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Protein

Fos-related antigen 2

Gene

FOSL2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 2
Short name:
FRA-2
Gene namesi
Name:FOSL2
Synonyms:FRA-2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764821 – 323Fos-related antigen 2Add BLAST323

Proteomic databases

PaxDbiP18625.

Expressioni

Inductioni

Serum inducible, and cycloheximide superinducible.

Gene expression databases

ExpressionAtlasiP18625. baseline and differential.

Interactioni

Subunit structurei

Heterodimer with JUN.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016284.

Structurei

3D structure databases

ProteinModelPortaliP18625.
SMRiP18625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 187bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 128Basic motifPROSITE-ProRule annotation3
Regioni129 – 136Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP18625.
KOiK09030.
PhylomeDBiP18625.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF36. PTHR23351:SF36. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P18625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQDYPGSFD TSSRGSSGSP GHPEPYSAGA AQQKFRVDMP GSGSAFIPTI
60 70 80 90 100
NAITTSQDLQ WMVQPTVITS MSSPYSRSHP YSHPLPPLSS VAGHTALQRP
110 120 130 140 150
GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE
160 170 180 190 200
KLQAETEVLE EEKSVLQKEI AELQKEKEKL EFMLVAHSPV CKISPEERRS
210 220 230 240 250
PPTSSLQSVR TGASGAVVVK QEPVEEEIPS SSLVLDKAQR SVIKPISIAG
260 270 280 290 300
GYYGEEALNT PIVVTSTPAI TPGSSNLVFT YPNVLDQESP LSPSESCSKA
310 320
HRRSSSSGDQ SSDSLNSPTL LAL
Length:323
Mass (Da):35,242
Last modified:November 1, 1990 - v1
Checksum:iE5C2468588F4C3F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10876 Genomic DNA. Translation: BAA01644.1.
PIRiA35909.
RefSeqiNP_001039301.1. NM_001045836.1.
UniGeneiGga.47044.

Genome annotation databases

EnsembliENSGALT00000016303; ENSGALP00000016284; ENSGALG00000010036.
GeneIDi421416.
KEGGigga:421416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10876 Genomic DNA. Translation: BAA01644.1.
PIRiA35909.
RefSeqiNP_001039301.1. NM_001045836.1.
UniGeneiGga.47044.

3D structure databases

ProteinModelPortaliP18625.
SMRiP18625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016284.

Proteomic databases

PaxDbiP18625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016303; ENSGALP00000016284; ENSGALG00000010036.
GeneIDi421416.
KEGGigga:421416.

Organism-specific databases

CTDi2355.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP18625.
KOiK09030.
PhylomeDBiP18625.

Miscellaneous databases

PROiP18625.

Gene expression databases

ExpressionAtlasiP18625. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF36. PTHR23351:SF36. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOSL2_CHICK
AccessioniPrimary (citable) accession number: P18625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 15, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.