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P18564

- ITB6_HUMAN

UniProt

P18564 - ITB6_HUMAN

Protein

Integrin beta-6

Gene

ITGB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.1 Publication

    GO - Molecular functioni

    1. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cell-matrix adhesion Source: InterPro
    3. extracellular matrix organization Source: Reactome
    4. inflammatory response Source: Ensembl
    5. integrin-mediated signaling pathway Source: UniProtKB-KW
    6. multicellular organismal development Source: InterPro
    7. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion, Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_13552. Integrin cell surface interactions.
    REACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    REACT_163906. ECM proteoglycans.
    SignaLinkiP18564.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin beta-6
    Gene namesi
    Name:ITGB6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6161. ITGB6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integrin complex Source: ProtInc
    3. plasma membrane Source: Reactome
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 788767Integrin beta-6PRO_0000016350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 454By similarity
    Disulfide bondi31 ↔ 41By similarity
    Disulfide bondi34 ↔ 70By similarity
    Disulfide bondi44 ↔ 59By similarity
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi197 ↔ 204By similarity
    Disulfide bondi252 ↔ 293By similarity
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi394 ↔ 406By similarity
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi426 ↔ 670By similarity
    Disulfide bondi452 ↔ 456By similarity
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi467 ↔ 479By similarity
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi476 ↔ 511By similarity
    Disulfide bondi481 ↔ 490By similarity
    Disulfide bondi492 ↔ 502By similarity
    Disulfide bondi517 ↔ 522By similarity
    Disulfide bondi519 ↔ 552By similarity
    Disulfide bondi524 ↔ 537By similarity
    Disulfide bondi539 ↔ 544By similarity
    Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi558 ↔ 563By similarity
    Disulfide bondi560 ↔ 591By similarity
    Disulfide bondi565 ↔ 574By similarity
    Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi576 ↔ 583By similarity
    Disulfide bondi597 ↔ 602By similarity
    Disulfide bondi599 ↔ 645By similarity
    Disulfide bondi604 ↔ 614By similarity
    Disulfide bondi617 ↔ 620By similarity
    Disulfide bondi624 ↔ 633By similarity
    Disulfide bondi630 ↔ 702By similarity
    Disulfide bondi649 ↔ 678By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP18564.
    PaxDbiP18564.
    PeptideAtlasiP18564.
    PRIDEiP18564.

    PTM databases

    PhosphoSiteiP18564.

    Expressioni

    Gene expression databases

    ArrayExpressiP18564.
    BgeeiP18564.
    CleanExiHS_ITGB6.
    GenevestigatoriP18564.

    Organism-specific databases

    HPAiHPA023626.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.6 Publications

    Protein-protein interaction databases

    BioGridi109900. 5 interactions.
    DIPiDIP-59187N.
    STRINGi9606.ENSP00000283249.

    Structurei

    Secondary structure

    1
    788
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi97 – 993
    Beta strandi103 – 1053
    Beta strandi109 – 1135
    Beta strandi118 – 1214
    Beta strandi124 – 1263
    Beta strandi133 – 1408
    Helixi143 – 1453
    Turni146 – 1527
    Helixi157 – 1648
    Beta strandi168 – 17710
    Helixi183 – 1853
    Helixi191 – 1933
    Beta strandi199 – 2013
    Beta strandi209 – 2113
    Beta strandi216 – 2183
    Helixi222 – 2287
    Beta strandi236 – 2405
    Helixi243 – 2519
    Helixi253 – 2564
    Beta strandi260 – 27213
    Helixi279 – 2813
    Turni282 – 2843
    Helixi302 – 3054
    Helixi312 – 32110
    Beta strandi326 – 3316
    Helixi332 – 3343
    Helixi335 – 34410
    Beta strandi349 – 3535
    Helixi358 – 3603
    Helixi361 – 37111
    Beta strandi377 – 3804
    Beta strandi384 – 3863
    Beta strandi414 – 4163
    Beta strandi419 – 4224
    Beta strandi431 – 4377
    Beta strandi444 – 4507
    Beta strandi487 – 4904
    Beta strandi492 – 4943
    Beta strandi505 – 5073
    Helixi510 – 5134
    Beta strandi515 – 5184
    Beta strandi521 – 5233
    Helixi542 – 5443

