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Protein

Anaerobic dimethyl sulfoxide reductase chain C

Gene

dmsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it.

GO - Molecular functioni

  • dimethyl sulfoxide reductase activity Source: EcoCyc

GO - Biological processi

  • anaerobic electron transport chain Source: InterPro
  • anaerobic respiration Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:DMSC-MONOMER.
ECOL316407:JW0879-MONOMER.
MetaCyc:DMSC-MONOMER.

Protein family/group databases

TCDBi5.A.3.3.2. the prokaryotic molybdopterin-containing oxidoreductase (pmo) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic dimethyl sulfoxide reductase chain C
Alternative name(s):
DMSO reductase anchor subunit
Gene namesi
Name:dmsC
Ordered Locus Names:b0896, JW0879
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10234. dmsC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicCurated9
Transmembranei10 – 32HelicalCuratedAdd BLAST23
Topological domaini33 – 43CytoplasmicCuratedAdd BLAST11
Transmembranei44 – 66HelicalCuratedAdd BLAST23
Topological domaini67 – 89PeriplasmicCuratedAdd BLAST23
Transmembranei90 – 107HelicalCuratedAdd BLAST18
Topological domaini108 – 114CytoplasmicCurated7
Transmembranei115 – 134HelicalCuratedAdd BLAST20
Topological domaini135 – 156PeriplasmicCuratedAdd BLAST22
Transmembranei157 – 174HelicalCuratedAdd BLAST18
Topological domaini175 – 182CytoplasmicCurated8
Transmembranei183 – 201HelicalCuratedAdd BLAST19
Topological domaini202 – 224PeriplasmicCuratedAdd BLAST23
Transmembranei225 – 242HelicalCuratedAdd BLAST18
Topological domaini243 – 254CytoplasmicCuratedAdd BLAST12
Transmembranei255 – 280HelicalCuratedAdd BLAST26
Topological domaini281 – 287PeriplasmicCurated7

GO - Cellular componenti

  • dimethyl sulfoxide reductase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799471 – 287Anaerobic dimethyl sulfoxide reductase chain CAdd BLAST287

Proteomic databases

PaxDbiP18777.
PRIDEiP18777.

Interactioni

Subunit structurei

Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).

Protein-protein interaction databases

BioGridi4260727. 5 interactors.
IntActiP18777. 1 interactor.
STRINGi511145.b0896.

Structurei

3D structure databases

ProteinModelPortaliP18777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To E.coli YnfH.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107KGK. Bacteria.
COG3302. LUCA.
HOGENOMiHOG000118381.
KOiK07308.
OMAiMVRVYNT.

Family and domain databases

InterProiIPR007059. DmsC.
[Graphical view]
PfamiPF04976. DmsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWHEWPL MIFTVFGQCV AGGFIVLALA LLKGDLRAEA QQRVIACMFG
60 70 80 90 100
LWVLMGIGFI ASMLHLGSPM RAFNSLNRVG ASALSNEIAS GSIFFAVGGI
110 120 130 140 150
GWLLAMLKKL SPALRTLWLI VTMVLGVIFV WMMVRVYNSI DTVPTWYSIW
160 170 180 190 200
TPMGFFLTMF MGGPLLGYLL LSLAGVDGWA MRLLPAISVL ALVVSGVVSV
210 220 230 240 250
MQGAELATIH SSVQQAAALV PDYGALMSWR IVLLAVALCL WIAPQLKGYQ
260 270 280
PAVPLLSVSF ILLLAGELIG RGVFYGLHMT VGMAVAS
Length:287
Mass (Da):30,826
Last modified:November 1, 1990 - v1
Checksum:iDB6D26ACD2BE0CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03412 Genomic DNA. Translation: AAA83845.1.
U00096 Genomic DNA. Translation: AAC73982.1.
AP009048 Genomic DNA. Translation: BAA35628.1.
PIRiS03787.
RefSeqiNP_415416.1. NC_000913.3.
WP_000534637.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73982; AAC73982; b0896.
BAA35628; BAA35628; BAA35628.
GeneIDi945502.
KEGGiecj:JW0879.
eco:b0896.
PATRICi32117003. VBIEscCol129921_0926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03412 Genomic DNA. Translation: AAA83845.1.
U00096 Genomic DNA. Translation: AAC73982.1.
AP009048 Genomic DNA. Translation: BAA35628.1.
PIRiS03787.
RefSeqiNP_415416.1. NC_000913.3.
WP_000534637.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP18777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260727. 5 interactors.
IntActiP18777. 1 interactor.
STRINGi511145.b0896.

Protein family/group databases

TCDBi5.A.3.3.2. the prokaryotic molybdopterin-containing oxidoreductase (pmo) family.

Proteomic databases

PaxDbiP18777.
PRIDEiP18777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73982; AAC73982; b0896.
BAA35628; BAA35628; BAA35628.
GeneIDi945502.
KEGGiecj:JW0879.
eco:b0896.
PATRICi32117003. VBIEscCol129921_0926.

Organism-specific databases

EchoBASEiEB0230.
EcoGeneiEG10234. dmsC.

Phylogenomic databases

eggNOGiENOG4107KGK. Bacteria.
COG3302. LUCA.
HOGENOMiHOG000118381.
KOiK07308.
OMAiMVRVYNT.

Enzyme and pathway databases

BioCyciEcoCyc:DMSC-MONOMER.
ECOL316407:JW0879-MONOMER.
MetaCyc:DMSC-MONOMER.

Miscellaneous databases

PROiP18777.

Family and domain databases

InterProiIPR007059. DmsC.
[Graphical view]
PfamiPF04976. DmsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMSC_ECOLI
AccessioniPrimary (citable) accession number: P18777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.