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P18608

- HMGN1_MOUSE

UniProt

P18608 - HMGN1_MOUSE

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Protein

Non-histone chromosomal protein HMG-14

Gene

Hmgn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.1 Publication

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin organization Source: MGI
  2. post-embryonic camera-type eye morphogenesis Source: MGI
  3. pyrimidine dimer repair by nucleotide-excision repair Source: MGI
  4. regulation of development, heterochronic Source: MGI
  5. regulation of epithelial cell proliferation Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: MGI
  7. response to UV-B Source: MGI
  8. response to UV-C Source: MGI
  9. transcription-coupled nucleotide-excision repair Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:Hmgn1
Synonyms:Hmg-14, Hmg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:96120. Hmgn1.

Subcellular locationi

Nucleus. Cytoplasm By similarity
Note: Cytoplasmic enrichment upon phosphorylation.By similarity

GO - Cellular componenti

  1. chromatin Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 9695Non-histone chromosomal protein HMG-14PRO_0000206692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine; by RPS6KA52 Publications
Modified residuei13 – 131N6-acetyllysine1 Publication
Modified residuei20 – 201Phosphoserine; by RPS6KA51 Publication
Modified residuei24 – 241Phosphoserine; by RPS6KA51 Publication
Modified residuei26 – 261N6-acetyllysine1 Publication
Modified residuei84 – 841Phosphoserine1 Publication
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei95 – 951Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation favors cytoplasmic localization By similarity. Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP18608.
PaxDbiP18608.
PRIDEiP18608.

PTM databases

PhosphoSiteiP18608.

Expressioni

Gene expression databases

BgeeiP18608.
CleanExiMM_HMGN1.
ExpressionAtlasiP18608. baseline.
GenevestigatoriP18608.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061012.

Structurei

3D structure databases

ProteinModelPortaliP18608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiNOG29368.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP18608.
KOiK11299.
OMAiEVANKET.
OrthoDBiEOG76MKC1.
PhylomeDBiP18608.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18608-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV
60 70 80 90
QIKGKRGAKG KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD
Length:96
Mass (Da):10,152
Last modified:January 23, 2007 - v2
Checksum:i65C4C09DE0973786
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53476 mRNA. Translation: CAA37569.1.
BC083138 mRNA. Translation: AAH83138.1.
BC088834 mRNA. Translation: AAH88834.1.
CCDSiCCDS28353.1.
PIRiS11219.
RefSeqiNP_032277.3. NM_008251.3.
XP_006544284.1. XM_006544221.1.
UniGeneiMm.2756.

Genome annotation databases

EnsembliENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681.
GeneIDi102641809.
15312.
KEGGimmu:102641809.
mmu:15312.
UCSCiuc008aco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53476 mRNA. Translation: CAA37569.1 .
BC083138 mRNA. Translation: AAH83138.1 .
BC088834 mRNA. Translation: AAH88834.1 .
CCDSi CCDS28353.1.
PIRi S11219.
RefSeqi NP_032277.3. NM_008251.3.
XP_006544284.1. XM_006544221.1.
UniGenei Mm.2756.

3D structure databases

ProteinModelPortali P18608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000061012.

PTM databases

PhosphoSitei P18608.

Proteomic databases

MaxQBi P18608.
PaxDbi P18608.
PRIDEi P18608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050884 ; ENSMUSP00000061012 ; ENSMUSG00000040681 .
GeneIDi 102641809.
15312.
KEGGi mmu:102641809.
mmu:15312.
UCSCi uc008aco.1. mouse.

Organism-specific databases

CTDi 3150.
MGIi MGI:96120. Hmgn1.

Phylogenomic databases

eggNOGi NOG29368.
GeneTreei ENSGT00730000110877.
HOGENOMi HOG000116394.
HOVERGENi HBG073479.
InParanoidi P18608.
KOi K11299.
OMAi EVANKET.
OrthoDBi EOG76MKC1.
PhylomeDBi P18608.

Miscellaneous databases

ChiTaRSi HMGN1. mouse.
NextBioi 287951.
PROi P18608.
SOURCEi Search...

Gene expression databases

Bgeei P18608.
CleanExi MM_HMGN1.
ExpressionAtlasi P18608. baseline.
Genevestigatori P18608.

Family and domain databases

InterProi IPR000079. HMGN_fam.
[Graphical view ]
PANTHERi PTHR23087. PTHR23087. 1 hit.
Pfami PF01101. HMG14_17. 1 hit.
[Graphical view ]
PRINTSi PR00925. NONHISHMG17.
SMARTi SM00527. HMG17. 1 hit.
[Graphical view ]
PROSITEi PS00355. HMG14_17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse non-histone chromosomal protein HMG-14 cDNA sequence."
    Landsman D., Bustin M.
    Nucleic Acids Res. 18:5311-5311(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Limb.
  3. "Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells."
    Vartiainen E., Palvimo J., Mahonen A., Linnala-Kankkunen A., Maeenpaeae P.H.
    FEBS Lett. 228:45-48(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19.
  4. "A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes."
    Barratt M.J., Hazzalin C.A., Zhelev N., Mahadevan L.C.
    EMBO J. 13:4524-4535(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-7.
  5. "Chromosomal protein HMGN1 modulates histone H3 phosphorylation."
    Lim J.-H., Catez F., Birger Y., West K.L., Prymakowska-Bosak M., Postnikov Y.V., Bustin M.
    Mol. Cell 15:573-584(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-7; SER-20 AND SER-24.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-87 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-13 AND LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHMGN1_MOUSE
AccessioniPrimary (citable) accession number: P18608
Secondary accession number(s): Q5HZY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3