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P18564

- ITB6_HUMAN

UniProt

P18564 - ITB6_HUMAN

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Protein

Integrin beta-6

Gene

ITGB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.1 Publication

GO - Molecular functioni

  1. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell-matrix adhesion Source: InterPro
  3. extracellular matrix organization Source: Reactome
  4. inflammatory response Source: Ensembl
  5. integrin-mediated signaling pathway Source: UniProtKB-KW
  6. multicellular organismal development Source: InterPro
  7. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
REACT_163906. ECM proteoglycans.
SignaLinkiP18564.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-6
Gene namesi
Name:ITGB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6161. ITGB6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 709688ExtracellularSequence AnalysisAdd
BLAST
Transmembranei710 – 73021HelicalSequence AnalysisAdd
BLAST
Topological domaini731 – 78858CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integrin complex Source: ProtInc
  4. plasma membrane Source: Reactome
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti100032. Hypocalcified amelogenesis imperfecta.
100031. Hypoplastic amelogenesis imperfecta.
PharmGKBiPA29960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 788767Integrin beta-6PRO_0000016350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 454By similarity
Disulfide bondi31 ↔ 41By similarity
Disulfide bondi34 ↔ 70By similarity
Disulfide bondi44 ↔ 59By similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi197 ↔ 204By similarity
Disulfide bondi252 ↔ 293By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi394 ↔ 406By similarity
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi426 ↔ 670By similarity
Disulfide bondi452 ↔ 456By similarity
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi467 ↔ 479By similarity
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi476 ↔ 511By similarity
Disulfide bondi481 ↔ 490By similarity
Disulfide bondi492 ↔ 502By similarity
Disulfide bondi517 ↔ 522By similarity
Disulfide bondi519 ↔ 552By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi539 ↔ 544By similarity
Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi560 ↔ 591By similarity
Disulfide bondi565 ↔ 574By similarity
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi576 ↔ 583By similarity
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 645By similarity
Disulfide bondi604 ↔ 614By similarity
Disulfide bondi617 ↔ 620By similarity
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi630 ↔ 702By similarity
Disulfide bondi649 ↔ 678By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18564.
PaxDbiP18564.
PeptideAtlasiP18564.
PRIDEiP18564.

PTM databases

PhosphoSiteiP18564.

Expressioni

Gene expression databases

BgeeiP18564.
CleanExiHS_ITGB6.
ExpressionAtlasiP18564. baseline and differential.
GenevestigatoriP18564.

Organism-specific databases

HPAiHPA023626.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.6 Publications

Protein-protein interaction databases

BioGridi109900. 5 interactions.
DIPiDIP-59187N.
STRINGi9606.ENSP00000283249.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LH9model-A76-546[»]
ProteinModelPortaliP18564.
SMRiP18564. Positions 23-775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 371241VWFAAdd
BLAST
Repeati456 – 50146IAdd
BLAST
Repeati502 – 54342IIAdd
BLAST
Repeati544 – 58239IIIAdd
BLAST
Repeati583 – 61937IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni456 – 619164Cysteine-rich tandem repeatsAdd
BLAST
Regioni731 – 75828Interaction with HAX1Add
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145803.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP18564.
KOiK06589.
OMAiEYCNCTT.
OrthoDBiEOG7T7GSB.
PhylomeDBiP18564.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P18564-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT
60 70 80 90 100
HPSGVGERCD TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD
110 120 130 140 150
IVQIAPQSLI LKLRPGGAQT LQVHVRQTED YPVDLYYLMD LSASMDDDLN
160 170 180 190 200
TIKELGSRLS KEMSKLTSNF RLGFGSFVEK PVSPFVKTTP EEIANPCSSI
210 220 230 240 250
PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE GGFDAIMQAA
260 270 280 290 300
VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE
310 320 330 340 350
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV
360 370 380 390 400
GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF
410 420 430 440 450
QHQKKCSHMK VGDTASFSVT VNIPHCERRS RHIIIKPVGL GDALELLVSP
460 470 480 490 500
ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA CHPGHMGPRC ECGEDMLSTD
510 520 530 540 550
SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD NFSCVRHKGL
560 570 580 590 600
LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG
610 620 630 640 650
KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK
660 670 680 690 700
LAGATISEEE DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK
710 720 730 740 750
DCPKPPNIPM IMLGVSLAIL LIGVVLLCIW KLLVSFHDRK EVAKFEAERS
760 770 780
KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ KVDLSTDC
Length:788
Mass (Da):85,936
Last modified:April 27, 2001 - v2
Checksum:iEDB7D533EC4C8C4D
GO
Isoform 2 (identifier: P18564-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     554-660: Missing.

Note: No experimental confirmation available. Gene prediction confirmed by EST data.

Show »
Length:681
Mass (Da):74,958
Checksum:iB761664C333068BB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti437 – 4371P → T.
Corresponds to variant rs2305820 [ dbSNP | Ensembl ].
VAR_049636

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei554 – 660107Missing in isoform 2. CuratedVSP_055189Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35198 mRNA. Translation: AAA36122.2.
AC092153 Genomic DNA. Translation: AAX93093.1.
AK313944 mRNA. Translation: BAG36662.1.
AC080166 Genomic DNA. Translation: AAY24053.1.
CH471058 Genomic DNA. Translation: EAX11390.1.
BC121178 mRNA. Translation: AAI21179.1.
S49380 Genomic DNA. Translation: AAB23690.1.
CCDSiCCDS2212.1. [P18564-1]
CCDS63040.1. [P18564-2]
PIRiA37057.
RefSeqiNP_000879.2. NM_000888.4. [P18564-1]
NP_001269282.1. NM_001282353.1. [P18564-1]
NP_001269284.1. NM_001282355.1. [P18564-2]
NP_001269317.1. NM_001282388.1.
UniGeneiHs.470399.

