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Protein

Anaerobic dimethyl sulfoxide reductase chain C

Gene

dmsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it.

GO - Molecular functioni

  • dimethyl sulfoxide reductase activity Source: EcoCyc

GO - Biological processi

  • anaerobic electron transport chain Source: InterPro
  • anaerobic respiration Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:DMSC-MONOMER.
ECOL316407:JW0879-MONOMER.
MetaCyc:DMSC-MONOMER.

Protein family/group databases

TCDBi5.A.3.3.2. the prokaryotic molybdopterin-containing oxidoreductase (pmo) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic dimethyl sulfoxide reductase chain C
Alternative name(s):
DMSO reductase anchor subunit
Gene namesi
Name:dmsC
Ordered Locus Names:b0896, JW0879
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10234. dmsC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99PeriplasmicCurated
Transmembranei10 – 3223HelicalCuratedAdd
BLAST
Topological domaini33 – 4311CytoplasmicCuratedAdd
BLAST
Transmembranei44 – 6623HelicalCuratedAdd
BLAST
Topological domaini67 – 8923PeriplasmicCuratedAdd
BLAST
Transmembranei90 – 10718HelicalCuratedAdd
BLAST
Topological domaini108 – 1147CytoplasmicCurated
Transmembranei115 – 13420HelicalCuratedAdd
BLAST
Topological domaini135 – 15622PeriplasmicCuratedAdd
BLAST
Transmembranei157 – 17418HelicalCuratedAdd
BLAST
Topological domaini175 – 1828CytoplasmicCurated
Transmembranei183 – 20119HelicalCuratedAdd
BLAST
Topological domaini202 – 22423PeriplasmicCuratedAdd
BLAST
Transmembranei225 – 24218HelicalCuratedAdd
BLAST
Topological domaini243 – 25412CytoplasmicCuratedAdd
BLAST
Transmembranei255 – 28026HelicalCuratedAdd
BLAST
Topological domaini281 – 2877PeriplasmicCurated

GO - Cellular componenti

  • dimethyl sulfoxide reductase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Anaerobic dimethyl sulfoxide reductase chain CPRO_0000079947Add
BLAST

Proteomic databases

PaxDbiP18777.

Interactioni

Subunit structurei

Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).

Protein-protein interaction databases

BioGridi4260727. 5 interactions.
IntActiP18777. 1 interaction.
STRINGi511145.b0896.

Structurei

3D structure databases

ProteinModelPortaliP18777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To E.coli YnfH.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107KGK. Bacteria.
COG3302. LUCA.
HOGENOMiHOG000118381.
KOiK07308.
OMAiMVRVYNT.

Family and domain databases

InterProiIPR007059. DmsC.
[Graphical view]
PfamiPF04976. DmsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWHEWPL MIFTVFGQCV AGGFIVLALA LLKGDLRAEA QQRVIACMFG
60 70 80 90 100
LWVLMGIGFI ASMLHLGSPM RAFNSLNRVG ASALSNEIAS GSIFFAVGGI
110 120 130 140 150
GWLLAMLKKL SPALRTLWLI VTMVLGVIFV WMMVRVYNSI DTVPTWYSIW
160 170 180 190 200
TPMGFFLTMF MGGPLLGYLL LSLAGVDGWA MRLLPAISVL ALVVSGVVSV
210 220 230 240 250
MQGAELATIH SSVQQAAALV PDYGALMSWR IVLLAVALCL WIAPQLKGYQ
260 270 280
PAVPLLSVSF ILLLAGELIG RGVFYGLHMT VGMAVAS
Length:287
Mass (Da):30,826
Last modified:November 1, 1990 - v1
Checksum:iDB6D26ACD2BE0CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03412 Genomic DNA. Translation: AAA83845.1.
U00096 Genomic DNA. Translation: AAC73982.1.
AP009048 Genomic DNA. Translation: BAA35628.1.
PIRiS03787.
RefSeqiNP_415416.1. NC_000913.3.
WP_000534637.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73982; AAC73982; b0896.
BAA35628; BAA35628; BAA35628.
GeneIDi945502.
KEGGiecj:JW0879.
eco:b0896.
PATRICi32117003. VBIEscCol129921_0926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03412 Genomic DNA. Translation: AAA83845.1.
U00096 Genomic DNA. Translation: AAC73982.1.
AP009048 Genomic DNA. Translation: BAA35628.1.
PIRiS03787.
RefSeqiNP_415416.1. NC_000913.3.
WP_000534637.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP18777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260727. 5 interactions.
IntActiP18777. 1 interaction.
STRINGi511145.b0896.

Protein family/group databases

TCDBi5.A.3.3.2. the prokaryotic molybdopterin-containing oxidoreductase (pmo) family.

Proteomic databases

PaxDbiP18777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73982; AAC73982; b0896.
BAA35628; BAA35628; BAA35628.
GeneIDi945502.
KEGGiecj:JW0879.
eco:b0896.
PATRICi32117003. VBIEscCol129921_0926.

Organism-specific databases

EchoBASEiEB0230.
EcoGeneiEG10234. dmsC.

Phylogenomic databases

eggNOGiENOG4107KGK. Bacteria.
COG3302. LUCA.
HOGENOMiHOG000118381.
KOiK07308.
OMAiMVRVYNT.

Enzyme and pathway databases

BioCyciEcoCyc:DMSC-MONOMER.
ECOL316407:JW0879-MONOMER.
MetaCyc:DMSC-MONOMER.

Miscellaneous databases

PROiP18777.

Family and domain databases

InterProiIPR007059. DmsC.
[Graphical view]
PfamiPF04976. DmsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMSC_ECOLI
AccessioniPrimary (citable) accession number: P18777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.