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LH9model-A76-546[»]
    ProteinModelPortaliP18564.
    SMRiP18564. Positions 23-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 709688ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini731 – 78858CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei710 – 73021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 371241VWFAAdd
    BLAST
    Repeati456 – 50146IAdd
    BLAST
    Repeati502 – 54342IIAdd
    BLAST
    Repeati544 – 58239IIIAdd
    BLAST
    Repeati583 – 61937IVAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni456 – 619164Cysteine-rich tandem repeatsAdd
    BLAST
    Regioni731 – 75828Interaction with HAX1Add
    BLAST

    Sequence similaritiesi

    Belongs to the integrin beta chain family.Curated
    Contains 1 VWFA domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145803.
    HOGENOMiHOG000252936.
    HOVERGENiHBG006190.
    InParanoidiP18564.
    KOiK06589.
    OMAiEYCNCTT.
    OrthoDBiEOG7T7GSB.
    PhylomeDBiP18564.
    TreeFamiTF105392.

    Family and domain databases

    Gene3Di1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProiIPR013111. EGF_extracell.
    IPR015812. Integrin_bsu.
    IPR015436. Integrin_bsu-6.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF11. PTHR10082:SF11. 1 hit.
    PfamiPF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002512. Integrin_B. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 1 hit.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P18564-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT    50
    HPSGVGERCD TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD 100
    IVQIAPQSLI LKLRPGGAQT LQVHVRQTED YPVDLYYLMD LSASMDDDLN 150
    TIKELGSRLS KEMSKLTSNF RLGFGSFVEK PVSPFVKTTP EEIANPCSSI 200
    PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE GGFDAIMQAA 250
    VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE 300
    YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV 350
    GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF 400
    QHQKKCSHMK VGDTASFSVT VNIPHCERRS RHIIIKPVGL GDALELLVSP 450
    ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA CHPGHMGPRC ECGEDMLSTD 500
    SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD NFSCVRHKGL 550
    LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG 600
    KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK 650
    LAGATISEEE DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK 700
    DCPKPPNIPM IMLGVSLAIL LIGVVLLCIW KLLVSFHDRK EVAKFEAERS 750
    KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ KVDLSTDC 788
    Length:788
    Mass (Da):85,936
    Last modified:April 27, 2001 - v2
    Checksum:iEDB7D533EC4C8C4D
    GO
    Isoform 2 (identifier: P18564-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         554-660: Missing.

    Note: No experimental confirmation available. Gene prediction confirmed by EST data.

    Show »
    Length:681
    Mass (Da):74,958
    Checksum:iB761664C333068BB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti437 – 4371P → T.
    Corresponds to variant rs2305820 [ dbSNP | Ensembl ].
    VAR_049636

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei554 – 660107Missing in isoform 2. CuratedVSP_055189Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35198 mRNA. Translation: AAA36122.2.
    AC092153 Genomic DNA. Translation: AAX93093.1.
    AK313944 mRNA. Translation: BAG36662.1.
    AC080166 Genomic DNA. Translation: AAY24053.1.
    CH471058 Genomic DNA. Translation: EAX11390.1.
    BC121178 mRNA. Translation: AAI21179.1.
    S49380 Genomic DNA. Translation: AAB23690.1.
    CCDSiCCDS2212.1. [P18564-1]
    CCDS63040.1. [P18564-2]
    PIRiA37057.
    RefSeqiNP_000879.2. NM_000888.4.
    NP_001269282.1. NM_001282353.1.
    NP_001269284.1. NM_001282355.1.
    NP_001269317.1. NM_001282388.1.
    UniGeneiHs.470399.

    Genome annotation databases

    EnsembliENST00000283249; ENSP00000283249; ENSG00000115221. [P18564-1]
    ENST00000409872; ENSP00000386367; ENSG00000115221. [P18564-1]
    ENST00000409967; ENSP00000386828; ENSG00000115221. [P18564-2]
    GeneIDi3694.
    KEGGihsa:3694.
    UCSCiuc002ubh.2. human. [P18564-1]

    Polymorphism databases

    DMDMi13432176.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35198 mRNA. Translation: AAA36122.2 .
    AC092153 Genomic DNA. Translation: AAX93093.1 .
    AK313944 mRNA. Translation: BAG36662.1 .
    AC080166 Genomic DNA. Translation: AAY24053.1 .
    CH471058 Genomic DNA. Translation: EAX11390.1 .
    BC121178 mRNA. Translation: AAI21179.1 .
    S49380 Genomic DNA. Translation: AAB23690.1 .
    CCDSi CCDS2212.1. [P18564-1 ]
    CCDS63040.1. [P18564-2 ]
    PIRi A37057.
    RefSeqi NP_000879.2. NM_000888.4.
    NP_001269282.1. NM_001282353.1.
    NP_001269284.1. NM_001282355.1.
    NP_001269317.1. NM_001282388.1.
    UniGenei Hs.470399.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LH9 model - A 76-546 [» ]
    ProteinModelPortali P18564.
    SMRi P18564. Positions 23-775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109900. 5 interactions.
    DIPi DIP-59187N.
    STRINGi 9606.ENSP00000283249.

