Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein E

Gene

APOE

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916361 – 305Apolipoprotein EAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Methionine sulfoxideBy similarity1
Modified residuei135PhosphoserineBy similarity1
Glycosylationi298O-linked (GalNAc...) threonineBy similarity1
Glycosylationi299O-linked (GalNAc...) serineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PaxDbiP18649.
PRIDEiP18649.

Expressioni

Tissue specificityi

Present in multiple tissues including liver, jejunum, urinary bladder, ileum, colon, brain, kidney, spleen, pancreas and testis. Secreted in plasma.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000006888.

Structurei

3D structure databases

ProteinModelPortaliP18649.
SMRiP18649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 891Add BLAST22
Repeati90 – 1112Add BLAST22
Repeati112 – 1333Add BLAST22
Repeati134 – 1554Add BLAST22
Repeati156 – 1775Add BLAST22
Repeati178 – 1996Add BLAST22
Repeati200 – 2217Add BLAST22
Repeati222 – 2438Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 2438 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni146 – 156LDL receptor bindingBy similarityAdd BLAST11
Regioni150 – 153Heparin-bindingBy similarity4
Regioni217 – 224Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiP18649.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

P18649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DVQPEPELER ELEPKVQQEL EPEAGWQTGQ PWEAALARFW DYLRWVQTLS
60 70 80 90 100
DQVQEGVLNT QVTQELTALM DETMKEVKAY KAELDEQLGP MTSETQARVA
110 120 130 140 150
KELQAAQARL RADMEDVRNR LTQYRGELQA MLGQSSEELR ARFASHMRKL
160 170 180 190 200
RKRVLRDAED LQRRLAVYKA GVREGAERSV SSIRERLWPL LEQARERNAK
210 220 230 240 250
VGALATQPLL ERADAWGQQL RGQLEEMSSR ARGHLEEMRE QIQEVRVKME
260 270 280 290 300
EQADQIRQKA EAFQARLKSW FEPLLEDMQR QWDGLVEKVQ AAVATIPTSK

PVEEP
Length:305
Mass (Da):35,354
Last modified:December 15, 1998 - v2
Checksum:i8524E4D3A162F9B1
GO

Sequence databases

PIRiA05310.
C60940.
UniGeneiCfa.16211.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPOE_CANLF
AccessioniPrimary (citable) accession number: P18649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 15, 1998
Last modified: May 10, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families