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Protein

Blood group Rh(CE) polypeptide

Gene

RHCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Protein family/group databases

TCDBi1.A.11.4.3. the ammonium transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(CE) polypeptide
Alternative name(s):
Rh polypeptide 1
Short name:
RhPI
Rh30A
RhIXB
Rhesus C/E antigens
CD_antigen: CD240CE
Gene namesi
Name:RHCE
Synonyms:RHC, RHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10008. RHCE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6006.
MalaCardsiRHCE.
MIMi111690. phenotype.
111700. gene+phenotype.
Orphaneti71275. Rh deficiency syndrome.
PharmGKBiPA34386.

Polymorphism and mutation databases

BioMutaiRHCE.
DMDMi132558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001681892 – 417Blood group Rh(CE) polypeptideAdd BLAST416

Proteomic databases

PaxDbiP18577.
PeptideAtlasiP18577.
PRIDEiP18577.

PTM databases

iPTMnetiP18577.
PhosphoSitePlusiP18577.

Expressioni

Tissue specificityi

Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts.1 Publication

Gene expression databases

BgeeiENSG00000188672.
CleanExiHS_RHCE.
ExpressionAtlasiP18577. baseline and differential.
GenevisibleiP18577. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000294413.

Structurei

3D structure databases

ProteinModelPortaliP18577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOVERGENiHBG004374.
InParanoidiP18577.
KOiK06579.
OrthoDBiEOG091G06KX.
PhylomeDBiP18577.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequences (14)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 14 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RHI (identifier: P18577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAL GLGFLTSNFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPPGKVVITL FSIRLATMSA MSVLISAGAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GTLRMVISNI FNTDYHMNLR HFYVFAAYFG LTVAWCLPKP LPKGTEDNDQ
210 220 230 240 250
RATIPSLSAM LGALFLWMFW PSVNSPLLRS PIQRKNAMFN TYYALAVSVV
260 270 280 290 300
TAISGSSLAH PQRKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISIGGAK CLPVCCNRVL GIHHISVMHS IFSLLGLLGE ITYIVLLVLH
360 370 380 390 400
TVWNGNGMIG FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHVAK
410
YFDDQVFWKF PHLAVGF
Length:417
Mass (Da):45,560
Last modified:January 23, 2007 - v2
Checksum:i29D33E778D9053DF
GO
Isoform RHIV (identifier: P18577-2) [UniParc]FASTAAdd to basket
Also known as: 1e

The sequence of this isoform differs from the canonical sequence as follows:
     314-354: VCCNRVLGIH...VLLVLHTVWN → DWLPGPPQHW...SQNMESTSCG
     355-417: Missing.

Show »
Length:354
Mass (Da):38,698
Checksum:i2ED52E5FF2B9085D
GO
Isoform RHVI (identifier: P18577-3) [UniParc]FASTAAdd to basket
Also known as: 7c

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:267
Mass (Da):28,702
Checksum:iBEF2BF74DCF531E1
GO
Isoform RHVIII (identifier: P18577-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-313: Missing.

Show »
Length:266
Mass (Da):29,256
Checksum:i728E70D6F0CEB46A
GO
Isoform 1c (identifier: P18577-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:372
Mass (Da):40,523
Checksum:iB3B22D8C3FD0E07B
GO
Isoform 1d (identifier: P18577-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LLPAVREKRS

Show »
Length:395
Mass (Da):43,553
Checksum:iEFABE59673D8AD25
GO
Isoform 1h (identifier: P18577-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-409: Missing.

Show »
Length:321
Mass (Da):34,967
Checksum:iE2A4BE357967545A
GO
Isoform 2e (identifier: P18577-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-308: TYVHSAVLAG...LVAGLISIGG → DWLPGPPQHW...SQNMESTSCG
     309-417: Missing.

