Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Blood group Rh(CE) polypeptide

Gene

RHCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Protein family/group databases

TCDBi1.A.11.4.3. the ammonia transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(CE) polypeptide
Alternative name(s):
Rh polypeptide 1
Short name:
RhPI
Rh30A
RhIXB
Rhesus C/E antigens
CD_antigen: CD240CE
Gene namesi
Name:RHCE
Synonyms:RHC, RHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10008. RHCE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiRHCE.
MIMi111690. phenotype.
111700. gene+phenotype.
Orphaneti71275. Rh deficiency syndrome.
PharmGKBiPA34386.

Polymorphism and mutation databases

BioMutaiRHCE.
DMDMi132558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 417416Blood group Rh(CE) polypeptidePRO_0000168189Add
BLAST

Proteomic databases

PaxDbiP18577.
PeptideAtlasiP18577.
PRIDEiP18577.

PTM databases

iPTMnetiP18577.
PhosphoSiteiP18577.

Expressioni

Tissue specificityi

Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts.1 Publication

Gene expression databases

BgeeiENSG00000188672.
CleanExiHS_RHCE.
ExpressionAtlasiP18577. baseline and differential.
GenevisibleiP18577. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000294413.

Structurei

3D structure databases

ProteinModelPortaliP18577.
SMRiP18577. Positions 3-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOVERGENiHBG004374.
InParanoidiP18577.
KOiK06579.
OrthoDBiEOG091G06KX.
PhylomeDBiP18577.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequences (14)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 14 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RHI (identifier: P18577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAL GLGFLTSNFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPPGKVVITL FSIRLATMSA MSVLISAGAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GTLRMVISNI FNTDYHMNLR HFYVFAAYFG LTVAWCLPKP LPKGTEDNDQ
210 220 230 240 250
RATIPSLSAM LGALFLWMFW PSVNSPLLRS PIQRKNAMFN TYYALAVSVV
260 270 280 290 300
TAISGSSLAH PQRKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISIGGAK CLPVCCNRVL GIHHISVMHS IFSLLGLLGE ITYIVLLVLH
360 370 380 390 400
TVWNGNGMIG FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHVAK
410
YFDDQVFWKF PHLAVGF
Length:417
Mass (Da):45,560
Last modified:January 23, 2007 - v2
Checksum:i29D33E778D9053DF
GO
Isoform RHIV (identifier: P18577-2) [UniParc]FASTAAdd to basket
Also known as: 1e

The sequence of this isoform differs from the canonical sequence as follows:
     314-354: VCCNRVLGIH...VLLVLHTVWN → DWLPGPPQHW...SQNMESTSCG
     355-417: Missing.

Show »
Length:354
Mass (Da):38,698
Checksum:i2ED52E5FF2B9085D
GO
Isoform RHVI (identifier: P18577-3) [UniParc]FASTAAdd to basket
Also known as: 7c

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:267
Mass (Da):28,702
Checksum:iBEF2BF74DCF531E1
GO
Isoform RHVIII (identifier: P18577-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-313: Missing.

Show »
Length:266
Mass (Da):29,256
Checksum:i728E70D6F0CEB46A
GO
Isoform 1c (identifier: P18577-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:372
Mass (Da):40,523
Checksum:iB3B22D8C3FD0E07B
GO
Isoform 1d (identifier: P18577-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LLPAVREKRS

Show »
Length:395
Mass (Da):43,553
Checksum:iEFABE59673D8AD25
GO
Isoform 1h (identifier: P18577-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-409: Missing.

Show »
Length:321
Mass (Da):34,967
Checksum:iE2A4BE357967545A
GO
Isoform 2e (identifier: P18577-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-308: TYVHSAVLAG...LVAGLISIGG → DWLPGPPQHW...SQNMESTSCG
     309-417: Missing.

Show »
Length:308
Mass (Da):34,215
Checksum:i3B4E7B35E439386C
GO
Isoform 4g (identifier: P18577-9) [UniParc]FASTAAdd to basket
Also known as: RhPI-Beta

The sequence of this isoform differs from the canonical sequence as follows:
     212-384: Missing.

Show »
Length:244
Mass (Da):27,259
Checksum:iD33E72E9B94F1D08
GO
Isoform 7a (identifier: P18577-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.

Show »
Length:312
Mass (Da):33,739
Checksum:iC852D699223E9A22
GO
Isoform 8a (identifier: P18577-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-220: Missing.
     301-313: Missing.

Show »
Length:346
Mass (Da):37,643
Checksum:iB72694FC03CA96A1
GO
Isoform 8e (identifier: P18577-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-203: TDYHMNLRHF...GTEDNDQRAT → DWLPGPPQHW...SQNMESTSCG
     204-417: Missing.

Show »
Length:203
Mass (Da):22,394
Checksum:iF219A5EB7706D655
GO
Isoform 8h (identifier: P18577-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-409: Missing.

Show »
Length:170
Mass (Da):18,663
Checksum:i8187115F3B54081F
GO
Isoform RhPI-Alpha (identifier: P18577-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-242: LLRSPIQRKNAMFNTY → DRFAPKSQNMESTSCG
     243-417: Missing.

Show »
Length:242
Mass (Da):26,852
Checksum:iE6EA91C2781C2782
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101R → W in ACK75562 (Ref. 13) Curated
Sequence conflicti12 – 121C → L AA sequence (PubMed:3135863).Curated
Sequence conflicti53 – 531D → G in CAA44812 (PubMed:1379850).Curated
Sequence conflicti61 – 611G → C in CAA44812 (PubMed:1379850).Curated
Sequence conflicti114 – 1141R → W in AAN75123 (PubMed:12393640).Curated
Sequence conflicti115 – 1151L → P in ACK75563 (Ref. 13) Curated
Sequence conflicti115 – 1151L → P in ACK75565 (Ref. 13) Curated
Sequence conflicti121 – 1211M → L in BAB16597 (PubMed:11724987).Curated
Sequence conflicti121 – 1211M → L in BAA82627 (PubMed:11724987).Curated
Sequence conflicti122 – 1221S → P in ACK75564 (Ref. 13) Curated
Sequence conflicti125 – 1251I → N in ACK75565 (Ref. 13) Curated
Sequence conflicti152 – 1521T → N in BAB16597 (PubMed:11724987).Curated
Sequence conflicti152 – 1521T → N in BAA82627 (PubMed:11724987).Curated
Sequence conflicti155 – 1551M → V in AAT35811 (Ref. 8) Curated
Sequence conflicti166 – 1661H → L in ACK75566 (Ref. 13) Curated
Sequence conflicti169 – 1691L → Q in ACK75567 (Ref. 13) Curated
Sequence conflicti201 – 2011R → T in ACK75568 (Ref. 13) Curated
Sequence conflicti217 – 2171W → R in ACK75569 (Ref. 13) Curated
Sequence conflicti241 – 2411T → I in ACK75570 (Ref. 13) Curated
Sequence conflicti250 – 2501V → M in AAN75124 (PubMed:12393640).Curated
Sequence conflicti273 – 2731A → V in AAN75122 (PubMed:12393640).Curated
Sequence conflicti303 – 3031L → Q in ACK75572 (Ref. 13) Curated
Sequence conflicti378 – 3781L → V in AAN75122 (PubMed:12393640).Curated
Sequence conflicti408 – 4092WK → DI AA sequence (PubMed:1898705).Curated

Polymorphismi

RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161W → C Associated with altered expression of E antigen. 10 Publications
VAR_006911
Natural varianti36 – 361A → T in C(X)/Rh9 antigen.
VAR_006912
Natural varianti41 – 411Q → R in C(W)/Rh8 antigen.
Corresponds to variant rs138268848 [ dbSNP | Ensembl ].
VAR_006913
Natural varianti60 – 601L → I.6 Publications
Corresponds to variant rs181860403 [ dbSNP | Ensembl ].
VAR_006914
Natural varianti68 – 681N → S.6 Publications
Corresponds to variant rs1053344 [ dbSNP | Ensembl ].
VAR_006915
Natural varianti103 – 1031P → S in C/Rh2 antigen. 6 Publications
Corresponds to variant rs676785 [ dbSNP | Ensembl ].
VAR_006916
Natural varianti127 – 1271A → V.1 Publication
Corresponds to variant rs1053346 [ dbSNP | Ensembl ].
VAR_055260
Natural varianti128 – 1281G → D.1 Publication
Corresponds to variant rs1053347 [ dbSNP | Ensembl ].
VAR_055261
Natural varianti154 – 1541R → T Found in antigen RhEKH. 1 Publication
VAR_013301
Natural varianti182 – 1821T → S.
Corresponds to variant rs1053350 [ dbSNP | Ensembl ].
VAR_055262
Natural varianti198 – 1981N → K.
Corresponds to variant rs1053354 [ dbSNP | Ensembl ].
VAR_055263
Natural varianti226 – 2261P → A in E/Rh5 antigen. 10 Publications
Corresponds to variant rs609320 [ dbSNP | Ensembl ].
VAR_006917
Natural varianti233 – 2331Q → E Found in antigen RhEFM. 2 Publications
VAR_013302
Natural varianti238 – 2381M → V Found in antigen RhEFM. 2 Publications
Corresponds to variant rs144163296 [ dbSNP | Ensembl ].
VAR_013303
Natural varianti245 – 2451L → V in VS antigen. 2 Publications
Corresponds to variant rs1053361 [ dbSNP | Ensembl ].
VAR_006918
Natural varianti263 – 2631R → G.1 Publication
Corresponds to variant rs1132763 [ dbSNP | Ensembl ].
VAR_057987
Natural varianti267 – 2671M → K.2 Publications
Corresponds to variant rs1132764 [ dbSNP | Ensembl ].
VAR_057988
Natural varianti323 – 3231H → P.
Corresponds to variant rs1053366 [ dbSNP | Ensembl ].
VAR_055264
Natural varianti325 – 3251I → S.
Corresponds to variant rs1053367 [ dbSNP | Ensembl ].
VAR_055265
Natural varianti329 – 3291H → D.
Corresponds to variant rs1053370 [ dbSNP | Ensembl ].
VAR_055266
Natural varianti329 – 3291H → R.
Corresponds to variant rs1053371 [ dbSNP | Ensembl ].
VAR_055267
Natural varianti330 – 3301S → Y.
Corresponds to variant rs1053372 [ dbSNP | Ensembl ].
VAR_055268
Natural varianti331 – 3311I → N.
Corresponds to variant rs1053373 [ dbSNP | Ensembl ].
VAR_055269
Natural varianti398 – 3981V → E.1 Publication
Corresponds to variant rs630612 [ dbSNP | Ensembl ].
VAR_057989