Genome annotation databases

EnsembliENST00000283249; ENSP00000283249; ENSG00000115221. [P18564-1]
ENST00000409872; ENSP00000386367; ENSG00000115221. [P18564-1]
ENST00000409967; ENSP00000386828; ENSG00000115221. [P18564-2]
GeneIDi3694.
KEGGihsa:3694.
UCSCiuc002ubh.2. human. [P18564-1]

Polymorphism databases

DMDMi13432176.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35198 mRNA. Translation: AAA36122.2 .
AC092153 Genomic DNA. Translation: AAX93093.1 .
AK313944 mRNA. Translation: BAG36662.1 .
AC080166 Genomic DNA. Translation: AAY24053.1 .
CH471058 Genomic DNA. Translation: EAX11390.1 .
BC121178 mRNA. Translation: AAI21179.1 .
S49380 Genomic DNA. Translation: AAB23690.1 .
CCDSi CCDS2212.1. [P18564-1 ]
CCDS63040.1. [P18564-2 ]
PIRi A37057.
RefSeqi NP_000879.2. NM_000888.4. [P18564-1 ]
NP_001269282.1. NM_001282353.1. [P18564-1 ]
NP_001269284.1. NM_001282355.1. [P18564-2 ]
NP_001269317.1. NM_001282388.1.
UniGenei Hs.470399.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LH9 model - A 76-546 [» ]
ProteinModelPortali P18564.
SMRi P18564. Positions 23-775.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109900. 5 interactions.
DIPi DIP-59187N.
STRINGi 9606.ENSP00000283249.

Chemistry

BindingDBi P18564.
ChEMBLi CHEMBL2111416.

PTM databases

PhosphoSitei P18564.

Polymorphism databases

DMDMi 13432176.

Proteomic databases

MaxQBi P18564.
PaxDbi P18564.
PeptideAtlasi P18564.
PRIDEi P18564.

Protocols and materials databases

DNASUi 3694.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283249 ; ENSP00000283249 ; ENSG00000115221 . [P18564-1 ]
ENST00000409872 ; ENSP00000386367 ; ENSG00000115221 . [P18564-1 ]
ENST00000409967 ; ENSP00000386828 ; ENSG00000115221 . [P18564-2 ]
GeneIDi 3694.
KEGGi hsa:3694.
UCSCi uc002ubh.2. human. [P18564-1 ]

Organism-specific databases

CTDi 3694.
GeneCardsi GC02M160920.
HGNCi HGNC:6161. ITGB6.
HPAi HPA023626.
MIMi 147558. gene.
neXtProti NX_P18564.
Orphaneti 100032. Hypocalcified amelogenesis imperfecta.
100031. Hypoplastic amelogenesis imperfecta.
PharmGKBi PA29960.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145803.
GeneTreei ENSGT00760000119064.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P18564.
KOi K06589.
OMAi EYCNCTT.
OrthoDBi EOG7T7GSB.
PhylomeDBi P18564.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
REACT_163906. ECM proteoglycans.
SignaLinki P18564.

Miscellaneous databases

GeneWikii Integrin,_beta_6.
GenomeRNAii 3694.
NextBioi 14479.
PROi P18564.
SOURCEi Search...

Gene expression databases

Bgeei P18564.
CleanExi HS_ITGB6.
ExpressionAtlasi P18564. baseline and differential.
Genevestigatori P18564.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction."
    Sheppard D., Rozzo C., Starr L., Quaranta V., Erle D.J., Pytela R.
    J. Biol. Chem. 265:11502-11507(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  2. Askins J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 18-24; 158; 642 AND 719.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
    Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.
    Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-197.
  8. "Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells."
    Agrez M.V., Shafren D.R., Gu X., Cox K., Sheppard D., Barry R.D.
    Virology 239:71-77(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COXSACKIEVIRUS B1 CAPSID PROTEINS.
  9. "The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus."
    Jackson T., Sheppard D., Denyer M., Blakemore W., King A.M.
    J. Virol. 74:4949-4956(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FMDV VP1.
  10. "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
    van Der Flier A., Kuikman I., Kramer D., Geerts D., Kreft M., Takafuta T., Shapiro S.S., Sonnenberg A.
    J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FLNB.
    Tissue: Keratinocyte and Skeletal muscle.
  11. "Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9."
    Williams C.H., Kajander T., Hyypia T., Jackson T., Sheppard D., Stanway G.
    J. Virol. 78:6967-6973(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COXSACKIEVIRUS A9 CAPSID PROTEINS.
  12. "Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins."
    Burman A., Clark S., Abrescia N.G., Fry E.E., Stuart D.I., Jackson T.
    J. Virol. 80:9798-9810(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FMDV VP1.
  13. "HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6."
    Ramsay A.G., Keppler M.D., Jazayeri M., Thomas G.J., Parsons M., Violette S., Weinreb P., Hart I.R., Marshall J.F.
    Cancer Res. 67:5275-5284(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HAX1, FUNCTION.

Entry informationi

Entry nameiITB6_HUMAN
AccessioniPrimary (citable) accession number: P18564
Secondary accession number(s): B2R9W5
, C9JA97, Q0VA95, Q16500, Q53RG5, Q53RR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3