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Protein

Ribosomal protein S6 kinase 2 alpha

Gene

RPS6KA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by multiple phosphorylations on threonine and serine residues.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121ATPPROSITE-ProRule annotation
Active sitei205 – 2051Proton acceptorBy similarity
Binding sitei464 – 4641ATPPROSITE-ProRule annotation
Active sitei552 – 5521Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 949ATPPROSITE-ProRule annotation
Nucleotide bindingi441 – 4499ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 1306.
ReactomeiR-GGA-198753. ERK/MAPK targets.
R-GGA-199920. CREB phosphorylation.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-442742. CREB phosphorylation through the activation of Ras.
R-GGA-444257. RSK activation.
R-GGA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase 2 alpha (EC:2.7.11.1)
Alternative name(s):
MAP kinase-activated protein kinase 1
Short name:
MAPK-activated protein kinase 1
Short name:
MAPKAP kinase 1
Short name:
MAPKAPK-1
Ribosomal protein S6 kinase II alpha
Short name:
S6KII-alpha
p90-RSK
Gene namesi
Name:RPS6KA
Synonyms:RSK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Ribosomal protein S6 kinase 2 alphaPRO_0000086210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei377 – 3771PhosphothreonineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei398 – 3981Phosphoserine; by autocatalysisBy similarity
Modified residuei590 – 5901PhosphothreonineBy similarity
Modified residuei749 – 7491PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated on Ser-398, as part of the activation process.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18652.

Expressioni

Tissue specificityi

Small and large intestine, spleen, stomach, and bursa, and to a lesser extent lung and kidney.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000497.

Structurei

3D structure databases

ProteinModelPortaliP18652.
SMRiP18652. Positions 71-358, 430-726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 339260Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini340 – 40970AGC-kinase C-terminalAdd
BLAST
Domaini435 – 692258Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 2 protein kinase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiP18652.
KOiK04373.
OMAiPWITQKD.
PhylomeDBiP18652.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAQLAEPW PNMELVQLDT ENGQAAPEEG GNPPCKAKSD ITWVEKDLVD
60 70 80 90 100
STDKGEGVVK EINITHHVKE GSEKADPSQF ELLKVLGQGS FGKVFLVRKI
110 120 130 140 150
TPPDSNHLYA MKVLKKATLK VRDRVRTKIE RDILADVNHP FVVKLHYAFQ
160 170 180 190 200
TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA LGLDHLHSLG
210 220 230 240 250
IIYRDLKPEN ILLDEEGHIK LTDFGLSKEA IDHEKKAYSF CGTVEYMAPE
260 270 280 290 300
VVNRQGHSHS ADWWSYGVLM FEMLTGSLPF QGKDRKETMT LILKAKLGMP
310 320 330 340 350
QFLSAEAQSL LRALFKRNPA NRLGSGPDGA EEIKRHPFYS TIDWNKLYRR
360 370 380 390 400
EIKPPFKPAV GQPDDTFYFD TEFTSRTPKD SPGIPPSAGA HQLFRGFSFV
410 420 430 440 450
ATGLMEDSKV KPAQPPLHSV VQQLHGKNIQ FSDGYVVKEA IGVGSYSVCK
460 470 480 490 500
RCIHKTTNME YAVKVIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK
510 520 530 540 550
YVYLVTELMR GGELLDKILR QKFFSEREAS SVLHTICKTV EYLHSQGVVH
560 570 580 590 600
RDLKPSNILY VDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP
610 620 630 640 650
EVLKRQGYDE GCDIWSLGVL LYTMLAGCTP FANGPSDTPE EILTRIGGGK
660 670 680 690 700
FSVNGGNWDT ISDVAKDLVS KMLHVDPHQR LTAKQVLQHP WITQKDSLPQ
710 720 730 740 750
SQLNYQDVQL VKGAMAATYS ALNSSKPSPQ LKPIESSILA QRRVKKLPST

TL
Length:752
Mass (Da):84,440
Last modified:November 1, 1990 - v1
Checksum:iCA4D74CCC934E236
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28488 mRNA. Translation: AAA21877.1.
PIRiA32571.
RefSeqiNP_001103241.1. NM_001109771.2.
UniGeneiGga.4333.

Genome annotation databases

EnsembliENSGALT00000000498; ENSGALP00000000497; ENSGALG00000000366.
GeneIDi386579.
KEGGigga:386579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28488 mRNA. Translation: AAA21877.1.
PIRiA32571.
RefSeqiNP_001103241.1. NM_001109771.2.
UniGeneiGga.4333.

3D structure databases

ProteinModelPortaliP18652.
SMRiP18652. Positions 71-358, 430-726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000497.

Proteomic databases

PaxDbiP18652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000498; ENSGALP00000000497; ENSGALG00000000366.
GeneIDi386579.
KEGGigga:386579.

Organism-specific databases

CTDi6195.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiP18652.
KOiK04373.
OMAiPWITQKD.
PhylomeDBiP18652.

Enzyme and pathway databases

BRENDAi2.7.11.1. 1306.
ReactomeiR-GGA-198753. ERK/MAPK targets.
R-GGA-199920. CREB phosphorylation.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-442742. CREB phosphorylation through the activation of Ras.
R-GGA-444257. RSK activation.
R-GGA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Miscellaneous databases

NextBioi20813942.
PROiP18652.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase."
    Alcorta D.A., Crews C.M., Sweet L.J., Bankston L., Jones S.W., Erikson R.L.
    Mol. Cell. Biol. 9:3850-3859(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKS6AA_CHICK
AccessioniPrimary (citable) accession number: P18652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.