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Protein

Cationic amino acid transporter 2

Gene

Slc7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Isoform 2 also functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), but it has much higher affinity for arginine than isoform 1. May play a role in classical or alternative activation of macrophages via its role in arginine transport.3 Publications

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • arginine transmembrane transporter activity Source: MGI
  • high-affinity arginine transmembrane transporter activity Source: MGI
  • high-affinity L-ornithine transmembrane transporter activity Source: MGI
  • high-affinity lysine transmembrane transporter activity Source: MGI
  • L-arginine transmembrane transporter activity Source: MGI
  • L-lysine transmembrane transporter activity Source: MGI
  • L-ornithine transmembrane transporter activity Source: MGI
  • low-affinity L-arginine transmembrane transporter activity Source: MGI

GO - Biological processi

  • L-arginine import across plasma membrane Source: MGI
  • L-arginine transport Source: MGI
  • L-lysine import across plasma membrane Source: MGI
  • L-ornithine import across plasma membrane Source: MGI
  • L-ornithine transmembrane transport Source: MGI
  • macrophage activation Source: MGI
  • nitric oxide biosynthetic process Source: MGI
  • nitric oxide production involved in inflammatory response Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of macrophage activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.2. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
20.5
Low affinity cationic amino acid transporter 21 Publication
Solute carrier family 7 member 2
T-cell early activation protein1 Publication
Short name:
TEA1 Publication
Gene namesi
Name:Slc7a2
Synonyms:Atrc2, Tea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99828. Slc7a2.

Subcellular locationi

  • Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5922HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 634ExtracellularSequence Analysis
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 10420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 16338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 1928CytoplasmicSequence Analysis
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 24835ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 30920HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 33930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 38525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Topological domaini407 – 4093ExtracellularSequence Analysis
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Topological domaini431 – 48959CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Topological domaini511 – 52313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54825HelicalSequence AnalysisAdd
BLAST
Topological domaini549 – 5568CytoplasmicSequence Analysis
Transmembranei557 – 57721HelicalSequence AnalysisAdd
BLAST
Topological domaini578 – 5814ExtracellularSequence Analysis
Transmembranei582 – 60221HelicalSequence AnalysisAdd
BLAST
Topological domaini603 – 65755CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Cationic amino acid transporter 2PRO_0000054265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Modified residuei645 – 6451Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP18581.
PaxDbiP18581.
PRIDEiP18581.

PTM databases

PhosphoSiteiP18581.

Expressioni

Tissue specificityi

Detected in liver (at protein level) (PubMed:8385111). Highest expression in liver and T-cells. Also expressed in brain and lung.2 Publications

Inductioni

By macrophage activation.1 Publication

Gene expression databases

ExpressionAtlasiP18581. baseline and differential.
GenevestigatoriP18581.

Structurei

3D structure databases

ProteinModelPortaliP18581.
SMRiP18581. Positions 45-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP18581.
KOiK13864.
OrthoDBiEOG72C501.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18581-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY
110 120 130 140 150
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF
160 170 180 190 200
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL
210 220 230 240 250
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWSPAKYV VSAGSLCALS
360 370 380 390 400
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM
410 420 430 440 450
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYD QPKYTPEKET
460 470 480 490 500
LESCTNATLK SESQVTMLQG QGFSLRTLFS PSALPTRQSA SLVSFLVGFL
510 520 530 540 550
AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCVAVI LTIWRQPQNQ
560 570 580 590 600
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY
610 620 630 640 650
GIRHSLEGNP RDEEDDEDAF SDNINAATEE KSAMQANDHH QRNLSLPFIL

HEKTSEC
Length:657
Mass (Da):71,856
Last modified:October 3, 2012 - v3
Checksum:i140CC99D3AB96082
GO
Isoform 2 (identifier: P18581-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Note: Affinity of isoform 2 for arginine uptake is 70-fold higher than for isoform 1.1 Publication

