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Protein

Integrin beta-6

Gene

ITGB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).2 Publications
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 (PubMed:9426447, PubMed:15194773). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex virus-1/HHV-1 (PubMed:24367260).3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell adhesion mediated by integrin Source: UniProtKB
  • cell-matrix adhesion Source: InterPro
  • extracellular matrix organization Source: Reactome
  • inflammatory response Source: Ensembl
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115221-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2129379. Molecules associated with elastic fibres.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
SignaLinkiP18564.
SIGNORiP18564.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-6
Gene namesi
Name:ITGB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6161. ITGB6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 709ExtracellularSequence analysisAdd BLAST688
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 788CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • integrin complex Source: ProtInc
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Involvement in diseasei

Amelogenesis imperfecta 1H (AI1H)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored.
See also OMIM:616221
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073328143A → T in AI1H. 1 PublicationCorresponds to variant rs140015315dbSNPEnsembl.1
Natural variantiVAR_073329196P → T in AI1H. 1 PublicationCorresponds to variant rs730880298dbSNPEnsembl.1
Natural variantiVAR_073330275H → Q in AI1H. 1 PublicationCorresponds to variant rs730882118dbSNPEnsembl.1

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation

Organism-specific databases

DisGeNETi3694.
MalaCardsiITGB6.
MIMi616221. phenotype.
OpenTargetsiENSG00000115221.
Orphaneti100032. Hypocalcified amelogenesis imperfecta.
100031. Hypoplastic amelogenesis imperfecta.
PharmGKBiPA29960.

Chemistry databases

ChEMBLiCHEMBL2111416.

Polymorphism and mutation databases

DMDMi13432176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001635022 – 788Integrin beta-6Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 454By similarity
Disulfide bondi31 ↔ 41By similarity
Disulfide bondi34 ↔ 70By similarity
Disulfide bondi44 ↔ 59By similarity
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi197 ↔ 204By similarity
Disulfide bondi252 ↔ 293By similarity
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi394 ↔ 406By similarity
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi426 ↔ 670By similarity
Disulfide bondi452 ↔ 456By similarity
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi467 ↔ 479By similarity
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi476 ↔ 511By similarity
Disulfide bondi481 ↔ 490By similarity
Disulfide bondi492 ↔ 502By similarity
Disulfide bondi517 ↔ 522By similarity
Disulfide bondi519 ↔ 552By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi539 ↔ 544By similarity
Glycosylationi541N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi560 ↔ 591By similarity
Disulfide bondi565 ↔ 574By similarity
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi576 ↔ 583By similarity
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 645By similarity
Disulfide bondi604 ↔ 614By similarity
Disulfide bondi617 ↔ 620By similarity
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi630 ↔ 702By similarity
Disulfide bondi649 ↔ 678By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18564.
MaxQBiP18564.
PaxDbiP18564.
PeptideAtlasiP18564.
PRIDEiP18564.

PTM databases

iPTMnetiP18564.
PhosphoSitePlusiP18564.

Expressioni

Gene expression databases

BgeeiENSG00000115221.
CleanExiHS_ITGB6.
ExpressionAtlasiP18564. baseline and differential.
GenevisibleiP18564. HS.

Organism-specific databases

HPAiCAB073536.
HPA023626.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881).3 Publications
(Microbial infection) Integrin ITGAV:ITGB6 interacts with coxsackievirus A9, coxsackievirus B1 capsid proteins (PubMed:9426447, PubMed:15194773).2 Publications
(Microbial infection) Integrin ITGAV:ITGB6 interacts with herpes simplex virus-1/HHV-1 gH:gL proteins.1 Publication

Protein-protein interaction databases

BioGridi109900. 5 interactors.
DIPiDIP-59187N.
STRINGi9606.ENSP00000283249.

Chemistry databases

BindingDBiP18564.

Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 26Combined sources3
Helixi31 – 34Combined sources4
Beta strandi42 – 44Combined sources3
Helixi62 – 68Combined sources7
Turni72 – 74Combined sources3
Beta strandi81 – 86Combined sources6
Helixi98 – 100Combined sources3
Beta strandi108 – 113Combined sources6
Beta strandi119 – 126Combined sources8
Beta strandi133 – 140Combined sources8
Helixi143 – 145Combined sources3
Helixi146 – 151Combined sources6
Helixi152 – 154Combined sources3
Helixi155 – 166Combined sources12
Beta strandi170 – 177Combined sources8
Turni183 – 185Combined sources3
Helixi190 – 194Combined sources5
Turni196 – 201Combined sources6
Beta strandi209 – 218Combined sources10
Helixi220 – 228Combined sources9
Beta strandi236 – 241Combined sources6
Helixi242 – 251Combined sources10
Helixi253 – 256Combined sources4
Beta strandi262 – 272Combined sources11
Helixi277 – 283Combined sources7
Beta strandi299 – 301Combined sources3
Turni302 – 306Combined sources5
Helixi312 – 321Combined sources10
Beta strandi324 – 330Combined sources7
Helixi332 – 342Combined sources11
Beta strandi349 – 352Combined sources4
Helixi360 – 371Combined sources12
Beta strandi375 – 382Combined sources8
Beta strandi387 – 393Combined sources7
Turni395 – 397Combined sources3
Beta strandi399 – 401Combined sources3
Beta strandi414 – 422Combined sources9
Beta strandi431 – 437Combined sources7
Beta strandi444 – 450Combined sources7
Helixi455 – 457Combined sources3
Beta strandi467 – 475Combined sources9
Beta strandi478 – 481Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LH9model-A76-546[»]
4UM8X-ray2.85B/D1-788[»]
4UM9X-ray2.50B/D18-491[»]
ProteinModelPortaliP18564.
SMRiP18564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 371VWFAAdd BLAST241
Repeati456 – 501IAdd BLAST46
Repeati502 – 543IIAdd BLAST42
Repeati544 – 582IIIAdd BLAST39
Repeati583 – 619IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni456 – 619Cysteine-rich tandem repeatsAdd BLAST164
Regioni731 – 758Interaction with HAX11 PublicationAdd BLAST28

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP18564.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG091G029W.
PhylomeDBiP18564.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18564-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT
60 70 80 90 100
HPSGVGERCD TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD
110 120 130 140 150
IVQIAPQSLI LKLRPGGAQT LQVHVRQTED YPVDLYYLMD LSASMDDDLN
160 170 180 190 200
TIKELGSRLS KEMSKLTSNF RLGFGSFVEK PVSPFVKTTP EEIANPCSSI
210 220 230 240 250
PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE GGFDAIMQAA
260 270 280 290 300
VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE
310 320 330 340 350
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV
360 370 380 390 400
GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF
410 420 430 440 450
QHQKKCSHMK VGDTASFSVT VNIPHCERRS RHIIIKPVGL GDALELLVSP
460 470 480 490 500
ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA CHPGHMGPRC ECGEDMLSTD
510 520 530 540 550
SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD NFSCVRHKGL
560 570 580 590 600
LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG
610 620 630 640 650
KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK
660 670 680 690 700
LAGATISEEE DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK
710 720 730 740 750
DCPKPPNIPM IMLGVSLAIL LIGVVLLCIW KLLVSFHDRK EVAKFEAERS
760 770 780
KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ KVDLSTDC
Length:788
Mass (Da):85,936
Last modified:April 27, 2001 - v2
Checksum:iEDB7D533EC4C8C4D
GO
Isoform 2 (identifier: P18564-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     554-660: Missing.

Note: No experimental confirmation available. Gene prediction confirmed by EST data.
Show »
Length:681
Mass (Da):74,958
Checksum:iB761664C333068BB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073328143A → T in AI1H. 1 PublicationCorresponds to variant rs140015315dbSNPEnsembl.1
Natural variantiVAR_073329196P → T in AI1H. 1 PublicationCorresponds to variant rs730880298dbSNPEnsembl.1
Natural variantiVAR_073330275H → Q in AI1H. 1 PublicationCorresponds to variant rs730882118dbSNPEnsembl.1
Natural variantiVAR_049636437P → T.Corresponds to variant rs2305820dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055189554 – 660Missing in isoform 2. CuratedAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35198 mRNA. Translation: AAA36122.2.
AC092153 Genomic DNA. Translation: AAX93093.1.
AK313944 mRNA. Translation: BAG36662.1.
AC080166 Genomic DNA. Translation: AAY24053.1.
CH471058 Genomic DNA. Translation: EAX11390.1.
BC121178 mRNA. Translation: AAI21179.1.
S49380 Genomic DNA. Translation: AAB23690.1.
CCDSiCCDS2212.1. [P18564-1]
CCDS63040.1. [P18564-2]
PIRiA37057.
RefSeqiNP_000879.2. NM_000888.4. [P18564-1]
NP_001269282.1. NM_001282353.1. [P18564-1]
NP_001269284.1. NM_001282355.1. [P18564-2]
NP_001269317.1. NM_001282388.1.
UniGeneiHs.470399.

