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Protein

Non-histone chromosomal protein HMG-14

Gene

Hmgn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • nucleosomal DNA binding Source: InterPro

GO - Biological processi

  • chromatin organization Source: MGI
  • positive regulation of NAD+ ADP-ribosyltransferase activity Source: MGI
  • post-embryonic camera-type eye morphogenesis Source: MGI
  • pyrimidine dimer repair by nucleotide-excision repair Source: MGI
  • regulation of development, heterochronic Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • response to UV-B Source: MGI
  • response to UV-C Source: MGI
  • transcription-coupled nucleotide-excision repair Source: MGI

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:Hmgn1
Synonyms:Hmg-14, Hmg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96120 Hmgn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066922 – 96Non-histone chromosomal protein HMG-14Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by RPS6KA52 Publications1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei20Phosphoserine; by RPS6KA51 Publication1
Modified residuei24ADP-ribosylserine; alternateBy similarity1
Modified residuei24Phosphoserine; alternate; by RPS6KA51 Publication1
Modified residuei26N6-acetyllysineCombined sources1
Modified residuei80PhosphothreonineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation favors cytoplasmic localization (By similarity). Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity2 Publications

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP18608
MaxQBiP18608
PaxDbiP18608
PeptideAtlasiP18608
PRIDEiP18608
TopDownProteomicsiP18608

PTM databases

iPTMnetiP18608
PhosphoSitePlusiP18608

Expressioni

Gene expression databases

BgeeiENSMUSG00000040681
CleanExiMM_HMGN1
ExpressionAtlasiP18608 baseline and differential
GenevisibleiP18608 MM

Interactioni

Protein-protein interaction databases

BioGridi200332, 1 interactor
STRINGi10090.ENSMUSP00000061012

Structurei

3D structure databases

ProteinModelPortaliP18608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J491 Eukaryota
ENOG410ZFVH LUCA
GeneTreeiENSGT00730000110877
HOGENOMiHOG000116394
HOVERGENiHBG073479
InParanoidiP18608
KOiK11299
OMAiPAVNREK
OrthoDBiEOG091G1AKE
PhylomeDBiP18608

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV
60 70 80 90
QIKGKRGAKG KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD
Length:96
Mass (Da):10,152
Last modified:January 23, 2007 - v2
Checksum:i65C4C09DE0973786
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53476 mRNA Translation: CAA37569.1
BC083138 mRNA Translation: AAH83138.1
BC088834 mRNA Translation: AAH88834.1
CCDSiCCDS28353.1
PIRiS11219
RefSeqiNP_032277.3, NM_008251.3
UniGeneiMm.2756

Genome annotation databases

EnsembliENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681
GeneIDi15312
KEGGimmu:15312
UCSCiuc008aco.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHMGN1_MOUSE
AccessioniPrimary (citable) accession number: P18608
Secondary accession number(s): Q5HZY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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