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Protein

Integrin alpha-1

Gene

Itga1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi497 – 505Sequence analysis9
Calcium bindingi579 – 587Sequence analysis9
Calcium bindingi641 – 649Sequence analysis9

GO - Molecular functioni

  • collagen binding Source: RGD
  • collagen binding involved in cell-matrix adhesion Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein phosphatase binding Source: Ensembl
  • receptor binding Source: RGD

GO - Biological processi

  • activation of MAPK activity Source: RGD
  • cell chemotaxis Source: RGD
  • cellular extravasation Source: Ensembl
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  • neuron projection morphogenesis Source: RGD
  • neutrophil chemotaxis Source: Ensembl
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
  • vasodilation Source: RGD

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-216083. Integrin cell surface interactions.
R-RNO-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
Gene namesi
Name:Itga1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2923. Itga1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1142ExtracellularSequence analysisAdd BLAST1114
Transmembranei1143 – 1165HelicalSequence analysisAdd BLAST23
Topological domaini1166 – 1180CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • acrosomal vesicle Source: RGD
  • basal part of cell Source: Ensembl
  • external side of plasma membrane Source: RGD
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • integrin alpha1-beta1 complex Source: Ensembl
  • membrane Source: RGD
  • membrane raft Source: RGD
  • neuron projection Source: RGD
  • perikaryon Source: RGD

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001623129 – 1180Integrin alpha-1Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 92By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi687 ↔ 696By similarity
Glycosylationi698N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi702 ↔ 755By similarity
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi807 ↔ 813By similarity
Glycosylationi820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi877 ↔ 885By similarity
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1007N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1029 ↔ 1062By similarity
Disulfide bondi1066 ↔ 1073By similarity
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1114N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18614.
PRIDEiP18614.

PTM databases

iPTMnetiP18614.
PhosphoSitePlusiP18614.
UniCarbKBiP18614.

Expressioni

Gene expression databases

BgeeiENSRNOG00000053550.
GenevisibleiP18614. RN.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity). Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling (By similarity).By similarity

GO - Molecular functioni

  • collagen binding Source: RGD
  • collagen binding involved in cell-matrix adhesion Source: Ensembl
  • protein phosphatase binding Source: Ensembl
  • receptor binding Source: RGD

Protein-protein interaction databases

IntActiP18614. 1 interactor.
MINTiMINT-1889950.
STRINGi10116.ENSRNOP00000016353.

Structurei

Secondary structure

11180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi171 – 178Combined sources8
Helixi186 – 197Combined sources12
Beta strandi208 – 222Combined sources15
Turni224 – 226Combined sources3
Helixi230 – 238Combined sources9
Helixi250 – 259Combined sources10
Turni260 – 262Combined sources3
Helixi264 – 266Combined sources3
Beta strandi273 – 282Combined sources10
Helixi287 – 289Combined sources3
Helixi290 – 299Combined sources10
Beta strandi302 – 309Combined sources8
Helixi311 – 315Combined sources5
Helixi321 – 328Combined sources8
Helixi335 – 338Combined sources4
Beta strandi339 – 345Combined sources7
Helixi346 – 350Combined sources5
Helixi352 – 359Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CK4X-ray2.20A/B167-364[»]
1MHPX-ray2.80A/B169-360[»]
2B2XX-ray2.20A/B151-364[»]
ProteinModelPortaliP18614.
SMRiP18614.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 91FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati101 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini175 – 364VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati365 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati422 – 474FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati475 – 537FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati556 – 614FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati618 – 678FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1168 – 1172GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB7. Eukaryota.
ENOG410YEM8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP18614.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG091G00TK.
PhylomeDBiP18614.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRRPASLE VTVACIWLLT VILGFCVSFN VDVKNSMSFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKARTGDVY KCPVGRERAM PCVKLDLPVN
110 120 130 140 150
TSIPNVTEIK ENMTFGSTLV TNPNGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS FAPVQECSTQ LDIVIVLDGS NSIYPWESVI AFLNDLLKRM
210 220 230 240 250
DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAANKI GRQGGLQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNYRL KQVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GHYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKALGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA NQMVIPHNTT FQTEPAKMNE PLASYLGYTV NSATIPGDVL
460 470 480 490 500
YIAGQPRYNH TGQVVIYKME DGNINILQTL GGEQIGSYFG SVLTTIDIDK
510 520 530 540 550
DSYTDLLLVG APMYMGTEKE EQGKVYVYAV NQTRFEYQMS LEPIRQTCCS
560 570 580 590 600
SLKDNSCTKE NKNEPCGARF GTAIAAVKDL NVDGFNDVVI GAPLEDDHAG
610 620 630 640 650
AVYIYHGSGK TIREAYAQRI PSGGDGKTLK FFGQSIHGEM DLNGDGLTDV
660 670 680 690 700
TIGGLGGAAL FWARDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT
710 720 730 740 750
MCFHVKLKSK EDSIYEADLQ YRVTLDSLRQ ISRSFFSGTQ ERKIQRNITV
760 770 780 790 800
RESECIRHSF YMLDKHDFQD SVRVTLDFNL TDPENGPVLD DALPNSVHEH
810 820 830 840 850
IPFAKDCGNK ERCISDLTLN VSTTEKSLLI VKSQHDKFNV SLTVKNKGDS
860 870 880 890 900
AYNTRTVVQH SPNLIFSGIE EIQKDSCESN QNITCRVGYP FLRAGETVTF
910 920 930 940 950
KIIFQFNTSH LSENAIIHLS ATSDSEEPLE SLNDNEVNIS IPVKYEVGLQ
960 970 980 990 1000
FYSSASEHHI SVAANETIPE FINSTEDIGN EINVFYTIRK RGHFPMPELQ
1010 1020 1030 1040 1050
LSISFPNLTA DGYPVLYPIG WSSSDNVNCR PRSLEDPFGI NSGKKMTISK
1060 1070 1080 1090 1100
SEVLKRGTIQ DCSSTCGVAT ITCSLLPSDL SQVNVSLLLW KPTFIRAHFS
1110 1120 1130 1140 1150
SLNLTLRGEL KSENSSLTLS SSNRKRELAI QISKDGLPGR VPLWVILLSA
1160 1170 1180
FAGLLLLMLL ILALWKIGFF KRPLKKKMEK
Length:1,180
Mass (Da):130,809
Last modified:November 1, 1990 - v1
Checksum:i8E5DA2BE02362EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52140 mRNA. Translation: CAA36384.1.
PIRiA35854.
RefSeqiNP_112256.1. NM_030994.2.
UniGeneiRn.91044.

Genome annotation databases

EnsembliENSRNOT00000086114; ENSRNOP00000074337; ENSRNOG00000053550.
GeneIDi25118.
KEGGirno:25118.

Similar proteinsi

Entry informationi

Entry nameiITA1_RAT
AccessioniPrimary (citable) accession number: P18614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: August 30, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families