P18685 (FRIH_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin heavy chain
Short name=Ferritin H subunit
EC=1.16.3.1

Gene names

Name:	FTH1
Synonyms:	FTH

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from sequence or structural similarity. Source: UniProtKB iron ion transport Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Ferritin heavy chain		PRO_0000201054
Regions
	Domain	11 – 160	150	Ferritin-like diiron
Sites
	Metal binding	28	1	Iron 1 By similarity
	Metal binding	63	1	Iron 1 By similarity
	Metal binding	63	1	Iron 2 By similarity
	Metal binding	66	1	Iron 1 By similarity
	Metal binding	108	1	Iron 2 By similarity
	Metal binding	142	1	Iron 2 By similarity
Experimental info
	Sequence conflict	79	1	A → G AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P18685 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 4BA0A64EF1356379	FASTA	171	20,063
	10 20 30 40 50 60 MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 70 80 90 100 110 120 HEEREHAERL MKLQNQRGAR IFLQDIKKPD RDDWENGLNA MECALCLERS VNQSLLELHK 130 140 150 160 170 LATEKNDPHL CDFIETHYLN EQVEAIKELG DHITNLRKMG ALWIGHGRVP L

References

[1]	"Differential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes." Sanyal B., Polak P.E., Szuchet S. J. Neurosci. Res. 46:187-197(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Crosslinks between intramolecular pairs of ferritin subunits: effects on both H and L subunits and on immunoreactivity of sheep spleen ferritin." McKenzie R.A., Yablonski M.J., Gillespie G.Y., Theil E.C. Arch. Biochem. Biophys. 272:88-96(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 72-102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U54800 mRNA. Translation: AAB19186.1.
UniGene	Oar.3212.
3D structure databases
ProteinModelPortal	P18685.
SMR	P18685. Positions 7-161.
ModBase	Search...
Proteomic databases
PRIDE	P18685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
CTD	2495.
Phylogenomic databases
HOVERGEN	HBG000410.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR014034. Ferritin_CS. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00540. FERRITIN_1. False negative. PS00204. FERRITIN_2. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRIH_SHEEP

Accession

Primary (citable) accession number: P18685

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program