Show »
Length:308
Mass (Da):34,215
Checksum:i3B4E7B35E439386C
GO
Isoform 4g (identifier: P18577-9) [UniParc]FASTAAdd to basket
Also known as: RhPI-Beta

The sequence of this isoform differs from the canonical sequence as follows:
     212-384: Missing.

Show »
Length:244
Mass (Da):27,259
Checksum:iD33E72E9B94F1D08
GO
Isoform 7a (identifier: P18577-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.

Show »
Length:312
Mass (Da):33,739
Checksum:iC852D699223E9A22
GO
Isoform 8a (identifier: P18577-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-220: Missing.
     301-313: Missing.

Show »
Length:346
Mass (Da):37,643
Checksum:iB72694FC03CA96A1
GO
Isoform 8e (identifier: P18577-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-203: TDYHMNLRHF...GTEDNDQRAT → DWLPGPPQHW...SQNMESTSCG
     204-417: Missing.

Show »
Length:203
Mass (Da):22,394
Checksum:iF219A5EB7706D655
GO
Isoform 8h (identifier: P18577-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-409: Missing.

Show »
Length:170
Mass (Da):18,663
Checksum:i8187115F3B54081F
GO
Isoform RhPI-Alpha (identifier: P18577-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-242: LLRSPIQRKNAMFNTY → DRFAPKSQNMESTSCG
     243-417: Missing.

Show »
Length:242
Mass (Da):26,852
Checksum:iE6EA91C2781C2782
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → W in ACK75562 (Ref. 13) Curated1
Sequence conflicti12C → L AA sequence (PubMed:3135863).Curated1
Sequence conflicti53D → G in CAA44812 (PubMed:1379850).Curated1
Sequence conflicti61G → C in CAA44812 (PubMed:1379850).Curated1
Sequence conflicti114R → W in AAN75123 (PubMed:12393640).Curated1
Sequence conflicti115L → P in ACK75563 (Ref. 13) Curated1
Sequence conflicti115L → P in ACK75565 (Ref. 13) Curated1
Sequence conflicti121M → L in BAB16597 (PubMed:11724987).Curated1
Sequence conflicti121M → L in BAA82627 (PubMed:11724987).Curated1
Sequence conflicti122S → P in ACK75564 (Ref. 13) Curated1
Sequence conflicti125I → N in ACK75565 (Ref. 13) Curated1
Sequence conflicti152T → N in BAB16597 (PubMed:11724987).Curated1
Sequence conflicti152T → N in BAA82627 (PubMed:11724987).Curated1
Sequence conflicti155M → V in AAT35811 (Ref. 8) Curated1
Sequence conflicti166H → L in ACK75566 (Ref. 13) Curated1
Sequence conflicti169L → Q in ACK75567 (Ref. 13) Curated1
Sequence conflicti201R → T in ACK75568 (Ref. 13) Curated1
Sequence conflicti217W → R in ACK75569 (Ref. 13) Curated1
Sequence conflicti241T → I in ACK75570 (Ref. 13) Curated1
Sequence conflicti250V → M in AAN75124 (PubMed:12393640).Curated1
Sequence conflicti273A → V in AAN75122 (PubMed:12393640).Curated1
Sequence conflicti303L → Q in ACK75572 (Ref. 13) Curated1
Sequence conflicti378L → V in AAN75122 (PubMed:12393640).Curated1
Sequence conflicti408 – 409WK → DI AA sequence (PubMed:1898705).Curated2