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei163 – 409247Missing in isoform 8h. 1 PublicationVSP_037505Add
BLAST
Alternative sequencei163 – 313151Missing in isoform RHVIII. 1 PublicationVSP_005701Add
BLAST
Alternative sequencei163 – 22058Missing in isoform 8a. 1 PublicationVSP_037506Add
BLAST
Alternative sequencei163 – 20341TDYHM…DQRAT → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 8e. 1 PublicationVSP_037507Add
BLAST
Alternative sequencei164 – 268105Missing in isoform RHVI and isoform 7a. 2 PublicationsVSP_005702Add
BLAST
Alternative sequencei204 – 417214Missing in isoform 8e. 1 PublicationVSP_037508Add
BLAST
Alternative sequencei212 – 384173Missing in isoform 4g. 2 PublicationsVSP_037509Add
BLAST
Alternative sequencei227 – 24216LLRSP…MFNTY → DRFAPKSQNMESTSCG in isoform RhPI-Alpha. 1 PublicationVSP_038405Add
BLAST
Alternative sequencei243 – 417175Missing in isoform RhPI-Alpha. 1 PublicationVSP_038406Add
BLAST
Alternative sequencei268 – 30841TYVHS…ISIGG → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 2e. 1 PublicationVSP_037510Add
BLAST
Alternative sequencei301 – 31313Missing in isoform 8a. 1 PublicationVSP_037511Add
BLAST
Alternative sequencei309 – 417109Missing in isoform 2e. 1 PublicationVSP_037512Add
BLAST
Alternative sequencei314 – 40996Missing in isoform 1h. 1 PublicationVSP_037513Add
BLAST
Alternative sequencei314 – 35441VCCNR…HTVWN → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform RHIV. 2 PublicationsVSP_005703Add
BLAST
Alternative sequencei355 – 41763Missing in isoform RHIV. 2 PublicationsVSP_005704Add
BLAST
Alternative sequencei358 – 41760MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAVREKRS in isoform 1d. 1 PublicationVSP_037514Add
BLAST
Alternative sequencei359 – 41759IGFQV…LAVGF → FAPKSQNMESTSCG in isoform RHVI and isoform 1c. 2 PublicationsVSP_005705Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54534 mRNA. Translation: CAA38401.1.
M34015 mRNA. Translation: AAA36567.1.
X63095 mRNA. Translation: CAA44809.1.
X63096 mRNA. Translation: CAA44810.1.
X63098 mRNA. Translation: CAA44812.1.
S57967 mRNA. Translation: AAB26080.1.
DQ266400 mRNA. Translation: ABB69097.1.
AB018644 mRNA. Translation: BAA33927.1.
AB018645 mRNA. Translation: BAA33928.1.
AB030388 mRNA. Translation: BAA82627.1.
AB049753 mRNA. Translation: BAB16597.1.
AF510065 mRNA. Translation: AAN75121.1.
AF510066 mRNA. Translation: AAN75122.1.
AF510067 mRNA. Translation: AAN75123.1.
AF510068 mRNA. Translation: AAN75124.1.
AY603478 mRNA. Translation: AAT35811.1.
DQ178642 mRNA. Translation: ABA25912.1.
DQ266353 mRNA. Translation: ABB97471.1.
DQ322275 mRNA. Translation: ABC55358.1.
AM398146 Genomic DNA. Translation: CAL44958.1.
FJ486155 Genomic DNA. Translation: ACK75562.1.
FJ486156 Genomic DNA. Translation: ACK75563.1.
FJ486157 Genomic DNA. Translation: ACK75564.1.
FJ486158 Genomic DNA. Translation: ACK75565.1.
FJ486159 Genomic DNA. Translation: ACK75566.1.
FJ486160 Genomic DNA. Translation: ACK75567.1.
FJ486161 Genomic DNA. Translation: ACK75568.1.
FJ486162 Genomic DNA. Translation: ACK75569.1.
FJ486163 Genomic DNA. Translation: ACK75570.1.
FJ486164 Genomic DNA. Translation: ACK75571.1.
FJ486165 Genomic DNA. Translation: ACK75572.1.
AL031284, AL928711 Genomic DNA. Translation: CAM12858.1.
AL928711, AL031284 Genomic DNA. Translation: CAH72605.1.
BC075081 mRNA. Translation: AAH75081.1.
BC139905 mRNA. Translation: AAI39906.1.
S70456 Genomic DNA. Translation: AAD14061.1.
BN000065 Genomic DNA. Translation: CAD29850.1.
CCDSiCCDS30634.1. [P18577-4]
CCDS30635.1. [P18577-1]
CCDS30636.1. [P18577-3]
CCDS30637.1. [P18577-2]
PIRiA30405.
I54193.
PC2032.
PC2033.
S78478.
S78479.
S78480.
RefSeqiNP_065231.3. NM_020485.4.
NP_619522.3. NM_138616.3. [P18577-4]
NP_619523.3. NM_138617.3. [P18577-3]
NP_619524.3. NM_138618.3.
UniGeneiHs.449968.
Hs.523054.

