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Protein

Maltose regulon regulatory protein MalI

Gene

malI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 28H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00361

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose regulon regulatory protein MalI
Gene namesi
Name:malI
Ordered Locus Names:b1620, JW1612
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10557 malI

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079661 – 342Maltose regulon regulatory protein MalIAdd BLAST342

Proteomic databases

PaxDbiP18811
PRIDEiP18811

Expressioni

Gene expression databases

CollecTFiEXPREG_00000930

Interactioni

Protein-protein interaction databases

BioGridi4261130, 18 interactors
DIPiDIP-10143N
IntActiP18811, 6 interactors
STRINGi316385.ECDH10B_1753

Structurei

3D structure databases

ProteinModelPortaliP18811
SMRiP18811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 61HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiENOG4107P2S Bacteria
COG1609 LUCA
HOGENOMiHOG000220179
InParanoidiP18811
KOiK16136
OMAiDADWTSV
PhylomeDBiP18811

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR001761 Peripla_BP/Lac1_sug-bd_dom
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PF00532 Peripla_BP_1, 1 hit
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAKKITIH DVALAAGVSV STVSLVLSGK GRISTATGER VNAAIEELGF
60 70 80 90 100
VRNRQASALR GGQSGVIGLI VRDLSAPFYA ELTAGLTEAL EAQGRMVFLL
110 120 130 140 150
HGGKDGEQLA QRFSLLLNQG VDGVVIAGAA GSSDDLRRMA EEKAIPVIFA
160 170 180 190 200
SRASYLDDVD TVRPDNMQAA QLLTEHLIRN GHQRIAWLGG QSSSLTRAER
210 220 230 240 250
VGGYCATLLK FGLPFHSDWV LECTSSQKQA AEAITALLRH NPTISAVVCY
260 270 280 290 300
NETIAMGAWF GLLKAGRQSG ESGVDRYFEQ QVSLAAFTDA TPTTLDDIPV
310 320 330 340
TWASTPAREL GITLADRMMQ KITHEETHSR NLIIPARLIA AK
Length:342
Mass (Da):36,625
Last modified:November 1, 1997 - v2
Checksum:iF1355C6E37FB2C14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287 – 297FTDATPTTLDD → IYRCDTNHTCMH (PubMed:2670898).CuratedAdd BLAST11
Sequence conflicti287 – 297FTDATPTTLDD → IYRCDTNHTCMH (PubMed:1856179).CuratedAdd BLAST11
Sequence conflicti317 – 342RMMQK…LIAAK → SHDAKNHP (PubMed:2670898).CuratedAdd BLAST26
Sequence conflicti317 – 342RMMQK…LIAAK → SHDAKNHP (PubMed:1856179).CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28539 Genomic DNA Translation: AAA24104.1
M60722 mRNA Translation: AAA24097.1
U00096 Genomic DNA Translation: AAC74692.1
AP009048 Genomic DNA Translation: BAA15371.1
PIRiF64918 RPECML
RefSeqiNP_416137.1, NC_000913.3
WP_000179510.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74692; AAC74692; b1620
BAA15371; BAA15371; BAA15371
GeneIDi947104
KEGGiecj:JW1612
eco:b1620
PATRICifig|1411691.4.peg.641

Similar proteinsi

Entry informationi

Entry nameiMALI_ECOLI
AccessioniPrimary (citable) accession number: P18811
Secondary accession number(s): P77151
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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