Show »
Length:658
Mass (Da):71,786
Checksum:i4DF5DF9EE57BB7EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421L → P in BAE32720 (PubMed:16141072).Curated
Sequence conflicti242 – 2421S → R in BAE32720 (PubMed:16141072).Curated
Sequence conflicti280 – 2801E → K in BAE42415 (PubMed:16141072).Curated
Sequence conflicti335 – 3351S → G in AAA75250 (PubMed:1694015).Curated
Sequence conflicti335 – 3351S → G in AAA37372 (PubMed:8385111).Curated
Sequence conflicti335 – 3351S → G in AAA37350 (PubMed:8385111).Curated
Sequence conflicti335 – 3351S → G in AAA20397 (PubMed:8195186).Curated
Sequence conflicti335 – 3351S → G in AAY87029 (PubMed:16239143).Curated
Sequence conflicti335 – 3351S → G in BAE42415 (PubMed:16141072).Curated
Sequence conflicti335 – 3351S → G in AAI27083 (PubMed:15489334).Curated
Sequence conflicti342 – 3421S → A in AAA75250 (PubMed:1694015).Curated
Sequence conflicti342 – 3421S → A in AAA37372 (PubMed:8385111).Curated
Sequence conflicti342 – 3421S → A in AAA37350 (PubMed:8385111).Curated
Sequence conflicti342 – 3421S → A in AAA20397 (PubMed:8195186).Curated
Sequence conflicti342 – 3421S → A in AAY87029 (PubMed:16239143).Curated
Sequence conflicti342 – 3421S → A in BAE42415 (PubMed:16141072).Curated
Sequence conflicti342 – 3421S → A in AAI27083 (PubMed:15489334).Curated
Sequence conflicti357 – 3571M → I in AAA75250 (PubMed:1694015).Curated
Sequence conflicti357 – 3571M → I in BAE32720 (PubMed:16141072).Curated
Sequence conflicti357 – 3571M → I in BAE42415 (PubMed:16141072).Curated
Sequence conflicti369 – 3691R → E in AAA75250 (PubMed:1694015).Curated
Sequence conflicti369 – 3691R → E in BAE32720 (PubMed:16141072).Curated
Sequence conflicti369 – 3691R → E in BAE42415 (PubMed:16141072).Curated
Sequence conflicti430 – 4301I → M in AAA37372 (PubMed:8385111).Curated
Sequence conflicti440 – 4401D → E in AAA75250 (PubMed:1694015).Curated
Sequence conflicti440 – 4401D → E in AAA37372 (PubMed:8385111).Curated
Sequence conflicti440 – 4401D → E in AAA37350 (PubMed:8385111).Curated
Sequence conflicti440 – 4401D → E in AAA20397 (PubMed:8195186).Curated
Sequence conflicti440 – 4401D → E in AAY87029 (PubMed:16239143).Curated
Sequence conflicti440 – 4401D → E in BAE42415 (PubMed:16141072).Curated
Sequence conflicti440 – 4401D → E in AAI27083 (PubMed:15489334).Curated
Sequence conflicti537 – 5371V → A in AAA75250 (PubMed:1694015).Curated
Sequence conflicti537 – 5371V → A in AAA37372 (PubMed:8385111).Curated
Sequence conflicti537 – 5371V → A in AAA37350 (PubMed:8385111).Curated
Sequence conflicti537 – 5371V → A in AAA20397 (PubMed:8195186).Curated
Sequence conflicti537 – 5371V → A in AAY87029 (PubMed:16239143).Curated
Sequence conflicti537 – 5371V → A in BAE42415 (PubMed:16141072).Curated
Sequence conflicti537 – 5371V → A in AAI27083 (PubMed:15489334).Curated
Sequence conflicti622 – 6221D → E in AAA75250 (PubMed:1694015).Curated
Sequence conflicti622 – 6221D → E in AAA37372 (PubMed:8385111).Curated
Sequence conflicti622 – 6221D → E in AAA37350 (PubMed:8385111).Curated
Sequence conflicti622 – 6221D → E in AAA20397 (PubMed:8195186).Curated
Sequence conflicti622 – 6221D → E in AAY87029 (PubMed:16239143).Curated
Sequence conflicti622 – 6221D → E in BAE42415 (PubMed:16141072).Curated
Sequence conflicti622 – 6221D → E in AAI27083 (PubMed:15489334).Curated
Sequence conflicti626 – 6261A → V in AAA75250 (PubMed:1694015).Curated
Sequence conflicti626 – 6261A → V in AAA37372 (PubMed:8385111).Curated
Sequence conflicti626 – 6261A → V in AAA37350 (PubMed:8385111).Curated
Sequence conflicti626 – 6261A → V in AAA20397 (PubMed:8195186).Curated
Sequence conflicti626 – 6261A → V in AAY87029 (PubMed:16239143).Curated
Sequence conflicti626 – 6261A → V in BAE42415 (PubMed:16141072).Curated
Sequence conflicti626 – 6261A → V in AAI27083 (PubMed:15489334).Curated
Sequence conflicti633 – 6331A → V in AAA75250 (PubMed:1694015).Curated
Sequence conflicti633 – 6331A → V in AAA37372 (PubMed:8385111).Curated
Sequence conflicti633 – 6331A → V in AAA37350 (PubMed:8385111).Curated
Sequence conflicti633 – 6331A → V in AAA20397 (PubMed:8195186).Curated
Sequence conflicti633 – 6331A → V in AAY87029 (PubMed:16239143).Curated
Sequence conflicti633 – 6331A → V in BAE42415 (PubMed:16141072).Curated
Sequence conflicti633 – 6331A → V in AAI27083 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPVIATLSSGA VA in isoform 2. 4 PublicationsVSP_000025Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62838 mRNA. Translation: AAA75250.1.
L03290 mRNA. Translation: AAA37372.1.
L11600 mRNA. Translation: AAA37350.1.
L29006 mRNA. Translation: AAA20397.1.
DQ086834 mRNA. Translation: AAY87029.1.
AK154621 mRNA. Translation: BAE32720.1.
AK171369 mRNA. Translation: BAE42415.1.
AC116511 Genomic DNA. No translation available.
BC127082 mRNA. Translation: AAI27083.1.
CCDSiCCDS22258.1. [P18581-1]
CCDS40327.1. [P18581-2]
PIRiA54011.
RefSeqiNP_001038205.1. NM_001044740.2. [P18581-2]
NP_031540.2. NM_007514.3. [P18581-1]
XP_006509316.1. XM_006509253.2. [P18581-2]
UniGeneiMm.4676.

