Reviewed, UniProtKB/Swiss-Prot P18583 (SON_HUMAN)

Names and origin

Protein names

Recommended name:
    SON protein
Alternative name(s):
    SON3
    Negative regulatory element-binding protein
      Short name=NRE-binding protein
    DBP-5
    Bax antagonist selected in saccharomyces 1
      Short name=BASS1

Gene names

Name:	SON
Synonyms:	C21orf50, DBP5, KIAA1019, NREBP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Represses hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. Might protect cells from apoptosis. Might be involved in pre-mRNA splicing By similarity.
Subcellular location	Nucleus speckle.
Tissue specificity	Widely expressed, with the higher expression seen in leukocyte and heart.
Domain	Contains 8 types of repeats which are distributed in 3 regions.
Miscellaneous	Colocalizes with the pre-mRNA splicing factor SFRS2/SC-35.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 G-patch domain.
Sequence caution	The sequence CAA44793.1 differs from that shown. Reason: Frameshift at positions 2315, 2412 and 2417. The sequence CAA45282.1 differs from that shown. Reason: Frameshift at position 2412.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	DNA-binding RNA-binding
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	anti-apoptosis Ref.12 Inferred from direct assay. Source: UniProtKB
Cellular component	nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Traceable author statement. Source: ProtInc double-stranded RNA binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAG	P61981	1	EBI-1053513,EBI-359832

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform F (identifier: P18583-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P18583-2)

The sequence of this isoform differs from the canonical sequence as follows:
     687-687: V → Q
     688-1006: Missing.
     2410-2426: RNGALTRPNCMFFLNRY → INGSAYQPSFASPNKKHAKATAATVVLQAMGLVPKDLMANATCFRSASRR

Isoform B (identifier: P18583-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2220-2303: PVDISTAMSE...KKDQFLRAAP → GRVKRQGRVR...SRLYSSRFWW
     2304-2426: Missing.

Isoform C (identifier: P18583-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2325: DQFLRAAPVTGGMGAVLMRKMGWREGEGLG → GQILVAVFLPRSVPAVLFTTLLLPRPRISS
     2326-2426: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform D (identifier: P18583-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2410-2426: RNGALTRPNCMFFLNRY → INGSAYQPSFASPNKKHAKATAATVVLQAMGLVPKDLMANATCFRSASRR

Isoform E (identifier: P18583-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2108-2108: K → F
     2109-2426: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform G (identifier: P18583-7)

The sequence of this isoform differs from the canonical sequence as follows:
     748-787: Missing.

Isoform H (identifier: P18583-8)

The sequence of this isoform differs from the canonical sequence as follows:
     687-689: VAQ → NVP
     690-2416: Missing.

Isoform I (identifier: P18583-9)

The sequence of this isoform differs from the canonical sequence as follows:
     770-770: S → SMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSS

Isoform J (identifier: P18583-10)

