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Protein

Potassium-transporting ATPase subunit beta

Gene

Atp4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

  • hydrogen:potassium-exchanging ATPase activity Source: RGD

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • gastric acid secretion Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organonitrogen compound Source: RGD
  • sodium ion transport Source: InterPro

Keywordsi

Biological processCell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:Atp4b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2178. Atp4b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 294ExtracellularSequence analysisAdd BLAST237

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190951 – 294Potassium-transporting ATPase subunit betaAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 266By similarity
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18598.
PRIDEiP18598.

PTM databases

iPTMnetiP18598.
PhosphoSitePlusiP18598.

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

GenevisibleiP18598. RN.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025957.

Chemistry databases

BindingDBiP18598.

Structurei

3D structure databases

ProteinModelPortaliP18598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 294immunoglobulin-likeBy similarityAdd BLAST101

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18598.
KOiK01543.
OMAiHYFPYYG.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP18598.
TreeFamiTF314618.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P18598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMAEFRQY CWNPDTGQML GRTPARWVWI SLYYAAFYVV
60 70 80 90 100
MTGLFALCIY VLMQTIDPYT PDYQDQLKSP GVTLRPDVYG ERGLQISYNI
110 120 130 140 150
SENSSWAGLT HTLHSFLAGY TPASQQDSIN CSSEKYFFQE TFSAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGLVDPSF GFEEGKPCFI IKMNRIVKFL PSNNTAPRVD
210 220 230 240 250
CTFQDDPQKP RKDIEPLQVQ YYPPNGTFSL HYFPYYGKKA QPHYSNPLVA
260 270 280 290
AKFLNVPKNT QVLIVCKIMA DHVTFDNPHD PYEGKVEFKL TIQK
Length:294
Mass (Da):33,689
Last modified:April 1, 1993 - v3
Checksum:iEE640D88835AD8AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136Y → H in AAA41330 (PubMed:2165052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34666
, L34661, L34662, L34663, L34664, L34665 Genomic DNA. Translation: AAA41332.1.
S76404 Genomic DNA. Translation: AAB21120.1.
M55655 mRNA. Translation: AAA41330.1.
M35535 mRNA. Translation: AAA63482.1.
PIRiA41199.
RefSeqiNP_036642.2. NM_012510.2.
UniGeneiRn.10033.

Genome annotation databases

EnsembliENSRNOT00000025958; ENSRNOP00000025957; ENSRNOG00000018543.
GeneIDi24217.
KEGGirno:24217.
UCSCiRGD:2178. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiATP4B_RAT
AccessioniPrimary (citable) accession number: P18598
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 1, 1993
Last modified: June 7, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families