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P18797 (MMOB_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methane monooxygenase regulatory protein B
Gene names
Name:mmoB
Ordered Locus Names:MCA1196
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate.

Subunit structure

The soluble methane monooxygenase (sMMO) consists of four components A/MMOH (composed of alpha/MmoX, beta/MmoY and gamma/MmoZ), B/MMOB (MmoB), C/MMOR (MmoC) and D/MMOD (MmoD).

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 141141Methane monooxygenase regulatory protein B
PRO_0000096507

Experimental info

Sequence conflict121I → F Ref.1
Sequence conflict121I → F Ref.4

Secondary structure

.......................... 141
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18797 [UniParc].

Last modified December 7, 2004. Version 2.
Checksum: 86A1496846C5840F

FASTA14115,984
        10         20         30         40         50         60 
MSVNSNAYDA GIMGLKGKDF ADQFFADENQ VVHESDTVVL VLKKSDEINT FIEEILLTDY 

        70         80         90        100        110        120 
KKNVNPTVNV EDRAGYWWIK ANGKIEVDCD EISELLGRQF NVYDFLVDVS STIGRAYTLG 

       130        140 
NKFTITSELM GLDRKLEDYH A 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of methane monooxygenase from Methylococcus capsulatus (Bath)."
Stainthorpe A.C., Murrell J.C., Salmond G.P.C., Dalton H., Lees V.
Arch. Microbiol. 152:154-159(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33009 / NCIMB 11132 / Bath.
[2]McDonald I., Murrell J.C.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath)."
Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S., Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E., Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J. expand/collapse author list , Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L., Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H., Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R., Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.
PLoS Biol. 2:1616-1628(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33009 / NCIMB 11132 / Bath.
[4]"Identification of the gene encoding the regulatory protein B of soluble methane monooxygenase."
Pilkington S.J., Salmond G.P.C., Murrell J.C., Dalton H.
FEMS Microbiol. Lett. 72:345-348(1990)
Cited for: IDENTIFICATION OF PROTEIN, PROTEIN SEQUENCE OF 3-19.
[5]"Structure of the soluble methane monooxygenase regulatory protein B."
Walters K.J., Gassner G.T., Lippard S.J., Wagner G.
Proc. Natl. Acad. Sci. U.S.A. 96:7877-7882(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[6]"Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath)."
Brandstetter H., Whittington D.A., Lippard S.J., Frederick C.A.
Chem. Biol. 6:441-449(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CIRCULAR DICHROISM ANALYSIS, 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M90050 Genomic DNA. Translation: AAF04158.2.
AE017282 Genomic DNA. Translation: AAU92726.1.
PIRJL0103.
RefSeqYP_113661.1. NC_002977.6.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CKVNMR-A1-141[»]
4GAMX-ray2.90D/I/N/S1-141[»]
ProteinModelPortalP18797.
SMRP18797. Positions 1-141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60130N.
STRING243233.MCA1196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU92726; AAU92726; MCA1196.
GeneID3103283.
KEGGmca:MCA1196.
PATRIC22606224. VBIMetCap22254_1228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG249775.
HOGENOMHOG000086316.
KOK16160.
OMASTIGRAY.
OrthoDBEOG6J48RG.
ProtClustDBCLSK2395508.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-3865.

Family and domain databases

Gene3D3.90.56.10. 1 hit.
InterProIPR003454. mOase_MmoB_DmpM.
[Graphical view]
PfamPF02406. MmoB_DmpM. 1 hit.
[Graphical view]
SUPFAMSSF56029. SSF56029. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP18797.

Entry information

Entry nameMMOB_METCA
AccessionPrimary (citable) accession number: P18797
Secondary accession number(s): Q609N6, Q9LCT7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 7, 2004
Last modified: November 13, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references