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Protein

Apolipoprotein E

Gene

APOE

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000199319 – 317Apolipoprotein EAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142Methionine sulfoxideBy similarity1
Glycosylationi211O-linked (GalNAc...)By similarity1
Glycosylationi310O-linked (GalNAc...)By similarity1
Glycosylationi311O-linked (GalNAc...)By similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

PaxDbiP18650.
PeptideAtlasiP18650.
PRIDEiP18650.

Expressioni

Tissue specificityi

Secreted in plasma.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003343.

Structurei

3D structure databases

ProteinModelPortaliP18650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 1001Add BLAST22
Repeati101 – 1222Add BLAST22
Repeati123 – 1443Add BLAST22
Repeati145 – 1664Add BLAST22
Repeati167 – 1885Add BLAST22
Repeati189 – 2106Add BLAST22
Repeati211 – 2327Add BLAST22
Repeati233 – 2548Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 2548 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni157 – 167LDL receptor bindingBy similarityAdd BLAST11
Regioni161 – 164Heparin-bindingBy similarity4
Regioni228 – 235Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiP18650.
KOiK04524.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLWVALVV TLLAGCRTED EPGPPPEVHV WWEESKWQGS QPWEQALGRF
60 70 80 90 100
WDYLRWVQSL SDQVQEELLS TKVTQELTEL IEESMKEVKA YREELEAQLG
110 120 130 140 150
PVTQETQARL SKELQAAQAR VGADMEDVRN RLVLYRSEVH NMLGQTTEEL
160 170 180 190 200
RSRLASHLRN VRKRLVRDTE DLQKRLAVYQ AGLREGAERS VSALRERLGP
210 220 230 240 250
LVEQGRLRAA TLSTRAGQPL RERAEAWGQK LRGRLEEMGS RTRDRLDEMR
260 270 280 290 300
DELEEVRTKV EEQGSQLRLQ AEAFQARLKG WFEPLVEDMR RQWAGLVERM
310
QSAVSISSST SAPSDNQ
Length:317
Mass (Da):36,599
Last modified:February 1, 1994 - v2
Checksum:i83E7F51A07785055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35S → P in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti160 – 161NV → KL in AAC29512 (PubMed:9682450).Curated2
Sequence conflicti166V → L in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti251 – 252DE → EQ in AAC29512 (PubMed:9682450).Curated2
Sequence conflicti273A → G in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti275Q → H in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti277R → L in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti289M → I in AAC29512 (PubMed:9682450).Curated1
Sequence conflicti303A → G in AAC29512 (PubMed:9682450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72835 mRNA. Translation: CAA51356.1.
U70240 Genomic DNA. Translation: AAC29512.1.
PIRiS33450.
RefSeqiNP_999473.1. NM_214308.1.
UniGeneiSsc.1342.

Genome annotation databases

GeneIDi397576.
KEGGissc:397576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72835 mRNA. Translation: CAA51356.1.
U70240 Genomic DNA. Translation: AAC29512.1.
PIRiS33450.
RefSeqiNP_999473.1. NM_214308.1.
UniGeneiSsc.1342.

3D structure databases

ProteinModelPortaliP18650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003343.

Proteomic databases

PaxDbiP18650.
PeptideAtlasiP18650.
PRIDEiP18650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397576.
KEGGissc:397576.

Organism-specific databases

CTDi348.

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiP18650.
KOiK04524.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOE_PIG
AccessioniPrimary (citable) accession number: P18650
Secondary accession number(s): O19099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1994
Last modified: October 5, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.