Reviewed, UniProtKB/Swiss-Prot P18786 (HISX_AZOBR)

Names and origin

Protein names

Recommended name:
    Putative histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:

hisD

Organism

Azospirillum brasilense

Taxonomic identifier

192 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Azospirillum

Protein attributes

Sequence length	128 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.
Caution	Highly divergent compared to other bacterial hisD.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 128	›128	Putative histidinol dehydrogenase HAMAP MF_01024		PRO_0000135719
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P18786-1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: BDF52031D2B04CCD	FASTA	128	14,111
	10 20 30 40 50 60 ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA GDGWGFAGLR 70 80 90 100 110 120 QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT MHTHALSGIA TDGHRRFRRR HLCRPRAS

References

[1]

"Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene." Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M. Mol. Gen. Genet. 216:224-229(1989) [PubMed: 2664449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sp6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X17435 Genomic DNA. Translation: CAA35477.1.
PIR	PE0006.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.23. 1315.
Family and domain databases
HAMAP	MF_01024. Divergent sequence. [Tree]
InterPro	IPR001692. Histidinol_DH_CS. [Graphical view]
PROSITE	PS00611. HISOL_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_AZOBR

Accession

Primary (citable) accession number: P18786

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)