Reviewed,
UniProtKB/Swiss-Prot P18827 (SDC1_HUMAN)
Last modified
May 26, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Syndecan-1 Short name=SYND1 Alternative name(s): CD_antigen=CD138 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 310 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. |
| Subunit structure | Interacts with CDCP1. Ref.8 |
| Subcellular location | |
| Sequence similarities | Belongs to the syndecan proteoglycan family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal Transmembrane |
| PTM | Glycoprotein Heparan sulfate Phosphoprotein Proteoglycan |
| Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | cytoskeletal protein binding Inferred from electronic annotation. Source: InterPro protein C-terminus bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 310 | 288 | Syndecan-1 | PRO_0000033499 | |||||
Regions | |||||||||
| Topological domain | 23 – 254 | 232 | Extracellular Potential | ||||||
| Transmembrane | 255 – 275 | 21 | Potential | ||||||
| Topological domain | 276 – 310 | 35 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Site | 250 – 251 | 2 | Cleavage of ectodomain Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 309 | 1 | Phosphotyrosine Ref.9 | ||||||
| Glycosylation | 37 | 1 | O-linked (Xyl...) (chondroitin sulfate) By similarity | ||||||
| Glycosylation | 43 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 45 | 1 | O-linked (Xyl...) (heparan sulfate) By similarity | ||||||
| Glycosylation | 47 | 1 | O-linked (Xyl...) (heparan sulfate) By similarity | ||||||
| Glycosylation | 206 | 1 | O-linked (Xyl...) (chondroitin sulfate) By similarity | ||||||
| Glycosylation | 216 | 1 | O-linked (Xyl...) (chondroitin sulfate) By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 76 | 1 | T → M: dbSNP rs2230922. | VAR_052242 | |||||
| Natural variant | 136 | 1 | L → Q: dbSNP rs10205485. | VAR_052243 | |||||
Experimental info | |||||||||
| Sequence conflict | 19 | 1 | P → L in AAA60605. Ref.2 | ||||||
| Sequence conflict | 259 | 1 | G → V in AAH08765. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts." Lories V., Cassiman J.-J., van de Berghe H., David G. J. Biol. Chem. 267:1116-1122(1992) [PubMed: 1339431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-136. Tissue: Fibroblast. |
| [2] | "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans." Mali M., Jaakkola P., Arvilommi A.-M., Jalkanen M. J. Biol. Chem. 265:6884-6889(1990) [PubMed: 2324102] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-136. Tissue: Mammary gland. |
| [3] | "Shift of syndecan-1 expression from epithelial to stromal cells during progression of solid tumours." Mennerich D., Vogel A., Klaman I., Dahl E., Lichtner R.B., Rosenthal A., Pohlenz H.D., Thierauch K.H., Sommer A. Eur. J. Cancer 40:1373-1382(2004) [PubMed: 15177497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-136. |
| [4] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-136. Tissue: Kidney. |
| [7] | "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p." Kaukonen J., Alanen-Kurki L., Jalkanen M., Palotie A. Hum. Genet. 99:295-297(1997) [PubMed: 9050911] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-310, VARIANT GLN-136. Tissue: Placenta. |
| [8] | "Adhesion signaling by a novel mitotic substrate of src kinases." Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M. Oncogene 24:5333-5343(2005) [PubMed: 16007225] [Abstract] Cited for: INTERACTION WITH CDCP1. |
| [9] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-309, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X60306 mRNA. Translation: CAA42851.1. J05392 mRNA. Translation: AAA60605.1. AJ551176 mRNA. Translation: CAD80245.1. AC104792 Genomic DNA. Translation: AAX93151.1. CH471053 Genomic DNA. Translation: EAX00828.1. BC008765 mRNA. Translation: AAH08765.1. Z48199 Genomic DNA. Translation: CAA88235.1. | |
| IPI | IPI00002441. |
| PIR | A41776. |
| RefSeq | NP_001006947.1. NP_002988.3. |
| UniGene | Hs.224607 Hs.712639 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:1123N. |
PTM databases | |
| PhosphoSite | P18827. |
Proteomic databases | |
| PRIDE | P18827. |
Genome annotation databases | |
| Ensembl | ENSG00000115884. Homo sapiens. [Contig view] |
| GeneID | 6382. |
| KEGG | hsa:6382. |
Organism-specific databases | |
| GeneCards | GC02M020264. |
| H-InvDB | HIX0001856. |
| HGNC | HGNC:10658. SDC1. |
| HPA | CAB002424. HPA006185. |
| MIM | 186355. gene. |
| PharmGKB | PA142672548. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P18827. |
| HOVERGEN | P18827. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | arf6_traffickingpathway. Arf6 trafficking events. avb3_integrin_pathway. Integrins in angiogenesis. syndecan_pathway. Proteogylcan syndecan-mediated signaling events. syndecan_1_pathway. Syndecan-1-mediated signaling events. |
| Reactome | REACT_602. Lipid and lipoprotein metabolism. |
Gene expression databases | |
| ArrayExpress | P18827. |
| Bgee | P18827. |
| CleanEx | HS_SDC1. |
| GermOnline | ENSG00000115884. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003585. Neurexin-like. IPR001050. Syndecan. [Graphical view] |
| PANTHER | PTHR10915. Syndecan. 1 hit. |
| Pfam | PF01034. Syndecan. 1 hit. [Graphical view] |
| SMART | SM00294. 4.1m. 1 hit. [Graphical view] |
| PROSITE | PS00964. SYNDECAN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 24782. |
| PMAP-CutDB | P18827. |
| SOURCE | Search... |
Entry information
| Entry name | SDC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P18827 Secondary accession number(s): Q53QV0, Q546D3, Q96HB7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


