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P18571

- NSP5_ROTGA

UniProt

P18571 - NSP5_ROTGA

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Protein
Non-structural protein 5
Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5
Short name:
NSP5
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Non-structural protein 5
PRO_0000149629Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili111 – 13525 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the rotavirus B NSP5 family.

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P18571-1 [UniParc]FASTAAdd to Basket

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MAEASEFNFT IKRKQRTMSD RRTREDTKQK KIEEKSDIDL VDSASVYSQE    50
SSRSNYSDAY DKLKREPMVE ESNDAKYRNF EFSEDEEVHR PSSKASDKSY 100
REMKRKHDDI NTSDSILEKL SELNLEIEKI KQMNQPITID AAFNMILRNV 150
DNLTIRQKQA LINAIVNSMN 170
Length:170
Mass (Da):19,938
Last modified:November 1, 1990 - v1
Checksum:i34DFC9F882F9FE91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34380 Genomic RNA. Translation: AAA42674.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34380 Genomic RNA. Translation: AAA42674.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020244. Rotavirus_B_NSP5.
[Graphical view ]
ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment."
    Chen G.-M., Hung T., Mackow E.R.
    Virology 175:605-609(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP5_ROTGA
AccessioniPrimary (citable) accession number: P18571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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