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Reviewed, UniProtKB/Swiss-Prot P18605 (ARY1_RABIT)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arylamine N-acetyltransferase 1
    EC=2.3.1.5
Alternative name(s):
    Arylamide acetylase 1
    Monomorphic arylamine N-acetyltransferase
      Short name=MNAT
    N-acetyltransferase type 1
      Short name=NAT-1
Gene names
Name: NAT1
Synonyms: AAC1
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the arylamine N-acetyltransferase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionarylamine N-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Arylamine N-acetyltransferase 1
PRO_0000107913

Regions

Region106 – 1072Substrate binding By similarity

Sites

Active site681Acyl-thioester intermediate By similarity
Active site1071 By similarity
Active site1221 By similarity
Binding site1031Coenzyme A By similarity
Binding site1041Coenzyme A; via amide nitrogen By similarity
Binding site2081Coenzyme A By similarity
Binding site2141Coenzyme A By similarity

Experimental info

Sequence conflict2851N → H in BAA00989. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P18605-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 31175E83651EE693

FASTA29033,780
        10         20         30         40         50         60 
MDIEAYYQRI GYKNPRNKLD LESLTDIFQH QIRTVPYENL SIHCGESMEL DLEAIFDQIV 

        70         80         90        100        110        120 
RRNRGGWCLQ VNYLLYWALT TTGFETTMLG GFVCGSHTDK YSTGMIHLIV QVTINGRNYI 

       130        140        150        160        170        180 
VDAGFGRSYQ MWQPVELISG KDQPQVPSIF RLREEGETWY LDQIRRQQHV PDQEFLNSEL 

       190        200        210        220        230        240 
LERKTHRKLY CFTLQPRTIE EFESANTYLQ ISPSSPFLDK SICSLQTPEG VHCLVGLILT 

       250        260        270        280        290 
FRTYNYKENT DLVEFKVLTE EEVEEVLKTI FNISLGKKLV SKNGNLFFTI

« Hide

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References

[1]"Nucleotide sequence of rabbit NAT1 encoding monomorphic arylamine N-acetyltransferase."
Blum M., Heim M., Meyer U.A.
Nucleic Acids Res. 18:5287-5287(1990) [PubMed: 2402454] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: New Zealand white.
Tissue: Liver.
[2]"Molecular and genetic analyses of arylamine N-acetyltransferase polymorphism of rabbit liver."
Sasaki Y., Ohsako S., Deguchi T.
J. Biol. Chem. 266:13243-13250(1991) [PubMed: 2071601] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.

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Cross-references

Sequence databases

X53765 Genomic DNA. Translation: CAA37785.1.
D10108 Genomic DNA. Translation: BAA00989.1.
PIRXYRBM. C39870.

3D structure databases

HSSPHSSP built from PDB template 1GX3 based on UniProtKB O86309.
SMRP18605. Positions 2-290.
ModBaseSearch...

Phylogenomic databases

HOVERGENP18605.

Enzyme and pathway databases

BRENDA2.3.1.5. 255.

Family and domain databases

InterProIPR001447. N-AcTrfase.
[Graphical view]
PANTHERPTHR11786. Acetyltransf2. 1 hit.
PfamPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSPR01543. ANATRNSFRASE.
ProDomPD002783. Acetyltransf2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

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Entry information

Entry nameARY1_RABIT
AccessionPrimary (citable) accession number: P18605
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents