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P18571

- NSP5_ROTGA

UniProt

P18571 - NSP5_ROTGA

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Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5
Short name:
NSP5
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Non-structural protein 5PRO_0000149629Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili111 – 13525Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus B NSP5 family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P18571-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEASEFNFT IKRKQRTMSD RRTREDTKQK KIEEKSDIDL VDSASVYSQE
60 70 80 90 100
SSRSNYSDAY DKLKREPMVE ESNDAKYRNF EFSEDEEVHR PSSKASDKSY
110 120 130 140 150
REMKRKHDDI NTSDSILEKL SELNLEIEKI KQMNQPITID AAFNMILRNV
160 170
DNLTIRQKQA LINAIVNSMN
Length:170
Mass (Da):19,938
Last modified:November 1, 1990 - v1
Checksum:i34DFC9F882F9FE91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34380 Genomic RNA. Translation: AAA42674.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34380 Genomic RNA. Translation: AAA42674.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020244. Rotavirus_B_NSP5.
[Graphical view ]
ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment."
    Chen G.-M., Hung T., Mackow E.R.
    Virology 175:605-609(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP5_ROTGA
AccessioniPrimary (citable) accession number: P18571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3