Polymorphismi

RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00691116W → C Associated with altered expression of E antigen. 10 Publications1
Natural variantiVAR_00691236A → T in C(X)/Rh9 antigen. 1
Natural variantiVAR_00691341Q → R in C(W)/Rh8 antigen. Corresponds to variant rs138268848dbSNPEnsembl.1
Natural variantiVAR_00691460L → I.6 PublicationsCorresponds to variant rs181860403dbSNPEnsembl.1
Natural variantiVAR_00691568N → S.6 PublicationsCorresponds to variant rs1053344dbSNPEnsembl.1
Natural variantiVAR_006916103P → S in C/Rh2 antigen. 6 PublicationsCorresponds to variant rs676785dbSNPEnsembl.1
Natural variantiVAR_055260127A → V.1 PublicationCorresponds to variant rs1053346dbSNPEnsembl.1
Natural variantiVAR_055261128G → D.1 PublicationCorresponds to variant rs1053347dbSNPEnsembl.1
Natural variantiVAR_013301154R → T Found in antigen RhEKH. 1 Publication1
Natural variantiVAR_055262182T → S.Corresponds to variant rs1053350dbSNPEnsembl.1
Natural variantiVAR_055263198N → K.Corresponds to variant rs1053354dbSNPEnsembl.1
Natural variantiVAR_006917226P → A in E/Rh5 antigen. 10 PublicationsCorresponds to variant rs609320dbSNPEnsembl.1
Natural variantiVAR_013302233Q → E Found in antigen RhEFM. 2 Publications1
Natural variantiVAR_013303238M → V Found in antigen RhEFM. 2 PublicationsCorresponds to variant rs144163296dbSNPEnsembl.1
Natural variantiVAR_006918245L → V in VS antigen. 2 PublicationsCorresponds to variant rs1053361dbSNPEnsembl.1
Natural variantiVAR_057987263R → G.1 PublicationCorresponds to variant rs1132763dbSNPEnsembl.1
Natural variantiVAR_057988267M → K.2 PublicationsCorresponds to variant rs1132764dbSNPEnsembl.1
Natural variantiVAR_055264323H → P.Corresponds to variant rs1053366dbSNPEnsembl.1
Natural variantiVAR_055265325I → S.Corresponds to variant rs1053367dbSNPEnsembl.1
Natural variantiVAR_055266329H → D.Corresponds to variant rs1053370dbSNPEnsembl.1
Natural variantiVAR_055267329H → R.Corresponds to variant rs1053371dbSNPEnsembl.1
Natural variantiVAR_055268330S → Y.Corresponds to variant rs1053372dbSNPEnsembl.1
Natural variantiVAR_055269331I → N.Corresponds to variant rs1053373dbSNPEnsembl.1
Natural variantiVAR_057989398V → E.1 PublicationCorresponds to variant rs630612dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037505163 – 409Missing in isoform 8h. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_005701163 – 313Missing in isoform RHVIII. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_037506163 – 220Missing in isoform 8a. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_037507163 – 203TDYHM…DQRAT → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 8e. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_005702164 – 268Missing in isoform RHVI and isoform 7a. 2 PublicationsAdd BLAST105
Alternative sequenceiVSP_037508204 – 417Missing in isoform 8e. 1 PublicationAdd BLAST214
Alternative sequenceiVSP_037509212 – 384Missing in isoform 4g. 2 PublicationsAdd BLAST173
