P18634 (ART10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin-related trafficking adapter 10

Gene names

Name:	ART10
Ordered Locus Names:	YLR392C
ORF Names:	L8084.13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli By similarity.
Subunit structure	Interacts with RSP5. Ref.6
Subcellular location	Cytoplasm Ref.4.
Post-translational modification	Ubiquitinated by RSP5. Ref.6
Miscellaneous	Present with 736 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the ART10 family.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay Ref.4. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RSP5	P39940	5	EBI-27197,EBI-16219

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Arrestin-related trafficking adapter 10		PRO_0000203235

Sequences

	Sequence		Length	Mass (Da)
	P18634 [UniParc]. Last modified November 1, 1997. Version 3. Checksum: 65399EA2FFFC2C23	FASTA	518	59,758
	10 20 30 40 50 60 MAPKISISLN PPYNGEFYSS NDQMSGIVSL QLTKALSIRK ISVILKGFSE TLTKIDQEYM 70 80 90 100 110 120 FQQNGMMMPG QDNKSFHTLM KFEQRVFPPD NVWNALDGSS KPFKVKPGSY NYSFQFDKFP 130 140 150 160 170 180 RKPECLKNHT AKTVAFVTRS NARLPPTFNS HWQEFNKIDN LDLYFYSFGK VIYMVQVQLE 190 200 210 220 230 240 LGKSSSWFKP FHKLIREIET FEFIPEPKDL IIEPDEDDNE ELNAFSNNSR GNSMVTNNEF 250 260 270 280 290 300 FNSSNLKVPS KDVKVVNGVG YIKSDRNFSQ ANSILIENGD IRSRPVSSVT STRQSTRLVN 310 320 330 340 350 360 GMKVFPSTYK MGLPDGESNM RIEVRSRDLK QIYRKDYLFR SGSQNFDKVY VVMEGNIASL 370 380 390 400 410 420 SKMQITPLKL QLNLLETTTY LSQGIANGNY SSLKLIEIDL NQLKSNKPLL DLNEIRENFD 430 440 450 460 470 480 GSMFECELRL KDHPILRKLV FNEEDYRHRG NRLYSFKTCT IKRTFSLQLL IEWGINGIRK 490 500 510 QSEVNIDPVQ IFCQVREHVE AEALPRYVPP PTYTEMAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"ATP 10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex." Ackerman S.H., Tzagoloff A. J. Biol. Chem. 265:9952-9959(1990) [PubMed: 2141026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast." Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D. Mol. Syst. Biol. 3:116-116(2007) [PubMed: 17551511] [Abstract] Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
[7]	"Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface." Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D. Cell 135:714-725(2008) [PubMed: 18976803] [Abstract] Cited for: GENE NAME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19729 Genomic DNA. Translation: AAB82352.1. J05463 Genomic DNA. Translation: AAB05631.1. BK006945 Genomic DNA. Translation: DAA09693.1.
PIR	S55948.
RefSeq	NP_013496.1. NM_001182280.1.
3D structure databases
ProteinModelPortal	P18634.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1946N.
IntAct	P18634. 2 interactions.
MINT	MINT-405132.
STRING	P18634.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR392C; YLR392C; YLR392C.
GeneID	851108.
KEGG	sce:YLR392C.
NMPDR	fig|4932.3.peg.4521.
Organism-specific databases
CYGD	YLR392c.
SGD	S000004384. ART10.
Phylogenomic databases
eggNOG	fuNOG11776.
HOGENOM	HBG202572.
OMA	EFIPEPK.
OrthoDB	EOG4JQ76G.
Gene expression databases
ArrayExpress	P18634.
Genevestigator	P18634.
GermOnline	YLR392C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	967812.

Entry information

Entry name

ART10_YEAST

Accession

Primary (citable) accession number: P18634
Secondary accession number(s): D6VZ27

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program