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Protein

Maltose regulon regulatory protein MalI

Gene

malI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 2820H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00361.
ECOL316407:JW1612-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose regulon regulatory protein MalI
Gene namesi
Name:malI
Ordered Locus Names:b1620, JW1612
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10557. malI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Maltose regulon regulatory protein MalIPRO_0000107966Add
BLAST

Proteomic databases

PaxDbiP18811.

Expressioni

Gene expression databases

CollecTFiEXPREG_00000930.

Interactioni

Protein-protein interaction databases

BioGridi4261130. 16 interactions.
DIPiDIP-10143N.
IntActiP18811. 6 interactions.
STRINGi511145.b1620.

Structurei

3D structure databases

ProteinModelPortaliP18811.
SMRiP18811. Positions 5-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6155HTH lacI-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107P2S. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220179.
InParanoidiP18811.
KOiK16136.
OMAiWVLECAS.
OrthoDBiEOG6SJJMM.
PhylomeDBiP18811.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
IPR001761. Peripla_BP/Lac1_sug-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
PF00532. Peripla_BP_1. 1 hit.
[Graphical view]
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAKKITIH DVALAAGVSV STVSLVLSGK GRISTATGER VNAAIEELGF
60 70 80 90 100
VRNRQASALR GGQSGVIGLI VRDLSAPFYA ELTAGLTEAL EAQGRMVFLL
110 120 130 140 150
HGGKDGEQLA QRFSLLLNQG VDGVVIAGAA GSSDDLRRMA EEKAIPVIFA
160 170 180 190 200
SRASYLDDVD TVRPDNMQAA QLLTEHLIRN GHQRIAWLGG QSSSLTRAER
210 220 230 240 250
VGGYCATLLK FGLPFHSDWV LECTSSQKQA AEAITALLRH NPTISAVVCY
260 270 280 290 300
NETIAMGAWF GLLKAGRQSG ESGVDRYFEQ QVSLAAFTDA TPTTLDDIPV
310 320 330 340
TWASTPAREL GITLADRMMQ KITHEETHSR NLIIPARLIA AK
Length:342
Mass (Da):36,625
Last modified:November 1, 1997 - v2
Checksum:iF1355C6E37FB2C14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 29711FTDATPTTLDD → IYRCDTNHTCMH (PubMed:2670898).CuratedAdd
BLAST
Sequence conflicti287 – 29711FTDATPTTLDD → IYRCDTNHTCMH (PubMed:1856179).CuratedAdd
BLAST
Sequence conflicti317 – 34226RMMQK…LIAAK → SHDAKNHP (PubMed:2670898).CuratedAdd
BLAST
Sequence conflicti317 – 34226RMMQK…LIAAK → SHDAKNHP (PubMed:1856179).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28539 Genomic DNA. Translation: AAA24104.1.
M60722 mRNA. Translation: AAA24097.1.
U00096 Genomic DNA. Translation: AAC74692.1.
AP009048 Genomic DNA. Translation: BAA15371.1.
PIRiF64918. RPECML.
RefSeqiNP_416137.1. NC_000913.3.
WP_000179510.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74692; AAC74692; b1620.
BAA15371; BAA15371; BAA15371.
GeneIDi947104.
KEGGiecj:JW1612.
eco:b1620.
PATRICi32118542. VBIEscCol129921_1691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28539 Genomic DNA. Translation: AAA24104.1.
M60722 mRNA. Translation: AAA24097.1.
U00096 Genomic DNA. Translation: AAC74692.1.
AP009048 Genomic DNA. Translation: BAA15371.1.
PIRiF64918. RPECML.
RefSeqiNP_416137.1. NC_000913.3.
WP_000179510.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP18811.
SMRiP18811. Positions 5-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261130. 16 interactions.
DIPiDIP-10143N.
IntActiP18811. 6 interactions.
STRINGi511145.b1620.

Proteomic databases

PaxDbiP18811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74692; AAC74692; b1620.
BAA15371; BAA15371; BAA15371.
GeneIDi947104.
KEGGiecj:JW1612.
eco:b1620.
PATRICi32118542. VBIEscCol129921_1691.

Organism-specific databases

EchoBASEiEB0552.
EcoGeneiEG10557. malI.

Phylogenomic databases

eggNOGiENOG4107P2S. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220179.
InParanoidiP18811.
KOiK16136.
OMAiWVLECAS.
OrthoDBiEOG6SJJMM.
PhylomeDBiP18811.

Enzyme and pathway databases

BioCyciEcoCyc:PD00361.
ECOL316407:JW1612-MONOMER.

Miscellaneous databases

PROiP18811.

Gene expression databases

CollecTFiEXPREG_00000930.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
IPR001761. Peripla_BP/Lac1_sug-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
PF00532. Peripla_BP_1. 1 hit.
[Graphical view]
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI."
    Reidl J., Roemisch K., Ehrmann M., Boos W.
    J. Bacteriol. 171:4888-4899(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system."
    Reidl J., Boos W.
    J. Bacteriol. 173:4862-4876(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiMALI_ECOLI
AccessioniPrimary (citable) accession number: P18811
Secondary accession number(s): P77151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.