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P18786

- HISX_AZOBR

UniProt

P18786 - HISX_AZOBR

Protein

Putative histidinol dehydrogenase

Gene

hisD

Organism
Azospirillum brasilense
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Pathwayi

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    OrganismiAzospirillum brasilense
    Taxonomic identifieri192 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 128›128Putative histidinol dehydrogenasePRO_0000135719Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P18786-1 [UniParc]FASTAAdd to Basket

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    ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA    50
    GDGWGFAGLR QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT 100
    MHTHALSGIA TDGHRRFRRR HLCRPRAS 128
    Length:128
    Mass (Da):14,111
    Last modified:November 1, 1990 - v1
    Checksum:iBDF52031D2B04CCD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17435 Genomic DNA. Translation: CAA35477.1.
    PIRiPE0006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17435 Genomic DNA. Translation: CAA35477.1 .
    PIRi PE0006.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene."
      Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M.
      Mol. Gen. Genet. 216:224-229(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sp6.

    Entry informationi

    Entry nameiHISX_AZOBR
    AccessioniPrimary (citable) accession number: P18786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Highly divergent compared to other bacterial HisD.Curated

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3