Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P18786 (HISX_AZOBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
OrganismAzospirillum brasilense
Taxonomic identifier192 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

Protein attributes

Sequence length128 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Caution

Highly divergent compared to other bacterial HisD.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionhistidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 128›128Putative histidinol dehydrogenase
PRO_0000135719

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P18786 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: BDF52031D2B04CCD

FASTA12814,111
        10         20         30         40         50         60 
ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA GDGWGFAGLR 

        70         80         90        100        110        120 
QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT MHTHALSGIA TDGHRRFRRR 


HLCRPRAS 

« Hide

References

[1]"Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene."
Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M.
Mol. Gen. Genet. 216:224-229(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sp6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17435 Genomic DNA. Translation: CAA35477.1.
PIRPE0006.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameHISX_AZOBR
AccessionPrimary (citable) accession number: P18786
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways