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P18570

- VP7_ROTGA

UniProt

P18570 - VP7_ROTGA

Protein

Outer capsid glycoprotein VP7

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.By similarity

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer capsid glycoprotein VP7
    OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
    Taxonomic identifieri10942 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion Curated. Host rough endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated; Lumenal side Curated
    Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.By similarity

    GO - Cellular componenti

    1. host cell rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. T=13 icosahedral viral capsid Source: UniProtKB-KW
    4. viral outer capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host endoplasmic reticulum, Host membrane, Membrane, Outer capsid protein, T=13 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Outer capsid glycoprotein VP7PRO_0000041131Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.By similarity

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 96Poly-Leu
    Compositional biasi62 – 676Poly-Ser

    Sequence similaritiesi

    Belongs to the rotavirus VP7 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR008818. Rotavirus_VP7.
    [Graphical view]
    PfamiPF05868. Rotavirus_VP7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLLLLVLA AAVTAQLNIV PSTHPEVCVL YADDHQADAN KFNGNFTQIF    50
    HSYNSITLSF MSYSSSSYDV IDIISKYDLS SCNILAIDVF NASMDFNVFL 100
    QSTNNCSKYN ANKVHHVKLP RGEEWFSYSK NLKFCPLSDS LIGMYCDTQL 150
    SDTYFEISTG GTYEVTDIPE FTQMGYTFHS SEEFYLCHRI SSEAWLNYHL 200
    FYRDYDVSGV ISKQVNWGNV WSGFKTFAQV LYKILDLFFN SKRNVEPRA 249
    Length:249
    Mass (Da):28,459
    Last modified:November 1, 1990 - v1
    Checksum:i0BE10CD1C8B2AFB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33872 Genomic RNA. Translation: AAA42675.1.
    PIRiA37080. VGXRHB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33872 Genomic RNA. Translation: AAA42675.1 .
    PIRi A37080. VGXRHB.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008818. Rotavirus_VP7.
    [Graphical view ]
    Pfami PF05868. Rotavirus_VP7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the gene encoding the group B rotavirus VP7 equivalent: primary characterization of the ADRV segment 9 RNA."
      Chen G.-M., Hung T., Mackow E.R.
      Virology 178:311-315(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP7_ROTGA
    AccessioniPrimary (citable) accession number: P18570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3