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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

  • hydrogen:potassium-exchanging ATPase activity Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • pH reduction Source: MGI
  • protein glycosylation in endoplasmic reticulum Source: MGI
  • regulation of proton transport Source: MGI
  • sodium ion transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BRENDAi3.6.3.10. 1749.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:ATP4B
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 291ExtracellularSequence analysisAdd BLAST234

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • plasma membrane Source: MGI
  • sodium:potassium-exchanging ATPase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190941 – 291Potassium-transporting ATPase subunit betaAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 263By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Stomach.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi1172148. 3 interactors.
STRINGi9986.ENSOCUP00000021394.

Structurei

3D structure databases

ProteinModelPortaliP18597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 291immunoglobulin-likeBy similarityAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18597.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMEEFRHY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MTGLFALCIY VLMQTIDPYT PDYQDQLKSP GVTLRPDVYG EKGLEIHYNI
110 120 130 140 150
SDNRTWTSLT HTLRSFLAGY SPAAQVDNIN CTSKTYFFQE SFGAPNHTKF
160 170 180 190 200
SCKFTADMLE NCSGLTDPSF GFKEGKPCFI IKMNRIVRFL PSNSTPPRVD
210 220 230 240 250
CTFLDMPHQA LTPLQVEYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL
260 270 280 290
LNVPTNTEVV VLCKILADHV TFDNPHDPYE GKVEFKLKIQ K
Length:291
Mass (Da):33,419
Last modified:November 1, 1990 - v1
Checksum:i6D2FE467A36CC103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35544 mRNA. Translation: AAA31256.1.
PIRiA36051.
RefSeqiNP_001075758.1. NM_001082289.1.
UniGeneiOcu.1881.

Genome annotation databases

EnsembliENSOCUT00000028473; ENSOCUP00000021394; ENSOCUG00000027254.
GeneIDi100009125.
KEGGiocu:100009125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35544 mRNA. Translation: AAA31256.1.
PIRiA36051.
RefSeqiNP_001075758.1. NM_001082289.1.
UniGeneiOcu.1881.

3D structure databases

ProteinModelPortaliP18597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1172148. 3 interactors.
STRINGi9986.ENSOCUP00000021394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000028473; ENSOCUP00000021394; ENSOCUG00000027254.
GeneIDi100009125.
KEGGiocu:100009125.

Organism-specific databases

CTDi496.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18597.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.

Enzyme and pathway databases

BRENDAi3.6.3.10. 1749.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4B_RABIT
AccessioniPrimary (citable) accession number: P18597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.