The sequence of this isoform differs from the canonical sequence as follows:
     2257-2282: IDAWAQLNSIPGQFTGSTGVQVLTQE → VCSSFLKKIIIYHQPTHTNVPVLMSK
     2283-2426: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2426	2426	SON protein		PRO_0000072037
Regions
	Repeat	1006 – 1011	6	1-1
	Repeat	1014 – 1019	6	1-2
	Repeat	1021 – 1026	6	1-3
	Repeat	1030 – 1035	6	1-4
	Repeat	1038 – 1043	6	1-5
	Repeat	1046 – 1051	6	1-6
	Repeat	1055 – 1060	6	1-7
	Repeat	1063 – 1068	6	1-8
	Repeat	1071 – 1076	6	1-9
	Repeat	1080 – 1085	6	1-10
	Repeat	1089 – 1094	6	1-11
	Repeat	1100 – 1105	6	1-12
	Repeat	1111 – 1116	6	1-13
	Repeat	1121 – 1126	6	1-14
	Repeat	1925 – 1931	7	2-1
	Repeat	1934 – 1952	19	3-1
	Repeat	1953 – 1959	7	2-2
	Repeat	1960 – 1966	7	2-3
	Repeat	1967 – 1973	7	2-4
	Repeat	1974 – 1980	7	2-5
	Repeat	1981 – 1987	7	2-6
	Repeat	1988 – 1994	7	2-7
	Repeat	1995 – 2013	19	3-2
	Domain	2305 – 2351	47	G-patch
	Domain	2371 – 2426	56	DRBM
	Region	726 – 895	170	17 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM
	Region	912 – 988	77	11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]
	Region	1006 – 1126	121	14 X 6 AA repeats of [ED]-R-S-M-M-S
	Region	1147 – 1179	33	3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]
	Region	1359 – 1390	32	4 X 8 AA tandem repeats of V-L-E-SS-[AVT]-VT
	Region	1925 – 1994	70	7 X 7 AA repeats of P-S-R-R-S-R-[TS]
	Region	1934 – 2013	80	2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S
	Region	2013 – 2039	27	3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R
Amino acid modifications
	Modified residue	94	1	Phosphoserine Ref.15
	Modified residue	152	1	Phosphoserine Ref.21
	Modified residue	154	1	Phosphoserine Ref.18
	Modified residue	283	1	Phosphoserine Ref.15 Ref.18 Ref.14 Ref.17
	Modified residue	348	1	Phosphoserine Ref.20
	Modified residue	910	1	Phosphoserine Ref.14
	Modified residue	1051	1	Phosphoserine Ref.20
	Modified residue	1556	1	Phosphoserine Ref.21 Ref.20
	Modified residue	1651	1	Phosphoserine Ref.14
	Modified residue	1688	1	Phosphoserine By similarity
	Modified residue	1697	1	Phosphoserine Ref.15 Ref.21 Ref.18 Ref.14 Ref.20
	Modified residue	1766	1	Phosphoserine Ref.14
	Modified residue	1769	1	Phosphoserine Ref.14
	Modified residue	1782	1	Phosphoserine Ref.21
	Modified residue	1783	1	Phosphoserine Ref.21
	Modified residue	1784	1	Phosphoserine By similarity
	Modified residue	1948	1	Phosphoserine Ref.21
	Modified residue	1950	1	Phosphoserine Ref.21
	Modified residue	1954	1	Phosphoserine Ref.21
	Modified residue	1961	1	Phosphoserine By similarity
	Modified residue	2009	1	Phosphoserine Ref.15 Ref.21
	Modified residue	2011	1	Phosphoserine Ref.15 Ref.21
	Modified residue	2013	1	Phosphoserine Ref.15 Ref.21 Ref.14
	Modified residue	2029	1	Phosphoserine Ref.15
	Modified residue	2031	1	Phosphoserine Ref.15
	Modified residue	2055	1	N6-acetyllysine Ref.16
	Modified residue	2129	1	Phosphoserine Ref.15 Ref.19
Natural variations
	Alternative sequence	687 – 689	3	VAQ → NVP in isoform H.		VSP_004411
	Alternative sequence	687	1	V → Q in isoform A.		VSP_004401
	Alternative sequence	688 – 1006	319	Missing in isoform A.		VSP_004402
	Alternative sequence	690 – 2416	1727	Missing in isoform H.		VSP_004412
	Alternative sequence	748 – 787	40	Missing in isoform G.		VSP_004410
	Alternative sequence	770	1	S → SMDSQMLASNTMDSQMLASN TMDSQMLASSTMDSQMLATS S in isoform I.		VSP_004413
	Alternative sequence	2108	1	K → F in isoform E.		VSP_004408
	Alternative sequence	2109 – 2426	318	Missing in isoform E.		VSP_004409
	Alternative sequence	2220 – 2303	84	PVDIS…LRAAP → GRVKRQGRVRRQMKQPAASH LTVTRCNSLCGTKPQSEKHR IAENSVITSLPNIGPSLHLW EGSPRYNYLASRFASRLYSS RFWW in isoform B.		VSP_004404
	Alternative sequence	2257 – 2282	26	IDAWA…VLTQE → VCSSFLKKIIIYHQPTHTNV PVLMSK in isoform J.		VSP_004414
	Alternative sequence	2283 – 2426	144	Missing in isoform J.		VSP_004415
	Alternative sequence	2296 – 2325	30	DQFLR…GEGLG → GQILVAVFLPRSVPAVLFTT LLLPRPRISS in isoform C.		VSP_004406
	Alternative sequence	2304 – 2426	123	Missing in isoform B.		VSP_004405
	Alternative sequence	2326 – 2426	101	Missing in isoform C.		VSP_004407
