Reviewed, UniProtKB/Swiss-Prot P18761 (CAH6_MOUSE)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 6
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VI
      Short name=CA-VI
    Carbonate dehydratase VI
    Secreted carbonic anhydrase
    Salivary carbonic anhydrase

Gene names

Name:	Ca6
Synonyms:	Car6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide. Its role in saliva is unknown.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Secreted.
Tissue specificity	Major constituent of saliva.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Ref.2
	Chain	18 – 317	300	Carbonic anhydrase 6		PRO_0000004242
Sites
	Metal binding	110	1	Zinc; catalytic By similarity
	Metal binding	112	1	Zinc; catalytic By similarity
	Metal binding	137	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 223		Potential
Experimental info
	Sequence conflict	18	1	H → G AA sequence Ref.2
	Sequence conflict	35	1	S → T AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P18761-1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 0399384F7B48283A	FASTA	317	36,349
	10 20 30 40 50 60 MRALVSVVSL FFLGIQAHSD WSYSGDDGVG ESQWSEQYPS CGGERQSPID VKTEEVMFNP 70 80 90 100 110 120 SLKPLSLVNY EKENLEFTMT NNGHTVSIDL PPSMYLETSD GTEFISKAFH FHWGGRDWEL 130 140 150 160 170 180 SGSEHTIDGI RSIMEAHFVH FNKEYGTYEN AKDQKNGLAV LAVLFKIDEY AENTYYSDII 190 200 210 220 230 240 SALKDIEKPG ETTTLKDTTI RDLLPKDVHH YYTYPGSLTT PPCTENVQWF VLRDRVTLSK 250 260 270 280 290 300 AQVVTIENSV MDHNNNTIQN GYRSTQPNNH RVVEANFLNV PDMYSSYHLY PKNMQKEILQ 310 PKKQKKTKKN RHFGSRK

References

[1]	"CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI." Sok J., Wang X.Z., Batchvarova N., Kuroda M., Harding H., Ron D. Mol. Cell. Biol. 19:495-504(1999) [PubMed: 9858573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. Tissue: Salivary gland.
[2]	"Tissue and species distribution of the secreted carbonic anhydrase isoenzyme." Fernley R.T., Darling P., Aldred P., Wright R.D., Coghlan J.P. Biochem. J. 259:91-96(1989) [PubMed: 2497732] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-38.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF079835 mRNA. Translation: AAD12540.1.
IPI	IPI00114881.
PIR	S03863.
UniGene	Mm.232523
3D structure databases
HSSP	HSSP built from PDB template 1BV3 based on UniProtKB P00918.
ModBase	Search...
Protein-protein interaction databases
STRING	P18761.
Proteomic databases
PRIDE	P18761.
Genome annotation databases
Ensembl	ENSMUST00000030817; ENSMUSP00000030817; ENSMUSG00000028972; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1333786. Car6.
Phylogenomic databases
HOVERGEN	P18761.
Enzyme and pathway databases
BRENDA	4.2.1.1. 244.
Gene expression databases
ArrayExpress	P18761.
Bgee	P18761.
CleanEx	MM_CAR6.
Genevestigator	P18761.
GermOnline	ENSMUSG00000028972. Mus musculus.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018428. Carbonic_anhydrase_CA6. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF17. Carbonic_anhydrase_CA6. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. False negative. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CAH6_MOUSE

Accession

Primary (citable) accession number: P18761
Secondary accession number(s): O88625

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	July 15, 1999
Last modified:	October 13, 2009
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)