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P18789 (CISY_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
Ordered Locus Names:CBU_1410
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulation

Allosterically inhibited by NADH.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Citrate synthase
PRO_0000169941

Sites

Active site3051 By similarity
Active site3631 By similarity

Sequences

Sequence LengthMass (Da)Tools
P18789 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 0AA6EEE541501881

FASTA43048,633
        10         20         30         40         50         60 
MSNRKAKLSF ENQSVEFPIY SPTLGKDVID VKTLGNHGAY ALDVGFYSTA ACESKITFID 

        70         80         90        100        110        120 
GEKGILLYRG YPIDQLADKS DYMEVCYLLM YGELPNKGEK EKFVRTIKEH TSVYEQVTKF 

       130        140        150        160        170        180 
FNGFHYDAHP MAMVLSTIGA LSAFYHDALD ITKPADRELS AIRLIAKMPT LAAMSYKYSI 

       190        200        210        220        230        240 
GQPFMHPRRA MNYAENFLHM LFGTPYEETE PDPVLARAMD RIFILHADHE QNASTTTVRV 

       250        260        270        280        290        300 
AGSTGANPFA CISAGISALW GPAHGGANEA CLNMLRKIGD EKNIGQYIKK AKDKNDPFRL 

       310        320        330        340        350        360 
MGFGHRVYKN YDPRAKVMQK TCYEVLDAVG RHNEPLFKLA IKLEKIALED DYFIEKKLYP 

       370        380        390        400        410        420 
NVDFYSGLTL NAIGIPSNMF TVIFALSRTV GWISHWMEMM SSPDHRLARP RQLYTGETER 

       430 
EVISLDKRQA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and linkage analysis of the Coxiella burnetii citrate synthase-encoding gene."
Heinzen R.A., Frazier M.E., Mallavia L.P.
Gene 109:63-69(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.
[3]"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
Strain: Nine Mile.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36338 Genomic DNA. Translation: AAA23307.1.
AE016828 Genomic DNA. Translation: AAO90908.1.
L33409 Genomic DNA. Translation: AAA74128.1.
PIRJQ1392.
RefSeqNP_820394.1. NC_002971.3.

3D structure databases

ProteinModelPortalP18789.
SMRP18789. Positions 2-428.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1410.

Proteomic databases

PRIDEP18789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90908; AAO90908; CBU_1410.
GeneID1209316.
KEGGcbu:CBU_1410.
PATRIC17931573. VBICoxBur82552_1410.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAKETCDEV.
OrthoDBEOG6P8TP4.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1397-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_COXBU
AccessionPrimary (citable) accession number: P18789
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names