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P18571 (NSP5_ROTGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 5

Short name=NSP5
OrganismRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifier10942 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus B NSP5 family.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   DomainCoiled coil
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Non-structural protein 5
PRO_0000149629

Regions

Coiled coil111 – 13525 Potential

Sequences

Sequence LengthMass (Da)Tools
P18571 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 34DFC9F882F9FE91

FASTA17019,938
        10         20         30         40         50         60 
MAEASEFNFT IKRKQRTMSD RRTREDTKQK KIEEKSDIDL VDSASVYSQE SSRSNYSDAY 

        70         80         90        100        110        120 
DKLKREPMVE ESNDAKYRNF EFSEDEEVHR PSSKASDKSY REMKRKHDDI NTSDSILEKL 

       130        140        150        160        170 
SELNLEIEKI KQMNQPITID AAFNMILRNV DNLTIRQKQA LINAIVNSMN 

« Hide

References

[1]"cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment."
Chen G.-M., Hung T., Mackow E.R.
Virology 175:605-609(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34380 Genomic RNA. Translation: AAA42674.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTGA
AccessionPrimary (citable) accession number: P18571
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families