Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo segment polarity protein

Gene

arm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis.1 Publication

GO - Molecular functioni

  • alpha-catenin binding Source: GO_Central
  • cadherin binding Source: UniProtKB
  • kinase binding Source: FlyBase
  • protein phosphatase binding Source: GO_Central
  • RNA polymerase II transcription coactivator activity Source: WormBase
  • signal transducer activity Source: InterPro
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • branch fusion, open tracheal system Source: FlyBase
  • branching morphogenesis of an epithelial tube Source: FlyBase
  • canonical Wnt signaling pathway Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell-cell adhesion Source: FlyBase
  • cell elongation involved in imaginal disc-derived wing morphogenesis Source: FlyBase
  • cell fate determination Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • chitin-based larval cuticle pattern formation Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • compound eye retinal cell programmed cell death Source: FlyBase
  • cuticle pattern formation Source: FlyBase
  • delamination Source: FlyBase
  • dorsal closure Source: FlyBase
  • epithelial cell type specification, open tracheal system Source: FlyBase
  • heart development Source: FlyBase
  • heart formation Source: FlyBase
  • imaginal disc-derived wing expansion Source: FlyBase
  • imaginal disc-derived wing margin morphogenesis Source: FlyBase
  • long-term memory Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • nervous system development Source: FlyBase
  • neuroblast development Source: FlyBase
  • neuroblast fate commitment Source: UniProtKB
  • oogenesis Source: FlyBase
  • photoreceptor cell differentiation Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • protein localization to adherens junction Source: FlyBase
  • protein localization to plasma membrane Source: FlyBase
  • segment polarity determination Source: FlyBase
  • somatic stem cell population maintenance Source: FlyBase
  • ventral furrow formation Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
  • zonula adherens assembly Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Segmentation polarity protein
Biological processCell adhesion, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-201681 TCF dependent signaling in response to WNT
R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209396 Phosphorylation of ARM
R-DME-209407 Transport of ARM to the nucleus
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209421 Transcription activation by ARM
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-DME-351906 Apoptotic cleavage of cell adhesion proteins
R-DME-375170 CDO in myogenesis
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-4086398 Ca2+ pathway
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-6798695 Neutrophil degranulation
R-DME-8951430 RUNX3 regulates WNT signaling
SignaLinkiP18824

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
ORF Names:CG11579
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000117 arm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642921 – 843Armadillo segment polarity proteinAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei650Phosphothreonine1 Publication1
Modified residuei688Phosphoserine1 Publication1
Modified residuei694Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated on Ser, Thr and Tyr residues (PubMed:7529201). Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue (PubMed:7529201). Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation (PubMed:7529201). Hypophosphorylated form of arm increases in steady-state levels (PubMed:7529201). Phosphorylated directly or indirectly by CkIalpha which stimulates its degradation (PubMed:11927557).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18824
PRIDEiP18824

PTM databases

iPTMnetiP18824

Expressioni

Tissue specificityi

Isoform cytoplasmic accumulates at low levels in axons, at high levels in specific cells along the CNS midline and in leg and eye imaginal disks. Isoform neural accumulates in the axon tracts of the CNS. Both isoforms accumulate in the peripheral nervous system.1 Publication

Developmental stagei

Present at all stages, but reaches the highest levels during early to mid-embryogenesis. Isoform cytoplasmic is the predominant one from the cellular blastoderm stage until germ-band retraction. Isoform neural is first seen after germ band retraction.

Gene expression databases

BgeeiFBgn0000117
ExpressionAtlasiP18824 baseline and differential
GenevisibleiP18824 DM

Interactioni

Subunit structurei

Interacts with Mer and Moe at the adherens junction (PubMed:8666669). Interacts with Inx2 (PubMed:15047872). Interacts with alpha-Cat (PubMed:25653389).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • alpha-catenin binding Source: GO_Central
  • cadherin binding Source: UniProtKB
  • kinase binding Source: FlyBase
  • protein phosphatase binding Source: GO_Central
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi57697, 118 interactors
DIPiDIP-19968N
IntActiP18824, 173 interactors
MINTiP18824
STRINGi7227.FBpp0089035

Structurei

3D structure databases

ProteinModelPortaliP18824
SMRiP18824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati159 – 200ARM 1Add BLAST42
Repeati201 – 242ARM 2Add BLAST42
Repeati243 – 284ARM 3Add BLAST42
Repeati285 – 326ARM 4Add BLAST42
Repeati327 – 368ARM 5Add BLAST42
Repeati369 – 410ARM 6Add BLAST42
Repeati411 – 449ARM 7Add BLAST39
Repeati450 – 496ARM 8Add BLAST47
Repeati497 – 538ARM 9Add BLAST42
Repeati539 – 584ARM 10Add BLAST46
Repeati585 – 608ARM 11Add BLAST24
Repeati609 – 647ARM 12Add BLAST39
Repeati648 – 689ARM 13; truncatedAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 158Asp/Glu-rich (acidic)Add BLAST158
Compositional biasi690 – 843Asp/Glu-rich (acidic)Add BLAST154

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
GeneTreeiENSGT00730000110821
InParanoidiP18824
KOiK02105
OMAiCPANHSA
OrthoDBiEOG091G03A5
PhylomeDBiP18824

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin
PfamiView protein in Pfam
PF00514 Arm, 4 hits
PRINTSiPR01869 BCATNINFAMLY
SMARTiView protein in SMART
SM00185 ARM, 12 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Cytoplasmic (identifier: P18824-1) [UniParc]FASTAAdd to basket
Also known as: A, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYMPAQNRT MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LGDSGIHSGA
60 70 80 90 100
VTQVPSLSGK EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ
110 120 130 140 150
RVRAAMFPET LEEGIEIPST QFDPQQPTAV QRLSEPSQML KHAVVNLINY
160 170 180 190 200
QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAIMNSP
210 220 230 240 250
QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK
260 270 280 290 300
LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK
310 320 330 340 350
FLAIVTDCLQ ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR
360 370 380 390 400
VLKVLSVCSS NKPAIVDAGG MQALAMHLGN MSPRLVQNCL WTLRNLSDAA
410 420 430 440 450
TKVEGLEALL QSLVQVLGST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG
460 470 480 490 500
GVDALVRTII NAGDREEITE PAVCALRHLT SRHVDSELAQ NAVRLNYGLS
510 520 530 540 550
VIVKLLHPPS RWPLIKAVIG LIRNLALCPA NHAPLREHGA IHHLVRLLMR
560 570 580 590 600
AFQDTERQRS SIATTGSQQP SAYADGVRME EIVEGTVGAL HILARESHNR
610 620 630 640 650
ALIRQQSVIP IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT
660 670 680 690 700
GPLTDLLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTNSLLREDN
710 720 730 740 750
NIWANADLGM GPDLQDMLGP EEAYEGLYGQ GPPSVHSSHG GRAFHQQGYD
760 770 780 790 800
TLPIDSMQGL EISSPVGGGG AGGAPGNGGA VGGASGGGGN IGAIPPSGAP
810 820 830 840
TSPYSMDMDV GEIDAGALNF DLDAMPTPPN DNNNLAAWYD TDC
Length:843
Mass (Da):91,153
Last modified:November 1, 1990 - v1
Checksum:i40DAD6FB83163049
GO
Isoform Neural (identifier: P18824-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     718-843: LGPEEAYEGL...NLAAWYDTDC → ILYQ

Show »
Length:721
Mass (Da):79,314
Checksum:i0E19594766E0847F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006738718 – 843LGPEE…YDTDC → ILYQ in isoform Neural. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54468 Genomic DNA Translation: CAA38350.1
AF001213 mRNA Translation: AAB58731.1
AE014298 Genomic DNA Translation: AAF45686.2
AE014298 Genomic DNA Translation: AAF45687.2
AE014298 Genomic DNA Translation: AAN09064.2
AE014298 Genomic DNA Translation: AAS65246.1
AL021106, AL021086 Genomic DNA Translation: CAA15946.1
AL021086, AL021106 Genomic DNA Translation: CAA15935.1
AY118525 mRNA Translation: AAM49894.1
PIRiT12689
RefSeqiNP_001259149.1, NM_001272220.1 [P18824-1]
NP_476665.2, NM_057317.4 [P18824-1]
NP_476666.1, NM_057318.4 [P18824-1]
NP_599100.1, NM_134273.2 [P18824-1]
NP_726775.2, NM_166912.2 [P18824-2]
NP_996328.1, NM_206605.2 [P18824-1]
UniGeneiDm.4782

Genome annotation databases

EnsemblMetazoaiFBtr0089988; FBpp0089031; FBgn0000117 [P18824-1]
FBtr0089989; FBpp0089032; FBgn0000117 [P18824-1]
FBtr0089990; FBpp0089033; FBgn0000117 [P18824-2]
FBtr0089991; FBpp0089034; FBgn0000117 [P18824-1]
FBtr0089992; FBpp0089035; FBgn0000117 [P18824-1]
FBtr0332583; FBpp0304835; FBgn0000117 [P18824-1]
GeneIDi31151
KEGGidme:Dmel_CG11579

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARM_DROME
AccessioniPrimary (citable) accession number: P18824
Secondary accession number(s): A4V3V0
, O02371, Q0KHX2, Q8IRW7, Q9W546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health