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Protein

Interferon-induced GTP-binding protein Mx1

Gene

Mx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTPSequence analysis8
Nucleotide bindingi169 – 173GTPSequence analysis5
Nucleotide bindingi238 – 241GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Myxoma resistance protein 1
Myxovirus resistance protein 1
Gene namesi
Name:Mx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3127. Mx1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity
  • Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Binds preferentially to negatively charged phospholipids.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065951 – 652Interferon-induced GTP-binding protein Mx1Add BLAST652

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP18588.
PRIDEiP18588.

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043001.

Structurei

3D structure databases

ProteinModelPortaliP18588.
SMRiP18588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Dynamin-type GAdd BLAST274
Domaini564 – 652GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 331GTPase domainBy similarityAdd BLAST272
Regioni332 – 357Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni357 – 526Middle domainBy similarityAdd BLAST170
Regioni358 – 622StalkBy similarityAdd BLAST265

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiP18588.
PhylomeDBiP18588.

Family and domain databases

InterProiView protein in InterPro
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiView protein in Pfam
PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PRINTSiPR00195. DYNAMIN.
SMARTiView protein in SMART
SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.

Sequencei

Sequence statusi: Complete.

P18588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERTSACRH GTPQKHPDTS EESQAMESVD NLCSQYEEKV RPCIDLIDSL
60 70 80 90 100
RALGVEQDLA LPAIAVIGDQ SSGKSSVLEA LSGVALPRGS GIVTRCPLVL
110 120 130 140 150
KLKQLKQGEK WSGKVIYKDT EIEISHPSLV EREINKAQNL IAGEGLKISS
160 170 180 190 200
DLISLEVSSP HVPDLTLIDL PGITRVAVGD QPADIEHKIK RLITEYIQKQ
210 220 230 240 250
ETINLVVVPS NVDIATTEAL KMAQEVDPQG DRTIGILTKP DLVDRGTEDK
260 270 280 290 300
VVDVVRNLVC HLKKGYMIVK CRGQQDIQEQ LSLAEALQKE QVFFKEHPQF
310 320 330 340 350
RVLLEDGKAT VPCLAKRLTM ELTSHICKSL PILENQINVN HQIASEELQK
360 370 380 390 400
YGADIPEDDS KRLSFLMNKI NVFNKDILSL VQAQENISWE ESRLFTKLRN
410 420 430 440 450
EFLAWNDYIE EHFKKTLGSS EKHSQMEKFE SHYRGRELPG FVDYKAFENI
460 470 480 490 500
IKKEVKALEE PALNMLHRVT TMVKNAFTKV SSNNFGDFLN LHSTAKSKIE
510 520 530 540 550
DIRFNQEKEA EKLIRLHFQM EHIVYCQDQA YKKALQEIRE KEAEKEKSTF
560 570 580 590 600
GAFQHNSPRK ELTTTEMTQH LNAYYQECGR NIGRQIPLII QYSILQTFGQ
610 620 630 640 650
EMEKAMLQLL QDTSKCNWFL TEQSDSREKK KFLKRRLLRL DEAQRKLAKF

SN
Length:652
Mass (Da):74,469
Last modified:November 1, 1990 - v1
Checksum:i603468914B0C6F6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52711 mRNA. Translation: CAA36935.1.
PIRiS11735.
UniGeneiRn.10373.

Genome annotation databases

UCSCiRGD:3127. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMX1_RAT
AccessioniPrimary (citable) accession number: P18588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 10, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families