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Protein

Citrate synthase

Gene

gltA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei305 – 3051PROSITE-ProRule annotation
Active sitei363 – 3631PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1397-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:CBU_1410
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Citrate synthasePRO_0000169941Add
BLAST

Proteomic databases

PRIDEiP18789.

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi227377.CBU_1410.

Structurei

3D structure databases

ProteinModelPortaliP18789.
SMRiP18789. Positions 2-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRKAKLSF ENQSVEFPIY SPTLGKDVID VKTLGNHGAY ALDVGFYSTA
60 70 80 90 100
ACESKITFID GEKGILLYRG YPIDQLADKS DYMEVCYLLM YGELPNKGEK
110 120 130 140 150
EKFVRTIKEH TSVYEQVTKF FNGFHYDAHP MAMVLSTIGA LSAFYHDALD
160 170 180 190 200
ITKPADRELS AIRLIAKMPT LAAMSYKYSI GQPFMHPRRA MNYAENFLHM
210 220 230 240 250
LFGTPYEETE PDPVLARAMD RIFILHADHE QNASTTTVRV AGSTGANPFA
260 270 280 290 300
CISAGISALW GPAHGGANEA CLNMLRKIGD EKNIGQYIKK AKDKNDPFRL
310 320 330 340 350
MGFGHRVYKN YDPRAKVMQK TCYEVLDAVG RHNEPLFKLA IKLEKIALED
360 370 380 390 400
DYFIEKKLYP NVDFYSGLTL NAIGIPSNMF TVIFALSRTV GWISHWMEMM
410 420 430
SSPDHRLARP RQLYTGETER EVISLDKRQA
Length:430
Mass (Da):48,633
Last modified:November 1, 1990 - v1
Checksum:i0AA6EEE541501881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36338 Genomic DNA. Translation: AAA23307.1.
AE016828 Genomic DNA. Translation: AAO90908.1.
L33409 Genomic DNA. Translation: AAA74128.1.
PIRiJQ1392.
RefSeqiNP_820394.1. NC_002971.3.
WP_010958208.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90908; AAO90908; CBU_1410.
GeneIDi1209316.
KEGGicbu:CBU_1410.
PATRICi17931573. VBICoxBur82552_1410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36338 Genomic DNA. Translation: AAA23307.1.
AE016828 Genomic DNA. Translation: AAO90908.1.
L33409 Genomic DNA. Translation: AAA74128.1.
PIRiJQ1392.
RefSeqiNP_820394.1. NC_002971.3.
WP_010958208.1. NC_002971.3.

3D structure databases

ProteinModelPortaliP18789.
SMRiP18789. Positions 2-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1410.

Proteomic databases

PRIDEiP18789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90908; AAO90908; CBU_1410.
GeneIDi1209316.
KEGGicbu:CBU_1410.
PATRICi17931573. VBICoxBur82552_1410.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.
BioCyciCBUR227377:GJ7S-1397-MONOMER.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and linkage analysis of the Coxiella burnetii citrate synthase-encoding gene."
    Heinzen R.A., Frazier M.E., Mallavia L.P.
    Gene 109:63-69(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.
  3. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
    Strain: Nine Mile.

Entry informationi

Entry nameiCISY_COXBU
AccessioniPrimary (citable) accession number: P18789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.