Alternative sequenceiVSP_038405227 – 242LLRSP…MFNTY → DRFAPKSQNMESTSCG in isoform RhPI-Alpha. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038406243 – 417Missing in isoform RhPI-Alpha. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_037510268 – 308TYVHS…ISIGG → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 2e. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_037511301 – 313Missing in isoform 8a. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037512309 – 417Missing in isoform 2e. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_037513314 – 409Missing in isoform 1h. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_005703314 – 354VCCNR…HTVWN → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform RHIV. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_005704355 – 417Missing in isoform RHIV. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_037514358 – 417MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAVREKRS in isoform 1d. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_005705359 – 417IGFQV…LAVGF → FAPKSQNMESTSCG in isoform RHVI and isoform 1c. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54534 mRNA. Translation: CAA38401.1.
M34015 mRNA. Translation: AAA36567.1.
X63095 mRNA. Translation: CAA44809.1.
X63096 mRNA. Translation: CAA44810.1.
X63098 mRNA. Translation: CAA44812.1.
S57967 mRNA. Translation: AAB26080.1.
DQ266400 mRNA. Translation: ABB69097.1.
AB018644 mRNA. Translation: BAA33927.1.
AB018645 mRNA. Translation: BAA33928.1.
AB030388 mRNA. Translation: BAA82627.1.
AB049753 mRNA. Translation: BAB16597.1.
AF510065 mRNA. Translation: AAN75121.1.
AF510066 mRNA. Translation: AAN75122.1.
AF510067 mRNA. Translation: AAN75123.1.
AF510068 mRNA. Translation: AAN75124.1.
AY603478 mRNA. Translation: AAT35811.1.
DQ178642 mRNA. Translation: ABA25912.1.
DQ266353 mRNA. Translation: ABB97471.1.
DQ322275 mRNA. Translation: ABC55358.1.
AM398146 Genomic DNA. Translation: CAL44958.1.
FJ486155 Genomic DNA. Translation: ACK75562.1.
FJ486156 Genomic DNA. Translation: ACK75563.1.
FJ486157 Genomic DNA. Translation: ACK75564.1.
FJ486158 Genomic DNA. Translation: ACK75565.1.
FJ486159 Genomic DNA. Translation: ACK75566.1.
FJ486160 Genomic DNA. Translation: ACK75567.1.
FJ486161 Genomic DNA. Translation: ACK75568.1.
FJ486162 Genomic DNA. Translation: ACK75569.1.
FJ486163 Genomic DNA. Translation: ACK75570.1.
FJ486164 Genomic DNA. Translation: ACK75571.1.
FJ486165 Genomic DNA. Translation: ACK75572.1.
AL031284, AL928711 Genomic DNA. Translation: CAM12858.1.
AL928711, AL031284 Genomic DNA. Translation: CAH72605.1.
BC075081 mRNA. Translation: AAH75081.1.
BC139905 mRNA. Translation: AAI39906.1.
S70456 Genomic DNA. Translation: AAD14061.1.
BN000065 Genomic DNA. Translation: CAD29850.1.
CCDSiCCDS30634.1. [P18577-4]
CCDS30635.1. [P18577-1]
CCDS30636.1. [P18577-3]
CCDS30637.1. [P18577-2]
CCDS81283.1. [P18577-5]
PIRiA30405.
I54193.
PC2032.
PC2033.
S78478.
S78479.
S78480.
RefSeqiNP_001317359.1. NM_001330430.1.
NP_065231.3. NM_020485.4.
NP_619522.3. NM_138616.3. [P18577-4]
NP_619523.3. NM_138617.3. [P18577-3]
NP_619524.3. NM_138618.3.
UniGeneiHs.449968.
Hs.523054.

