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P18570

- VP7_ROTGA

UniProt

P18570 - VP7_ROTGA

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Protein

Outer capsid glycoprotein VP7

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors (By similarity).By similarity

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid glycoprotein VP7
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion Curated. Host rough endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated; Lumenal side Curated
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles (By similarity).By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell membrane Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. T=13 icosahedral viral capsid Source: UniProtKB-KW
  5. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host endoplasmic reticulum, Host membrane, Membrane, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Outer capsid glycoprotein VP7PRO_0000041131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi105 – 1051N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer; in the presence of calcium (By similarity). Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer (By similarity).By similarity

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 96Poly-Leu
Compositional biasi62 – 676Poly-Ser

Sequence similaritiesi

Belongs to the rotavirus VP7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR008818. Rotavirus_VP7.
[Graphical view]
PfamiPF05868. Rotavirus_VP7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLLLLVLA AAVTAQLNIV PSTHPEVCVL YADDHQADAN KFNGNFTQIF
60 70 80 90 100
HSYNSITLSF MSYSSSSYDV IDIISKYDLS SCNILAIDVF NASMDFNVFL
110 120 130 140 150
QSTNNCSKYN ANKVHHVKLP RGEEWFSYSK NLKFCPLSDS LIGMYCDTQL
160 170 180 190 200
SDTYFEISTG GTYEVTDIPE FTQMGYTFHS SEEFYLCHRI SSEAWLNYHL
210 220 230 240
FYRDYDVSGV ISKQVNWGNV WSGFKTFAQV LYKILDLFFN SKRNVEPRA
Length:249
Mass (Da):28,459
Last modified:November 1, 1990 - v1
Checksum:i0BE10CD1C8B2AFB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33872 Genomic RNA. Translation: AAA42675.1.
PIRiA37080. VGXRHB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33872 Genomic RNA. Translation: AAA42675.1 .
PIRi A37080. VGXRHB.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008818. Rotavirus_VP7.
[Graphical view ]
Pfami PF05868. Rotavirus_VP7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of the gene encoding the group B rotavirus VP7 equivalent: primary characterization of the ADRV segment 9 RNA."
    Chen G.-M., Hung T., Mackow E.R.
    Virology 178:311-315(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP7_ROTGA
AccessioniPrimary (citable) accession number: P18570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3