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P18570 (VP7_ROTGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Outer capsid glycoprotein VP7
OrganismRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifier10942 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.

Subunit structure

Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.

Subcellular location

Virion Potential. Host rough endoplasmic reticulum membrane; Single-pass membrane protein; Lumenal side Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

Sequence similarities

Belongs to the rotavirus VP7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Outer capsid glycoprotein VP7
PRO_0000041131

Regions

Transmembrane7 – 2317Helical; Potential
Compositional bias4 – 96Poly-Leu
Compositional bias62 – 676Poly-Ser

Amino acid modifications

Glycosylation451N-linked (GlcNAc...); by host Potential
Glycosylation911N-linked (GlcNAc...); by host Potential
Glycosylation1051N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P18570 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 0BE10CD1C8B2AFB3

FASTA24928,459
        10         20         30         40         50         60 
MASLLLLVLA AAVTAQLNIV PSTHPEVCVL YADDHQADAN KFNGNFTQIF HSYNSITLSF 

        70         80         90        100        110        120 
MSYSSSSYDV IDIISKYDLS SCNILAIDVF NASMDFNVFL QSTNNCSKYN ANKVHHVKLP 

       130        140        150        160        170        180 
RGEEWFSYSK NLKFCPLSDS LIGMYCDTQL SDTYFEISTG GTYEVTDIPE FTQMGYTFHS 

       190        200        210        220        230        240 
SEEFYLCHRI SSEAWLNYHL FYRDYDVSGV ISKQVNWGNV WSGFKTFAQV LYKILDLFFN 


SKRNVEPRA 

« Hide

References

[1]"Identification of the gene encoding the group B rotavirus VP7 equivalent: primary characterization of the ADRV segment 9 RNA."
Chen G.-M., Hung T., Mackow E.R.
Virology 178:311-315(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33872 Genomic RNA. Translation: AAA42675.1.
PIRVGXRHB. A37080.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008818. Rotavirus_VP7.
[Graphical view]
PfamPF05868. Rotavirus_VP7. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP7_ROTGA
AccessionPrimary (citable) accession number: P18570
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families