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P18608

- HMGN1_MOUSE

UniProt

P18608 - HMGN1_MOUSE

Protein

Non-histone chromosomal protein HMG-14

Gene

Hmgn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin organization Source: MGI
    2. post-embryonic camera-type eye morphogenesis Source: MGI
    3. pyrimidine dimer repair by nucleotide-excision repair Source: MGI
    4. regulation of development, heterochronic Source: MGI
    5. regulation of epithelial cell proliferation Source: MGI
    6. regulation of transcription from RNA polymerase II promoter Source: MGI
    7. response to UV-B Source: MGI
    8. response to UV-C Source: MGI
    9. transcription-coupled nucleotide-excision repair Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-histone chromosomal protein HMG-14
    Alternative name(s):
    High mobility group nucleosome-binding domain-containing protein 1
    Gene namesi
    Name:Hmgn1
    Synonyms:Hmg-14, Hmg14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:96120. Hmgn1.

    Subcellular locationi

    Nucleus. Cytoplasm By similarity
    Note: Cytoplasmic enrichment upon phosphorylation.By similarity

    GO - Cellular componenti

    1. chromatin Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 9695Non-histone chromosomal protein HMG-14PRO_0000206692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71Phosphoserine; by RPS6KA52 Publications
    Modified residuei13 – 131N6-acetyllysine1 Publication
    Modified residuei20 – 201Phosphoserine; by RPS6KA51 Publication
    Modified residuei24 – 241Phosphoserine; by RPS6KA51 Publication
    Modified residuei26 – 261N6-acetyllysine1 Publication
    Modified residuei84 – 841Phosphoserine1 Publication
    Modified residuei87 – 871Phosphoserine1 Publication
    Modified residuei95 – 951Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation favors cytoplasmic localization By similarity. Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP18608.
    PRIDEiP18608.

    PTM databases

    PhosphoSiteiP18608.

    Expressioni

    Gene expression databases

    BgeeiP18608.
    CleanExiMM_HMGN1.
    GenevestigatoriP18608.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000061012.

    Structurei

    3D structure databases

    ProteinModelPortaliP18608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGN family.Curated

    Phylogenomic databases

    eggNOGiNOG29368.
    GeneTreeiENSGT00730000110877.
    HOGENOMiHOG000116394.
    HOVERGENiHBG073479.
    InParanoidiP18608.
    KOiK11299.
    OMAiEVANKET.
    OrthoDBiEOG76MKC1.
    PhylomeDBiP18608.

    Family and domain databases

    InterProiIPR000079. HMGN_fam.
    [Graphical view]
    PANTHERiPTHR23087. PTHR23087. 1 hit.
    PfamiPF01101. HMG14_17. 1 hit.
    [Graphical view]
    PRINTSiPR00925. NONHISHMG17.
    SMARTiSM00527. HMG17. 1 hit.
    [Graphical view]
    PROSITEiPS00355. HMG14_17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18608-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV   50
    QIKGKRGAKG KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD 96
    Length:96
    Mass (Da):10,152
    Last modified:January 23, 2007 - v2
    Checksum:i65C4C09DE0973786
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53476 mRNA. Translation: CAA37569.1.
    BC083138 mRNA. Translation: AAH83138.1.
    BC088834 mRNA. Translation: AAH88834.1.
    CCDSiCCDS28353.1.
    PIRiS11219.
    RefSeqiNP_032277.3. NM_008251.3.
    XP_006544284.1. XM_006544221.1.
    UniGeneiMm.2756.

    Genome annotation databases

    EnsembliENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681.
    GeneIDi102641809.
    15312.
    KEGGimmu:102641809.
    mmu:15312.
    UCSCiuc008aco.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53476 mRNA. Translation: CAA37569.1 .
    BC083138 mRNA. Translation: AAH83138.1 .
    BC088834 mRNA. Translation: AAH88834.1 .
    CCDSi CCDS28353.1.
    PIRi S11219.
    RefSeqi NP_032277.3. NM_008251.3.
    XP_006544284.1. XM_006544221.1.
    UniGenei Mm.2756.

    3D structure databases

    ProteinModelPortali P18608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000061012.

    PTM databases

    PhosphoSitei P18608.

    Proteomic databases

    PaxDbi P18608.
    PRIDEi P18608.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050884 ; ENSMUSP00000061012 ; ENSMUSG00000040681 .
    GeneIDi 102641809.
    15312.
    KEGGi mmu:102641809.
    mmu:15312.
    UCSCi uc008aco.1. mouse.

    Organism-specific databases

    CTDi 3150.
    MGIi MGI:96120. Hmgn1.

    Phylogenomic databases

    eggNOGi NOG29368.
    GeneTreei ENSGT00730000110877.
    HOGENOMi HOG000116394.
    HOVERGENi HBG073479.
    InParanoidi P18608.
    KOi K11299.
    OMAi EVANKET.
    OrthoDBi EOG76MKC1.
    PhylomeDBi P18608.

    Miscellaneous databases

    ChiTaRSi HMGN1. mouse.
    NextBioi 287951.
    PROi P18608.
    SOURCEi Search...

    Gene expression databases

    Bgeei P18608.
    CleanExi MM_HMGN1.
    Genevestigatori P18608.

    Family and domain databases

    InterProi IPR000079. HMGN_fam.
    [Graphical view ]
    PANTHERi PTHR23087. PTHR23087. 1 hit.
    Pfami PF01101. HMG14_17. 1 hit.
    [Graphical view ]
    PRINTSi PR00925. NONHISHMG17.
    SMARTi SM00527. HMG17. 1 hit.
    [Graphical view ]
    PROSITEi PS00355. HMG14_17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse non-histone chromosomal protein HMG-14 cDNA sequence."
      Landsman D., Bustin M.
      Nucleic Acids Res. 18:5311-5311(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Limb.
    3. "Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells."
      Vartiainen E., Palvimo J., Mahonen A., Linnala-Kankkunen A., Maeenpaeae P.H.
      FEBS Lett. 228:45-48(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-19.
    4. "A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes."
      Barratt M.J., Hazzalin C.A., Zhelev N., Mahadevan L.C.
      EMBO J. 13:4524-4535(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-7.
    5. "Chromosomal protein HMGN1 modulates histone H3 phosphorylation."
      Lim J.-H., Catez F., Birger Y., West K.L., Prymakowska-Bosak M., Postnikov Y.V., Bustin M.
      Mol. Cell 15:573-584(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-7; SER-20 AND SER-24.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-87 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-13 AND LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiHMGN1_MOUSE
    AccessioniPrimary (citable) accession number: P18608
    Secondary accession number(s): Q5HZY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3