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P18634

- ART10_YEAST

UniProt

P18634 - ART10_YEAST

Protein

Arrestin-related trafficking adapter 10

Gene

ART10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32457-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arrestin-related trafficking adapter 10
    Gene namesi
    Name:ART10
    Ordered Locus Names:YLR392C
    ORF Names:L8084.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR392c.
    SGDiS000004384. ART10.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Arrestin-related trafficking adapter 10PRO_0000203235Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by RSP5.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP18634.
    PaxDbiP18634.

    Expressioni

    Gene expression databases

    GenevestigatoriP18634.

    Interactioni

    Subunit structurei

    Interacts with RSP5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RSP5P399404EBI-27197,EBI-16219

    Protein-protein interaction databases

    BioGridi31651. 9 interactions.
    DIPiDIP-1946N.
    IntActiP18634. 2 interactions.
    MINTiMINT-405132.
    STRINGi4932.YLR392C.

    Structurei

    3D structure databases

    ProteinModelPortaliP18634.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ART10 family.Curated

    Phylogenomic databases

    eggNOGiNOG41805.
    OMAiRVFPPDN.
    OrthoDBiEOG7Z0K5B.

    Sequencei

    Sequence statusi: Complete.

    P18634-1 [UniParc]FASTAAdd to Basket

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    MAPKISISLN PPYNGEFYSS NDQMSGIVSL QLTKALSIRK ISVILKGFSE    50
    TLTKIDQEYM FQQNGMMMPG QDNKSFHTLM KFEQRVFPPD NVWNALDGSS 100
    KPFKVKPGSY NYSFQFDKFP RKPECLKNHT AKTVAFVTRS NARLPPTFNS 150
    HWQEFNKIDN LDLYFYSFGK VIYMVQVQLE LGKSSSWFKP FHKLIREIET 200
    FEFIPEPKDL IIEPDEDDNE ELNAFSNNSR GNSMVTNNEF FNSSNLKVPS 250
    KDVKVVNGVG YIKSDRNFSQ ANSILIENGD IRSRPVSSVT STRQSTRLVN 300
    GMKVFPSTYK MGLPDGESNM RIEVRSRDLK QIYRKDYLFR SGSQNFDKVY 350
    VVMEGNIASL SKMQITPLKL QLNLLETTTY LSQGIANGNY SSLKLIEIDL 400
    NQLKSNKPLL DLNEIRENFD GSMFECELRL KDHPILRKLV FNEEDYRHRG 450
    NRLYSFKTCT IKRTFSLQLL IEWGINGIRK QSEVNIDPVQ IFCQVREHVE 500
    AEALPRYVPP PTYTEMAS 518
    Length:518
    Mass (Da):59,758
    Last modified:November 1, 1997 - v3
    Checksum:i65399EA2FFFC2C23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19729 Genomic DNA. Translation: AAB82352.1.
    J05463 Genomic DNA. Translation: AAB05631.1.
    BK006945 Genomic DNA. Translation: DAA09693.1.
    PIRiS55948.
    RefSeqiNP_013496.3. NM_001182280.3.

    Genome annotation databases

    EnsemblFungiiYLR392C; YLR392C; YLR392C.
    GeneIDi851108.
    KEGGisce:YLR392C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19729 Genomic DNA. Translation: AAB82352.1 .
    J05463 Genomic DNA. Translation: AAB05631.1 .
    BK006945 Genomic DNA. Translation: DAA09693.1 .
    PIRi S55948.
    RefSeqi NP_013496.3. NM_001182280.3.

    3D structure databases

    ProteinModelPortali P18634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31651. 9 interactions.
    DIPi DIP-1946N.
    IntActi P18634. 2 interactions.
    MINTi MINT-405132.
    STRINGi 4932.YLR392C.

    Proteomic databases

    MaxQBi P18634.
    PaxDbi P18634.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR392C ; YLR392C ; YLR392C .
    GeneIDi 851108.
    KEGGi sce:YLR392C.

    Organism-specific databases

    CYGDi YLR392c.
    SGDi S000004384. ART10.

    Phylogenomic databases

    eggNOGi NOG41805.
    OMAi RVFPPDN.
    OrthoDBi EOG7Z0K5B.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32457-MONOMER.

    Miscellaneous databases

    NextBioi 967812.

    Gene expression databases

    Genevestigatori P18634.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "ATP 10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex."
      Ackerman S.H., Tzagoloff A.
      J. Biol. Chem. 265:9952-9959(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast."
      Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D.
      Mol. Syst. Biol. 3:116-116(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
    7. "Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface."
      Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D.
      Cell 135:714-725(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
    8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiART10_YEAST
    AccessioniPrimary (citable) accession number: P18634
    Secondary accession number(s): D6VZ27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 736 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3