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Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-thioester intermediateBy similarity
Binding sitei103 – 1031Coenzyme ABy similarity
Binding sitei104 – 1041Coenzyme A; via amide nitrogenBy similarity
Active sitei107 – 1071By similarity
Active sitei122 – 1221By similarity
Binding sitei208 – 2081Coenzyme ABy similarity
Binding sitei214 – 2141Coenzyme ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name:
MNAT
N-acetyltransferase type 1
Short name:
NAT-1
Gene namesi
Name:NAT1
Synonyms:AAC1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Arylamine N-acetyltransferase 1PRO_0000107913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024297.

Structurei

3D structure databases

ProteinModelPortaliP18605.
SMRiP18605. Positions 2-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiP18605.
KOiK00622.
TreeFamiTF106311.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

P18605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEAYYQRI GYKNPRNKLD LESLTDIFQH QIRTVPYENL SIHCGESMEL
60 70 80 90 100
DLEAIFDQIV RRNRGGWCLQ VNYLLYWALT TTGFETTMLG GFVCGSHTDK
110 120 130 140 150
YSTGMIHLIV QVTINGRNYI VDAGFGRSYQ MWQPVELISG KDQPQVPSIF
160 170 180 190 200
RLREEGETWY LDQIRRQQHV PDQEFLNSEL LERKTHRKLY CFTLQPRTIE
210 220 230 240 250
EFESANTYLQ ISPSSPFLDK SICSLQTPEG VHCLVGLILT FRTYNYKENT
260 270 280 290
DLVEFKVLTE EEVEEVLKTI FNISLGKKLV SKNGNLFFTI
Length:290
Mass (Da):33,780
Last modified:November 1, 1990 - v1
Checksum:i31175E83651EE693
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851N → H in BAA00989 (PubMed:2071601).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53765 Genomic DNA. Translation: CAA37785.1.
D10108 Genomic DNA. Translation: BAA00989.1.
PIRiC39870. XYRBM.
RefSeqiNP_001164620.1. NM_001171149.1.
XP_008265477.1. XM_008267255.1.
XP_008265479.1. XM_008267257.1.
UniGeneiOcu.7552.

Genome annotation databases

GeneIDi100328959.
KEGGiocu:100328959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53765 Genomic DNA. Translation: CAA37785.1.
D10108 Genomic DNA. Translation: BAA00989.1.
PIRiC39870. XYRBM.
RefSeqiNP_001164620.1. NM_001171149.1.
XP_008265477.1. XM_008267255.1.
XP_008265479.1. XM_008267257.1.
UniGeneiOcu.7552.

3D structure databases

ProteinModelPortaliP18605.
SMRiP18605. Positions 2-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328959.
KEGGiocu:100328959.

Organism-specific databases

CTDi9.

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiP18605.
KOiK00622.
TreeFamiTF106311.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.
ProtoNetiSearch...

Entry informationi

Entry nameiARY1_RABIT
AccessioniPrimary (citable) accession number: P18605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.