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P18634 (ART10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arrestin-related trafficking adapter 10
Gene names
Name:ART10
Ordered Locus Names:YLR392C
ORF Names:L8084.13
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli By similarity.

Subunit structure

Interacts with RSP5. Ref.6

Subcellular location

Cytoplasm Ref.4.

Post-translational modification

Ubiquitinated by RSP5. Ref.6

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ART10 family.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCytoplasm
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSP5P399404EBI-27197,EBI-16219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Arrestin-related trafficking adapter 10
PRO_0000203235

Sequences

Sequence LengthMass (Da)Tools
P18634 [UniParc].

Last modified November 1, 1997. Version 3.
Checksum: 65399EA2FFFC2C23

FASTA51859,758
        10         20         30         40         50         60 
MAPKISISLN PPYNGEFYSS NDQMSGIVSL QLTKALSIRK ISVILKGFSE TLTKIDQEYM 

        70         80         90        100        110        120 
FQQNGMMMPG QDNKSFHTLM KFEQRVFPPD NVWNALDGSS KPFKVKPGSY NYSFQFDKFP 

       130        140        150        160        170        180 
RKPECLKNHT AKTVAFVTRS NARLPPTFNS HWQEFNKIDN LDLYFYSFGK VIYMVQVQLE 

       190        200        210        220        230        240 
LGKSSSWFKP FHKLIREIET FEFIPEPKDL IIEPDEDDNE ELNAFSNNSR GNSMVTNNEF 

       250        260        270        280        290        300 
FNSSNLKVPS KDVKVVNGVG YIKSDRNFSQ ANSILIENGD IRSRPVSSVT STRQSTRLVN 

       310        320        330        340        350        360 
GMKVFPSTYK MGLPDGESNM RIEVRSRDLK QIYRKDYLFR SGSQNFDKVY VVMEGNIASL 

       370        380        390        400        410        420 
SKMQITPLKL QLNLLETTTY LSQGIANGNY SSLKLIEIDL NQLKSNKPLL DLNEIRENFD 

       430        440        450        460        470        480 
GSMFECELRL KDHPILRKLV FNEEDYRHRG NRLYSFKTCT IKRTFSLQLL IEWGINGIRK 

       490        500        510 
QSEVNIDPVQ IFCQVREHVE AEALPRYVPP PTYTEMAS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"ATP 10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex."
Ackerman S.H., Tzagoloff A.
J. Biol. Chem. 265:9952-9959(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast."
Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D.
Mol. Syst. Biol. 3:116-116(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
[7]"Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface."
Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D.
Cell 135:714-725(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE NAME.
[8]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19729 Genomic DNA. Translation: AAB82352.1.
J05463 Genomic DNA. Translation: AAB05631.1.
BK006945 Genomic DNA. Translation: DAA09693.1.
PIRS55948.
RefSeqNP_013496.3. NM_001182280.3.

3D structure databases

ProteinModelPortalP18634.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31651. 9 interactions.
DIPDIP-1946N.
IntActP18634. 2 interactions.
MINTMINT-405132.
STRING4932.YLR392C.

Proteomic databases

PaxDbP18634.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR392C; YLR392C; YLR392C.
GeneID851108.
KEGGsce:YLR392C.

Organism-specific databases

CYGDYLR392c.
SGDS000004384. ART10.

Phylogenomic databases

eggNOGNOG41805.
OMARVFPPDN.
OrthoDBEOG7Z0K5B.

Enzyme and pathway databases

BioCycYEAST:G3O-32457-MONOMER.

Gene expression databases

GenevestigatorP18634.

Family and domain databases

ProtoNetSearch...

Other

NextBio967812.

Entry information

Entry nameART10_YEAST
AccessionPrimary (citable) accession number: P18634
Secondary accession number(s): D6VZ27
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families