Genome annotation databases

EnsembliENSMUST00000057784; ENSMUSP00000058866; ENSMUSG00000031596. [P18581-1]
ENSMUST00000098816; ENSMUSP00000096414; ENSMUSG00000031596. [P18581-2]
ENSMUST00000117077; ENSMUSP00000113729; ENSMUSG00000031596. [P18581-2]
GeneIDi11988.
KEGGimmu:11988.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62838 mRNA. Translation: AAA75250.1.
L03290 mRNA. Translation: AAA37372.1.
L11600 mRNA. Translation: AAA37350.1.
L29006 mRNA. Translation: AAA20397.1.
DQ086834 mRNA. Translation: AAY87029.1.
AK154621 mRNA. Translation: BAE32720.1.
AK171369 mRNA. Translation: BAE42415.1.
AC116511 Genomic DNA. No translation available.
BC127082 mRNA. Translation: AAI27083.1.
CCDSiCCDS22258.1. [P18581-1]
CCDS40327.1. [P18581-2]
PIRiA54011.
RefSeqiNP_001038205.1. NM_001044740.2. [P18581-2]
NP_031540.2. NM_007514.3. [P18581-1]
XP_006509316.1. XM_006509253.2. [P18581-2]
UniGeneiMm.4676.

3D structure databases

ProteinModelPortaliP18581.
SMRiP18581. Positions 45-431.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.3.3.2. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiP18581.

Proteomic databases

MaxQBiP18581.
PaxDbiP18581.
PRIDEiP18581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057784; ENSMUSP00000058866; ENSMUSG00000031596. [P18581-1]
ENSMUST00000098816; ENSMUSP00000096414; ENSMUSG00000031596. [P18581-2]
ENSMUST00000117077; ENSMUSP00000113729; ENSMUSG00000031596. [P18581-2]
GeneIDi11988.
KEGGimmu:11988.

Organism-specific databases

CTDi6542.
MGIiMGI:99828. Slc7a2.

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP18581.
KOiK13864.
OrthoDBiEOG72C501.
TreeFamiTF315212.

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc7a2. mouse.
NextBioi280145.
PROiP18581.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP18581. baseline and differential.
GenevestigatoriP18581.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor."
    Macleod C.L., Finley K., Kakuda D., Kozak C.A., Wilkinson M.F.
    Mol. Cell. Biol. 10:3663-3674(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: AKR/J.
    Tissue: T-cell.
  2. "Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver."
    Closs E.I., Albritton L.M., Kim J.W., Cunningham J.M.
    J. Biol. Chem. 268:7538-7544(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: Liver.
  3. "Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family."
    Kavanaugh M.P., Wang H., Zhang Z., Zhang W., Wu Y.N., Dechant E., North R.A., Kabat D.
    J. Biol. Chem. 269:15445-15450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: Swiss Webster / NIH.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. "Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages."
    Yeramian A., Martin L., Serrat N., Arpa L., Soler C., Bertran J., McLeod C., Palacin M., Modolell M., Lloberas J., Celada A.
    J. Immunol. 176:5918-5924(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  9. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTR2_MOUSE
AccessioniPrimary (citable) accession number: P18581
Secondary accession number(s): E9QPL9
, Q38RA6, Q3TB99, Q3U3R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: April 29, 2015
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.