	Alternative sequence	2410 – 2426	17	RNGAL…FLNRY → INGSAYQPSFASPNKKHAKA TAATVVLQAMGLVPKDLMAN ATCFRSASRR in isoform A and isoform D.		VSP_004403
	Natural variant	870	1	T → A: dbSNP rs11908823.		VAR_056990
	Natural variant	1575	1	R → C: dbSNP rs13047599.		VAR_056991
Experimental info
	Sequence conflict	126	1	E → K Ref.4
	Sequence conflict	129	1	Y → K Ref.4
	Sequence conflict	473	1	S → P Ref.2
	Sequence conflict	473	1	S → P Ref.6
	Sequence conflict	1402	1	Y → S Ref.7
	Sequence conflict	1495	1	N → I Ref.7
	Sequence conflict	1538	1	N → S Ref.7
	Sequence conflict	1643	1	I → II Ref.7
	Sequence conflict	1692	1	L → I Ref.7
	Sequence conflict	1692	1	L → R Ref.11
	Sequence conflict	1693	1	A → R Ref.11
	Sequence conflict	1820 – 1821	2	SS → PH Ref.7
	Sequence conflict	1820 – 1821	2	SS → PH Ref.11
	Sequence conflict	1939	1	R → S Ref.12
	Sequence conflict	2090	1	E → V Ref.2
	Sequence conflict	2090	1	E → V Ref.7
	Sequence conflict	2148	1	P → F Ref.2
	Sequence conflict	2148	1	P → F Ref.7
	Sequence conflict	2413 – 2416	4	ALTR → SPYQ Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform F [UniParc]. Last modified January 23, 2002. Version 3. Checksum: BBD0E3A604791E03	FASTA	2,426	263,846
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 2110 2120 2130 2140 2150 2160 TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 2170 2180 2190 2200 2210 2220 KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP 2230 2240 2250 2260 2270 2280 VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT 2290 2300 2310 2320 2330 2340 QEQLANTGAQ AWIKKDQFLR AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK 2350 2360 2370 2380 2390 2400 TDRKGLVAVG ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH 2410 2420 RKHFLFRVLR NGALTRPNCM FFLNRY
	Isoform A. Checksum: 4CF239651020F78F	FASTA	2,140	232,323
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTQRSM MSSYERSMMS YERSMMSPMA ERSMMSAYER 730 740 750 760 770 780 SMMSAYERSM MSPMAERSMM SAYERSMMSA YERSMMSPMA DRSMMSMGAD RSMMSSYSAA 790 800 810 820 830 840 DRSMMSSYSA ADRSMMSSYT ADRSMMSMAA DSYTDSYTDT YTEAYMVPPL PPEEPPTMPP 850 860 870 880 890 900 LPPEEPPMTP PLPPEEPPEG PALPTEQSAL TAENTWPTEV PSLPSEESVS QPEPPVSQSE 910 920 930 940 950 960 ISEPSAVPTD YSVSASDPSV LVSEAAVTVP EPPPEPESSI TLTPVESAVV AEEHEVVPER 970 980 990 1000 1010 1020 PVTCMVSETP AMSAEPTVLA SEPPVMSETA ETFDSMRASG HVASEVSTSL LVPAVTTPVL 1030 1040 1050 1060 1070 1080 AESILEPPAM AAPESSAMAV LESSAVTVLE SSTVTVLESS TVTVLEPSVV TVPEPPVVAE 1090 1100 1110 1120 1130 1140 PDYVTIPVPV VSALEPSVPV LEPAVSVLQP SMIVSEPSVS VQESTVTVSE PAVTVSEQTQ 1150 1160 1170 1180 1190 1200 VIPTEVAIES TPMILESSIM SSHVMKGINL SSGDQNLAPE IGMQEIALHS GEEPHAEEHL 1210 1220 1230 1240 1250 1260 KGDFYESEHG INIDLNINNH LIAKEMEHNT VCAAGTSPVG EIGEEKILPT SETKQRTVLD 1270 1280 1290 1300 1310 1320 TYPGVSEADA GETLSSTGPF ALEPDATGTS KGIEFTTAST LSLVNKYDVD LSLTTQDTEH 1330 1340 1350 1360 1370 1380 DMVISTSPSG GSEADIEGPL PAKDIHLDLP SNNNLVSKDT EEPLPVKESD QTLAALLSPK 1390 1400 1410 1420 1430 1440 ESSGGEKEVP PPPKETLPDS GFSANIEDIN EADLVRPLLP KDMERLTSLR AGIEGPLLAS 1450 1460 1470 1480 1490 1500 DVGRDRSAAS PVVSSMPERA SESSSEEKDD YEIFVKVKDT HEKSKKNKNR DKGEKEKKRD 1510 1520 1530 1540 1550 1560 SSLRSRSKRS KSSEHKSRKR TSESRSRARK RSSKSKSHRS QTRSRSRSRR RRRSSRSRSK 1570 1580 1590 1600 1610 1620 SRGRRSVSKE KRKRSPKHRS KSRERKRKRS SSRDNRKTVR ARSRTPSRRS RSHTPSRRRR 1630 1640 1650 1660 1670 1680 SRSVGRRRSF SISPSRRSRT PSRRSRTPSR RSRTPSRRSR TPSRRSRTPS RRSRTPSRRR 1690 1700 1710 1720 1730 1740 RSRSVVRRRS FSISPVRLRR SRTPLRRRFS RSPIRRKRSR SSERGRSPKR LTDLDKAQLL 1750 1760 1770 1780 1790 1800 EIAKANAAAM CAKAGVPLPP NLKPAPPPTI EEKVAKKSGG ATIEELTEKC KQIAQSKEDD 1810 1820 1830 1840 1850 1860 DVIVNKPHVS DEEEEEPPFY HHPFKLSEPK PIFFNLNIAA AKPTPPKSQV TLTKEFPVSS 1870 1880 1890 1900 1910 1920 GSQHRKKEAD SVYGEWVPVE KNGEENKDDD NVFSSNLPSE PVDISTAMSE RALAQKRLSE 1930 1940 1950 1960 1970 1980 NAFDLEAMSM LNRAQERIDA WAQLNSIPGQ FTGSTGVQVL TQEQLANTGA QAWIKKDQFL 1990 2000 2010 2020 2030 2040 RAAPVTGGMG AVLMRKMGWR EGEGLGKNKE GNKEPILVDF KTDRKGLVAV GERAQKRSGN 2050 2060 2070 2080 2090 2100 FSAAMKDLSG KHPVSALMEI CNKRRWQPPE FLLVHDSGPD HRKHFLFRVL INGSAYQPSF 2110 2120 2130 2140 ASPNKKHAKA TAATVVLQAM GLVPKDLMAN ATCFRSASRR
