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Protein

HTH-type transcriptional regulator SyrM

Gene

syrM

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts in trans to stimulate nod gene expression via nodD3 and exo gene expression via SyrA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi49 – 6820H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Nodulation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator SyrM
Alternative name(s):
Symbiotic regulator
Gene namesi
Name:syrM
Ordered Locus Names:RA0462
ORF Names:SMa0849
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326HTH-type transcriptional regulator SyrMPRO_0000105753Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP18561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 8958HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000103695.
OMAiYLMASQV.
OrthoDBiEOG6PZX9W.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPTWKRPH RAKFAGVSDA AQQRQMPNLA SIDLNLLVDL EALLQYRHIT
60 70 80 90 100
QAAQHVGRSQ PAMSRALSRL RGMLKDDLLV AGSRGLVLTP LAECLTQMLP
110 120 130 140 150
SVLDAIRQMM NLSLAPAQRR WKVTMAMPDH QAVVLLPHLL PRLHERAPHL
160 170 180 190 200
DIVTDPLLGG ALGLLEQGEI DVVVGQMGAA PLGYLRRRLY ADSFTCVLRH
210 220 230 240 250
NHPALAQEWT IEAFAALRHV AIASEPDELF GQIYDRLTKL GLQRGDPMVV
260 270 280 290 300
STVLTAAVLI AATDSVLVVP SRVATRVAAM LSLAVIPPPV ELRPYEVALI
310 320
WHERCHRDPE HRWLRGEIAA AASTAG
Length:326
Mass (Da):35,897
Last modified:November 1, 1990 - v1
Checksum:i412F888B1F1FF6C1
GO

Sequence cautioni

The sequence CAA43667.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 2416PHRAK…AAQQR → RIGPNLPVSVTPHNK (PubMed:1809842).CuratedAdd
BLAST
Sequence conflicti227 – 2271D → G in CAA43667 (PubMed:1809842).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33495 Genomic DNA. Translation: AAB38371.1.
X61396 Genomic DNA. Translation: CAA43667.1. Different initiation.
AE006469 Genomic DNA. Translation: AAK65120.1.
PIRiA44505.
F95319.
S18575.
RefSeqiNP_435708.1. NC_003037.1.
WP_010967445.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65120; AAK65120; SMa0849.
GeneIDi1235498.
KEGGisme:SMa0849.
PATRICi23627388. VBISinMel96828_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33495 Genomic DNA. Translation: AAB38371.1.
X61396 Genomic DNA. Translation: CAA43667.1. Different initiation.
AE006469 Genomic DNA. Translation: AAK65120.1.
PIRiA44505.
F95319.
S18575.
RefSeqiNP_435708.1. NC_003037.1.
WP_010967445.1. NC_003037.1.

3D structure databases

ProteinModelPortaliP18561.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65120; AAK65120; SMa0849.
GeneIDi1235498.
KEGGisme:SMa0849.
PATRICi23627388. VBISinMel96828_0473.

Phylogenomic databases

HOGENOMiHOG000103695.
OMAiYLMASQV.
OrthoDBiEOG6PZX9W.

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5470-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and translational product of a new nodulation-regulatory locus: syrM has sequence similarity to NodD proteins."
    Barnett M.J., Long S.R.
    J. Bacteriol. 172:3695-3700(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47.
  2. "Involvement of the syrM and nodD3 genes of Rhizobium meliloti in nod gene activation and in optimal nodulation of the plant host."
    Kondorosi E., Buire M., Cren M., Iyer N., Hoffmann B., Kondorosi A.
    Mol. Microbiol. 5:3035-3048(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AK631.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiSYRM_RHIME
AccessioniPrimary (citable) accession number: P18561
Secondary accession number(s): Q53001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 9, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Has two translation start codons in proximity to each other leading to a protein of 326 or 301 AA.

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.