    Chemistry

    BindingDBi P18564.
    ChEMBLi CHEMBL2111416.

    PTM databases

    PhosphoSitei P18564.

    Polymorphism databases

    DMDMi 13432176.

    Proteomic databases

    MaxQBi P18564.
    PaxDbi P18564.
    PeptideAtlasi P18564.
    PRIDEi P18564.

    Protocols and materials databases

    DNASUi 3694.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283249 ; ENSP00000283249 ; ENSG00000115221 . [P18564-1 ]
    ENST00000409872 ; ENSP00000386367 ; ENSG00000115221 . [P18564-1 ]
    ENST00000409967 ; ENSP00000386828 ; ENSG00000115221 . [P18564-2 ]
    GeneIDi 3694.
    KEGGi hsa:3694.
    UCSCi uc002ubh.2. human. [P18564-1 ]

    Organism-specific databases

    CTDi 3694.
    GeneCardsi GC02M160920.
    HGNCi HGNC:6161. ITGB6.
    HPAi HPA023626.
    MIMi 147558. gene.
    neXtProti NX_P18564.
    PharmGKBi PA29960.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145803.
    HOGENOMi HOG000252936.
    HOVERGENi HBG006190.
    InParanoidi P18564.
    KOi K06589.
    OMAi EYCNCTT.
    OrthoDBi EOG7T7GSB.
    PhylomeDBi P18564.
    TreeFami TF105392.

    Enzyme and pathway databases

    Reactomei REACT_13552. Integrin cell surface interactions.
    REACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    REACT_163906. ECM proteoglycans.
    SignaLinki P18564.

    Miscellaneous databases

    GeneWikii Integrin,_beta_6.
    GenomeRNAii 3694.
    NextBioi 14479.
    PROi P18564.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18564.
    Bgeei P18564.
    CleanExi HS_ITGB6.
    Genevestigatori P18564.

    Family and domain databases

    Gene3Di 1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProi IPR013111. EGF_extracell.
    IPR015812. Integrin_bsu.
    IPR015436. Integrin_bsu-6.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF11. PTHR10082:SF11. 1 hit.
    Pfami PF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002512. Integrin_B. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 1 hit.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction."
      Sheppard D., Rozzo C., Starr L., Quaranta V., Erle D.J., Pytela R.
      J. Biol. Chem. 265:11502-11507(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    2. Askins J.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 18-24; 158; 642 AND 719.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
      Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.
      Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-197.
    8. "Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells."
      Agrez M.V., Shafren D.R., Gu X., Cox K., Sheppard D., Barry R.D.
      Virology 239:71-77(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH COXSACKIEVIRUS B1 CAPSID PROTEINS.
    9. "The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus."
      Jackson T., Sheppard D., Denyer M., Blakemore W., King A.M.
      J. Virol. 74:4949-4956(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FMDV VP1.
    10. "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
      van Der Flier A., Kuikman I., Kramer D., Geerts D., Kreft M., Takafuta T., Shapiro S.S., Sonnenberg A.
      J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FLNB.
      Tissue: Keratinocyte and Skeletal muscle.
    11. "Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9."
      Williams C.H., Kajander T., Hyypia T., Jackson T., Sheppard D., Stanway G.
      J. Virol. 78:6967-6973(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH COXSACKIEVIRUS A9 CAPSID PROTEINS.
    12. "Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins."
      Burman A., Clark S., Abrescia N.G., Fry E.E., Stuart D.I., Jackson T.
      J. Virol. 80:9798-9810(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FMDV VP1.
    13. "HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6."
      Ramsay A.G., Keppler M.D., Jazayeri M., Thomas G.J., Parsons M., Violette S., Weinreb P., Hart I.R., Marshall J.F.
      Cancer Res. 67:5275-5284(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HAX1, FUNCTION.

    Entry informationi

    Entry nameiITB6_HUMAN
    AccessioniPrimary (citable) accession number: P18564
    Secondary accession number(s): B2R9W5
    , C9JA97, Q0VA95, Q16500, Q53RG5, Q53RR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3