Genome annotation databases

EnsembliENST00000294413; ENSP00000294413; ENSG00000188672.
GeneIDi6006.
KEGGihsa:6006.
UCSCiuc001bkf.4. human. [P18577-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54534 mRNA. Translation: CAA38401.1.
M34015 mRNA. Translation: AAA36567.1.
X63095 mRNA. Translation: CAA44809.1.
X63096 mRNA. Translation: CAA44810.1.
X63098 mRNA. Translation: CAA44812.1.
S57967 mRNA. Translation: AAB26080.1.
DQ266400 mRNA. Translation: ABB69097.1.
AB018644 mRNA. Translation: BAA33927.1.
AB018645 mRNA. Translation: BAA33928.1.
AB030388 mRNA. Translation: BAA82627.1.
AB049753 mRNA. Translation: BAB16597.1.
AF510065 mRNA. Translation: AAN75121.1.
AF510066 mRNA. Translation: AAN75122.1.
AF510067 mRNA. Translation: AAN75123.1.
AF510068 mRNA. Translation: AAN75124.1.
AY603478 mRNA. Translation: AAT35811.1.
DQ178642 mRNA. Translation: ABA25912.1.
DQ266353 mRNA. Translation: ABB97471.1.
DQ322275 mRNA. Translation: ABC55358.1.
AM398146 Genomic DNA. Translation: CAL44958.1.
FJ486155 Genomic DNA. Translation: ACK75562.1.
FJ486156 Genomic DNA. Translation: ACK75563.1.
FJ486157 Genomic DNA. Translation: ACK75564.1.
FJ486158 Genomic DNA. Translation: ACK75565.1.
FJ486159 Genomic DNA. Translation: ACK75566.1.
FJ486160 Genomic DNA. Translation: ACK75567.1.
FJ486161 Genomic DNA. Translation: ACK75568.1.
FJ486162 Genomic DNA. Translation: ACK75569.1.
FJ486163 Genomic DNA. Translation: ACK75570.1.
FJ486164 Genomic DNA. Translation: ACK75571.1.
FJ486165 Genomic DNA. Translation: ACK75572.1.
AL031284, AL928711 Genomic DNA. Translation: CAM12858.1.
AL928711, AL031284 Genomic DNA. Translation: CAH72605.1.
BC075081 mRNA. Translation: AAH75081.1.
BC139905 mRNA. Translation: AAI39906.1.
S70456 Genomic DNA. Translation: AAD14061.1.
BN000065 Genomic DNA. Translation: CAD29850.1.
CCDSiCCDS30634.1. [P18577-4]
CCDS30635.1. [P18577-1]
CCDS30636.1. [P18577-3]
CCDS30637.1. [P18577-2]
PIRiA30405.
I54193.
PC2032.
PC2033.
S78478.
S78479.
S78480.
RefSeqiNP_065231.3. NM_020485.4.
NP_619522.3. NM_138616.3. [P18577-4]
NP_619523.3. NM_138617.3. [P18577-3]
NP_619524.3. NM_138618.3.
UniGeneiHs.449968.
Hs.523054.

3D structure databases

ProteinModelPortaliP18577.
SMRiP18577. Positions 3-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000294413.

Protein family/group databases

TCDBi1.A.11.4.3. the ammonia transporter channel (amt) family.

PTM databases

iPTMnetiP18577.
PhosphoSiteiP18577.

Polymorphism and mutation databases

BioMutaiRHCE.
DMDMi132558.

Proteomic databases

PaxDbiP18577.
PeptideAtlasiP18577.
PRIDEiP18577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294413; ENSP00000294413; ENSG00000188672.
GeneIDi6006.
KEGGihsa:6006.
UCSCiuc001bkf.4. human. [P18577-1]

Organism-specific databases

CTDi6006.
GeneCardsiRHCE.
H-InvDBHIX0023511.
HGNCiHGNC:10008. RHCE.
MalaCardsiRHCE.
MIMi111690. phenotype.
111700. gene+phenotype.
neXtProtiNX_P18577.
Orphaneti71275. Rh deficiency syndrome.
PharmGKBiPA34386.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOVERGENiHBG004374.
InParanoidiP18577.
KOiK06579.
OrthoDBiEOG091G06KX.
PhylomeDBiP18577.
TreeFamiTF314450.

Miscellaneous databases

GeneWikiiRHCE_(gene).
GenomeRNAii6006.
PROiP18577.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188672.
CleanExiHS_RHCE.
ExpressionAtlasiP18577. baseline and differential.
GenevisibleiP18577. HS.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHCE_HUMAN
AccessioniPrimary (citable) accession number: P18577
Secondary accession number(s): A7DW68
, B7UDF3, B7UDF4, B7UDF5, B7UDF6, B7UDF7, B7UDF8, B7UDF9, B7UDG0, B7UDG1, B7UDG2, B7UDG3, Q02163, Q02164, Q02165, Q16160, Q2MJW0, Q2VC86, Q3LTM6, Q6AZX5, Q6J2U3, Q7RU06, Q8IZT2, Q8IZT3, Q8IZT4, Q8IZT5, Q9UD13, Q9UD14, Q9UD15, Q9UD16, Q9UD73, Q9UD74, Q9UEC2, Q9UEC3, Q9UPN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.