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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

  • hydrogen:potassium-exchanging ATPase activity Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • pH reduction Source: MGI
  • protein glycosylation in endoplasmic reticulum Source: MGI
  • regulation of proton transport Source: MGI
  • sodium ion transport Source: InterPro

Keywordsi

Biological processCell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BRENDAi3.6.3.10. 1749.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:ATP4B
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 291ExtracellularSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190941 – 291Potassium-transporting ATPase subunit betaAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 263By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

BgeeiENSOCUG00000027254.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi1172148. 3 interactors.
STRINGi9986.ENSOCUP00000021394.

Structurei

3D structure databases

ProteinModelPortaliP18597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 291immunoglobulin-likeBy similarityAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18597.
KOiK01543.
OMAiHYFPYYG.
OrthoDBiEOG091G0DJ4.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P18597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMEEFRHY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MTGLFALCIY VLMQTIDPYT PDYQDQLKSP GVTLRPDVYG EKGLEIHYNI
110 120 130 140 150
SDNRTWTSLT HTLRSFLAGY SPAAQVDNIN CTSKTYFFQE SFGAPNHTKF
160 170 180 190 200
SCKFTADMLE NCSGLTDPSF GFKEGKPCFI IKMNRIVRFL PSNSTPPRVD
210 220 230 240 250
CTFLDMPHQA LTPLQVEYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL
260 270 280 290
LNVPTNTEVV VLCKILADHV TFDNPHDPYE GKVEFKLKIQ K
Length:291
Mass (Da):33,419
Last modified:November 1, 1990 - v1
Checksum:i6D2FE467A36CC103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35544 mRNA. Translation: AAA31256.1.
PIRiA36051.
RefSeqiNP_001075758.1. NM_001082289.1.
UniGeneiOcu.1881.

Genome annotation databases

EnsembliENSOCUT00000028473; ENSOCUP00000021394; ENSOCUG00000027254.
GeneIDi100009125.
KEGGiocu:100009125.

Similar proteinsi

Entry informationi

Entry nameiATP4B_RABIT
AccessioniPrimary (citable) accession number: P18597
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families