Genome annotation databases

EnsembliENST00000294413; ENSP00000294413; ENSG00000188672.
GeneIDi6006.
KEGGihsa:6006.
UCSCiuc001bkf.4. human. [P18577-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54534 mRNA. Translation: CAA38401.1.
M34015 mRNA. Translation: AAA36567.1.
X63095 mRNA. Translation: CAA44809.1.
X63096 mRNA. Translation: CAA44810.1.
X63098 mRNA. Translation: CAA44812.1.
S57967 mRNA. Translation: AAB26080.1.
DQ266400 mRNA. Translation: ABB69097.1.
AB018644 mRNA. Translation: BAA33927.1.
AB018645 mRNA. Translation: BAA33928.1.
AB030388 mRNA. Translation: BAA82627.1.
AB049753 mRNA. Translation: BAB16597.1.
AF510065 mRNA. Translation: AAN75121.1.
AF510066 mRNA. Translation: AAN75122.1.
AF510067 mRNA. Translation: AAN75123.1.
AF510068 mRNA. Translation: AAN75124.1.
AY603478 mRNA. Translation: AAT35811.1.
DQ178642 mRNA. Translation: ABA25912.1.
DQ266353 mRNA. Translation: ABB97471.1.
DQ322275 mRNA. Translation: ABC55358.1.
AM398146 Genomic DNA. Translation: CAL44958.1.
FJ486155 Genomic DNA. Translation: ACK75562.1.
FJ486156 Genomic DNA. Translation: ACK75563.1.
FJ486157 Genomic DNA. Translation: ACK75564.1.
FJ486158 Genomic DNA. Translation: ACK75565.1.
FJ486159 Genomic DNA. Translation: ACK75566.1.
FJ486160 Genomic DNA. Translation: ACK75567.1.
FJ486161 Genomic DNA. Translation: ACK75568.1.
FJ486162 Genomic DNA. Translation: ACK75569.1.
FJ486163 Genomic DNA. Translation: ACK75570.1.
FJ486164 Genomic DNA. Translation: ACK75571.1.
FJ486165 Genomic DNA. Translation: ACK75572.1.
AL031284, AL928711 Genomic DNA. Translation: CAM12858.1.
AL928711, AL031284 Genomic DNA. Translation: CAH72605.1.
BC075081 mRNA. Translation: AAH75081.1.
BC139905 mRNA. Translation: AAI39906.1.
S70456 Genomic DNA. Translation: AAD14061.1.
BN000065 Genomic DNA. Translation: CAD29850.1.
CCDSiCCDS30634.1. [P18577-4]
CCDS30635.1. [P18577-1]
CCDS30636.1. [P18577-3]
CCDS30637.1. [P18577-2]
CCDS81283.1. [P18577-5]
PIRiA30405.
I54193.
PC2032.
PC2033.
S78478.
S78479.
S78480.
RefSeqiNP_001317359.1. NM_001330430.1.
NP_065231.3. NM_020485.4.
NP_619522.3. NM_138616.3. [P18577-4]
NP_619523.3. NM_138617.3. [P18577-3]
NP_619524.3. NM_138618.3.
UniGeneiHs.449968.
Hs.523054.

3D structure databases

ProteinModelPortaliP18577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000294413.

Protein family/group databases

TCDBi1.A.11.4.3. the ammonium transporter channel (amt) family.

PTM databases

iPTMnetiP18577.
PhosphoSitePlusiP18577.

Polymorphism and mutation databases

BioMutaiRHCE.
DMDMi132558.

Proteomic databases

PaxDbiP18577.
PeptideAtlasiP18577.
PRIDEiP18577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294413; ENSP00000294413; ENSG00000188672.
GeneIDi6006.
KEGGihsa:6006.
UCSCiuc001bkf.4. human. [P18577-1]

Organism-specific databases

CTDi6006.
DisGeNETi6006.
GeneCardsiRHCE.
H-InvDBHIX0023511.
HGNCiHGNC:10008. RHCE.
MalaCardsiRHCE.
MIMi111690. phenotype.
111700. gene+phenotype.
neXtProtiNX_P18577.
Orphaneti71275. Rh deficiency syndrome.
PharmGKBiPA34386.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOVERGENiHBG004374.
InParanoidiP18577.
KOiK06579.
OrthoDBiEOG091G06KX.
PhylomeDBiP18577.
TreeFamiTF314450.

Miscellaneous databases

GeneWikiiRHCE_(gene).
GenomeRNAii6006.
PROiP18577.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188672.
CleanExiHS_RHCE.
ExpressionAtlasiP18577. baseline and differential.
GenevisibleiP18577. HS.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHCE_HUMAN
AccessioniPrimary (citable) accession number: P18577
Secondary accession number(s): A7DW68
, B7UDF3, B7UDF4, B7UDF5, B7UDF6, B7UDF7, B7UDF8, B7UDF9, B7UDG0, B7UDG1, B7UDG2, B7UDG3, Q02163, Q02164, Q02165, Q16160, Q2MJW0, Q2VC86, Q3LTM6, Q6AZX5, Q6J2U3, Q7RU06, Q8IZT2, Q8IZT3, Q8IZT4, Q8IZT5, Q9UD13, Q9UD14, Q9UD15, Q9UD16, Q9UD73, Q9UD74, Q9UEC2, Q9UEC3, Q9UPN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.