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P18761 (CAH6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbonic anhydrase 6
EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name=CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Gene names
Name:Ca6
Synonyms:Car6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Subcellular location

Secreted.

Tissue specificity

Major constituent of saliva.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionLyase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from direct assay Ref.1. Source: MGI

extracellular space

Inferred from direct assay Ref.1. Source: MGI

   Molecular functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.4
Chain18 – 317300Carbonic anhydrase 6
PRO_0000004242

Regions

Region219 – 2202Substrate binding By similarity

Sites

Active site841Proton acceptor By similarity
Active site1451 By similarity
Metal binding1101Zinc; catalytic By similarity
Metal binding1121Zinc; catalytic By similarity
Metal binding1371Zinc; catalytic By similarity

Amino acid modifications

Glycosylation2551N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 223 Potential

Experimental info

Sequence conflict181H → G AA sequence Ref.4
Sequence conflict351S → T AA sequence Ref.4
Sequence conflict1851N → D in AAD12540. Ref.1
Sequence conflict2021N → D in AAD12540. Ref.1
Sequence conflict2351K → R in AAD12540. Ref.1
Sequence conflict2811Q → P in AAD12540. Ref.1
Sequence conflict2911L → P in AAD12540. Ref.1
Sequence conflict3141W → G in AAD12540. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P18761 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 6A933F9551954240

FASTA31736,495
        10         20         30         40         50         60 
MRALVSVVSL FFLGIQAHSD WSYSGDDGVG ESQWSEQYPS CGGERQSPID VKTEEVMFNP 

        70         80         90        100        110        120 
SLKPLSLVNY EKENLEFTMT NNGHTVSIDL PPSMYLETSD GTEFISKAFH FHWGGRDWEL 

       130        140        150        160        170        180 
SGSEHTIDGI RSIMEAHFVH FNKEYGTYEN AKDQKNGLAV LAVLFKIDEY AENTYYSDII 

       190        200        210        220        230        240 
SALKNIEKPG ETTTLKDTTI RNLLPKDVHH YYTYPGSLTT PPCTENVQWF VLRDKVTLSK 

       250        260        270        280        290        300 
AQVVTIENSV MDHNNNTIQN GYRSTQPNNH RVVEANFLNV QDMYSSYHLY LKNMQKEILQ 

       310 
PKKQKKTKKN RHFWSRK

« Hide

References

« Hide 'large scale' references
[1]"CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI."
Sok J., Wang X.Z., Batchvarova N., Kuroda M., Harding H., Ron D.
Mol. Cell. Biol. 19:495-504(1999) [PubMed: 9858573] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Salivary gland.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Tissue and species distribution of the secreted carbonic anhydrase isoenzyme."
Fernley R.T., Darling P., Aldred P., Wright R.D., Coghlan J.P.
Biochem. J. 259:91-96(1989) [PubMed: 2497732] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-38.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF079835 mRNA. Translation: AAD12540.1.
AL606903 Genomic DNA. Translation: CAM19425.1.
CH466594 Genomic DNA. Translation: EDL14887.1.
IPIIPI00114881.
PIRS03863.
RefSeqNP_033932.2. NM_009802.2.
UniGeneMm.232523.

3D structure databases

ProteinModelPortalP18761.
SMRP18761. Positions 32-279.
ModBaseSearch...

Protein-protein interaction databases

STRINGP18761.

Proteomic databases

PRIDEP18761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030817; ENSMUSP00000030817; ENSMUSG00000028972.
GeneID12353.
KEGGmmu:12353.

Organism-specific databases

CTD12353.
MGIMGI:1333786. Car6.

Phylogenomic databases

eggNOGroNOG16063.
HOVERGENHBG002837.
InParanoidP18761.
OrthoDBEOG43FGWZ.

Gene expression databases

ArrayExpressP18761.
BgeeP18761.
CleanExMM_CAR6.
GenevestigatorP18761.
GermOnlineENSMUSG00000028972. Mus musculus.

Family and domain databases

InterProIPR001148. a_carbonic_anhydrase.
IPR023561. Carbonic_anhydrase_a-class.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
Gene3DG3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KOK01672.
PANTHERPTHR18952:SF17. Carbonic_anhydrase_CA6. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. Euk_COanhd. 1 hit.
PROSITEPS00162. ALPHA_CA_1. False negative.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281012.
SOURCESearch...

Entry information

Entry nameCAH6_MOUSE
AccessionPrimary (citable) accession number: P18761
Secondary accession number(s): B1ARR5, O88625
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: January 25, 2012
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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