	Isoform B. Checksum: B1D7B9CF021F057D	FASTA	2,303	250,404
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 2110 2120 2130 2140 2150 2160 TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 2170 2180 2190 2200 2210 2220 KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEG 2230 2240 2250 2260 2270 2280 RVKRQGRVRR QMKQPAASHL TVTRCNSLCG TKPQSEKHRI AENSVITSLP NIGPSLHLWE 2290 2300 GSPRYNYLAS RFASRLYSSR FWW
	Isoform C. Checksum: 76F59AD2F29074CE	FASTA	2,325	252,270
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 2110 2120 2130 2140 2150 2160 TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 2170 2180 2190 2200 2210 2220 KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP 2230 2240 2250 2260 2270 2280 VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT 2290 2300 2310 2320 QEQLANTGAQ AWIKKGQILV AVFLPRSVPA VLFTTLLLPR PRISS
	Isoform D. Checksum: 463FD501FEBA09F1	FASTA	2,459	267,051
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 2110 2120 2130 2140 2150 2160 TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 2170 2180 2190 2200 2210 2220 KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP 2230 2240 2250 2260 2270 2280 VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT 2290 2300 2310 2320 2330 2340 QEQLANTGAQ AWIKKDQFLR AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK 2350 2360 2370 2380 2390 2400 TDRKGLVAVG ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH 2410 2420 2430 2440 2450 RKHFLFRVLI NGSAYQPSFA SPNKKHAKAT AATVVLQAMG LVPKDLMANA TCFRSASRR
	Isoform E. Checksum: 6F9D252454858B8D	FASTA	2,108	228,197
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA TIEELTEF
	Isoform G. Checksum: C8D378AE8E45292F	FASTA	2,386	259,610
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATSS MDSQMLATST MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT 850 860 870 880 890 900 MDAQMLASGT MDAQMLASST QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD 910 920 930 940 950 960 AYRLGQDPYR LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 970 980 990 1000 1010 1020 MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS 1030 1040 1050 1060 1070 1080 AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA 1090 1100 1110 1120 1130 1140 DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP 1150 1160 1170 1180 1190 1200 ALPTEQSALT AENTWPTEVP SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL 1210 1220 1230 1240 1250 1260 VSEAAVTVPE PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 1270 1280 1290 1300 1310 1320 EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL 1330 1340 1350 1360 1370 1380 ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL 1390 1400 1410 1420 1430 1440 EPAVSVLQPS MIVSEPSVSV QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS 1450 1460 1470 1480 1490 1500 SHVMKGINLS SGDQNLAPEI GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL 1510 1520 1530 1540 1550 1560 IAKEMEHNTV CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 1570 1580 1590 1600 1610 1620 LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP 1630 1640 1650 1660 1670 1680 AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG 1690 1700 1710 1720 1730 1740 FSANIEDINE ADLVRPLLPK DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS 1750 1760 1770 1780 1790 1800 ESSSEEKDDY EIFVKVKDTH EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT 1810 1820 1830 1840 1850 1860 SESRSRARKR SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 1870 1880 1890 1900 1910 1920 SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP 1930 1940 1950 1960 1970 1980 SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS 1990 2000 2010 2020 2030 2040 RTPLRRRFSR SPIRRKRSRS SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN 2050 2060 2070 2080 2090 2100 LKPAPPPTIE EKVAKKSGGA TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH 2110 2120 2130 2140 2150 2160 HPFKLSEPKP IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 2170 2180 2190 2200 2210 2220 NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW 2230 2240 2250 2260 2270 2280 AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKDQFLR AAPVTGGMGA VLMRKMGWRE 2290 2300 2310 2320 2330 2340 GEGLGKNKEG NKEPILVDFK TDRKGLVAVG ERAQKRSGNF SAAMKDLSGK HPVSALMEIC 2350 2360 2370 2380 NKRRWQPPEF LLVHDSGPDH RKHFLFRVLR NGALTRPNCM FFLNRY
	Isoform H. Checksum: 0D0EC41FB50DC72E	FASTA	699	73,874
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 TSELSTMTVS QSLEVPSTTA LESYNTNVPP NCMFFLNRY
	Isoform I. Checksum: AACA1B99E22ABE5B	FASTA	2,466	268,109
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLASNT 790 800 810 820 830 840 MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 850 860 870 880 890 900 MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST MDSQMLATSS 910 920 930 940 950 960 MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST QDSAMLGSKS PDPYRLAQDP 970 980 990 1000 1010 1020 YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA 1030 1040 1050 1060 1070 1080 PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS 1090 1100 1110 1120 1130 1140 MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 1150 1160 1170 1180 1190 1200 RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP PEEPPTMPPL 1210 1220 1230 1240 1250 1260 PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP SLPSEESVSQ PEPPVSQSEI 1270 1280 1290 1300 1310 1320 SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT LTPVESAVVA EEHEVVPERP 1330 1340 1350 1360 1370 1380 VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA 1390 1400 1410 1420 1430 1440 ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 1450 1460 1470 1480 1490 1500 DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP AVTVSEQTQV 1510 1520 1530 1540 1550 1560 IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI GMQEIALHSG EEPHAEEHLK 1570 1580 1590 1600 1610 1620 GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE IGEEKILPTS ETKQRTVLDT 1630 1640 1650 1660 1670 1680 YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD 1690 1700 1710 1720 1730 1740 MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 1750 1760 1770 1780 1790 1800 SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA GIEGPLLASD 1810 1820 1830 1840 1850 1860 VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH EKSKKNKNRD KGEKEKKRDS 1870 1880 1890 1900 1910 1920 SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS 1930 1940 1950 1960 1970 1980 RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS 1990 2000 2010 2020 2030 2040 RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 2050 2060 2070 2080 2090 2100 SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL TDLDKAQLLE 2110 2120 2130 2140 2150 2160 IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA TIEELTEKCK QIAQSKEDDD 2170 2180 2190 2200 2210 2220 VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG 2230 2240 2250 2260 2270 2280 SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN 2290 2300 2310 2320 2330 2340 AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKDQFLR 2350 2360 2370 2380 2390 2400 AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK TDRKGLVAVG ERAQKRSGNF 2410 2420 2430 2440 2450 2460 SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH RKHFLFRVLR NGALTRPNCM FFLNRY
	Isoform J. Checksum: 13D1ECA78855B6D3	FASTA	2,282	247,839
	10 20 30 40 50 60 MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 70 80 90 100 110 120 IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 130 140 150 160 170 180 KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 190 200 210 220 230 240 ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 250 260 270 280 290 300 ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 310 320 330 340 350 360 EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 370 380 390 400 410 420 LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 430 440 450 460 470 480 STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPSVMAQELP 490 500 510 520 530 540 GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 550 560 570 580 590 600 EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 610 620 630 640 650 660 MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 670 680 690 700 710 720 TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 730 740 750 760 770 780 METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 790 800 810 820 830 840 MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 850 860 870 880 890 900 MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 910 920 930 940 950 960 QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 970 980 990 1000 1010 1020 DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 1030 1040 1050 1060 1070 1080 ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 1090 1100 1110 1120 1130 1140 RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 1150 1160 1170 1180 1190 1200 TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 1210 1220 1230 1240 1250 1260 SLPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 1270 1280 1290 1300 1310 1320 LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 1330 1340 1350 1360 1370 1380 VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 1390 1400 1410 1420 1430 1440 VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 1450 1460 1470 1480 1490 1500 QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 1510 1520 1530 1540 1550 1560 GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 1570 1580 1590 1600 1610 1620 IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 1630 1640 1650 1660 1670 1680 SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 1690 1700 1710 1720 1730 1740 EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 1750 1760 1770 1780 1790 1800 DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 1810 1820 1830 1840 1850 1860 EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 1870 1880 1890 1900 1910 1920 TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 1930 1940 1950 1960 1970 1980 RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 1990 2000 2010 2020 2030 2040 PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 2050 2060 2070 2080 2090 2100 SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 2110 2120 2130 2140 2150 2160 TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 2170 2180 2190 2200 2210 2220 KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP 2230 2240 2250 2260 2270 2280 VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERVCSS FLKKIIIYHQ PTHTNVPVLM SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F).
[2]	"Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON." Sun C.-T., Lo W.-Y., Wang I.-H., Lo Y.-H., Shiou S.-R., Lai C.-K., Ting L.-P. J. Biol. Chem. 276:24059-24067(2001) [PubMed: 11306577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM G), VARIANT CYS-1575. Tissue: Liver.
[3]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Brain.
[4]	"mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs." Casadei R., Strippoli P., D'Addabbo P., Canaider S., Lenzi L., Vitale L., Giannone S., Frabetti F., Facchin F., Carinci P., Zannotti M. Gene 321:185-193(2003) [PubMed: 14637006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-689 (ISOFORM H). Tissue: Placenta.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-130. Tissue: Smooth muscle.
[6]	"Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114, VARIANT CYS-1575. Tissue: Umbilical cord blood.
[7]	"Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells." Chumakov I.M., Berdichevskii F.B., Sokolova N.V., Reznikov M.V., Prasolov V.S. Mol. Biol. (Mosk.) 25:731-740(1991) [PubMed: 1944255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 554-2426 (ISOFORM A).
[8]	"The human SON gene: the large and small transcripts contains various 5'-terminal sequences." Bliskovskii V.V., Kirillov A.V., Zakhariev V.M., Chumakov I.M. Mol. Biol. (Mosk.) 26:807-812(1992) [PubMed: 1435774] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-1079 (ISOFORM I). Tissue: Placenta.
[9]	"Coding part of the son gene small transcript contains four areas of complete tandem repeats." Bliskovskii V.V., Berdichevskii F.B., Tkachenko A.V., Belova M.E., Chumakov I.M. Mol. Biol. (Mosk.) 26:793-806(1992) [PubMed: 1435773] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1009-1131. Tissue: Placenta.
[10]	"A cDNA clone for a novel nuclear protein with DNA binding activity." Mattioni T., Hume C.R., Konigorski S., Hayes P., Osterweil Z., Lee J.S. Chromosoma 101:618-624(1992) [PubMed: 1424986] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1145-2426 (ISOFORM F).
[11]	"Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins." Berdichevskii F.B., Chumakov I.M., Kiselev L.L. Mol. Biol. (Mosk.) 22:794-801(1988) [PubMed: 3054499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1692-2175 (ISOFORM A).
[12]	"A selection system for human apoptosis inhibitors using yeast." Greenhalf W., Lee J., Chaudhuri B. Yeast 15:1307-1321(1999) [PubMed: 10509013] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1939-2426 (ISOFORM J). Tissue: Cerebellum.
[13]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[14]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-910; SER-1651; SER-1697; SER-1766; SER-1769 AND SER-2013, MASS SPECTROMETRY. Tissue: Epithelium.
[15]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-283; SER-1697; SER-2009; SER-2011; SER-2013; SER-2029; SER-2031 AND SER-2129, MASS SPECTROMETRY. Tissue: Epithelium.
[16]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2055, MASS SPECTROMETRY. Tissue: Epithelium.
[17]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, MASS SPECTROMETRY. Tissue: Epithelium.
[18]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154; SER-283 AND SER-1697, MASS SPECTROMETRY. Tissue: Epithelium.
[19]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2129, MASS SPECTROMETRY.
[20]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-1051; SER-1556 AND SER-1697, MASS SPECTROMETRY.
[21]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-1556; SER-1697; SER-1782; SER-1783; SER-1948; SER-1950; SER-1954; SER-2009; SER-2011 AND SER-2013, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF380179 mRNA. Translation: AAL34497.1. AF380180 mRNA. Translation: AAL34498.1. AF380181 mRNA. Translation: AAL34499.1. AF380182 mRNA. Translation: AAL34500.1. AF380183 mRNA. Translation: AAL34501.1. AF380184 mRNA. Translation: AAL34502.1. AY026895 mRNA. Translation: AAK07692.1. AB028942 mRNA. Translation: BAA82971.2. Different initiation. AF435977 mRNA. Translation: AAL30810.1. AK024752 mRNA. Translation: BAB14985.1. AF161428 mRNA. Translation: AAF28988.1. AF161430 mRNA. Translation: AAF28990.1. X63751 mRNA. Translation: CAC69885.1. X63753 mRNA. Translation: CAA45282.1. Frameshift. X63071 mRNA. Translation: CAA44793.1. Frameshift. M36428 Genomic DNA. Translation: AAA36624.1. AF139897 mRNA. Translation: AAD50078.1.
IPI	IPI00000192. IPI00217930. IPI00218617. IPI00218618. IPI00218619. IPI00218620. IPI00218621. IPI00218622. IPI00218624. IPI00748258.
PIR	S26650.
RefSeq	NP_115571.1. NP_620305.1.
UniGene	Hs.517262
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P18583. 1 interaction.
PTM databases
PhosphoSite	P18583.
Proteomic databases
PRIDE	P18583.
Genome annotation databases
Ensembl	ENSG00000159140. Homo sapiens. [Contig view]
GeneID	6651.
KEGG	hsa:6651.
Organism-specific databases
GeneCards	GC21P033837.
HGNC	HGNC:11183. SON.
MIM	182465. gene.
PharmGKB	PA27459.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P18583.
Gene expression databases
ArrayExpress	P18583.
Bgee	P18583.
GermOnline	ENSG00000159140. Homo sapiens.
Family and domain databases
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000467. G_patch. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF01585. G-patch. 1 hit. [Graphical view]
ProDom	PD153432. Csurface_antigen. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00443. G_patch. 1 hit. [Graphical view]
PROSITE	PS50137. DS_RBD. 1 hit. PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25923.
SOURCE	Search...

Entry information

Entry name

SON_HUMAN

Accession

Primary (citable) accession number: P18583
Secondary accession number(s): O14487 , O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)