Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P18573 (GDA9_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha/beta-gliadin MM1
Alternative name(s):
Prolamin
OrganismTriticum aestivum (Wheat) [Complete proteome]
Taxonomic identifier4565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gliadin is the major seed storage protein in wheat.

Post-translational modification

Substrate of transglutaminase.

Allergenic properties

Causes an allergic reaction in human. Is the cause of the celiac disease, also known as celiac sprue or gluten-sensitive enteropathy. Ref.2

Miscellaneous

An internal 33-mer peptide seems to be the primary initiator of the inflammatory response to gluten.

The alpha/beta-gliadins can be divided into 5 homology classes. Sequence divergence between the classes is due to single base substitutions and to duplications or deletions within or near direct repeats. There are more than a 100 copies of the gene for alpha/beta-gliadin per haploid genome.

Sequence similarities

Belongs to the gliadin/glutenin family.

Ontologies

Keywords
   DiseaseAllergen
   DomainRepeat
Signal
   Molecular functionSeed storage protein
Storage protein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Molecular_functionnutrient reservoir activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 307287Alpha/beta-gliadin MM1
PRO_0000032275

Sequences

Sequence LengthMass (Da)Tools
P18573 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 06C1858BD96F1E08

FASTA30735,397
        10         20         30         40         50         60 
MKTFLILALL AIVATTARIA VRVPVPQLQP QNPSQQQPQE QVPLVQQQQF PGQQQPFPPQ 

        70         80         90        100        110        120 
QPYPQPQPFP SQQPYLQLQP FPQPQLPYPQ PQLPYPQPQL PYPQPQPFRP QQPYPQSQPQ 

       130        140        150        160        170        180 
YSQPQQPISQ QQQQQQQQQQ QKQQQQQQQQ ILQQILQQQL IPCRDVVLQQ HSIAYGSSQV 

       190        200        210        220        230        240 
LQQSTYQLVQ QLCCQQLWQI PEQSRCQAIH NVVHAIILHQ QQQQQQQQQQ QPLSQVSFQQ 

       250        260        270        280        290        300 
PQQQYPSGQG SFQPSQQNPQ AQGSVQPQQL PQFEEIRNLA LETLPAMCNV YIPPYCTIAP 


VGIFGTN 

« Hide

References

[1]"Nucleotide sequence of a cDNA encoding an alpha/beta-type gliadin from hexaploid wheat (Triticum aestivum)."
Garcia-Maroto F., Manana C., Garcia-Olmedo F., Carbonero P.
Plant Mol. Biol. 14:867-868(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Chinese Spring.
Tissue: Endosperm.
[2]"Structural basis for gluten intolerance in celiac sprue."
Shan L., Molberg O., Parrot I., Hausch F., Filiz F., Gray G.M., Sollid L.M., Khosla C.
Science 297:2275-2279(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALLERGEN.
[3]"A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease."
Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T., Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., van Heel D.A., McCluskey J., Rossjohn J., Anderson R.P.
Immunity 27:23-34(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 243-260 IN COMPLEX WITH HLA-DQA1/HLA-DQB1 HETERODIMER.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17361 mRNA. Translation: CAA35238.1.
PIRS10015.
UniGeneTa.55043.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NNAX-ray2.10C243-260[»]
4GG6X-ray3.20I/J243-260[»]
4OZFX-ray2.70J96-105[»]
4OZGX-ray3.00I/J96-105[»]
4OZHX-ray2.80I/J96-105[»]
4OZIX-ray3.20I/J79-89[»]
ProteinModelPortalP18573.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP18573.

Family and domain databases

Gene3D1.10.120.10. 2 hits.
InterProIPR016140. Bifunc_inhib/LTP/seed_store.
IPR001954. Glia_glutenin.
IPR001376. Gliadin.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamPF13016. Gliadin. 1 hit.
[Graphical view]
PRINTSPR00208. GLIADGLUTEN.
PR00209. GLIADIN.
SMARTSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMSSF47699. SSF47699. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceP18573.

Entry information

Entry nameGDA9_WHEAT
AccessionPrimary (citable) accession number: P18573
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references