQAAVTSHP HGGMQPGLHE 130 140 150 160 170 180 TSAPTAPGQP DHQPPRVEGG GTSVIKEVVE DGTANQLPAG EGSGEQDFTF ETSGENTAVA 190 200 210 220 230 240 AVEPGLRNQP PVDEGATGAS QSLLDRKEVL GGVIAGGLVG LIFAVCLVAF MLYRMKKKDE 250 260 GSYSLEEPKQ ANGGAYQKPT KQEEFYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of syndecan, an integral membrane proteoglycan." Saunders S., Jalkanen M., O'Farrell S., Bernfield M. J. Cell Biol. 108:1547-1556(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary gland.
[2]	"Structural organization and genomic sequence of mouse syndecan-1 gene." Vihinen T., Auvinen P., Alanen-Kurki L., Jalkanen M. J. Biol. Chem. 268:17261-17269(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Strain: BALB/c. Tissue: Liver.
[3]	"Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant." Romaris M., Coomans C., Ceulemans H., Bruystens A.-M., Vekemans S., David G. J. Biol. Chem. 274:18667-18674(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: NMRI. Tissue: Embryo.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Czech II. Tissue: Mammary gland.
[5]	"Organization and promoter activity of the mouse syndecan-1 gene." Hinkes M.T., Goldberger O., Neumann P., Kokenyeji R., Bernfield M. J. Biol. Chem. 268:11440-11448(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22. Strain: BALB/c. Tissue: Liver.
[6]	"Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1." Kokenyesi R., Bernfield M. J. Biol. Chem. 269:12304-12309(1994) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT SER-37; SER-207 AND SER-217.
[7]	"Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase." Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M. J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SHEDDING.
[8]	"Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site." Wang Z., Gotte M., Bernfield M., Reizes O. Biochemistry 44:12355-12361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE SITE AT ALA-243, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15487 mRNA. Translation: CAA33514.1. Z22532 Genomic DNA. Translation: CAA80254.1. AF134897 mRNA. Translation: AAD42345.1. BC010560 mRNA. Translation: AAH10560.1. L11565 Genomic DNA. Translation: AAA40159.1.
IPI	IPI00115450. IPI00125849.
PIR	S06619.
RefSeq	NP_035649.1. NM_011519.2.
UniGene	Mm.2580.
3D structure databases
ProteinModelPortal	P18828.
SMR	P18828. Positions 278-311.
ModBase	Search...
PTM databases
PhosphoSite	P18828.
Proteomic databases
PaxDb	P18828.
PRIDE	P18828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592. ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592.
GeneID	20969.
KEGG	mmu:20969.
UCSC	uc007nad.1. mouse.
Organism-specific databases
CTD	6382.
MGI	MGI:1349162. Sdc1.
Phylogenomic databases
eggNOG	NOG86393.
HOGENOM	HOG000133092.
HOVERGEN	HBG017783.
InParanoid	P18828.
KO	K06257.
OMA	KQANGGA.
OrthoDB	EOG46DM3T.
Enzyme and pathway databases
Reactome	REACT_112621. Metabolism. REACT_118324. Disease.
Gene expression databases
ArrayExpress	P18828.
Bgee	P18828.
CleanEx	MM_SDC1.
Genevestigator	P18828.
GermOnline	ENSMUSG00000020592. Mus musculus.
Family and domain databases
InterPro	IPR003585. Neurexin-like. IPR001050. Syndecan. [Graphical view]
PANTHER	PTHR10915. PTHR10915. 1 hit.
Pfam	PF01034. Syndecan. 1 hit. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. [Graphical view]
PROSITE	PS00964. SYNDECAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SDC1. mouse.
NextBio	299930.
PMAP-CutDB	P18828.
SOURCE	Search...

Entry information

Entry name

SDC1_MOUSE

Accession

Primary (citable) accession number: P18828
Secondary accession number(s): Q62278, Q9WVD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program