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Protein

Carbonic anhydrase 6

Gene

Ca6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorBy similarity
Metal bindingi110 – 1101Zinc; catalyticBy similarity
Metal bindingi112 – 1121Zinc; catalyticBy similarity
Metal bindingi137 – 1371Zinc; catalyticBy similarity
Active sitei145 – 1451By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 6 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name:
CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Gene namesi
Name:Ca6
Synonyms:Car6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333786. Car6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 317300Carbonic anhydrase 6PRO_0000004242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 223Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18761.
PaxDbiP18761.
PRIDEiP18761.

Expressioni

Tissue specificityi

Major constituent of saliva.

Gene expression databases

BgeeiP18761.
CleanExiMM_CAR6.
ExpressionAtlasiP18761. baseline and differential.
GenevisibleiP18761. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030817.

Structurei

3D structure databases

ProteinModelPortaliP18761.
SMRiP18761. Positions 32-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2202Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOVERGENiHBG002837.
InParanoidiP18761.
KOiK01672.
OMAiHGSQWTY.
OrthoDBiEOG7WMCK7.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF110. PTHR18952:SF110. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALVSVVSL FFLGIQAHSD WSYSGDDGVG ESQWSEQYPS CGGERQSPID
60 70 80 90 100
VKTEEVMFNP SLKPLSLVNY EKENLEFTMT NNGHTVSIDL PPSMYLETSD
110 120 130 140 150
GTEFISKAFH FHWGGRDWEL SGSEHTIDGI RSIMEAHFVH FNKEYGTYEN
160 170 180 190 200
AKDQKNGLAV LAVLFKIDEY AENTYYSDII SALKNIEKPG ETTTLKDTTI
210 220 230 240 250
RNLLPKDVHH YYTYPGSLTT PPCTENVQWF VLRDKVTLSK AQVVTIENSV
260 270 280 290 300
MDHNNNTIQN GYRSTQPNNH RVVEANFLNV QDMYSSYHLY LKNMQKEILQ
310
PKKQKKTKKN RHFWSRK
Length:317
Mass (Da):36,495
Last modified:July 27, 2011 - v3
Checksum:i6A933F9551954240
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181H → G AA sequence (PubMed:2497732).Curated
Sequence conflicti35 – 351S → T AA sequence (PubMed:2497732).Curated
Sequence conflicti185 – 1851N → D in AAD12540 (PubMed:9858573).Curated
Sequence conflicti202 – 2021N → D in AAD12540 (PubMed:9858573).Curated
Sequence conflicti235 – 2351K → R in AAD12540 (PubMed:9858573).Curated
Sequence conflicti281 – 2811Q → P in AAD12540 (PubMed:9858573).Curated
Sequence conflicti291 – 2911L → P in AAD12540 (PubMed:9858573).Curated
Sequence conflicti314 – 3141W → G in AAD12540 (PubMed:9858573).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079835 mRNA. Translation: AAD12540.1.
AL606903 Genomic DNA. Translation: CAM19425.1.
CH466594 Genomic DNA. Translation: EDL14887.1.
CCDSiCCDS51386.1.
PIRiS03863.
RefSeqiNP_033932.2. NM_009802.2.
UniGeneiMm.232523.

Genome annotation databases

EnsembliENSMUST00000030817; ENSMUSP00000030817; ENSMUSG00000028972.
GeneIDi12353.
KEGGimmu:12353.
UCSCiuc008vxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079835 mRNA. Translation: AAD12540.1.
AL606903 Genomic DNA. Translation: CAM19425.1.
CH466594 Genomic DNA. Translation: EDL14887.1.
CCDSiCCDS51386.1.
PIRiS03863.
RefSeqiNP_033932.2. NM_009802.2.
UniGeneiMm.232523.

3D structure databases

ProteinModelPortaliP18761.
SMRiP18761. Positions 32-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030817.

Proteomic databases

MaxQBiP18761.
PaxDbiP18761.
PRIDEiP18761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030817; ENSMUSP00000030817; ENSMUSG00000028972.
GeneIDi12353.
KEGGimmu:12353.
UCSCiuc008vxm.1. mouse.

Organism-specific databases

CTDi12353.
MGIiMGI:1333786. Car6.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOVERGENiHBG002837.
InParanoidiP18761.
KOiK01672.
OMAiHGSQWTY.
OrthoDBiEOG7WMCK7.
TreeFamiTF316425.

Enzyme and pathway databases

ReactomeiR-MMU-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

NextBioi281012.
PROiP18761.
SOURCEiSearch...

Gene expression databases

BgeeiP18761.
CleanExiMM_CAR6.
ExpressionAtlasiP18761. baseline and differential.
GenevisibleiP18761. MM.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF110. PTHR18952:SF110. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI."
    Sok J., Wang X.Z., Batchvarova N., Kuroda M., Harding H., Ron D.
    Mol. Cell. Biol. 19:495-504(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Salivary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Tissue and species distribution of the secreted carbonic anhydrase isoenzyme."
    Fernley R.T., Darling P., Aldred P., Wright R.D., Coghlan J.P.
    Biochem. J. 259:91-96(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-38.

Entry informationi

Entry nameiCAH6_MOUSE
AccessioniPrimary (citable) accession number: P18761
Secondary accession number(s): B1ARR5, O88625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: January 20, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.