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Protein

Basigin

Gene

Bsg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-210991 Basigin interactions
R-MMU-216083 Integrin cell surface interactions
R-MMU-433692 Proton-coupled monocarboxylate transport
R-MMU-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
Basic immunoglobulin superfamily
HT7 antigen
Membrane glycoprotein gp42
CD_antigen: CD147
Gene namesi
Name:Bsg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88208 Bsg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 325ExtracellularSequence analysisAdd BLAST304
Transmembranei326 – 349HelicalSequence analysisAdd BLAST24
Topological domaini350 – 389CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001451922 – 389BasiginAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi157 ↔ 203PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi242 ↔ 305PROSITE-ProRule annotation
Glycosylationi270N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi275N-linked (GlcNAc...) asparagine; atypical2 Publications1
Glycosylationi306N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi309N-linked (GlcNAc...) asparagine; atypical1 Publication1
Modified residuei358PhosphothreonineCombined sources1
Modified residuei372PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated. During spermatogenesis, probably deglycosylated during epididymal transit.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP18572
PaxDbiP18572
PeptideAtlasiP18572
PRIDEiP18572

PTM databases

iPTMnetiP18572
PhosphoSitePlusiP18572
SwissPalmiP18572

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in retina. Isoform 2 is widely expressed, including adult organs, embryos and EC cells. Expressed in spermatozoa.2 Publications

Developmental stagei

In developing eye expressed at embryonic days E12, E15 and E18, and at postnatal days P1, P7, P14, and P21. Expression progressed from a more generalized distribution throughout the undifferentiated neural retina to specific staining of retina-pigmented epithilia, the MCs, photoreceptor cells and the ciliary apparatus. Expression is highest at P21. Isoform 1 and isoform 2 are expressed at equivalent levels at P7, isoform 1 is more abundant at P14, P21 and P28. In uterus during the peri-implantation period strongly expressed in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. In ovary during sexual maturation expressed in the granulosa cells of preantral follicles at days 20 and 25 after birth. Expressed during corpus luteum formation.3 Publications

Inductioni

By estrogen in the uterine epithelium of ovariectomized animals. By eCG in ovary.2 Publications

Gene expression databases

BgeeiENSMUSG00000023175
CleanExiMM_BSG
ExpressionAtlasiP18572 baseline and differential
GenevisibleiP18572 MM

Interactioni

Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface (By similarity). Interacts with AJAP1 (By similarity). Interacts with ATP1B2, MAG and L1CAM. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. Interacts with SLC16A11 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198392, 1 interactor
IntActiP18572, 5 interactors
MINTiP18572
STRINGi10090.ENSMUSP00000070751

Structurei

3D structure databases

ProteinModelPortaliP18572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 219Ig-like C2-typeAdd BLAST82
Domaini221 – 319Ig-like V-typeAdd BLAST99

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00390000010516
HOGENOMiHOG000263411
HOVERGENiHBG008120
InParanoidiP18572
KOiK06535
OMAiQWWFEGN
OrthoDBiEOG091G07LY
PhylomeDBiP18572
TreeFamiTF326759

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR009151 Basigin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR10075:SF12 PTHR10075:SF12, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18572-1) [UniParc]FASTAAdd to basket
Also known as: 5A11/Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALLLALA FTLLSGQGAC AAAGFLKAPL SQERWAGGSV VLHCEAVGSP
60 70 80 90 100
IPEIQWWFEG NAPNDSCSQL WDGARLDRVH IHAAYRQHAA SSLSVDGLTA
110 120 130 140 150
EDTGTYECRA SSDPDRNHLT RPPRVKWVRA QASVVVLEPG TIQTSVQEVN
160 170 180 190 200
SKTQLTCSLN SSGVDIVGHR WMRGGKVLQE DTLPDLHTKY IVDADDRSGE
210 220 230 240 250
YSCIFLPEPV GRSEINVEGP PRIKVGKKSE HSSEGELAKL VCKSDASYPP
260 270 280 290 300
ITDWFWFKTS DTGEEEAITN STEANGKYVV VSTPEKSQLT ISNLDVNVDP
310 320 330 340 350
GTYVCNATNA QGTTRETISL RVRSRMAALW PFLGIVAEVL VLVTIIFIYE
360 370 380
KRRKPDQTLD EDDPGAAPLK GSGTHMNDKD KNVRQRNAT
Length:389
Mass (Da):42,445
Last modified:August 31, 2004 - v2
Checksum:iB1E484C3386BEB20
GO
Isoform 2 (identifier: P18572-2) [UniParc]FASTAAdd to basket
Also known as: 5A11/Basigin

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Show »
Length:273
Mass (Da):29,674
Checksum:i0FE654472A619094
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01150224 – 139Missing in isoform 2. 4 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00611 mRNA Translation: BAA00486.1
D82019 Genomic DNA Translation: BAA11508.1
S63813 mRNA Translation: AAB27567.2
Y16256 mRNA Translation: CAA76140.1
AY089967 mRNA Translation: AAM09957.1
AK002332 mRNA Translation: BAB22018.1
BC010270 mRNA Translation: AAH10270.1
CCDSiCCDS23985.1 [P18572-1]
CCDS35967.1 [P18572-2]
PIRiJX0107
S43512
RefSeqiNP_001070652.1, NM_001077184.1 [P18572-2]
NP_033898.1, NM_009768.2 [P18572-1]
UniGeneiMm.726

Genome annotation databases

EnsembliENSMUST00000067036; ENSMUSP00000070751; ENSMUSG00000023175 [P18572-1]
ENSMUST00000179781; ENSMUSP00000136487; ENSMUSG00000023175 [P18572-2]
GeneIDi12215
KEGGimmu:12215
UCSCiuc007fzl.1 mouse [P18572-1]
uc007fzm.1 mouse [P18572-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBASI_MOUSE
AccessioniPrimary (citable) accession number: P18572
Secondary accession number(s): Q6LDB0, Q7TSC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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