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P18608 (HMGN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene names
Name:Hmgn1
Synonyms:Hmg-14, Hmg14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. Ref.5

Subcellular location

Nucleus. Cytoplasm By similarity. Note: Cytoplasmic enrichment upon phosphorylation By similarity.

Post-translational modification

Phosphorylation favors cytoplasmic localization By similarity. Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.

Sequence similarities

Belongs to the HMGN family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandDNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin organization

Inferred from mutant phenotype PubMed 12660172. Source: MGI

post-embryonic camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 16466397. Source: MGI

pyrimidine dimer repair by nucleotide-excision repair

Inferred from mutant phenotype PubMed 12660172. Source: MGI

regulation of development, heterochronic

Inferred from genetic interaction PubMed 11133167. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16466397. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 21278158. Source: MGI

response to UV-B

Inferred from mutant phenotype PubMed 12660172. Source: MGI

response to UV-C

Inferred from direct assay PubMed 12660172. Source: MGI

transcription-coupled nucleotide-excision repair

Inferred from mutant phenotype PubMed 12660172. Source: MGI

   Cellular_componentchromatin

Inferred from electronic annotation. Source: InterPro

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from direct assay PubMed 11133167PubMed 16466397. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin binding

Inferred from direct assay PubMed 12660172. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 9695Non-histone chromosomal protein HMG-14
PRO_0000206692

Amino acid modifications

Modified residue71Phosphoserine; by RPS6KA5 Ref.4 Ref.5
Modified residue131N6-acetyllysine Ref.8
Modified residue201Phosphoserine; by RPS6KA5 Ref.5
Modified residue241Phosphoserine; by RPS6KA5 Ref.5
Modified residue261N6-acetyllysine Ref.8
Modified residue841Phosphoserine Ref.6
Modified residue871Phosphoserine Ref.6
Modified residue951Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P18608 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 65C4C09DE0973786

FASTA9610,152
        10         20         30         40         50         60 
MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV QIKGKRGAKG 

        70         80         90 
KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD 

« Hide

References

« Hide 'large scale' references
[1]"Mouse non-histone chromosomal protein HMG-14 cDNA sequence."
Landsman D., Bustin M.
Nucleic Acids Res. 18:5311-5311(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Limb.
[3]"Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells."
Vartiainen E., Palvimo J., Mahonen A., Linnala-Kankkunen A., Maeenpaeae P.H.
FEBS Lett. 228:45-48(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-19.
[4]"A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes."
Barratt M.J., Hazzalin C.A., Zhelev N., Mahadevan L.C.
EMBO J. 13:4524-4535(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-7.
[5]"Chromosomal protein HMGN1 modulates histone H3 phosphorylation."
Lim J.-H., Catez F., Birger Y., West K.L., Prymakowska-Bosak M., Postnikov Y.V., Bustin M.
Mol. Cell 15:573-584(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION AT SER-7; SER-20 AND SER-24.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-87 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[7]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[8]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-13 AND LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53476 mRNA. Translation: CAA37569.1.
BC083138 mRNA. Translation: AAH83138.1.
BC088834 mRNA. Translation: AAH88834.1.
PIRS11219.
RefSeqNP_032277.3. NM_008251.3.
XP_006544284.1. XM_006544221.1.
UniGeneMm.2756.

3D structure databases

ProteinModelPortalP18608.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000061012.

PTM databases

PhosphoSiteP18608.

Proteomic databases

PaxDbP18608.
PRIDEP18608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681.
GeneID102641809.
15312.
KEGGmmu:100044391.
mmu:15312.
UCSCuc008aco.1. mouse.

Organism-specific databases

CTD3150.
MGIMGI:96120. Hmgn1.

Phylogenomic databases

eggNOGNOG29368.
GeneTreeENSGT00730000110877.
HOGENOMHOG000116394.
HOVERGENHBG073479.
InParanoidP18608.
KOK11299.
OMAENKKAQS.
OrthoDBEOG76MKC1.
PhylomeDBP18608.

Gene expression databases

BgeeP18608.
CleanExMM_HMGN1.
GenevestigatorP18608.

Family and domain databases

InterProIPR000079. HMGN_fam.
[Graphical view]
PANTHERPTHR23087. PTHR23087. 1 hit.
PfamPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSPR00925. NONHISHMG17.
SMARTSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHMGN1. mouse.
NextBio287951.
PROP18608.
SOURCESearch...

Entry information

Entry nameHMGN1_MOUSE
AccessionPrimary (citable) accession number: P18608
Secondary accession number(s): Q5HZY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot