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P18581

- CTR2_MOUSE

UniProt

P18581 - CTR2_MOUSE

Protein

Low affinity cationic amino acid transporter 2

Gene

Slc7a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages.2 Publications

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: MGI
    2. high-affinity arginine transmembrane transporter activity Source: MGI
    3. L-amino acid transmembrane transporter activity Source: MGI
    4. L-lysine transmembrane transporter activity Source: MGI
    5. L-ornithine transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. arginine transport Source: MGI
    2. L-alpha-amino acid transmembrane transport Source: GOC
    3. L-amino acid transport Source: MGI
    4. lysine transport Source: MGI
    5. macrophage activation Source: MGI
    6. nitric oxide biosynthetic process Source: MGI
    7. nitric oxide production involved in inflammatory response Source: MGI
    8. ornithine transport Source: MGI
    9. regulation of inflammatory response Source: MGI
    10. regulation of macrophage activation Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.3.2. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity cationic amino acid transporter 2
    Short name:
    CAT-2
    Short name:
    CAT2
    Alternative name(s):
    20.5
    Solute carrier family 7 member 2
    T-cell early activation protein
    Short name:
    TEA
    Gene namesi
    Name:Slc7a2
    Synonyms:Atrc2, Tea
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99828. Slc7a2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Low affinity cationic amino acid transporter 2PRO_0000054265Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Modified residuei645 – 6451Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP18581.
    PRIDEiP18581.

    PTM databases

    PhosphoSiteiP18581.

    Expressioni

    Tissue specificityi

    Highest expression in liver and T-cells. Also expressed in brain and lung.1 Publication

    Inductioni

    By macrophage activation.1 Publication

    Gene expression databases

    ArrayExpressiP18581.
    GenevestigatoriP18581.

    Structurei

    3D structure databases

    ProteinModelPortaliP18581.
    SMRiP18581. Positions 45-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 634ExtracellularSequence Analysis
    Topological domaini85 – 10420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 16338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 1928CytoplasmicSequence Analysis
    Topological domaini214 – 24835ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 33930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 38525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini407 – 4093ExtracellularSequence Analysis
    Topological domaini431 – 48959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini511 – 52313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini549 – 5568CytoplasmicSequence Analysis
    Topological domaini578 – 5814ExtracellularSequence Analysis
    Topological domaini603 – 65755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 30920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54825HelicalSequence AnalysisAdd
    BLAST
    Transmembranei557 – 57721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei582 – 60221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00700000104437.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiQ38RA6.
    KOiK13864.
    OrthoDBiEOG72C501.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P18581-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA    50
    GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY 100
    LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF 150
    KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL 200
    VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM 250
    PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 300
    MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWSPAKYV VSAGSLCALS 350
    TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM 400
    AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYD QPKYTPEKET 450
    LESCTNATLK SESQVTMLQG QGFSLRTLFS PSALPTRQSA SLVSFLVGFL 500
    AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCVAVI LTIWRQPQNQ 550
    QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY 600
    GIRHSLEGNP RDEEDDEDAF SDNINAATEE KSAMQANDHH QRNLSLPFIL 650
    HEKTSEC 657
    Length:657
    Mass (Da):71,856
    Last modified:October 3, 2012 - v3
    Checksum:i140CC99D3AB96082
    GO
    Isoform 2 (identifier: P18581-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

    Note: Affinity of isoform 2 for arginine uptake is 70-fold higher than for isoform 1.

    Show »
    Length:658
    Mass (Da):71,786
    Checksum:i4DF5DF9EE57BB7EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421L → P in BAE32720. (PubMed:16141072)Curated
    Sequence conflicti242 – 2421S → R in BAE32720. (PubMed:16141072)Curated
    Sequence conflicti280 – 2801E → K in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti335 – 3351S → G in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti335 – 3351S → G in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti335 – 3351S → G in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti335 – 3351S → G in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti335 – 3351S → G in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti335 – 3351S → G in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti335 – 3351S → G in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti342 – 3421S → A in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti342 – 3421S → A in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti342 – 3421S → A in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti342 – 3421S → A in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti342 – 3421S → A in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti342 – 3421S → A in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti342 – 3421S → A in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti357 – 3571M → I in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti357 – 3571M → I in BAE32720. (PubMed:16141072)Curated
    Sequence conflicti357 – 3571M → I in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti369 – 3691R → E in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti369 – 3691R → E in BAE32720. (PubMed:16141072)Curated
    Sequence conflicti369 – 3691R → E in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti430 – 4301I → M in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti440 – 4401D → E in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti440 – 4401D → E in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti440 – 4401D → E in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti440 – 4401D → E in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti440 – 4401D → E in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti440 – 4401D → E in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti440 – 4401D → E in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti537 – 5371V → A in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti537 – 5371V → A in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti537 – 5371V → A in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti537 – 5371V → A in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti537 – 5371V → A in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti537 – 5371V → A in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti537 – 5371V → A in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti622 – 6221D → E in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti622 – 6221D → E in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti622 – 6221D → E in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti622 – 6221D → E in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti622 – 6221D → E in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti622 – 6221D → E in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti622 – 6221D → E in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti626 – 6261A → V in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti626 – 6261A → V in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti626 – 6261A → V in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti626 – 6261A → V in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti626 – 6261A → V in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti626 – 6261A → V in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti626 – 6261A → V in AAI27083. (PubMed:15489334)Curated
    Sequence conflicti633 – 6331A → V in AAA75250. (PubMed:1694015)Curated
    Sequence conflicti633 – 6331A → V in AAA37372. (PubMed:8385111)Curated
    Sequence conflicti633 – 6331A → V in AAA37350. (PubMed:8385111)Curated
    Sequence conflicti633 – 6331A → V in AAA20397. (PubMed:8195186)Curated
    Sequence conflicti633 – 6331A → V in AAY87029. (PubMed:16239143)Curated
    Sequence conflicti633 – 6331A → V in BAE42415. (PubMed:16141072)Curated
    Sequence conflicti633 – 6331A → V in AAI27083. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPVIATLSSGA VA in isoform 2. 4 PublicationsVSP_000025Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62838 mRNA. Translation: AAA75250.1.
    L03290 mRNA. Translation: AAA37372.1.
    L11600 mRNA. Translation: AAA37350.1.
    L29006 mRNA. Translation: AAA20397.1.
    DQ086834 mRNA. Translation: AAY87029.1.
    AK154621 mRNA. Translation: BAE32720.1.
    AK171369 mRNA. Translation: BAE42415.1.
    AC116511 Genomic DNA. No translation available.
    BC127082 mRNA. Translation: AAI27083.1.
    CCDSiCCDS22258.1. [P18581-1]
    CCDS40327.1. [P18581-2]
    PIRiA54011.
    RefSeqiNP_001038205.1. NM_001044740.2. [P18581-2]
    NP_031540.2. NM_007514.3. [P18581-1]
    XP_006509316.1. XM_006509253.1. [P18581-2]
    UniGeneiMm.4676.

    Genome annotation databases

    EnsembliENSMUST00000057784; ENSMUSP00000058866; ENSMUSG00000031596. [P18581-1]
    ENSMUST00000098816; ENSMUSP00000096414; ENSMUSG00000031596. [P18581-2]
    ENSMUST00000117077; ENSMUSP00000113729; ENSMUSG00000031596. [P18581-2]
    GeneIDi11988.
    KEGGimmu:11988.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62838 mRNA. Translation: AAA75250.1 .
    L03290 mRNA. Translation: AAA37372.1 .
    L11600 mRNA. Translation: AAA37350.1 .
    L29006 mRNA. Translation: AAA20397.1 .
    DQ086834 mRNA. Translation: AAY87029.1 .
    AK154621 mRNA. Translation: BAE32720.1 .
    AK171369 mRNA. Translation: BAE42415.1 .
    AC116511 Genomic DNA. No translation available.
    BC127082 mRNA. Translation: AAI27083.1 .
    CCDSi CCDS22258.1. [P18581-1 ]
    CCDS40327.1. [P18581-2 ]
    PIRi A54011.
    RefSeqi NP_001038205.1. NM_001044740.2. [P18581-2 ]
    NP_031540.2. NM_007514.3. [P18581-1 ]
    XP_006509316.1. XM_006509253.1. [P18581-2 ]
    UniGenei Mm.4676.

    3D structure databases

    ProteinModelPortali P18581.
    SMRi P18581. Positions 45-431.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.3.3.2. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei P18581.

    Proteomic databases

    PaxDbi P18581.
    PRIDEi P18581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057784 ; ENSMUSP00000058866 ; ENSMUSG00000031596 . [P18581-1 ]
    ENSMUST00000098816 ; ENSMUSP00000096414 ; ENSMUSG00000031596 . [P18581-2 ]
    ENSMUST00000117077 ; ENSMUSP00000113729 ; ENSMUSG00000031596 . [P18581-2 ]
    GeneIDi 11988.
    KEGGi mmu:11988.

    Organism-specific databases

    CTDi 6542.
    MGIi MGI:99828. Slc7a2.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00700000104437.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi Q38RA6.
    KOi K13864.
    OrthoDBi EOG72C501.
    TreeFami TF315212.

    Miscellaneous databases

    ChiTaRSi SLC7A2. mouse.
    NextBioi 280145.
    PROi P18581.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18581.
    Genevestigatori P18581.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor."
      Macleod C.L., Finley K., Kakuda D., Kozak C.A., Wilkinson M.F.
      Mol. Cell. Biol. 10:3663-3674(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: AKR/J.
      Tissue: T-cell.
    2. "Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver."
      Closs E.I., Albritton L.M., Kim J.W., Cunningham J.M.
      J. Biol. Chem. 268:7538-7544(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Liver.
    3. "Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family."
      Kavanaugh M.P., Wang H., Zhang Z., Zhang W., Wu Y.N., Dechant E., North R.A., Kabat D.
      J. Biol. Chem. 269:15445-15450(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: Swiss Webster / NIH.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J and NOD.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    8. "Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages."
      Yeramian A., Martin L., Serrat N., Arpa L., Soler C., Bertran J., McLeod C., Palacin M., Modolell M., Lloberas J., Celada A.
      J. Immunol. 176:5918-5924(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCTR2_MOUSE
    AccessioniPrimary (citable) accession number: P18581
    Secondary accession number(s): E9QPL9
    , Q38RA6, Q3TB99, Q3U3R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3