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P18571

- NSP5_ROTGA

UniProt

P18571 - NSP5_ROTGA

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
    Taxonomic identifieri10942 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Non-structural protein 5PRO_0000149629Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili111 – 13525Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus B NSP5 family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR020244. Rotavirus_B_NSP5.
    [Graphical view]
    ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P18571-1 [UniParc]FASTAAdd to Basket

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    MAEASEFNFT IKRKQRTMSD RRTREDTKQK KIEEKSDIDL VDSASVYSQE    50
    SSRSNYSDAY DKLKREPMVE ESNDAKYRNF EFSEDEEVHR PSSKASDKSY 100
    REMKRKHDDI NTSDSILEKL SELNLEIEKI KQMNQPITID AAFNMILRNV 150
    DNLTIRQKQA LINAIVNSMN 170
    Length:170
    Mass (Da):19,938
    Last modified:November 1, 1990 - v1
    Checksum:i34DFC9F882F9FE91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34380 Genomic RNA. Translation: AAA42674.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34380 Genomic RNA. Translation: AAA42674.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020244. Rotavirus_B_NSP5.
    [Graphical view ]
    ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment."
      Chen G.-M., Hung T., Mackow E.R.
      Virology 175:605-609(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP5_ROTGA
    AccessioniPrimary (citable) accession number: P18571
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3