Genome annotation databases

EnsembliENST00000283249; ENSP00000283249; ENSG00000115221. [P18564-1]
ENST00000409872; ENSP00000386367; ENSG00000115221. [P18564-1]
ENST00000409967; ENSP00000386828; ENSG00000115221. [P18564-2]
GeneIDi3694.
KEGGihsa:3694.
UCSCiuc010fou.4. human. [P18564-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35198 mRNA. Translation: AAA36122.2.
AC092153 Genomic DNA. Translation: AAX93093.1.
AK313944 mRNA. Translation: BAG36662.1.
AC080166 Genomic DNA. Translation: AAY24053.1.
CH471058 Genomic DNA. Translation: EAX11390.1.
BC121178 mRNA. Translation: AAI21179.1.
S49380 Genomic DNA. Translation: AAB23690.1.
CCDSiCCDS2212.1. [P18564-1]
CCDS63040.1. [P18564-2]
PIRiA37057.
RefSeqiNP_000879.2. NM_000888.4. [P18564-1]
NP_001269282.1. NM_001282353.1. [P18564-1]
NP_001269284.1. NM_001282355.1. [P18564-2]
NP_001269317.1. NM_001282388.1.
UniGeneiHs.470399.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LH9model-A76-546[»]
4UM8X-ray2.85B/D1-788[»]
4UM9X-ray2.50B/D18-491[»]
ProteinModelPortaliP18564.
SMRiP18564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109900. 5 interactors.
DIPiDIP-59187N.
STRINGi9606.ENSP00000283249.

Chemistry databases

BindingDBiP18564.
ChEMBLiCHEMBL2111416.

PTM databases

iPTMnetiP18564.
PhosphoSitePlusiP18564.

Polymorphism and mutation databases

DMDMi13432176.

Proteomic databases

EPDiP18564.
MaxQBiP18564.
PaxDbiP18564.
PeptideAtlasiP18564.
PRIDEiP18564.

Protocols and materials databases

DNASUi3694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283249; ENSP00000283249; ENSG00000115221. [P18564-1]
ENST00000409872; ENSP00000386367; ENSG00000115221. [P18564-1]
ENST00000409967; ENSP00000386828; ENSG00000115221. [P18564-2]
GeneIDi3694.
KEGGihsa:3694.
UCSCiuc010fou.4. human. [P18564-1]

Organism-specific databases

CTDi3694.
DisGeNETi3694.
GeneCardsiITGB6.
HGNCiHGNC:6161. ITGB6.
HPAiCAB073536.
HPA023626.
MalaCardsiITGB6.
MIMi147558. gene.
616221. phenotype.
neXtProtiNX_P18564.
OpenTargetsiENSG00000115221.
Orphaneti100032. Hypocalcified amelogenesis imperfecta.
100031. Hypoplastic amelogenesis imperfecta.
PharmGKBiPA29960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP18564.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG091G029W.
PhylomeDBiP18564.
TreeFamiTF105392.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115221-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2129379. Molecules associated with elastic fibres.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
SignaLinkiP18564.
SIGNORiP18564.

Miscellaneous databases

GeneWikiiIntegrin,_beta_6.
GenomeRNAii3694.
PROiP18564.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115221.
CleanExiHS_ITGB6.
ExpressionAtlasiP18564. baseline and differential.
GenevisibleiP18564. HS.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITB6_HUMAN
AccessioniPrimary (citable) accession number: P18564
Secondary accession number(s): B2R9W5
, C9JA97, Q0VA95, Q16500, Q53RG5, Q53RR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.