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Protein

Non-histone chromosomal protein HMG-14

Gene

Hmgn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • nucleosomal DNA binding Source: InterPro

GO - Biological processi

  • chromatin organization Source: MGI
  • positive regulation of NAD+ ADP-ribosyltransferase activity Source: MGI
  • post-embryonic camera-type eye morphogenesis Source: MGI
  • pyrimidine dimer repair by nucleotide-excision repair Source: MGI
  • regulation of development, heterochronic Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to UV-B Source: MGI
  • response to UV-C Source: MGI
  • transcription-coupled nucleotide-excision repair Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:Hmgn1
Synonyms:Hmg-14, Hmg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96120. Hmgn1.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Cytoplasmic enrichment upon phosphorylation.By similarity

GO - Cellular componenti

  • chromatin Source: InterPro
  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066922 – 96Non-histone chromosomal protein HMG-14Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by RPS6KA52 Publications1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei20Phosphoserine; by RPS6KA51 Publication1
Modified residuei24Phosphoserine; by RPS6KA51 Publication1
Modified residuei26N6-acetyllysineCombined sources1
Modified residuei80PhosphothreonineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation favors cytoplasmic localization (By similarity). Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP18608.
MaxQBiP18608.
PaxDbiP18608.
PeptideAtlasiP18608.
PRIDEiP18608.
TopDownProteomicsiP18608.

PTM databases

iPTMnetiP18608.
PhosphoSitePlusiP18608.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040681.
CleanExiMM_HMGN1.
ExpressionAtlasiP18608. baseline and differential.
GenevisibleiP18608. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061012.

Structurei

3D structure databases

ProteinModelPortaliP18608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J491. Eukaryota.
ENOG410ZFVH. LUCA.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP18608.
KOiK11299.
OMAiPDKAEPK.
OrthoDBiEOG091G1AKE.
PhylomeDBiP18608.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV
60 70 80 90
QIKGKRGAKG KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD
Length:96
Mass (Da):10,152
Last modified:January 23, 2007 - v2
Checksum:i65C4C09DE0973786
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53476 mRNA. Translation: CAA37569.1.
BC083138 mRNA. Translation: AAH83138.1.
BC088834 mRNA. Translation: AAH88834.1.
CCDSiCCDS28353.1.
PIRiS11219.
RefSeqiNP_032277.3. NM_008251.3.
UniGeneiMm.2756.

Genome annotation databases

EnsembliENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681.
GeneIDi15312.
KEGGimmu:15312.
UCSCiuc008aco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53476 mRNA. Translation: CAA37569.1.
BC083138 mRNA. Translation: AAH83138.1.
BC088834 mRNA. Translation: AAH88834.1.
CCDSiCCDS28353.1.
PIRiS11219.
RefSeqiNP_032277.3. NM_008251.3.
UniGeneiMm.2756.

3D structure databases

ProteinModelPortaliP18608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061012.

PTM databases

iPTMnetiP18608.
PhosphoSitePlusiP18608.

Proteomic databases

EPDiP18608.
MaxQBiP18608.
PaxDbiP18608.
PeptideAtlasiP18608.
PRIDEiP18608.
TopDownProteomicsiP18608.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681.
GeneIDi15312.
KEGGimmu:15312.
UCSCiuc008aco.1. mouse.

Organism-specific databases

CTDi3150.
MGIiMGI:96120. Hmgn1.

Phylogenomic databases

eggNOGiENOG410J491. Eukaryota.
ENOG410ZFVH. LUCA.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP18608.
KOiK11299.
OMAiPDKAEPK.
OrthoDBiEOG091G1AKE.
PhylomeDBiP18608.

Enzyme and pathway databases

ReactomeiR-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

ChiTaRSiHmgn1. mouse.
PROiP18608.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040681.
CleanExiMM_HMGN1.
ExpressionAtlasiP18608. baseline and differential.
GenevisibleiP18608. MM.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN1_MOUSE
AccessioniPrimary (citable) accession number: P18608
Secondary accession number(s): Q5HZY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.