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P18634

- ART10_YEAST

UniProt

P18634 - ART10_YEAST

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Protein

Arrestin-related trafficking adapter 10

Gene

ART10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.By similarity

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-related trafficking adapter 10
Gene namesi
Name:ART10
Ordered Locus Names:YLR392C
ORF Names:L8084.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR392c.
SGDiS000004384. ART10.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Arrestin-related trafficking adapter 10PRO_0000203235Add
BLAST

Post-translational modificationi

Ubiquitinated by RSP5.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP18634.
PaxDbiP18634.

Expressioni

Gene expression databases

GenevestigatoriP18634.

Interactioni

Subunit structurei

Interacts with RSP5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399404EBI-27197,EBI-16219

Protein-protein interaction databases

BioGridi31651. 9 interactions.
DIPiDIP-1946N.
IntActiP18634. 2 interactions.
MINTiMINT-405132.
STRINGi4932.YLR392C.

Structurei

3D structure databases

ProteinModelPortaliP18634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ART10 family.Curated

Phylogenomic databases

eggNOGiNOG41805.
InParanoidiP18634.
OMAiRVFPPDN.
OrthoDBiEOG7Z0K5B.

Sequencei

Sequence statusi: Complete.

P18634 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKISISLN PPYNGEFYSS NDQMSGIVSL QLTKALSIRK ISVILKGFSE
60 70 80 90 100
TLTKIDQEYM FQQNGMMMPG QDNKSFHTLM KFEQRVFPPD NVWNALDGSS
110 120 130 140 150
KPFKVKPGSY NYSFQFDKFP RKPECLKNHT AKTVAFVTRS NARLPPTFNS
160 170 180 190 200
HWQEFNKIDN LDLYFYSFGK VIYMVQVQLE LGKSSSWFKP FHKLIREIET
210 220 230 240 250
FEFIPEPKDL IIEPDEDDNE ELNAFSNNSR GNSMVTNNEF FNSSNLKVPS
260 270 280 290 300
KDVKVVNGVG YIKSDRNFSQ ANSILIENGD IRSRPVSSVT STRQSTRLVN
310 320 330 340 350
GMKVFPSTYK MGLPDGESNM RIEVRSRDLK QIYRKDYLFR SGSQNFDKVY
360 370 380 390 400
VVMEGNIASL SKMQITPLKL QLNLLETTTY LSQGIANGNY SSLKLIEIDL
410 420 430 440 450
NQLKSNKPLL DLNEIRENFD GSMFECELRL KDHPILRKLV FNEEDYRHRG
460 470 480 490 500
NRLYSFKTCT IKRTFSLQLL IEWGINGIRK QSEVNIDPVQ IFCQVREHVE
510
AEALPRYVPP PTYTEMAS
Length:518
Mass (Da):59,758
Last modified:November 1, 1997 - v3
Checksum:i65399EA2FFFC2C23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19729 Genomic DNA. Translation: AAB82352.1.
J05463 Genomic DNA. Translation: AAB05631.1.
BK006945 Genomic DNA. Translation: DAA09693.1.
PIRiS55948.
RefSeqiNP_013496.3. NM_001182280.3.

Genome annotation databases

EnsemblFungiiYLR392C; YLR392C; YLR392C.
GeneIDi851108.
KEGGisce:YLR392C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19729 Genomic DNA. Translation: AAB82352.1 .
J05463 Genomic DNA. Translation: AAB05631.1 .
BK006945 Genomic DNA. Translation: DAA09693.1 .
PIRi S55948.
RefSeqi NP_013496.3. NM_001182280.3.

3D structure databases

ProteinModelPortali P18634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31651. 9 interactions.
DIPi DIP-1946N.
IntActi P18634. 2 interactions.
MINTi MINT-405132.
STRINGi 4932.YLR392C.

Proteomic databases

MaxQBi P18634.
PaxDbi P18634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR392C ; YLR392C ; YLR392C .
GeneIDi 851108.
KEGGi sce:YLR392C.

Organism-specific databases

CYGDi YLR392c.
SGDi S000004384. ART10.

Phylogenomic databases

eggNOGi NOG41805.
InParanoidi P18634.
OMAi RVFPPDN.
OrthoDBi EOG7Z0K5B.

Enzyme and pathway databases

BioCyci YEAST:G3O-32457-MONOMER.

Miscellaneous databases

NextBioi 967812.

Gene expression databases

Genevestigatori P18634.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "ATP 10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex."
    Ackerman S.H., Tzagoloff A.
    J. Biol. Chem. 265:9952-9959(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast."
    Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D.
    Mol. Syst. Biol. 3:116-116(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
  7. "Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface."
    Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D.
    Cell 135:714-725(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiART10_YEAST
AccessioniPrimary (citable) accession number: P18634
Secondary accession number(s): D6VZ27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3